13. Multiple sclerosis/Neuromyelitis optica Clinical trials / Disease details
Clinical trials : 3,342 / Drugs : 2,355 - (DrugBank : 406) / Drug target genes : 269 - Drug target pathways : 241
Showing 1 to 10 of 3,342 diseases
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04880577 (ClinicalTrials.gov) | September 15, 2022 | 30/4/2021 | Tenofovir Alafenamide for Treatment of Symptoms and Neuroprotection in Relapsing Remitting Multiple Sclerosis Tenofovir Alafenamide for Treatment of Symptoms and Neuroprotection in Relapsing Remitting Multiple ... | Tenofovir Alafenamide for Treatment of Symptoms and Neuroprotection in Relapsing Remitting Multiple Sclerosis Tenofovir Alafenamide for Treatment of Symptoms and Neuroprotection in Relapsing Remitting Multiple ... | Multiple Sclerosis, Relapsing-Remitting;Fatigue | Drug: TENOFOVIR ALAFENAMIDE FUMARATE 25 Mg ORAL TABLET [VEMLIDY];Drug: Placebo | Harvard Medical School | Gilead Sciences | Not yet recruiting | 18 Years | N/A | All | 60 | Phase 2 | NULL |
| 2 | NCT05266469 (ClinicalTrials.gov) | May 1, 2022 | 23/2/2022 | Exploring the Profiles of RMS Patients on Ofatumumab or Ocrelizumab in a Real-World Setting in the Gulf Exploring the Profiles of RMS Patients on Ofatumumab or Ocrelizumab in a Real-World Setting in the G ... | Exploring the Characteristics and Profiles of Relapsing Multiple Sclerosis Patients Initiated on Ofatumumab or Ocrelizumab in a Real-World Setting in the Gulf Region Exploring the Characteristics and Profiles of Relapsing Multiple SclerosisPatients Initiated on Ofat ... | Relapsing Multiple Sclerosis | Other: Ofatumumab;Other: Ocrelizumab | Novartis Pharmaceuticals | NULL | Not yet recruiting | 18 Years | 100 Years | All | 240 | NULL | |
| 3 | NCT05285891 (ClinicalTrials.gov) | April 30, 2022 | 8/3/2022 | Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis | Randomized, Blinded Discontinuation Trial of Ocrelizumab in Early Relapsing Multiple Sclerosis (AMS05) Randomized, Blinded Discontinuation Trial of Ocrelizumab in Early Relapsing Multiple Sclerosis(AMS05 ... | Multiple Sclerosis | Biological: Ocrelizumab;Drug: Placebo for Ocrelizumab | National Institute of Allergy and Infectious Diseases (NIAID) | Autoimmunity Centers of Excellence (ACE) | Not yet recruiting | 18 Years | 55 Years | All | 175 | Phase 4 | NULL |
| 4 | NCT05090033 (ClinicalTrials.gov) | April 30, 2022 | 22/9/2021 | Characterizing the Use of Ofatumumab in a Real World Setting | Secondary Use of Data Study Characterizing Kesimpta (Ofatumumab) Onboarding and Utilization in RMS Patients Using MSGo, With a Non-interventional Primary Use of Data Sub-study Comparing Patient Reported Outcomes Relative to Clinical Outcomes (EAFToS) Secondary Use of Data Study Characterizing Kesimpta (Ofatumumab) Onboarding and Utilization in RMS P ... | Relapsing Multiple Sclerosis | Other: ofatumumab | Novartis Pharmaceuticals | NULL | Not yet recruiting | 18 Years | N/A | All | 3500 | NULL | |
| 5 | NCT05284175 (ClinicalTrials.gov) | April 2022 | 9/3/2022 | A Study of Orelabrutinib in Patients With AQP4-IgG Positive Neuromyelitis Optica Spectrum Disorder | A Prospective, Self-controlled Study to Explore Efficacy and Safety of Orelabrutinib in AQP4-IgG Positive Neuromyelitis Optica Spectrum Disorder A Prospective, Self-controlled Study to Explore Efficacy and Safety of Orelabrutinib in AQP4-IgG Pos ... | Neuromyelitis Optica Spectrum Disorder | Drug: Orelabrutinib | Peking Union Medical College Hospital | Beijing InnoCare Pharma Tech Co., Ltd.;GCP ClinPlus Co., Ltd. | Not yet recruiting | 18 Years | 75 Years | All | 23 | N/A | China |
