272. Fibrodysplasia ossificans progressiva Clinical trials / Disease details
Clinical trials : 40 / Drugs : 36 - (DrugBank : 6) / Drug target genes : 27 - Drug target pathways : 95
Showing 1 to 10 of 40 diseases
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05027802 (ClinicalTrials.gov) | March 15, 2022 | 25/8/2021 | A Rollover Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged =14 Years With Fibrodysplasia Ossificans Progressiva (FOP) Who Have Completed the Relevant Parent Studies. A Rollover Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Fe ... | Rollover Study; Multicentre, Phase III, Open-label Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged =14 Years With Fibrodysplasia Ossificans Progressiva (FOP) Who Have Completed Study PVO-1A-301 or PVO-1A-202/PVO-1A-204 and May Benefit From Palovarotene Therapy. Rollover Study; Multicentre, Phase III, Open-label Study to Further Evaluate the Safety and Efficacy ... | Fibrodysplasia Ossificans Progressiva (FOP) | Drug: Palovarotene | Ipsen | NULL | Not yet recruiting | 14 Years | N/A | All | 87 | Phase 3 | NULL |
| 2 | EUCTR2020-002858-24-SE (EUCTR) | 24/01/2022 | 27/11/2020 | A study assessing the efficacy and safety of an investigational drug called IPN60130 for the treatment of fibrodysplasia ossificans progressiva in participants aged 5 years of age and older A study assessing the efficacy and safety of an investigational drug called IPN60130 for the treatme ... | A Phase 2, two-part, placebo-controlled, parallel-group, double-blind study to assess the efficacy and safety of 2 dosage regimens of oral IPN60130 for the treatment of fibrodysplasia ossificans progressiva in male and female participants 5 years of age and older - FALKON A Phase 2, two-part, placebo-controlled, parallel-group, double-blind study to assess the efficacy a ... | fibrodysplasia ossificans progressiva (FOP) MedDRA version: 20.0;Level: PT;Classification code 10068715;Term: Fibrodysplasia ossificans progressiva;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] fibrodysplasia ossificans progressiva(FOP) MedDRA version: 20.0;Level: PT;Classification code 100687 ... | Product Name: IPN60130 10 mg capsules INN or Proposed INN: Not yet available Other descriptive name: (R)-tetrahydrofuran-3-yl 4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4- yl)pyridine-2-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate sesquisuccinate Product Name: IPN60130 50 mg capsules INN or Proposed INN: Not yet available Other descriptive name: (R)-tetrahydrofuran-3-yl 4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4- yl)pyridine-2-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate sesquisuccinate Product Name: IPN60130 10 mg capsules INN or Proposed INN: Not yet available Other descriptive name: ( ... | Clementia Pharmaceuticals Inc, an Ipsen Company | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 90 | Phase 2 | United States;Spain;Russian Federation;Colombia;Italy;United Kingdom;France;Mexico;Canada;Argentina;Brazil;Australia;Germany;Netherlands;Japan;China;Korea, Republic of;Sweden United States;Spain;Russian Federation;Colombia;Italy;United Kingdom;France;Mexico;Canada;Argentina; ... | ||
| 3 | NCT05090891 (ClinicalTrials.gov) | December 20, 2021 | 8/10/2021 | To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia O ... | A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and ... | Fibrodysplasia Ossificans Progressiva (FOP) | Drug: INCB000928;Drug: placebo | Incyte Corporation | NULL | Not yet recruiting | 12 Years | 99 Years | All | 60 | Phase 2 | NULL |
