96. Crohn disease Clinical trials / Disease details


Clinical trials : 2,400 Drugs : 1,391 - (DrugBank : 267) / Drug target genes : 170 - Drug target pathways : 215

  
16 trials found
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1NCT04186247
(ClinicalTrials.gov)
December 20212/12/2019Personalized AZithromycin/metronidAZole Therapy in Pediatric Crohn's Disease (CD)Personalized AZithromycin/metronidAZole, in Combination With Standard Induction Therapy, to Achieve a Fecal Microbiome Community Structure and Metagenome Changes Associated With Sustained Remission in Pediatric Crohn's Disease (CD): a Pilot StudyCrohn Disease;Pediatric Crohns DiseaseDrug: Azithromycin;Drug: Metronidazole;Other: Standard of CareUniversity of North Carolina, Chapel HillCrohn's and Colitis Foundation;University of AmsterdamNot yet recruiting3 Years17 YearsAll20Phase 2United States;Canada;Israel;Netherlands
2NCT04682522
(ClinicalTrials.gov)
March 21, 20219/12/2020Flagyl Microbiome in Crohn's DiseaseDoes the Microbiome Change With Flagyl Treatment After Ileocolic Resection for Crohn's DiseaseCrohn DiseaseDrug: Metronidazole OralUniversity of LouisvilleNULLRecruiting20 Years80 YearsAll36Phase 4United States
3EUCTR2019-004219-29-NL
(EUCTR)
21/04/202004/02/2020Personalized antibiotic therapy in combination with standard therapy to achieve a fecal profile associated with prolonged complaint-free period in pediatric Crohn’s DiseasePersonalized AZithromycin/metronidAZole, in combination with standard induction therapy, to achieve a fecal microbiome community structure and metagenome changes associated with sustained remission in pediatric Crohn’s Disease (CD): a pilot study” - PAZAZ Crohn's Disease;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]Trade Name: Azithromycin
Product Name: Azithromycin
INN or Proposed INN: Azithromycin
Other descriptive name: AZITHROMYCIN
Trade Name: Metronidazole
Product Name: Metronidazole
INN or Proposed INN: METRONIDAZOLE
Other descriptive name: METRONIDAZOLE
Amsterdam UMCNULLNot RecruitingFemale: yes
Male: yes
20Phase 2United States;Canada;Israel;Netherlands
4JPRN-UMIN000025846
2017/02/0101/02/2017A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease ulcerative colitis, Crohn's diseaseAdministration of the fecal material from healthy donors to patients after taking three kinds of antibiotics (Amoxicillin, fosmycin, metronidazole) for two weeksJuntendo university school of medicineDepartment of gastroenterologyNULLRecruiting16years-oldNot applicableMale and Female60Not selectedJapan
5JPRN-jRCTs031180415
01/02/201722/03/2019A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel diseaseSingle center non-randomized study: A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease Inflammatory Bowel Disease (Ulcerative Colitis, Crohn's Disease)
Inflammatory Bowel Disease (Ulcerative Colitis, Crohn's Disease)
AFM therapy arm : three antibiotics, amoxicillin (1500 mg/day), fosfomycin (3000 mg/day) and metronidazole (750 mg/day) are administered orally to patients for 2 weeks. For pediatric patients, amoxicillin (50mg/kg), fosfomycin (120mg/kg) and metronidazole (20mg/kg) are administered orally for 2 weeks (the upper limit is the same amount as adults).
FMT arm : Approximately 150 to 250 g of donor stool is diluted with saline (500 mL) and filtered to remove crude components. The diluted and filtered fecal suspension is transferred into the patients colon from cecum to rectum during total colonoscopy. As usual examinations, the patient undergoes biopsy of inflammatory site.
A-FMT arm : Patient undergoes FMT two days after AFM therapy.
