46. Malignant rheumatoid arthritis Clinical trials / Disease details
Clinical trials : 4,325 / Drugs : 2,671 - (DrugBank : 417) / Drug target genes : 187 - Drug target pathways : 224
Showing 1 to 10 of 137 diseases
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05246293 (ClinicalTrials.gov) | March 2, 2022 | 17/1/2022 | Tofacitinib in the Treatment of Rheumatoid Arthritis-related Interstitial Lung Disease. | Safety and Tolerability of Tofacitinib in the Treatment of Rheumatoid Arthritis-related Interstitial Lung Disease (RAILDTo Trial). Safety and Tolerability of Tofacitinibin the Treatment of Rheumatoid Arthritis-related Interstitial ... | Rheumatoid Arthritis;Interstitial Lung Disease | Drug: Tofacitinib | National Institute of Respiratory Diseases, Mexico | NULL | Not yet recruiting | 18 Years | N/A | All | 60 | Phase 2 | Mexico |
| 2 | EUCTR2021-004131-84-NL (EUCTR) | 14/02/2022 | 08/09/2021 | Comparing the effectiveness of tofacitinib extended release (XR) chronotherapy, morning versus evening dosing, in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients from a patient’s, clinical as well as a translational point of view. Comparing the effectiveness of tofacitinibextended release (XR) chronotherapy, morning versus evenin ... | Chronotherapy in Inflammatory Arthritis (ChronIA trial): a crossover randomized controlled trial comparing the effectiveness of morning and evening dosing of tofacitinib extended-release - ChronIA trial Chronotherapy in Inflammatory Arthritis (ChronIA trial): a crossover randomized controlled trial com ... | Rheumatoid arthritis or psoriatic arthritis according to respectively 2010 criteria or CASPAR criteria MedDRA version: 23.1;Level: PT;Classification code 10039073;Term: Rheumatoid arthritis;System Organ Class: 10028395 - Musculoskeletal and connective tissue disorders MedDRA version: 21.0;Level: LLT;Classification code 10037160;Term: Psoriatic arthritis;System Organ Class: 10028395 - Musculoskeletal and connective tissue disorders;Therapeutic area: Diseases [C] - Immune System Diseases [C20] Rheumatoid arthritis or psoriatic arthritis according to respectively 2010 criteria or CASPAR criter ... | Trade Name: Xeljanz XR Product Name: Tofacitinib XR Product Code: EMEA/H/C/004214 | Erasmus Medical Center | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 84 | Phase 4 | Netherlands | ||
| 3 | NCT05133297 (ClinicalTrials.gov) | January 2022 | 15/11/2021 | The Safety and Efficacy of TLL-018 in Active Rheumatoid Arthritis | A Phase 2A, Randomized, Double-blind, Double-dummy, Tofacitinib-parallel-group Study to Evaluate the Safety and Efficacy of TLL-018 in Active Rheumatoid Arthritis Who Had an Inadequate Response or Intolerance to Methotrexate. A Phase 2A, Randomized, Double-blind, Double-dummy, Tofacitinib-parallel-group Study to Evaluate the ... | Rheumatoid Arthritis | Drug: TLL-018;Drug: Tofacitinib | Hangzhou Highlightll Pharmaceutical Co., Ltd | NULL | Recruiting | 18 Years | 75 Years | All | 100 | Phase 2 | China |
| 4 | NCT04876781 (ClinicalTrials.gov) | November 1, 2021 | 20/4/2021 | Korean Post-marketing Surveillance for Xeljanz XR | Korean Post-marketing Surveillance for Xeljanz XR (Registered) | Active Moderate to Severe Rheumatoid Arthritis;Active Ankylosing Spondylitis | Drug: Tofacitinib XR | Pfizer | NULL | Not yet recruiting | 18 Years | N/A | All | 200 | NULL | |