| 6 | NCT05232825 (ClinicalTrials.gov) | March 31, 2022 | 27/1/2022 | A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investiga ... | A Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis A Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical ... | Relapsing Multiple Sclerosis;Primary Progressive Multiple Sclerosis | Drug: Ocrelizumab IV;Drug: Ocrelizumab SC;Drug: Methylprednisolone IV;Drug: Diphenhydramine IV;Drug: Dexamethasone given orally;Drug: Desloratadine given orally Drug: OcrelizumabIV;Drug: OcrelizumabSC;Drug: MethylprednisoloneIV;Drug: DiphenhydramineIV;Drug: Dex ... | Hoffmann-La Roche | NULL | Not yet recruiting | 18 Years | 65 Years | All | 232 | Phase 3 | United States;Brazil;Canada;Czechia;Italy;Poland;Russian Federation;Spain;Turkey;Ukraine |
| 7 | NCT04998812 (ClinicalTrials.gov) | March 31, 2022 | 6/8/2021 | A Study Evaluating B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancy | A Phase IV Multicenter, Open-Label Study Evaluating B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancy A Phase IV Multicenter, Open-Label Study Evaluating B Cell Levels In Infants Potentially Exposed To ... | Multiple Sclerosis;Clinically Isolated Syndrome | Drug: Ocrelizumab | Hoffmann-La Roche | PPD;LabCorp;Illingworth | Recruiting | 18 Years | 40 Years | Female | 44 | Phase 4 | United States;France;Spain;United Kingdom;Canada;Germany;Italy;Switzerland |
| 8 | NCT05285904 (ClinicalTrials.gov) | March 30, 2022 | 8/3/2022 | Kesimpta® (Ofatumumab) in Swiss Multiple Sclerosis Patients - an Observational Study | Kesimpta® (Ofatumumab) in Swiss Multiple Sclerosis Patients - an Observational Study (KOSMOS) | Multiple Sclerosis | Other: Ofatumumab | Novartis Pharmaceuticals | NULL | Not yet recruiting | 18 Years | 99 Years | All | 149 | NULL | |
| 9 | NCT05265728 (ClinicalTrials.gov) | March 25, 2022 | 23/2/2022 | A Study to Evaluate Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of Natalizumab (BG00002) Administered Subcutaneously to Japanese Participants With Relapsing-Remitting Multiple Sclerosis A Study to Evaluate Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of Na ... | A Single-Arm, Open-Label, Phase 3 Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of Natalizumab (BG00002) Administered to Japanese Participants With Relapsing-Remitting Multiple Sclerosis Via a Subcutaneous Route of Administration A Single-Arm, Open-Label, Phase 3 Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Phar ... | Multiple Sclerosis, Relapsing-Remitting | Drug: Natalizumab | Biogen | NULL | Not yet recruiting | 18 Years | 65 Years | All | 20 | Phase 3 | NULL |
| 10 | NCT05062083 (ClinicalTrials.gov) | March 24, 2022 | 29/9/2021 | PET Imaging of Cyclooxygenase-2 in Multiple Sclerosis | PET Imaging of Cyclooxygenase-2 in Multiple Sclerosis | Multiple Sclerosis | Drug: 11C-MCI | National Institute of Mental Health (NIMH) | University of Maryland | Recruiting | 18 Years | 80 Years | All | 16 | Phase 2 | United States |