265. Lipodystrophy Clinical trials / Disease details


Clinical trials : 116 Drugs : 170 - (DrugBank : 61) / Drug target genes : 26 - Drug target pathways : 97

  
16 trials found
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1NCT05088460
(ClinicalTrials.gov)
January 24, 202212/10/2021A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD)A Randomized Double-Blind Placebo-Controlled Study of the LEPR Agonist Antibody REGN4461 for the Treatment of Metabolic Abnormalities in Patients With Familial Partial LipodystrophyFamilial Partial Lipodystrophy;Metabolic AbnormalitiesDrug: REGN4461;Drug: Matching PlaceboRegeneron PharmaceuticalsNULLNot yet recruiting18 YearsN/AAll40Phase 2NULL
2NCT04159415
(ClinicalTrials.gov)
January 7, 20207/11/2019Study of REGN4461, a Leptin Receptor Agonist Antibody, in Patients With Generalized LipodystrophyA Randomized, Double-Blind, Placebo-Controlled Study of REGN4461, a Leptin Receptor Agonist Antibody, in Patients With Generalized LipodystrophyGeneralized LipodystrophyDrug: Placebo;Drug: Low-Dose REGN4461;Drug: High-dose REGN4461Regeneron PharmaceuticalsNULLActive, not recruiting12 YearsN/AAll16Phase 2United States;Peru;Russian Federation;Turkey
3EUCTR2017-003014-22-AT
(EUCTR)
25/06/201829/05/2018Leptin in hepatic lipid metabolism in humansThe role of leptin in regulating hepatic lipid metabolism in humans - Leptin and hepatic lipid metabolism lipodystrophy patients, patients after liver transplantation and healthy controls;Therapeutic area: Diseases [C] - Nutritional and Metabolic Diseases [C18]Trade Name: Myalept
Product Name: Myalept
INN or Proposed INN: metrelpetin
Other descriptive name: METRELEPTIN
Medical University of ViennaNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
43Phase 2Austria
4NCT03262610
(ClinicalTrials.gov)
February 17, 201722/8/2017Setemelanotide in a Single Patient With Partial LipodystrophyExpanded-access for the Use of Setemelanotide in a Single Patient With Partial Lipodystrophy (LD) Associated With Leptin Deficiency and Multiple Autoimmune DiseasesHypertriglyceridemiaDrug: SetmelanotideRhythm Pharmaceuticals, Inc.NULLNo longer available15 Years15 YearsFemaleUnited States
5NCT02654977
(ClinicalTrials.gov)
September 29, 201520/1/2015CLINICAL PROTOCOL to Investigate the Long-term Safety and Efficacy of Metreleptin in Various Forms of Partial LipodystrophyCLINICAL PROTOCOL to Investigate the Long-term Safety and Efficacy of Recombinant Human Leptin (METRELEPTIN) in Various Forms of Partial LipodystrophyFamilial Partial Lipodystrophy;Nonalcoholic Steatohepatitis;NAFLDDrug: MetreleptinUniversity of MichiganNULLCompleted5 YearsN/AAll11Phase 2United States
6NCT01778556
(ClinicalTrials.gov)
January 26, 201326/1/2013Short-term Effects of Leptin in People With LipodystrophyShort Term Effects of Leptin Withdrawal or Initiation in Lipodystrophy Independent of Energy IntakeLipodystrophyBiological: MetreleptinNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NULLCompleted14 Years70 YearsAll25Phase 2United States
7NCT01679197
(ClinicalTrials.gov)
October 8, 201231/8/2012Clinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With LipodystrophyClinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With LipodystrophyFatty Liver Disease, Nonalcoholic;Nonalcoholic Steatohepatitis;LipodystrophyDrug: MetreleptinUniversity of MichiganNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Completed5 YearsN/AAll23Phase 2United States
8JPRN-UMIN000003679