| 5 | NCT05080218 (ClinicalTrials.gov) | October 2021 | 6/10/2021 | COVID-19 VaccinE Response in Rheumatology Patients | The SARS-CoV-2 Vaccine Response and Safety in Rheumatology Patients and the Influence of Temporary Interruptions in Immunomodulatory Therapy The SARS-CoV-2 Vaccine Response and Safety in Rheumatology Patients and the Influence of Temporary I ... | Rheumatoid Arthritis;Psoriatic Arthritis;Spondylarthritis | Drug: Upadacitinib;Drug: Abatacept;Drug: Secukinumab;Drug: Tofacitinib;Drug: TNF Inhibitor;Drug: Canakinumab Injection Drug: Upadacitinib;Drug: Abatacept;Drug: Secukinumab;Drug: Tofacitinib;Drug: TNF Inhibitor;Drug: Can ... | Jeffrey Curtis | University of Alabama at Birmingham;University of Nebraska;University of Pennsylvania;AbbVie;Bristol-Myers Squibb;Novartis;Eli Lilly and Company;Pfizer University of Alabama at Birmingham;University of Nebraska;University of Pennsylvania;AbbVie;Bristol ... | Not yet recruiting | 18 Years | 85 Years | All | 1000 | Phase 4 | United States |
| 6 | EUCTR2021-001560-14-ES (EUCTR) | 13/08/2021 | 11/06/2021 | Use of tofacitinib in patients with treatment-refractory rheumatoid arthritis. | Single-center, open-label, uncontrolled clinical trial to evaluate the association between the expression of the JAK / STAT pathway and the response to tofacitinib in patients with refractory rheumatoid arthritis. Single-center, open-label, uncontrolled clinical trial to evaluate the association between the expre ... | Refractory rheumatoid arthritis;Therapeutic area: Diseases [C] - Immune System Diseases [C20] | Trade Name: XELJANZ INN or Proposed INN: TOFACITINIB | FUNDACION JIMENEZ DIAZ HEALTH RESEARCH INSTITUTE | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 42 | Phase 4 | Spain | ||
| 7 | ChiCTR2100048185 | 2021-07-01 | 2021-07-04 | The efficacy and safety of Tofacitinib in the treatment of DMARDS naive rheumatoid arthtits patients | The efficacy and safety of Tofacitinib virus MTX in the treatment of DMARDS naive rheumatoid arthtits patients--a randomized controlled trial The efficacy and safety of Tofacitinibvirus MTX in the treatment of DMARDS naive rheumatoid arthtits ... | Rheumatoid Arthritis | Experimental group:Tofacitinib 5mg twice per day;Control group:Methotrexate; | Peking University First Hospital | NULL | Pending | 18 | Both | Experimental group:112;Control group:112; | Phase 4 | China | |
| 8 | NCT04927000 (ClinicalTrials.gov) | May 31, 2021 | 31/5/2021 | The Role of Tofacitinib in Steroid Withdrawal in Rheumatoid Arthritis | The Role of Tofacitinib in Steroid Withdrawal in Rheumatoid Arthritis | Rheumatoid Arthritis | Drug: Tofacitinib | Second Affiliated Hospital, School of Medicine, Zhejiang University | NULL | Recruiting | 30 Years | 65 Years | Female | 170 | Phase 4 | China |
| 9 | NCT04798287 (ClinicalTrials.gov) | March 10, 2021 | 11/3/2021 | Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)-Cancer Endpoints | Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)-Cancer Endpoints | Rheumatoid Arthritis | Drug: Tofacitinib;Drug: TNF Inhibitor | Brigham and Women's Hospital | NULL | Active, not recruiting | 18 Years | N/A | All | 105711 | United States | |
| 10 | NCT04772248 (ClinicalTrials.gov) | February 22, 2021 | 23/2/2021 | Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)- Cardiovascular Endpoints Safety of TofAcitinibin Routine Care Patients With Rheumatoid Arthritis (STAR-RA)- Cardiovascular En ... | Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)- Cardiovascular Endpoints Safety of TofAcitinibin Routine Care Patients With Rheumatoid Arthritis (STAR-RA)- Cardiovascular En ... | Rheumatoid Arthritis | Drug: Tofacitinib;Drug: TNF Inhibitor | Brigham and Women's Hospital | NULL | Completed | 18 Years | N/A | All | 105711 | United States |