97. Ulcerative colitis Clinical trials / Disease details

Clinical trials : 2,527 / Drugs : 1,465 - (DrugBank : 259) / Drug target genes : 144 - Drug target pathways : 202

9 trials found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-jRCTs031200103	01/09/2020	01/09/2020	Alginate combined fecal microbiota transplantation for ulcerative colitis	Single center randomized study: Alginate combined fecal microbiota transplantation for ulcerative colitis	Ulcerative colitis Ulcerative colitis	A-FMT plus algin acid therapy arm Patients are performed Colonoscopy before participating in this clinical research and make sure the patients is eligible. Patient undergoes FMT two days after AFM therapy. Approximately 150 g to 200 g of fresh stool provided in advance from a donor is dissolved in 500 ml of physiological saline, and the treated stool that has been processed to remove excess residues and the like through a filter is stored frozen at minus 80 degree celsius. The diluted and filtered fecal suspension with dextrin added is transferred into the patients colon from cecum to rectum during total colonoscopy. As usual examinations, the patient undergoes biopsy of inflammatory site. For the next 8weeks, patients take algin acid two times a day every single day. A-FMT plus placebo arm Patients are performed Colonoscopy before participating in this clinical research and make sure the patients is eligible. Patient undergoes FMT two days after AFM therapy. Approximately 150 g to 200 g of fresh stool provided in advance from a donor is dissolved in 500 ml of physiological saline, and the treated stool that has been processed to remove excess residues and the like through a filter is stored frozen at minus 80 degree celsius. The diluted and filtered fecal suspension with dextrin added is transferred into the patients colon from cecum to rectum during total colonoscopy. As usual examinations, the patient undergoes biopsy of inflammatory site. For the next 8weeks, patients take Placebo two times a day every single day.	Ishikawa Dai	NULL	Recruiting	>= 20age old	Not applicable	Both	60	N/A	Japan
2	NCT03773445 (ClinicalTrials.gov)	March 1, 2019	25/11/2018	Golimumab Trough Levels in Patients With Ulcerative Colitis	Association of Golimumab Trough Levels With Endoscopic and Histologic Healing in Patients With Ulcerative Colitis	Ulcerative Colitis	Diagnostic Test: Golimumab trough levels;Diagnostic Test: Antibodies to golimumab;Diagnostic Test: Histology;Diagnostic Test: Colonoscopy	Hospital San Carlos, Madrid	Hospital Universitario La Fe;Hospital Universitario 12 de Octubre;Hospital Universitario Ramon y Cajal;Gregorio Marañón Hospital;Complejo Hospitalario de Navarra;Hospital Universitario Fundación Alcorcón;Hospital Infanta Sofia;Hospital Clínico Universitario de Valencia;Puerta de Hierro University Hospital;Hospital Universitario La Paz;Hospital Universitario de Fuenlabrada;Merck Sharp & Dohme Corp.	Recruiting	18 Years	N/A	All	100		Spain
3	NCT03581149 (ClinicalTrials.gov)	March 26, 2018	27/3/2018	Tolerability and Efficacy of Sodium Picosulfate/Magnesium Citrate Versus PEG/Ascorbic Acid in Ulcerative Colitis Patients	Tolerability and Efficacy of Low-Volume Sodium Picosulfate/Magnesium Citrate Versus 2L Polyethylene Glycol/Ascorbic Acid in Patients With Ulcerative Colitis Undergoing Colonoscopy: A Randomized Controlled Trial	Ulcerative Colitis	Drug: Sodium Picosulfate/Magnesium Citrate Laxative;Drug: 2L polyethylene glycol/ascorbic acid	American University of Beirut Medical Center	NULL	Recruiting	18 Years	65 Years	All	68	Phase 4	Lebanon
