288. Autoimmune acquired coagulation factor deficiency Clinical trials / Disease details
Clinical trials : 205 / Drugs : 238 - (DrugBank : 31) / Drug target genes : 18 - Drug target pathways : 26
Showing 1 to 10 of 205 diseases
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04580407 (ClinicalTrials.gov) | November 9, 2021 | 5/10/2020 | Study of TAK-672 in Participants With Acquired Hemophilia A | A Phase 2/3, Open-Label, Non-controlled Study to Evaluate the Efficacy and Safety of B-Domain Deleted Recombinant Porcine Factor VIII (rpFVIII, TAK-672), in the Treatment of Serious Bleeding Episode in Japanese Subjects With Acquired Hemophilia A (AHA) A Phase 2/3, Open-Label, Non-controlled Study to Evaluate the Efficacy and Safety of B-Domain Delete ... | Acquired Hemophilia A | Biological: TAK-672 | Takeda | NULL | Recruiting | 18 Years | N/A | All | 5 | Phase 2/Phase 3 | Japan |
| 2 | NCT04567511 (ClinicalTrials.gov) | September 1, 2021 | 29/7/2020 | Hemlibra in Mild Hemophilia A | Prospective, Single-Arm, Open-Label Use of Hemlibra (Emicizumab) in the Treatment of Mild Hemophilia A Prospective, Single-Arm, Open-Label Use of Hemlibra (Emicizumab) in the Treatment of Mild Hemophilia ... | Factor VIII Deficiency, Congenital | Drug: Emicizumab | Indiana Hemophilia &Thrombosis Center, Inc. | Genentech, Inc. | Recruiting | 5 Years | 45 Years | Male | 40 | Phase 4 | United States |
| 3 | NCT04953884 (ClinicalTrials.gov) | July 28, 2021 | 18/6/2021 | Efficacy, PK, Immunogenicity and Safety of Wilate in Severe Von Willebrand Disease VWD) Patients <6 Years of Age Efficacy, PK, Immunogenicity and Safety of Wilate in Severe Von Willebrand Disease VWD) Patients <6 ... | Clinical Study to Investigate the Efficacy, Pharmacokinetics, Immunogenicity and Safety of Wilate in Severe Von Willebrand Disease Patients Under the Age of 6 Years Clinical Study to Investigate the Efficacy, Pharmacokinetics, Immunogenicity and Safety of Wilate in ... | Von Willebrand Disease | Drug: wilate | Octapharma | NULL | Recruiting | N/A | 5 Years | All | 12 | Phase 3 | United States;Belarus;Moldova, Republic of;North Macedonia;Russian Federation;Ukraine |
| 4 | EUCTR2019-004430-42-AT (EUCTR) | 22/06/2021 | 22/04/2021 | Evaluation of the effect of emicizumab in patients suffering from acute bleeds with previously no family history. Evaluation of the effect of emicizumab in patients suffering from acute bleeds with previously no fa ... | Emicizumab in Patients with Acquired Hemophilia A: Multicenter, Single-Arm, Open-Label Clinical Trial Emicizumab in Patients with Acquired Hemophilia A: Multicenter, Single-Arm, Open-Label Clinical Tria ... | Acquired Hemophilia A (AHA) MedDRA version: 22.1;Level: LLT;Classification code 10053761;Term: Acquired hemophilia with anti FVIII, XI, or XIII;System Organ Class: 100000004851 MedDRA version: 20.0;Classification code 10053760;Term: Acquired hemophilia;System Organ Class: 100000004851;Therapeutic area: Body processes [G] - Immune system processes [G12] Acquired Hemophilia A(AHA) MedDRA version: 22.1;Level: LLT;Classification code 10053761;Term: Acquir ... | Trade Name: Hemlibra® INN or Proposed INN: Emicizumab Other descriptive name: RO5534262 EMICIZUMAB | GWT-TUD GmbH | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 47 | Phase 2 | Austria;Germany | ||
| 5 | NCT04344860 (ClinicalTrials.gov) | June 4, 2021 | 9/4/2020 | Prevent Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial | Prospective, Randomized Trial Comparing Recombinant Von Willebrand Factor (rVWF) Plus Tranexamic Acid vs. rVWF Alone to Reduce Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial Prospective, Randomized Trial Comparing Recombinant Von Willebrand Factor (rVWF) Plus Tranexamic Aci ... | Von Willebrand Diseases;Postpartum Hemorrhage | Drug: Recombinant Von Willebrand factor;Drug: Tranexamic Acid Injection [Cyklokapron] | Margaret Ragni | NULL | Recruiting | 18 Years | N/A | Female | 20 | Phase 3 | United States |
