25. Progressive multifocal leukoencephalopathy Clinical trials / Disease details


Clinical trials : 25 Drugs : 35 - (DrugBank : 21) / Drug target genes : 8 - Drug target pathways : 37

  
4 trials found
No.TrialIDDate_
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Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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PhaseCountries
1NCT05236777
(ClinicalTrials.gov)
January 1, 20192/2/2022TOPIK Study: A Study to Report Progressive Multifocal Leukoencephalopathy and Other Serious Opportunistic Infections in Natalizumab Treated ParticipantsLong-term Surveillance of Patients With Multiple Sclerosis to Report Progressive Multifocal Leukoencephalopathy and Other Serious Opportunistic Infections Among Patients Treated With NatalizumabMultiple SclerosisDrug: NatalizumabBiogenAssociation for Functional Rehabilitation, Recreation and Applied Kinesiology ImpulseRecruitingN/AN/AAll600Czechia
2NCT01970410
(ClinicalTrials.gov)
October 201322/10/2013Sub-Study: Analysis of JCV Antibody Index in MS Patients Treated With Teriflunomide - SWITCH-JCVSwitching Relapsing Multiple Sclerosis Patients Treated With Natalizumab at Risk for Progressive Multifocal Leukoencephalopathy to Teriflunomide: Is This Safe and Effective? (Sub-study: SWITCH-JCV)Multiple SclerosisDrug: teriflunomideProvidence Health & ServicesMultiple Sclerosis Center of Northeastern New YorkActive, not recruiting21 Years60 YearsAll41Phase 4United States
3EUCTR2010-020369-26-DE
(EUCTR)
29/11/201018/08/2010High-Dose Corticosteroids for Immune Reconstitution Inflammatory Syndrome in Patients Who Develop Progressive Multifocal Leukoencephalopathy on NatalizumabHigh-Dose Corticosteroids for Immune Reconstitution Inflammatory Syndrome in Patients Who Develop Progressive Multifocal Leukoencephalopathy on Natalizumab Immune Reconstitution Inflammatory Syndrome
MedDRA version: 12.1;Level: PT;Classification code 10054014;Term: Immune reconstitution syndrome
Product Name: methylprednisolone
INN or Proposed INN: METHYLPREDNISOLONE
Product Name: prednisolone
INN or Proposed INN: PREDNISOLONE
Product Name: prednisolone
INN or Proposed INN: PREDNISOLONE
Product Name: prednisolone
INN or Proposed INN: PREDNISOLONE
Product Name: prednisolone
INN or Proposed INN: PREDNISOLONE
Product Name: prednisolone
INN or Proposed INN: PREDNISOLONE
Product Name: prednisolone
INN or Proposed INN: PREDNISOLONE
Biogen IdecNULLNot RecruitingFemale: yes
Male: yes
20Germany
4NCT01211665
(ClinicalTrials.gov)
September 201029/7/2010Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS)High-Dose Corticosteroids for Immune Reconstitution Inflammatory Syndrome in Patients Who Develop Progressive Multifocal Leukoencephalopathy on NatalizumabImmune Reconstitution Inflammatory Syndrome;Leukoencephalopathy, Progressive MultifocalDrug: Methylprednisolone;Drug: PrednisoloneBiogenElan PharmaceuticalsTerminated18 YearsN/AAll3Phase 4United States;Germany