17. Multiple system atrophy Clinical trials / Disease details

Clinical trials : 118 / Drugs : 163 - (DrugBank : 49) / Drug target genes : 61 - Drug target pathways : 112

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04680065 (ClinicalTrials.gov)	April 2022	15/12/2020	GDNF Gene Therapy for Multiple System Atrophy	Randomized, Double-Blind, Placebo-controlled Safety Study of Glial Cell Line-Derived Neurotrophic Fa ...	Multiple System Atrophy	Biological: AAV2-GDNF gene therapy;Procedure: Sham (Placebo) Surgery	Brain Neurotherapy Bio, Inc.	NULL	Not yet recruiting	35 Years	75 Years	All	9	Phase 1	United States
2	NCT05109091 (ClinicalTrials.gov)	January 2022	22/10/2021	Study of ATH434 in Participants With Multiple System Atrophy	A Randomized, Double-Blind, Placebo-Controlled Study of ATH434 in Multiple System Atrophy	Multiple System Atrophy	Drug: ATH434 dose level 1;Drug: ATH434 dose level 2;Drug: Placebo	Alterity Therapeutics	NULL	Not yet recruiting	30 Years	78 Years	All	60	Phase 2	NULL
3	NCT05167721 (ClinicalTrials.gov)	December 15, 2021	30/11/2021	Randomized Double-Blind Placebo-Controlled Adaptive Design Trial Of Intrathecally Administered Autol ...	Randomized Double-Blind Placebo-Controlled Adaptive Design Trial Of Intrathecally Administered Autol ...	Multiple System Atrophy	Biological: Autologous Mesenchymal Stem Cells;Other: Placebo	Mayo Clinic	NULL	Recruiting	30 Years	70 Years	All	76	Phase 2	United States
4	NCT03446807 (ClinicalTrials.gov)	December 2021	20/2/2018	Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism	Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism	Parkinson Disease;Multiple System Atrophy;Progressive Supranuclear Palsy	Drug: Droxidopa;Drug: Placebo Oral Tablet	Loma Linda University	H. Lundbeck A/S	Not yet recruiting	50 Years	N/A	All	32	Phase 2	United States
5	NCT05104476 (ClinicalTrials.gov)	November 16, 2021	15/10/2021	A Study of Lu AF82422 in Participants With Multiple System Atrophy	Interventional, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Assess the Eff ...	Multiple System Atrophy	Drug: Lu AF82422;Drug: Placebo	H. Lundbeck A/S	NULL	Recruiting	40 Years	75 Years	All	60	Phase 2	United States;Japan
6	NCT04468919 (ClinicalTrials.gov)	July 1, 2021	8/7/2020	Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit	Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit	Amyotrophic Lateral Sclerosis;Brainstem Stroke;Muscular Dystrophies;Parkinson's Disease and Parkinso ...	Behavioral: BCI-FIT multi-modal access;Behavioral: BCI-FIT adaptive signal modeling;Behavioral: BCI- ...	Oregon Health and Science University	NULL	Not yet recruiting	18 Years	75 Years	All	60	N/A	United States
7	ChiCTR2100046394	2021-06-01	2021-05-15	Research of Pelvic Floor Electrical Stimulation for Defecation and Urination Dysfunction in Patients ...	Research of Pelvic Floor Electrical Stimulation for Defecation and Urination Dysfunction in Patients ...	multiple system atrophy	Experimental group:Drug (tolterodine) combined with electrical stimulation;	Xuanwu Hospital, Capital Medical University	NULL	Recruiting	30	75	Both	Experimental group:50;	N/A	China
8	NCT04782830 (ClinicalTrials.gov)	February 5, 2021	1/3/2021	Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms	Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms	Orthostatic; Hypotension, Neurogenic;Autonomic Failure;Pure Autonomic Failure;Multiple System Atroph ...	Device: Accelerometer;Drug: placebo pill;Drug: Midodrine or atomoxetine pill	Vanderbilt University Medical Center	NULL	Recruiting	40 Years	80 Years	All	29	N/A	United States
9	NCT04616456 (ClinicalTrials.gov)	December 30, 2020	26/10/2020	Effect of Verdiperstat on Microglial Activation in Well-characterized MSA Patients	Effect of Verdiperstat on Microglial Activation in Well-characterized MSA Patients	Multiple System Atrophy;Multiple System Atrophy, Cerebellar Variant;Multiple System Atrophy, Parkins ...	Drug: [F-18]PBR06;Drug: Verdiperstat	Brigham and Women's Hospital	Biohaven Pharmaceuticals, Inc.	Active, not recruiting	18 Years	N/A	All	25	Early Phase 1	United States
10	NCT04620382 (ClinicalTrials.gov)	November 9, 2020	27/10/2020	Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Pat ...	Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Pat ...	Neurogenic Orthostatic Hypotension;Autonomic Failure;Pure Autonomic Failure;Multiple System Atrophy; ...	Drug: Midodrine;Drug: Placebo pill;Device: Abdominal compression;Device: sham compression	Vanderbilt University Medical Center	National Heart, Lung, and Blood Institute (NHLBI)	Recruiting	40 Years	80 Years	All	31	Early Phase 1	United States

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