86. Pulmonary arterial hypertension Clinical trials / Disease details


Clinical trials : 1,181 Drugs : 701 - (DrugBank : 126) / Drug target genes : 105 - Drug target pathways : 192

  
6 trials found
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1NCT03344159
(ClinicalTrials.gov)
April 1, 201828/9/2017Spironolactone Therapy in Chronic Stable Right HF TrialSpironolactone Therapy in Chronic Stable Right HF TrialChronic Right-Sided Heart Failure;Pulmonary Arterial Hypertension;Pulmonary Hypertension, Primary, 2;Pulmonary Hypertension, Primary, 3;Pulmonary Hypertension, Primary, 4;Cardiomyopathy Right VentricularDrug: Spironolactone;Drug: Placebo;Radiation: PET/CT Scan: Two PET scans using 1. C-11 HED and 2. N-13 Ammonia or rubidium-82;Diagnostic Test: Cardiac MRI (Gadolinium enhanced)Ottawa Heart Institute Research CorporationNULLRecruiting18 YearsN/AAll30Phase 4Canada
2NCT02253394
(ClinicalTrials.gov)
September 201517/9/2014The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension StudyThe Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension Study (The CAPS-PAH Study)Pulmonary Arterial HypertensionDrug: Ambrisentan plus Spironolactone;Drug: Ambrisentan plus PlaceboBrigham and Women's HospitalGilead SciencesTerminated18 YearsN/AAll2Phase 4United States
3NCT01712620
(ClinicalTrials.gov)
January 10, 201420/10/2012Spironolactone for Pulmonary Arterial HypertensionA Pilot Study of the Effect of Spironolactone Therapy on Exercise Capacity and Endothelial Dysfunction in Pulmonary Arterial HypertensionPulmonary Arterial HypertensionDrug: Spironolactone;Drug: PlaceboNational Institutes of Health Clinical Center (CC)National Heart, Lung, and Blood Institute (NHLBI);National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);University of Pennsylvania;University of Maryland Medical Center;Medstar Health Research Institute;New England Medical Center, Tufts University School of MedicineRecruiting18 YearsN/AAll70Phase 2United States
4NCT01468571
(ClinicalTrials.gov)
July 20113/11/2011Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial HypertensionEffects of Spironolactone on Collagen Metabolism in Pulmonary Arterial HypertensionPulmonary HypertensionDrug: Spironolactone;Drug: PlaceboBaylor College of MedicineNational Heart, Lung, and Blood Institute (NHLBI)Recruiting18 YearsN/ABoth50Phase 4United States
5NCT00811486
(ClinicalTrials.gov)
January 200918/12/2008Body Volume Regulation in Pulmonary Arterial Hypertension With Right Ventricular FailureBody Volume Regulation in Pulmonary Arterial Hypertension With Right Ventricular FailureRight Heart Failure;Pulmonary HypertensionDrug: Spironolactone and conivaptanUniversity of Colorado, DenverNULLWithdrawn18 Years75 YearsBoth0N/AUnited States
6NCT00240656
(ClinicalTrials.gov)
October 200517/10/2005Spironolactone Combined With Captopril and Carvedilol for the Treatment of Pulmonary Arterial HypertensionOfficial Title: Spironolactone Combined With Captopril and Carvedilol for the Treatment of Patients With Pulmonary Arterial Hypertension Associated With Congenital Heart Disease—Focus on Pulmonary Artery RemodelingHypertension, PulmonaryDrug: spironolactone captopril carvedilolHebei Medical UniversityNULLCompletedN/A80 YearsBothPhase 1China