| 4 | NCT05039515 (ClinicalTrials.gov) | December 1, 2021 | 2/9/2021 | Study to Assess the Efficacy and Safety of 2 Dosage Regimens of Oral IPN60130 for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP). Study to Assess the Efficacy and Safety of 2 Dosage Regimens of Oral IPN60130 for the Treatment of F ... | A Phase 2, Two-part, Placebo-controlled, Parallel-group, Double-blind Study to Assess the Efficacy and Safety of 2 Dosage Regimens of Oral IPN60130 for the Treatment of Fibrodysplasia Ossificans Progressiva in Male and Female Participants 5 Years of Age and Older. A Phase 2, Two-part, Placebo-controlled, Parallel-group, Double-blind Study to Assess the Efficacy a ... | Fibrodysplasia Ossificans Progressiva | Drug: IPN60130;Drug: Placebo | Clementia Pharmaceuticals Inc. | Ipsen | Recruiting | 5 Years | N/A | All | 90 | Phase 2 | United States;France;Italy;Korea, Republic of;Spain;Sweden;United Kingdom |
| 5 | EUCTR2020-002858-24-ES (EUCTR) | 19/10/2021 | 27/07/2021 | A study assessing the efficacy and safety of an investigational drug called IPN60130 for the treatment of fibrodysplasia ossificans progressiva in participants aged 5 years of age and older A study assessing the efficacy and safety of an investigational drug called IPN60130 for the treatme ... | A Phase 2, two-part, placebo-controlled, parallel-group, double-blind study to assess the efficacy and safety of 2 dosage regimens of oral IPN60130 for the treatment of fibrodysplasia ossificans progressiva in male and female participants 5 years of age and older A Phase 2, two-part, placebo-controlled, parallel-group, double-blind study to assess the efficacy a ... | fibrodysplasia ossificans progressiva (FOP) MedDRA version: 20.0;Level: PT;Classification code 10068715;Term: Fibrodysplasia ossificans progressiva;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] fibrodysplasia ossificans progressiva(FOP) MedDRA version: 20.0;Level: PT;Classification code 100687 ... | Product Name: IPN60130 10 mg capsules INN or Proposed INN: not yet available Other descriptive name: (R)-tetrahydrofuran-3-yl 4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4- yl)pyridine-2-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate sesquisuccinate Product Name: IPN60130 50 mg capsules INN or Proposed INN: Not yet available Other descriptive name: (R)-tetrahydrofuran-3-yl 4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4- yl)pyridine-2-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate sesquisuccinate Product Name: IPN60130 10 mg capsules INN or Proposed INN: not yet available Other descriptive name: ( ... | Clementia Pharmaceuticals Inc, an Ipsen Company | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 90 | Phase 2 | United States;Spain;Russian Federation;Colombia;United Kingdom;Italy;France;Mexico;Canada;Argentina;Brazil;Australia;Netherlands;Germany;China;Japan;Sweden;Korea, Republic of United States;Spain;Russian Federation;Colombia;United Kingdom;Italy;France;Mexico;Canada;Argentina; ... | ||
| 6 | NCT04577820 (ClinicalTrials.gov) | October 13, 2021 | 30/9/2020 | Study to Assess the Efficacy and Safety of Garetosmab in Japanese Adult Patients With Fibrodysplasia Ossificans Progressiva (FOP) Study to Assess the Efficacy and Safety of Garetosmab in Japanese Adult Patients With Fibrodysplasia ... | Evaluation of Efficacy and Safety of Garetosmab in Japanese Adult Patients With Fibrodysplasia Ossificans Progressiva Evaluation of Efficacy and Safety of Garetosmab in Japanese Adult Patients With Fibrodysplasia Ossif ... | Fibrodyplasia Ossificans Progressiva (FOP);Heterotopic Ossification (HO) | Drug: garetosmab | Regeneron Pharmaceuticals | NULL | Withdrawn | 18 Years | 60 Years | All | 0 | Phase 3 | NULL |
