294. Congenital diaphragmatic hernia Clinical trials / Disease details

Clinical trials : 15 / Drugs : 36 - (DrugBank : 6) / Drug target genes : 5 - Drug target pathways : 14

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05213676 (ClinicalTrials.gov)	January 1, 2023	27/1/2022	Inhaled Nitric Oxide (iNO) for Congenital Diaphragmatic Hernia(CDH) - The NoNO Trial - a Multi-cente ...	Inhaled Nitric Oxide (iNO) for Congenital Diaphragmatic Hernia(CDH) - The NoNO Trial - a Multi-cente ...	Congenital Diaphragmatic Hernia	Drug: Inhaled Nitric Oxide (iNO) use;Other: De-implementation of Inhaled Nitric Oxide (iNO) use	The University of Texas Health Science Center, Houston	NULL	Not yet recruiting	N/A	1 Month	All	600	Phase 4	United States
2	ChiCTR2000037331	2020-09-01	2020-08-28	AI-assisted diagnosis and treatment engine based on a fully structured congenital diaphragmatic hern ...	AI-assisted diagnosis and treatment engine based on a fully structured congenital diaphragmatic hern ...	Congenital diaphragmatic hernia	intervention group:sildenafil + conventional therapy;control group:conventional therapy;	Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine	NULL	Recruiting	0	5	Both	intervention group:100;control group:100;		China
3	EUCTR2017-000421-13-IT (EUCTR)	20/03/2020	06/10/2020	Newborns with Congenital diaphragmatic hernia; iNO versus sildenafil	Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: a ...	Congenital diaphragmatic herniawith pulmonary hypertension MedDRA version: 20.0;Level: SOC;Classific ...	Trade Name: REVATIO - 0.8 MG/ML - SOLUZIONE INIETTABILE - USO ENDOVENOSO - FLACONCINO(VETRO) 1 FLACO ...	ERASMUS MEDICAL CENTER	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	330	Phase 3	Spain;Belgium;Austria;Norway;Netherlands;Germany;Italy;Sweden
4	EUCTR2017-000421-13-BE (EUCTR)	07/02/2019	19/02/2019	Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Ni ...	Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: a ...	Congenital diaphragmatic herniawith pulmonary hypertension;Therapeutic area: Diseases [C] - Congenit ...	Trade Name: revatio 0.8mg/ml solution for injection Trade Name: INOmax 800ppm mol/mol inhalatiegas INN ...	Erasmus MC	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	330	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (P ...	Belgium;Austria;Netherlands
5	NCT03526588 (ClinicalTrials.gov)	August 1, 2018	27/4/2018	Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diap ...	Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diap ...	Congenital Diaphragmatic Hernia	Biological: Autologous umbilical cord blood	The University of Texas Health Science Center, Houston	Texas Medical Center Regenerative Medicine Consortium	Recruiting	N/A	7 Days	All	20	Phase 1	United States
6	EUCTR2017-000421-13-AT (EUCTR)	13/07/2018	08/05/2018	Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Ni ...	Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: a ...	Congenital diaphragmatic herniawith pulmonary hypertension;Therapeutic area: Diseases [C] - Congenit ...	Trade Name: revatio 0.8mg/ml solution for injection INN or Proposed INN: Sildenafil Trade Name: INOmax ...	Erasmus MC	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	330	Phase 4	Austria;Netherlands
7	NCT03787160 (ClinicalTrials.gov)	March 22, 2018	10/7/2018	Microbiome and Volatile Organic Compounds in Patients With CDH	Determining the Effect of Probiotics on Microbiome and Volatile Organic Compounds in Patients After ...	Congenital Diaphragmatic Hernia	Diagnostic Test: initial VOC;Diagnostic Test: initial fecal microbiome;Diagnostic Test: initial pulm ...	Medical University of Graz	University of Rostock	Completed	6 Years	16 Years	All	18	N/A	Austria
8	NCT02951130 (ClinicalTrials.gov)	August 22, 2017	14/10/2016	Milrinone in Congenital Diaphragmatic Hernia	Milrinone in Congenital Diaphragmatic Hernia	Congenital Diaphragmatic Hernia;Persistent Pulmonary Hypertension of the Newborn;Hypoxemic Respirato ...	Drug: Milrinone;Drug: Placebo (5% Dextrose)	NICHD Neonatal Research Network	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Recruiting	N/A	168 Hours	All	66	Phase 2	United States
9	EUCTR2017-000421-13-NL (EUCTR)	27/07/2017	07/06/2017	Treatment of high blood pressure in the lungs in newborns with a defect inthe diaphragm; inhaled Nit ...	Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxideversus intravenous Sildenafil:an ...	Congenital diaphragmatic herniawith pulmonary hypertension;Therapeutic area: Diseases [C] - Congenit ...	Trade Name: revatio 0.8mg/ml solution for injection Trade Name: INOmax 800ppm mol/mol inhalatiegas	Erasmus MC	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	90	Phase 3	Belgium;Austria;Norway;Netherlands;Sweden
10	EUCTR2013-002026-22-NL (EUCTR)	24/10/2013	27/06/2013	Adminstration of omeprazole by rectiole or oral tablet for the treatment of reflux disease in neonat ...	Rectal and oral omeprazole treatment of gastroesophageal reflux in infants with esophageal atresia o ...	GORD,;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]	Trade Name: Losec Product Name: Omeprazol Product Code: NA Trade Name: Losec Product Name: Omeprazol Prod ...	ErasmusMC	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Netherlands

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