13. Multiple sclerosis/Neuromyelitis optica Clinical trials / Disease details
Clinical trials : 3,342 / Drugs : 2,355 - (DrugBank : 406) / Drug target genes : 269 - Drug target pathways : 241
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04510220 (ClinicalTrials.gov) | September 21, 2020 | 31/7/2020 | 9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis | Open-label, Observational, Prospective, 9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis | Relapsing Multiple Sclerosis | Drug: Ofatumumab;Drug: [F-18]PBR06 | Brigham and Women's Hospital | Novartis | Recruiting | 18 Years | 60 Years | All | 10 | Phase 3 | United States |
| 2 | NCT04144257 (ClinicalTrials.gov) | March 12, 2020 | 28/10/2019 | Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue | Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue | Multiple Sclerosis | Drug: [F-18]PBR06;Drug: [C-11]Methylreboxetine | Brigham and Women's Hospital | U.S. Army Medical Research Acquisition Activity | Recruiting | 18 Years | 60 Years | All | 12 | Phase 1/Phase 2 | United States |
| 3 | NCT03983252 (ClinicalTrials.gov) | July 2019 | 31/5/2019 | Effect of Alemtuzumab on Microglial Activation Positron Emission Tomography (PET) in Multiple Sclerosis | Effect of Alemtuzumab on Microglial Activation Assessed Using Novel [F-18]-Based Positron Emission Tomography (PET) Ligand in Multiple Sclerosis | Multiple Sclerosis | Drug: [F-18]PBR06 | Brigham and Women's Hospital | Genzyme, a Sanofi Company | Not yet recruiting | 18 Years | 60 Years | All | 10 | Phase 1/Phase 2 | United States |
| 4 | NCT02649985 (ClinicalTrials.gov) | May 2, 2016 | 6/1/2016 | Microglial Activation Positron Emission Tomography (PET) Brain Imaging in Multiple Sclerosis and Alzheimer's Disease | Microglial Activation Positron Emission Tomography (PET) Brain Imaging in Multiple Sclerosis and Alzheimer's Disease | Multiple Sclerosis;Alzheimer's Disease | Drug: [F-18]PBR06;Drug: [C-11]PBR28 | Brigham and Women's Hospital | NULL | Recruiting | 18 Years | 85 Years | All | 105 | Phase 1/Phase 2 | United States |