| 7 | EUCTR2020-002858-24-IT (EUCTR) | 09/06/2021 | 04/06/2021 | A study assessing the efficacy and safety of an investigational drug calledIPN60130 for the treatment of fibrodysplasia ossificans progressiva inparticipants aged 5 years of age and older A study assessing the efficacy and safety of an investigational drug calledIPN60130 for the treatmen ... | A Phase 2, two-part, placebo-controlled, parallel-group, double-blind study to assess the efficacy and safety of 2 dosage regimens of oral IPN60130 for the treatment of fibrodysplasia ossificans progressiva in male and female participants 5 years of age and older - - A Phase 2, two-part, placebo-controlled, parallel-group, double-blind study to assess the efficacy a ... | fibrodysplasia ossificans progressiva (FOP) MedDRA version: 20.0;Level: PT;Classification code 10068715;Term: Fibrodysplasia ossificans progressiva;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] fibrodysplasia ossificans progressiva(FOP) MedDRA version: 20.0;Level: PT;Classification code 100687 ... | Product Name: IPN60130 10 mg capsules Product Code: [-] Other descriptive name: (R)-tetrahydrofuran-3-yl 4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4- yl)pyridine-2yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate Product Name: IPN60130 50 mg capsules Product Code: [-] Other descriptive name: (R)-tetrahydrofuran-3-yl 4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4- yl)pyridine-2yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate Product Name: IPN60130 10 mg capsules Product Code: [-] Other descriptive name: (R)-tetrahydrofuran-3- ... | CLEMENTIA PHARMACEUTICALS INC. | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 90 | Phase 2 | United States;Spain;Russian Federation;United Kingdom;Italy;France;Mexico;Canada;Argentina;Brazil;Australia;Germany;Netherlands;China;Japan;Sweden;Korea, Republic of United States;Spain;Russian Federation;United Kingdom;Italy;France;Mexico;Canada;Argentina;Brazil;Au ... | ||
| 8 | NCT04818398 (ClinicalTrials.gov) | April 1, 2021 | 24/3/2021 | Study of Single-Ascending Doses of DS-6016a in Healthy Japanese Subjects | Single-Ascending Dose Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of DS-6016a After Subcutaneous Injection in Healthy Japanese Subjects Single-Ascending Dose Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of DS-6 ... | Fibrodysplasia Ossificans Progressiva | Drug: DS-6016a;Drug: Placebo | Daiichi Sankyo Co., Ltd. | NULL | Active, not recruiting | 20 Years | 45 Years | Male | 48 | Phase 1 | Japan |
| 9 | NCT04307953 (ClinicalTrials.gov) | August 5, 2020 | 11/3/2020 | Saracatinib Trial TO Prevent FOP | Saracatinib Trial TO Prevent FOP | Fibrodysplasia Ossificans Progressiva | Drug: AZD0530 Difumarate;Drug: Matching placebo | VU University Medical Center | Royal National Orthopaedic Hospital NHS Trust;Klinikum Garmisch-Patenkirchen;University of Oxford;Brigham and Women's Hospital;AstraZeneca;Innovative Medicines Initiative Royal National Orthopaedic Hospital NHS Trust;Klinikum Garmisch-Patenkirchen;University of Oxford;Br ... | Recruiting | 18 Years | 65 Years | All | 20 | Phase 2 | Germany;Netherlands;United Kingdom |
| 10 | EUCTR2019-003324-20-NL (EUCTR) | 08/01/2020 | 16/10/2019 | A clinical trial to judge the safety, tolerability and effects on abnormal bone formation of reseach medication AZD 0530 (sarcatinib) in patients with FOP A clinical trial to judge the safety, tolerability and effects on abnormal bone formation of reseach ... | Saracatinib trial TO Prevent FOP - STOPFOP | Fibrodyplasia Ossificans Progressiva (FOP) MedDRA version: 20.0;Level: PT;Classification code 10068715;Term: Fibrodysplasia ossificans progressiva;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05] Fibrodyplasia Ossificans Progressiva (FOP) MedDRA version: 20.0;Level: PT;Classification code 100687 ... | Product Name: Saracatinib Product Code: AZD0530 INN or Proposed INN: Saracatinib Other descriptive name: SARACATINIB DIFUMARATE Product Name: Saracatinib Product Code: AZD0530 INN or Proposed INN: Saracatinib Other descriptive name ... | VU University Medical Center | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 20 | Phase 2 | Netherlands |