Ishikawa DaiNULLRecruiting>= 6age oldNot applicableBoth120N/AJapan
6JPRN-UMIN000013369
2014/04/0120/03/2014Efficacy of preoperative oral antibiotics prophylaxis for prevention of surgical site infections in patients with Crohn's disease Crohn's diseaseOral antibiotics will be administrated on the day before surgery (500mg of kanamycin and 500mg of metronidazole at 14:00, 15:00, and 21:00)
without oral antibiotics
Hyogo college of medicineNULLComplete: follow-up complete20years-old70years-oldMale and Female240Phase 2Japan
7EUCTR2012-005226-29-PL
(EUCTR)
16/01/201419/09/2013Antibiotic therapy for children with active Crohn's diseaseAzithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease - AZCRO Crohn's disease;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]Product Name: azithromycin
Trade Name: metronidazole
Product Name: metronidazole
Product Name: azithromycin
Product Name: azithromycin
Erasmus MCHospital S. Joao;University hospital Brussel;Jagiellonian University Medical CollegeNot RecruitingFemale: yes
Male: yes
70Portugal;United States;Canada;Belgium;Poland;Israel;Netherlands
8EUCTR2012-005226-29-PT
(EUCTR)
20/12/201324/09/2013Antibiotic therapy for children with active Crohn's diseaseAzithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease - AZCRO Crohn's disease;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]Product Name: azithromycin
INN or Proposed INN: azithromycin
Other descriptive name: AZITHROMYCIN
Trade Name: metronidazole
Product Name: metronidazole
INN or Proposed INN: METRONIDAZOLE
Other descriptive name: Metronidazole
Centro Hospitalar de São João E.P.E.NULLNot RecruitingFemale: yes
Male: yes
70Phase 3United States;Portugal;Canada;Poland;Belgium;Israel;Netherlands
9EUCTR2012-005226-29-BE
(EUCTR)
26/04/201314/03/2013Antibiotic therapy for children with active Crohn's diseaseAzithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease - AZCRO Crohn's disease;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]Product Name: azithromycin
Trade Name: metronidazole
Product Name: metronidazole
Wolfson Medical CenterNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
70Portugal;United States;Canada;Poland;Belgium;Israel;Netherlands
10NCT01596894
(ClinicalTrials.gov)
October 201212/4/2012Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's DiseaseA Randomized, Single Blinded, Controlled, Multi Center Phase 4 Study for Induction of Remission in Active Pediatric Crohn's Disease, Using 2 Months Antibiotic Course of Azithromycin Combined With Metronidazole vs. Metronidazole Alone.Crohn's DiseaseDrug: Azithromycin + Metronidazole;Drug: MetronidazoleProf. Arie LevineNULLCompleted5 Years17 YearsAll73Phase 4Israel
11NCT01564823
(ClinicalTrials.gov)
June 201231/1/2012Adalimumab on Preventing Post-chirurgic Recurrence on Crohn´s DiseaseAdalimumab on Preventing Postoperative Recurrence of Crohn's DiseaseCrohn´s DiseaseDrug: Metronidazole;Drug: Azathioprine;Drug: AdalimumabGrupo Espanol de Trabajo en Enfermedad de Crohn y Colitis UlcerosaEffice Servicios Para la Investigacion S.L.Completed18 YearsN/ABoth86Phase 3Spain
12EUCTR2011-000885-36-ES
(EUCTR)
26/12/201129/11/2011Adalimub treatment to prevent recurrency post-surgery in Crohn disease.Multicentric, randomized double blind clinical trial and paralell groups to compare Adalimub vs Azatioprina efficacy prevention in Crhon disease post-surgical recurrency after 52 weeks of treatment - APPRECIA Compare efficay of Adalimub vs Azatioprina to prevent surgical intervention in Chron disease;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]Trade Name: Humira
Product Name: Humira
INN or Proposed INN: Adalimumab
Other descriptive name: Adalimumab
Trade Name: Imurel
Product Name: Imurel
INN or Proposed INN: Azatioprina
Other descriptive name: Imurel
Trade Name: Flagyl
Product Name: Flagyl
INN or Proposed INN: Metronidazol
Other descriptive name: Flagyl
GETECCUNULLNot RecruitingFemale: yes
Male: yes
Spain
13NCT00774969
(ClinicalTrials.gov)
October 200716/10/2008Evaluation of the Pharmacokinetics of Metronidazole 10% Ointment Applied Peri Anally in Healthy Volunteers and Patients With Perianal Crohn's DiseasePhase 1 Study to Evaluate the Pharmacokinetics of Metronidazole 10% Ointment Applied Peri-Anally in Healthy Volunteers and Patients With Perianal Crohn's DiseasePerianal Crohns'Drug: MetronidazoleS.L.A. Pharma AGNULLCompleted18 Years65 YearsBoth19Phase 1United Kingdom
14NCT00257699
(ClinicalTrials.gov)
May 200622/11/2005Study of Antibiotics in the Treatment of Colonic Crohn's DiseaseMetronidazole and Ciprofloxacin in the Treatment of Colonic Crohn's Disease: The MACINTOCC Trial.Crohn's DiseaseDrug: Metronidazole placebo;Drug: ciprofloxacin placebo;Drug: ciprofloxacin;Drug: metronidazoleMount Sinai Hospital, CanadaCrohn's and Colitis FoundationTerminated16 YearsN/ABoth12Phase 2Canada
15NCT00509639
(ClinicalTrials.gov)
May 200530/7/2007Evaluation of Topical 10% Metronidazole Ointment for the Treatment of Active Perianal Crohn's DiseasePhase III Study to Evaluate the Effect of 10% Metronidazole Ointment, Applied Topically Three Times a Day in and Around the Anus and the Change in Perianal Crohn's Disease ActivityCrohn's DiseaseDrug: 10% Metronidazole OintmentS.L.A. Pharma AGNULLCompleted18 YearsN/ABoth74Phase 3United States;United Kingdom
16EUCTR2012-005226-29-NL
(EUCTR)
08/03/2013Antibiotic therapy for children with active Crohn's diseaseAzithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease - AZCRO Crohn's disease;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]Product Name: azithromycin
Trade Name: metronidazole
Product Name: metronidazole
Wolfson Medical CenterNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
70United States;Canada;Israel;Netherlands