6. Parkinson disease Clinical trials / Disease details
Clinical trials : 2,298 / Drugs : 2,202 - (DrugBank : 350) / Drug target genes : 188 - Drug target pathways : 202
Showing 1 to 10 of 134 diseases
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05116813 (ClinicalTrials.gov) | October 25, 2021 | 1/11/2021 | Open-label Safety Study of Dipraglurant (ADX48621) in Patients With Parkinson's Disease Receiving Levodopa-based Therapy Open-label Safety Study of Dipraglurant (ADX48621) in Patients With Parkinson's Disease Receiving Le ... | An Open-label Safety Study of Dipraglurant (ADX48621) in Patients With Parkinson's Disease Receiving Levodopa-based Therapy With or Without Concomitant Dopaminergic Medications An Open-label Safety Study of Dipraglurant (ADX48621) in Patients With Parkinson's Disease Receiving ... | Parkinson Disease;Dyskinesia, Drug-Induced;Dyskinesias | Drug: Dipraglurant | Addex Pharma S.A. | NULL | Recruiting | 30 Years | 85 Years | All | 140 | Phase 2/Phase 3 | United States |
| 2 | NCT05022147 (ClinicalTrials.gov) | October 4, 2021 | 9/8/2021 | Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease | ENGAGE-PD: Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease | Parkinson Disease;Gait Disorders, Neurologic;Disease Progression;Subthalamic Nucleus;Accidental Fall;Deep Brain Stimulation Parkinson Disease;Gait Disorders, Neurologic;Disease Progression;Subthalamic Nucleus;Accidental Fall ... | Device: High-Frequency-Only Stimulation;Device: Low-Frequency-Only Stimulation;Device: Alternating, 50 sec High-Frequency, 10 sec Low-Frequency Stimulation;Device: Alternating, 50 sec High-Frequency, 50 sec Low-Frequency Stimulation;Device: Alternating, 10 sec High-Frequency, 50 sec Low-Frequency Stimulation;Device: Alternating, 10 sec High-Frequency, 10 sec Low-Frequency Stimulation;Drug: OFF Dopaminergic Medication;Drug: ON Dopaminergic Medication Device: High-Frequency-Only Stimulation;Device: Low-Frequency-Only Stimulation;Device: Alternating, ... | The Cleveland Clinic | NULL | Recruiting | 21 Years | N/A | All | 12 | Phase 1 | United States |
| 3 | NCT04265209 (ClinicalTrials.gov) | October 2021 | 6/2/2020 | [18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson's Diseases and Essential Tremor [18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson's Diseases and Es ... | Non-inferiority Study of the Molecular Imaging of Dopamine Transporters Using [123I]-FP/CIT-SPECT and [18F] LBT-999-PET to Distinguish Between Parkinson's Disease and Essential Tremor. Non-inferiority Study of the Molecular Imaging of DopamineTransporters Using [123I]-FP/CIT-SPECT and ... | Parkinson Disease;Essential Tremor | Drug: SPECT;Drug: PET | Zionexa | NULL | Not yet recruiting | 35 Years | 80 Years | All | 112 | Phase 3 | NULL |
| 4 | NCT04802733 (ClinicalTrials.gov) | May 3, 2021 | 12/3/2021 | Phase 1 Safety and Tolerability Study of MSK-DA01 Cell Therapy for Advanced Parkinson's Disease | Phase 1 Study To Assess the Safety and Tolerability of Human Embryonic Stem Cell-Derived Midbrain Dopamine Neuron Cell Therapy (MSK-DA01) For Advanced Parkinson's Disease Phase 1 Study To Assess the Safety and Tolerability of Human Embryonic Stem Cell-Derived Midbrain Do ... | Advanced Parkinson's Disease | Biological: MSK-DA01;Device: MSK-DA01 Cell Delivery Device | BlueRock Therapeutics | Memorial Sloan Kettering Cancer Center | Recruiting | 50 Years | 76 Years | All | 12 | Phase 1 | United States;Canada |
| 5 | EUCTR2018-004892-11-IT (EUCTR) | 22/04/2021 | 07/10/2020 | A randomized, double-blind, placebo controlled, multicentre study to evaluate the effect of safinamide on freezing of gait (FOG) in mid- to late-stage fluctuating PD patients A randomized, double-blind, placebo controlled, multicentre study to evaluate the effect of safinami ... | A randomized, double-blind, placebo controlled, multicentre study to evaluate the effect of safinamide on freezing of gait (FOG) in mid- to late-stage fluctuating PD patients - SteP-on A randomized, double-blind, placebo controlled, multicentre study to evaluate the effect of safinami ... | •Subjects of both genders over 18 years of age, with a clinical diagnosis of idiopathic PD•A Modified Hoehn and Yahr stage of = 4 in the off” state;•A stable (4 weeks since last modification) anti-parkinsonian therapy; •The presence of FOG (defined as the persistence of gait hesitation and failure in starting the gait or the reported sensation of having the legs frozen” or glued to the ground”) even on an optimized dopaminergic treatment (patients with FOG item 3 score >0) MedDRA version: 21.1;Level: LLT;Classification code 10013113;Term: Disease Parkinson's;System Organ Class: 100000004852;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] •Subjects of both genders over 18 years of age, with a clinical diagnosis of idiopathic PD•A Modifie ... | Trade Name: XADAGO - 100 MG- COMPRESSA RIVESTITA CON FILM- USO ORALE- BLISTER (PVC/PVDC/ALLUMINIO)- 30 COMPRESSE Product Name: Xadago Product Code: [043906039] INN or Proposed INN: SAFINAMIDE METANSOLFONATO Trade Name: XADAGO - 50 MG- COMPRESSA RIVESTITA CON FILM- USO ORALE- BLISTER (PVC/PVDC/ALLUMINIO)- 30 COMPRESSE Product Name: Xadago Product Code: [043906039] INN or Proposed INN: SAFINAMIDE METANSOLFONATO Trade Name: XADAGO- 100 MG- COMPRESSA RIVESTITA CON FILM- USO ORALE- BLISTER (PVC/PVDC/ALLUMINIO)- 3 ... | OSPEDALE SANTA MARIA DELLA MISERICORDIA | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 128 | Phase 3 | Italy | ||
