51. Scleroderma Clinical trials / Disease details

Clinical trials : 523 / Drugs : 608 - (DrugBank : 156) / Drug target genes : 114 - Drug target pathways : 215

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04432545 (ClinicalTrials.gov)	September 1, 2022	10/6/2020	Infusion of Allogeneic Mesenchymal Stem Cells in Patients With Diffuse Cutaneous Systemic SclerosisW ...	Infusion of Allogeneic Stromal Mesenchymal Stem Cells From Wharton´s Jelly in Patients With Diffuse ...	Systemic Sclerosis Pulmonary;Pulmonary Hypertension;Pulmonary Fibrosis	Biological: Mesenchymal Stem Cells from Wharton ´s jellyintravenous infusion of Mesenchymal Stem Cel ...	Universidad de la Sabana	Fundación Neumologica Colombiana;Stem Medicina Regenerativa;CryoHoldco LATAM	Available	18 Years	65 Years	All			Colombia
2	NCT03800017 (ClinicalTrials.gov)	September 1, 2022	21/11/2018	Skeletal Muscle Function in Interstitial Lung Disease	Investigating the Role of Skeletal Muscle Dysfunction on Dyspnea and Exercise Intolerance in Interst ...	Interstitial Lung Disease;Idiopathic Pulmonary Fibrosis;Hypersensitivity Pneumonitis;Scleroderma;Non ...	Biological: Hyperoxia	University of British Columbia	NULL	Not yet recruiting	40 Years	80 Years	All	40	N/A	NULL
3	NCT04356287 (ClinicalTrials.gov)	April 2022	15/4/2020	Treatment With Human Umbilical Cord-derived Mesenchymal Stromal Cells in Systemic Sclerosis	Phase I/II Randomized Controlled Trial of Umbilical Cord-derived mesenChymAl stRomal cElls in System ...	Sclerosis, Systemic;Mesenchymal Stem Cells	Biological: UCMSC;Other: Placebo	Marie Hudson, MD	Assistance Publique - Hôpitaux de Paris;University Paris 7 - Denis Diderot;Université de Montréal;Me ...	Not yet recruiting	18 Years	N/A	All	18	Phase 1/Phase 2	NULL
4	NCT05214014 (ClinicalTrials.gov)	March 1, 2022	29/11/2021	Treatment of Systemic Sclerosis With Autologous Regulatory ?-cells	Treatment of Patients With Systemic Sclerosis With Autologous Regulatory ?-cells	Systemic Sclerosis	Biological: Autologous Regulatory ?-cells;Other: Standard treatment according to the clinical protoc ...	Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus	Belarusian State Medical University	Not yet recruiting	18 Years	80 Years	All	30	Phase 1/Phase 2	NULL
5	NCT05198557 (ClinicalTrials.gov)	March 2022	6/1/2022	A Study of MT-0551 in Patients With Systemic Sclerosis	Phase 3 Study of MT-0551 in Patients With Systemic Sclerosis (Placebo-Controlled Double-Blind Study)	Systemic Sclerosis	Drug: Inebilizumab;Drug: Placebo	Mitsubishi Tanabe Pharma Corporation	NULL	Not yet recruiting	20 Years	80 Years	All	80	Phase 3	Japan
6	NCT04986605 (ClinicalTrials.gov)	March 2022	1/6/2021	Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis	The Effectiveness of ECP in Diffuse Cutaneous Systemic Sclerosis	Diffuse Cutaneous Systemic Sclerosis	Other: Extracorporeal Photopheresis (ECP) with Methoxsalen	Lawson Health Research Institute	Mallinckrodt	Not yet recruiting	18 Years	N/A	All	15	Phase 2	Canada
7	NCT05236491 (ClinicalTrials.gov)	March 2022	10/2/2022	COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases	COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases	Rheumatoid Arthritis;Autoimmune Rheumatologic Disease;Systemic Lupus Erythematosus;Systemic Vasculit ...	Biological: COVID-19 vaccine	Paul R Fortin	Canadian Institutes of Health Research (CIHR)	Not yet recruiting	18 Years	N/A	All	287	Phase 2/Phase 3	NULL
8	NCT04380831 (ClinicalTrials.gov)	February 24, 2022	30/4/2020	TBI Using IMRT and Cyclophosphamide Prior to Stem Cell Transplant for the Treatment of Severe System ...	Pilot Study of Total Body Irradiation Using Intensity Modulated Radiation Therapy (IMRT) and Cycloph ...	Systemic Scleroderma	Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;Drug: Cyclophosphamide;Radiation: Inte ...	City of Hope Medical Center	National Cancer Institute (NCI)	Recruiting	18 Years	65 Years	All	15	Early Phase 1	United States
9	NCT05270668 (ClinicalTrials.gov)	February 22, 2022	27/2/2022	Phase 2 Safety and Efficacy Study of PRA023 in Subjects With Systemic SclerosisAssociated With Inter ...	A Double Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of PRA023 i ...	Diffuse Cutaneous Systemic Sclerosis;Interstitial Lung Disease	Drug: PRA023 IV;Device: Companion diagnostic ( CDx);Drug: Placebo	Prometheus Biosciences, Inc.	PPD	Recruiting	18 Years	N/A	All	100	Phase 2	United States
10	JPRN-jRCT2031210521	15/02/2022	26/12/2021	Phase 3 Study of MT-0551 in Patients with Systemic Sclerosis	Phase 3 Study of MT-0551 in Patients with Systemic Sclerosis(Placebo-Controlled Double-Blind Study) ...	Systemic Sclerosis	(1)MT-0551 group Participants will receive intravenous (IV) inebilizumabon Day 1 and Day 15 of rando ...	Kondou Kazuoki	NULL	Pending	>= 20age old	<= 80age old	Both	80	Phase 3	Japan

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