4	JPRN-jRCTs031180415	01/02/2017	22/03/2019	A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease	Single center non-randomized study: A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease	Inflammatory Bowel Disease (Ulcerative Colitis, Crohn's Disease) Inflammatory Bowel Disease (Ulcerative Colitis, Crohn's Disease)	AFM therapy arm : three antibiotics, amoxicillin (1500 mg/day), fosfomycin (3000 mg/day) and metronidazole (750 mg/day) are administered orally to patients for 2 weeks. For pediatric patients, amoxicillin (50mg/kg), fosfomycin (120mg/kg) and metronidazole (20mg/kg) are administered orally for 2 weeks (the upper limit is the same amount as adults). FMT arm : Approximately 150 to 250 g of donor stool is diluted with saline (500 mL) and filtered to remove crude components. The diluted and filtered fecal suspension is transferred into the patients colon from cecum to rectum during total colonoscopy. As usual examinations, the patient undergoes biopsy of inflammatory site. A-FMT arm : Patient undergoes FMT two days after AFM therapy.	Ishikawa Dai	NULL	Recruiting	>= 6age old	Not applicable	Both	120	N/A	Japan
5	NCT04434872 (ClinicalTrials.gov)	July 2015	28/5/2015	Fecal Microbiota Transplantation as a Treatment for Ulcerative Colitis		Ulcerative Colitis	Procedure: Colonoscopy;Procedure: Gastroscopy;Drug: Fecal Microbiota;Procedure: Enema	Tel-Aviv Sourasky Medical Center	NULL	Terminated	18 Years	70 Years	All	80	Phase 2	Israel
6	JPRN-UMIN000013892	2013/07/01	06/05/2014	A prospective randomized controlled trial of AJG522 versus standard PEG plus E as bowel preparation for colonoscopy		Ulcerative colitis and so on	AJG522 PEG plus E (Niflec®)	Gunma University Graduate School of Medicine	NULL	Complete: follow-up complete	20years-old	Not applicable	Male and Female	80	Phase 4	Japan
7	EUCTR2011-005693-36-IT (EUCTR)	09/01/2012	02/03/2012	Evaluation of the number of colon intraephitelial tumours in patients with ulcerative colitis after oral administration of the vital dye methylene blue	Intraepithelial neoplasia detection rate after single oral dose of methylene blue MMX modified release tablets administered to patients with long standing ulcerative colitis undergoing colonoscopy - NA	Patients affecetd by Long standing ulcerative colitis MedDRA version: 14.1;Level: SOC;Classification code 10017947;Term: Gastrointestinal disorders;System Organ Class: 10017947 - Gastrointestinal disorders;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]	Product Name: Methylene blue 25mg tablets Product Code: NA INN or Proposed INN: METHYLENE BLUE Other descriptive name: NA	COSMO TECHNOLOGIES LTD	NULL	Not Recruiting			Female: yes Male: yes			Italy
8	NCT00292175 (ClinicalTrials.gov)	February 2006	14/2/2006	NBI With Magnification for Dysplasia Detection in Ulcerative Colitis	Randomised,Controlled Trial of Narrow Band Imaging With Magnification (NBI) Versus White Light Endoscopy for Dysplasia Detection in Ulcerative Colitis Surveillance	Ulcerative Colitis	Procedure: Narrow Band Imaging;Procedure: colonoscopy	London North West Healthcare NHS Trust	Nottingham University Hospitals NHS Trust	Recruiting	18 Years	N/A	Both	110	N/A	United Kingdom
9	EUCTR2004-000733-12-CZ (EUCTR)	14/07/2004	01/07/2004	A phase III, randomized, multi-center, double-blind, parallel-group, placebo controlled study to evaluate the safety and efficacy of SPD476 (mesalazine) given twice daily (2.4g/day) versus SPD476 given as a single dose (4.8g/day) in subject with acute mild to moderate ulcerative colitis.	A phase III, randomized, multi-center, double-blind, parallel-group, placebo controlled study to evaluate the safety and efficacy of SPD476 (mesalazine) given twice daily (2.4g/day) versus SPD476 given as a single dose (4.8g/day) in subject with acute mild to moderate ulcerative colitis.	Subjects who have newly diagnosed or have a diagnosis of relapsing (relapses1 and a Physician Global Assessment of <2). The original diagnosis of UC must be established by sigmoidoscopy, colonoscopy, or barium enema and have compatible histology.	Product Name: Mesalazine Product Code: SPD476 INN or Proposed INN: Mesalazinum Other descriptive name: 5-amino salicylic acid (5-ASA)	Shire Pharmaceutical Development Inc	NULL	Not Recruiting			Female: yes Male: yes	255	Phase 3	Czech Republic