| 6 | NCT04770935 (ClinicalTrials.gov) | May 3, 2021 | 22/2/2021 | To Assess the Pharmacokinetics and Safety and Tolerability of Efanesoctocog Alfa (BIVV001)in Adults With Type 2N and 3 Von Willebrand Disease (VWD) To Assess the Pharmacokinetics and Safety and Tolerability of Efanesoctocog Alfa (BIVV001)in Adults ... | A Phase 1, Open-Label Study to Assess the Pharmacokinetics, and Safety and Tolerability of a Single Intravenous Injection of rFVIIIFc-VWF-XTEN (BIVV001) in Adults With Type 2N and 3 Von Willebrand Disease (VWD) A Phase 1, Open-Label Study to Assess the Pharmacokinetics, and Safety and Tolerability of a Single ... | Von Willebrand's Disease (VWD) | Drug: efanesoctocog alfa (BIVV001) | Bioverativ, a Sanofi company | NULL | Recruiting | 18 Years | 65 Years | All | 9 | Phase 1 | United States;France |
| 7 | NCT04188639 (ClinicalTrials.gov) | March 23, 2021 | 4/12/2019 | Emicizumab in Acquired Hemophilia A | Emicizumab in Patients With Acquired Hemophilia A: Multicenter, Single-arm, Open-label Clinical Trial Emicizumab in Patients With Acquired Hemophilia A: Multicenter, Single-arm, Open-label Clinical Tria ... | Hemophilia A, Acquired | Drug: Emicizumab Injection | GWT-TUD GmbH | Hoffmann-La Roche;Hannover Medical School | Recruiting | 18 Years | N/A | All | 51 | Phase 2 | Austria;Germany |
| 8 | EUCTR2019-004430-42-DE (EUCTR) | 25/01/2021 | 20/11/2020 | Evaluation of the effect of emicizumab in patients suffering from acute bleeds with previously no family history. Evaluation of the effect of emicizumab in patients suffering from acute bleeds with previously no fa ... | Emicizumab in Patients with Acquired Hemophilia A: Multicenter, Single-Arm, Open-Label Clinical Trial Emicizumab in Patients with Acquired Hemophilia A: Multicenter, Single-Arm, Open-Label Clinical Tria ... | Acquired Hemophilia A (AHA) MedDRA version: 22.1;Level: LLT;Classification code 10053761;Term: Acquired hemophilia with anti FVIII, XI, or XIII;System Organ Class: 100000004851 MedDRA version: 20.0;Classification code 10053760;Term: Acquired hemophilia;System Organ Class: 100000004851;Therapeutic area: Body processes [G] - Immune system processes [G12] Acquired Hemophilia A(AHA) MedDRA version: 22.1;Level: LLT;Classification code 10053761;Term: Acquir ... | Trade Name: Hemlibra® INN or Proposed INN: Emicizumab Other descriptive name: RO5534262 EMICIZUMAB | GWT-TUD GmbH | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 47 | Phase 2 | Austria;Germany | ||
| 9 | NCT04119908 (ClinicalTrials.gov) | January 2021 | 7/10/2019 | Videomicroscopy for the Prediction of Bleeding in Constitutional Haemorrhagic Diseases | Interest of Sublingual Videomicroscopy for the Prediction of Bleeding in Von Willebrand Disease and Other Constitutional Haemorrhagic Diseases Interest of Sublingual Videomicroscopy for the Prediction of Bleeding in Von Willebrand Diseaseand O ... | Von Willebrand Diseases;Glanzmann Thrombasthenia | Device: Sublingual videomicroscopy;Biological: blood sample | University Hospital, Lille | NULL | Not yet recruiting | 18 Years | N/A | All | 400 | N/A | NULL |
| 10 | EUCTR2018-004675-13-HR (EUCTR) | 28/11/2020 | 02/12/2020 | Study to investigate the study drug (WILATE) in patients with Von Willebrand Disease. | CLINICAL STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF WILATEDURING PROPHYLAXIS IN PREVIOUSLY TREATED PATIENTS WITH VON WILLEBRAND DISEASE (VWD) CLINICAL STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF WILATEDURING PROPHYLAXIS IN PREVIOUSLY TREA ... | Von Willebrand disease, type 3, type 2 (except 2N), or severe type 1 MedDRA version: 20.0;Level: LLT;Classification code 10055168;Term: Von Willebrand's factor deficiency;System Organ Class: 100000004850;Therapeutic area: Diseases [C] - Blood and lymphatic diseases [C15] Von Willebrand disease, type 3, type 2 (except 2N), or severe type 1 MedDRA version: 20.0;Level: LLT ... | Trade Name: Wilate 500 Product Name: Wilate INN or Proposed INN: Human Coagulation Factor VIII, Von Willebrand Factor Complex Other descriptive name: HUMAN COAGULATION FACTOR VIII, VON WILLEBRAND FACTOR COMPLEX Trade Name: Wilate 1000 Product Name: Wilate INN or Proposed INN: Human Coagulation Factor VIII, Von Willebrand Factor Complex Other descriptive name: HUMAN COAGULATION FACTOR VIII, VON WILLEBRAND FACTOR COMPLEX Trade Name: Wilate500 Product Name: Wilate INN or Proposed INN: Human Coagulation Factor VIII, Von Wil ... | Octapharma AG | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 28 | Phase 3 | United States;Belarus;Hungary;Ukraine;Lebanon;Croatia;Russian Federation;Bulgaria |