60. Aplastic anemia Clinical trials / Disease details

Clinical trials : 235 / Drugs : 381 - (DrugBank : 83) / Drug target genes : 44 - Drug target pathways : 160

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05031897 (ClinicalTrials.gov)	October 25, 2021	31/8/2021	Reduced-Intensity Conditioning for the Prevention of Treatment-Related Mortality in Patients Who Und ...	A 2 Step Approach to Haploidentical Transplant Using Radiation-Based Reduced Intensity Conditioning	Acute Lymphoblastic Leukemia;Acute Myeloid Leukemia;Aplastic Anemia;Chronic Lymphocytic Leukemia;Chr ...	Procedure: Hematopoietic Cell Transplantation;Drug: Mycophenolate Mofetil;Drug: Tacrolimus;Drug: Cycl ...	Thomas Jefferson University	NULL	Recruiting	18 Years	N/A	All	67	Phase 2	United States
2	NCT05018936 (ClinicalTrials.gov)	October 1, 2021	19/8/2021	Efficacy and Safety of Hetrombopag in Non-severe Aplastic Anemia	Efficacy and Safety of Hetrombopag in Non-severe Aplastic Anemia: a Prospective Single Arm Study	Aplastic Anemia;Drug Effect	Drug: Hetrombopag	Peking Union Medical College Hospital	NULL	Not yet recruiting	18 Years	75 Years	All	40	Phase 2/Phase 3	China
3	NCT05049668 (ClinicalTrials.gov)	October 2021	13/9/2021	RACE 2: a Long Term Follow-up of Patients Participating in the RACE Trial	Long-term Follow-up of Patients Participating in RACE: the Prospective Randomized Multicenter Study ...	Severe Aplastic Anemia	Drug: ATGAM plus CsA with or without Eltrombopag	European Society for Blood and Marrow Transplantation	NULL	Enrolling by invitation	N/A	N/A	All	197		France
4	NCT05088655 (ClinicalTrials.gov)	June 25, 2021	12/10/2021	A Bioequivalence Study of Hetrombopag in Healthy Subjects	Bioequivalence Study of Different Formulations of Hetrombopag Olamine Tablets in Healthy Subjects	Sever Aplastic Anaemia	Drug: Hetrombopag Olamine Tablet	Jiangsu HengRui Medicine Co., Ltd.	NULL	Recruiting	18 Years	45 Years	All	57	Phase 1	China
5	ChiCTR2100047288	2021-06-01	2021-06-11	Efficacy and safety of combined immunosuppressive therapy plus umbilical cord blood infusion in myel ...	Efficacy and safety of combined immunosuppressive therapy plus umbilical cord blood infusion in myel ...	myelodysplastic syndromes/aplastic anemi	Experimental group1:According to the classification, ATG + CsA/CSAalone is used as the pretreatment ...	The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital)	NULL	Recruiting	18	90	Both	Experimental group1:10;Experimental group2:10;		China
6	ChiCTR2100045322	2021-06-01	2021-04-12	Efficacy and safety of umbilical cord mesenchymal stem cells combined with standard immunosuppressiv ...	Efficacy and safety of umbilical cord mesenchymal stem cells combined with standard immunosuppressiv ...	pediatric acquired severe aplastic anemia	Experimental group:Anti-thymocyte globulin+CiclosporinA+Mesenchymal stem cell;Control group:Anti-thy ...	Institute of Hematology & Blood Disease Hospital Chinese Academy of Medical Sciences	NULL	Recruiting	1	16	Both	Experimental group:32;Control group:32;		China
7	NCT04854889 (ClinicalTrials.gov)	April 22, 2021	14/4/2021	Efficacy and Safety of Low-dose Decitabine in Refractory Aplastic Anemia	Efficacy and Safety of Low-dose Decitabine in Refractory Aplastic Anemia(LODACA): a Phase 2, Single- ...	Refractory Aplastic Anemia	Drug: Decitabine	Institute of Hematology & Blood Diseases Hospital	NULL	Recruiting	12 Years	N/A	All	45	Phase 2	China
8	ChiCTR2100043229	2021-02-22	2021-02-09	A Single-Center, Single-Arm, Phase II Clinical Study of the Efficacy and Safety of Cyclosporine Comb ...	A Single-Center, Single-Arm, Phase II Clinical Study of the Efficacy and Safety of Cyclosporine Comb ...	Aplastic anemia	Durgs Group:Elrombopag combined with Cyclosporine;	Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences	NULL	Recruiting	18	85	Both	Durgs Group:61;	Phase 2	China
9	NCT04728789 (ClinicalTrials.gov)	February 1, 2021	1/12/2020	Avatrombopag Usage in NSAA	Efficacy and Safety of Avatrombopag in Non-severe Aplastic Anemia- a Multicenter Prospective Single ...	Aplastic Anemia;Drug Effect	Drug: Avatrombopag 20 MG	Peking Union Medical College Hospital	NULL	Not yet recruiting	18 Years	75 Years	All	40	Phase 2/Phase 3	China
10	NCT04558736 (ClinicalTrials.gov)	January 21, 2021	9/9/2020	Haploidentical HCT for Severe Aplastic Anemia	Haploidentical Donor Hematopoietic Cell Transplantation for Patients With Severe Aplastic Anemia	Aplastic Anemia;Bone Marrow Failure Syndrome	Drug: Anti-Thymocyte Globulin (Rabbit);Drug: Fludarabine;Drug: Cyclophosphamide;Drug: Mesna;Drug: G- ...	St. Jude Children's Research Hospital	NULL	Recruiting	N/A	21 Years	All	21	Phase 2	United States

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