2. Amyotrophic lateral sclerosis Clinical trials / Disease details

Clinical trials : 624 / Drugs : 611 - (DrugBank : 160) / Drug target genes : 172 - Drug target pathways : 225

8 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03280056 (ClinicalTrials.gov)	August 28, 2017	29/8/2017	Safety and Efficacy of Repeated Administrations of NurOwn® in ALS Patients	A Phase 3, Randomized Double-Blind, Placebo-Controlled Multicenter Study to Evaluate Efficacy and Sa ...	Amyotrophic Lateral Sclerosis (ALS)	Biological: NurOwn® (MSC-NTF cells);Other: Placebo;Other: Bone Marrow aspiration	Brainstorm-Cell Therapeutics	California Institute for Regenerative Medicine (CIRM)	Completed	18 Years	60 Years	All	263	Phase 3	United States
2	NCT04821479 (ClinicalTrials.gov)	January 1, 2016	19/10/2020	Repeated Mesenchymal Stem Cell Injections in ALS	Safety and Clinical Effects of Repeated Intrathecal Injections of Autologous Mesenchymal Stem Cellsi ...	Amyotrophic Lateral Sclerosis	Biological: Mesenchymal stem cells (MSC)	Hadassah Medical Organization	NULL	Completed	18 Years	65 Years	All	20	Phase 1/Phase 2	NULL
3	NCT02987413 (ClinicalTrials.gov)	April 28, 2015	1/7/2016	Escalated Application of Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis Patients	Safety and Efficacy of Mesenchymal Stem Cells Escalated Application in Amyotrophic Lateral Sclerosis ...	Motor Neuron Disease	Biological: Autologous Mesenchymal stem cells (MSCs)	Hospital e Maternidade Dr. Christóvão da Gama	IEP São Lucas - Instituto de Ensino e Pesquisa;Clinica Jordy Sinapse;TECHLIFE - Centro de Tecnologia ...	Completed	18 Years	N/A	All	3	Phase 1	Brazil
4	NCT02017912 (ClinicalTrials.gov)	May 2014	17/12/2013	Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study of Autologous MSC-NTF Cells ...	A Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study to Evaluate Safety and Eff ...	Amyotrophic Lateral Sclerosis (ALS)	Biological: Autologous MSC-NTF cells;Biological: Placebo	Brainstorm-Cell Therapeutics	NULL	Completed	18 Years	75 Years	All	48	Phase 2	United States
5	EUCTR2011-006254-85-ES (EUCTR)	08/02/2013	09/08/2012	Clinical trial to value the safety and efficacy of administration of stem cells derived from own pat ...	Placebo controlled, randomized and triple blind multicentric phase I/II clinical trial to evaluate t ...	Amyotrophic lateral sclerosis (ALS) MedDRA version: 14.1;Level: PT;Classification code 10002026;Term ...	Product Name: Células madre mesenquimales de tejido adiposo autólogo INN or Proposed INN: NA Other des ...	FUNDACIÓN PROGRESO Y SALUD	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes		Phase 1/2	Spain
6	NCT01609283 (ClinicalTrials.gov)	May 2012	18/5/2012	A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotroph ...	A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotroph ...	Amyotrophic Lateral Sclerosis	Biological: autologous mesenchymal stem cells	Mayo Clinic	NULL	Completed	18 Years	N/A	All	27	Phase 1	United States
7	EUCTR2011-000362-35-CZ (EUCTR)	29/03/2012	05/04/2011	Safety and Efficacy of Stem Cell Therapy of Motor Neuron Disease.	A Prospective, Non-randomized, Open Label Study to Assess the Safety and the Efficacy of Autologous ...	Amyotrophic lateral sclerosis MedDRA version: 17.0;Level: PT;Classification code 10002026;Term: Amyo ...	Product Name: Suspension of human autologous MSC 3P in 1,5 ml Product Code: AMSC INN or Proposed INN: ...	Bioinova, s.r.o.	NULL	Not Recruiting			Female: yes Male: yes	30	Phase 2	Czech Republic
8	NCT01142856 (ClinicalTrials.gov)	June 2010	10/6/2010	Mesenchymal Stem Cells for Treatment of Amyotrophic Lateral Sclerosis (ALS)	A Single Patient Treatment Protocol for Autologous Mesenchymal Stem Cell Intraspinal Therapy in Amyo ...	Amyotrophic Lateral Sclerosis	Biological: autologous mesenchymal stem cells	Mayo Clinic	NULL	Completed	18 Years	N/A	Both	1	Phase 1	United States

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