| 6 | EUCTR2019-000247-27-FR (EUCTR) | 31/03/2021 | 05/03/2019 | Study to demonstrate an at least equivalent performance of a new test in brain imaging test compared to the reference examination to establish the differential diagnosis between Parkinson's Disease and Essential Tremor. Study to demonstrate an at least equivalent performance of a new test in brain imaging test compared ... | Non-inferiority study of the molecular imaging of dopamine transporters using [123I]-FP/CIT-SPECT and [18F] LBT-999-PET to distinguish between Parkinson’s Disease and Essential Tremor. - DATTEP Non-inferiority study of the molecular imaging of dopaminetransporters using [123I]-FP/CIT-SPECT and ... | Patients suffering from an essential tremor or with Parkinson's disease. MedDRA version: 20.0;Level: PT;Classification code 10061536;Term: Parkinson's disease;System Organ Class: 10029205 - Nervous system disorders MedDRA version: 20.0;Classification code 10015496;Term: Essential tremor;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Diagnosis [E01] Patients suffering from an essential tremor or with Parkinson's disease. MedDRA version: 20.0;Level: ... | Trade Name: DaTSCAN 74 MBq/ml solution for injection Product Code: [18F] LBT-999 | ZIONEXA | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 112 | Phase 3 | France | ||
| 7 | ChiCTR2000037624 | 2020-10-01 | 2020-08-29 | Clinical efficacy of dopamine agonist Pramipexol in the treatment of cognitive impairment in PATIENTS with PD-RBD and its population pharmacokinetic study Clinical efficacy of dopamineagonist Pramipexol in the treatment of cognitive impairment in PATIENTS ... | Clinical efficacy of dopamine agonist Pramipexol in the treatment of cognitive impairment in PATIENTS with PD-RBD and its population pharmacokinetic study Clinical efficacy of dopamineagonist Pramipexol in the treatment of cognitive impairment in PATIENTS ... | Parkinson's disease | experimental group:Pramipexol + dopa hydrazine combination therapy;control group: dopa hydrazine; | Shanghai General Hospital | NULL | Recruiting | 18 | 85 | Both | experimental group:50;control group:50; | China | |
| 8 | NCT03665493 (ClinicalTrials.gov) | September 30, 2020 | 4/9/2018 | Dopamine Effect on Inhibitory Control | Dopamine Effect on Inhibitory Control | Idiopathic Parkinson's Disease | Drug: PD patients H&Y=1.5-2 Medications ON;Drug: PD patients H&Y=1.5-2 Medications OFF;Behavioral: Healthy age-matched controls;Drug: PD patients H&Y=3 Medications OFF;Drug: PD patients H&Y=3 Medications ON Drug: PD patients H&Y=1.5-2 Medications ON;Drug: PD patients H&Y=1.5-2 Medications OFF;Behavioral: H ... | Giovanni Mirabella | NULL | Recruiting | 40 Years | 70 Years | All | 102 | N/A | Italy |
| 9 | NCT04332276 (ClinicalTrials.gov) | September 18, 2020 | 25/3/2020 | Dopaminergic restauratIon by intraVEntriculaire Administration | A New Concept of Continuous Dopaminergic Stimulation by Cerebroventricular Administration of A-dopamine (Dopamine Stored in Anaerobia) for Severe Motor Fluctuations in Parkinson's Disease? A New Concept of Continuous Dopaminergic Stimulation by Cerebroventricular Administration of A-dopam ... | Parkinson Disease | Drug: A-dopamine;Drug: optimized oral treatment | University Hospital, Lille | InBrain Pharma | Recruiting | 45 Years | 75 Years | All | 20 | Phase 1/Phase 2 | France |
| 10 | NCT04193527 (ClinicalTrials.gov) | June 18, 2020 | 2/12/2019 | A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon ... | A Multicentre, Phase 3, Clinical Study to Compare the Striatal Uptake of a Dopamine Transporter Radioligand, DaTSCAN™ Ioflupane (123I) Injection, After Intravenous Administration to Chinese Patients With a Diagnosis of Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy, or Essential Tremor and to Healthy Controls A Multicentre, Phase 3, Clinical Study to Compare the Striatal Uptake of a DopamineTransporter Radio ... | Parkinsonian Syndrome;Parkinson Disease(PD);Multiple System Atrophy (MSA);Progressive Supranuclear Palsy (PSP) Parkinsonian Syndrome;Parkinson Disease(PD);Multiple System Atrophy (MSA);Progressive Supranuclear P ... | Drug: DaTSCAN™ Ioflupane (123I) Injection | GE Healthcare | PPD | Completed | 40 Years | 80 Years | All | 172 | Phase 3 | China |