2010/08/0101/06/2010Long-term safety clinical trial of leptin-replacement therapy in patients with lipodystrophy after introduction of the treatment lipodytrophysubcutaneous injection of human recombinant leptinKyoto University HospitalNULLComplete: follow-up complete6years-oldNot applicableMale and Female11Not selectedJapan
9JPRN-UMIN000002818
2010/08/0101/01/2010Phase 2 trial of leptin-replacement therapy for patients with lipodystrophy lipodystrophyadministration of recombinant methionyl human leptinDepartment of Medicine and Clinical Science, Kyoto University Graduate School of MedicineTranslational Research Center, Kyoto University HospitalNULLComplete: follow-up complete6years-oldNot applicableMale and Female3Phase 2Japan
10NCT00362440
(ClinicalTrials.gov)
August 20069/8/2006Combination of Insulin Sensitizer and Leptin as Treatment for the HAART -Induced Metabolic SyndromeA Combination of Insulin Sensitizer and Leptin as Treatment for the HAART -Induced Metabolic Syndrome: A Randomized, Double-blind, Placebo-controlled Clinical TrialHIV LipodystrophyDrug: Leptin;Drug: Pioglitazone or metformin;Drug: PlaceboBeth Israel Deaconess Medical CenterAmerican Diabetes AssociationCompleted18 YearsN/AAll9Phase 2United States
11NCT00896298
(ClinicalTrials.gov)
April 20068/5/2009Trial of Leptin Replacement Therapy in Patients With LipodystrophyDouble-Blind, Placebo-Controlled Trial of Leptin Replacement Therapy in Patients With LipodystrophyHypoleptinemia;Generalized Lipodystrophy;Partial Lipodystrophy;Insulin ResistanceDrug: Leptin;Drug: PlaceboUniversity of Texas Southwestern Medical CenterNULLCompleted6 Years70 YearsAll25Phase 2/Phase 3United States
12NCT01511016
(ClinicalTrials.gov)
February 200311/1/2012Leptin for Abnormal Lipid Kinetics in HIV Lipodystrophy SyndromeThe Effect of Leptin Therapy on Abnormal Lipid Kinetics in Subjects With HIV Lipodystrophy SyndromeHIV LipodystrophyDrug: Human recombinant leptin (metreleptin);Drug: PlaceboBaylor College of MedicineNULLCompleted18 Years64 YearsMale17N/AUnited States
13NCT00461552
(ClinicalTrials.gov)
January 200316/4/2007Therapeutic Approaches to HAART-Induced LipodystrophyTherapeutic Approaches to HAART-Induced LipodystrophyHIV Infections;LipodystrophyDrug: Leptin;Other: PlaceboUniversity of Texas Southwestern Medical CenterAmylin Pharmaceuticals, LLC.Completed14 Years65 YearsAll23Phase 2United States
14NCT00140244
(ClinicalTrials.gov)
December 200130/8/2005Randomized, Placebo-Controlled Study of Leptin for the Treatment of HIV Lipodystrophy and Metabolic SyndromeRole of Leptin in Highly Active Antiretroviral Therapy (HAART)-Induced Lipodystrophy and Metabolic Syndrome in HAART-Treated HIV PatientsHAART-induced Lipodystrophy and Metabolic SyndromeDrug: r-metHuLeptin;Drug: PlaceboBeth Israel Deaconess Medical CenterNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);AmgenCompleted18 YearsN/AAll7Phase 2United States
15NCT00025883
(ClinicalTrials.gov)
October 200127/10/2001Leptin to Treat LipodystrophyLong-Term Efficacy of Leptin Replacement in Treatment of LipodystrophyLipodystrophyDrug: MetreleptinNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NULLCompleted6 MonthsN/AAll103Phase 2United States
16NCT00005905
(ClinicalTrials.gov)
June 20009/6/2000Leptin to Treat LipodystrophyEfficacy of Leptin Replacement in Treatment of LipodystrophyLipodystrophyDrug: hu Leptin (A-100)National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NULLCompletedN/AN/ABoth20Phase 2United States