Tumor Necrosis Factor Inhibitors ( DrugBank: - )

1 disease

ID	Disease name (Link within this page)	Number of trials
46	Malignant rheumatoid arthritis	18

46. Malignant rheumatoid arthritis

Clinical trials : 4,325 / Drugs : 2,671 - (DrugBank : 417) / Drug target genes : 187 - Drug target pathways : 224

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04255134 (ClinicalTrials.gov)	September 7, 2020	14/11/2019	Biologics for Rheumatoid Arthritis Pain (BIORA-PAIN)	Comparison of Abatacept With Tumor Necrosis Factor Inhibitorsin the Treatment of Rheumatoid Arthriti ...	Rheumatoid Arthritis	Drug: Abatacept Injection;Drug: Adalimumab Injection	St George's, University of London	NULL	Recruiting	18 Years	75 Years	All	60	Phase 4	United Kingdom
2	NCT04529902 (ClinicalTrials.gov)	August 17, 2020	25/8/2020	Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - TNFi vs Abatacept	Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines - Tumor Necrosis Factor Inhib ...	Rheumatoid Arthritis	Drug: Tumor Necrosis Factor Inhibitors;Drug: Abatacept	Brigham and Women's Hospital	National Institute on Aging (NIA);Rutgers University;Johns Hopkins University	Completed	18 Years	N/A	All	63013		United States
3	NCT04115423 (ClinicalTrials.gov)	April 1, 2020	2/10/2019	A Retrospective Cohort Study on the Risk of Serious Infections in Rheumatoid Arthritis Patients Rece ...	A Retrospective Cohort Study to Examine the Risk of Serious Infections in Rheumatoid Arthritis Patie ...	Infection;Rheumatoid Arthritis	Drug: Tocilizumab;Drug: Tumor Necrosis Factor Inhibitor (etanercept, infliximab, adalimumab, and gol ...	Sungkyunkwan University	Ministry of Food and Drug Safety, Korea	Active, not recruiting	18 Years	N/A	All	9508		Korea, Republic of
4	EUCTR2019-004468-23-GB (EUCTR)	10/02/2020	26/02/2020	Biologics for RA Pain ( BIORA-PAIN)	Comparison of abatacept with tumor necrosis factor inhibitorsin the treatment of rheumatoid arthriti ...	Rheumatoid arthritis;Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05]	Trade Name: Abatacept Product Name: Abatacept INN or Proposed INN: Abatacept Trade Name: Humira Product ...	St George's, University of London	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	60	Phase 4	United Kingdom
5	NCT03449758 (ClinicalTrials.gov)	March 5, 2018	8/2/2018	Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid Arthritis	Effect of Sarilumab on Patient-reported Outcomes in Patients With Moderately to Severely Active Rheu ...	Rheumatoid Arthritis	Drug: SARILUMAB;Drug: Azathioprine;Drug: Chloroquine;Drug: Hydroxychloroquine;Drug: Leflunomide;Drug ...	Sanofi	Regeneron Pharmaceuticals	Completed	18 Years	N/A	All	84	Phase 4	France
6	EUCTR2012-002323-15-HR (EUCTR)	17/07/2013	30/03/2015	A Phase 3 Study in Moderate to Severe Rheumatoid Arthritis	A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of ...	Moderately to severely active rheumatoid arthritis MedDRA version: 17.1;Level: PT;Classification cod ...	Product Name: baricitinib Product Code: LY3009104 INN or Proposed INN: baricitinib Other descriptive na ...	Eli Lilly and Company	NULL	Not Recruiting			Female: yes Male: yes	525	Phase 3	United States;Greece;Spain;Turkey;Austria;Israel;Italy;Switzerland;United Kingdom;India;France;Mexic ...
7	EUCTR2012-002323-15-GR (EUCTR)	15/04/2013	29/03/2013	A Phase 3 Study in Moderate to Severe Rheumatoid Arthritis	A Randomized, Double-Blind, Placebo-Controlled, Phase 3Study Evaluating the Efficacy and Safety of B ...	Moderately to severely active rheumatoid arthritis MedDRA version: 14.1;Level: PT;Classification cod ...	Product Name: baricitinib Product Code: LY3009104 Other descriptive name: baricitinib Product Name: bar ...	Eli Lilly and Company	NULL	Not Recruiting			Female: yes Male: yes	525	Phase 3	United States;Greece;Spain;Turkey;Austria;Israel;Italy;Switzerland;United Kingdom;India;France;Mexic ...
8	EUCTR2012-002323-15-GB (EUCTR)	21/03/2013	21/12/2012	A Phase 3 Study in Moderate to Severe Rheumatoid Arthritis	A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of ...	Moderately to severely active rheumatoid arthritis MedDRA version: 16.0;Level: PT;Classification cod ...	Product Name: baricitinib Product Code: LY3009104 Other descriptive name: baricitinib Product Name: bar ...	Eli Lilly and Company	NULL	Not Recruiting			Female: yes Male: yes	525	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (P ...	Korea, Republic of;Japan;Germany;Netherlands;Denmark;Australia;Croatia;Belgium;Poland;Argentina;Cana ...
9	EUCTR2012-002323-15-DK (EUCTR)	08/02/2013	08/01/2013	A Phase 3 Study in Moderate to Severe Rheumatoid Arthritis	A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of ...	Moderately to severely active rheumatoid arthritis MedDRA version: 14.1;Level: PT;Classification cod ...	Product Name: baricitinib Product Code: LY3009104 Other descriptive name: baricitinib Product Name: bar ...	Eli Lilly and Company	NULL	Not Recruiting			Female: yes Male: yes	525	Phase 3	United States;Greece;Spain;Turkey;Austria;Israel;Italy;Switzerland;United Kingdom;India;France;Mexic ...
10	EUCTR2012-002323-15-BE (EUCTR)	28/01/2013	20/12/2012	A Phase 3 Study in Moderate to Severe Rheumatoid Arthritis	A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of ...	Moderately to severely active rheumatoid arthritis MedDRA version: 14.1;Level: PT;Classification cod ...	Product Name: baricitinib Product Code: LY3009104 Other descriptive name: baricitinib Product Name: bar ...	Eli Lilly and Company	NULL	Not Recruiting			Female: yes Male: yes	525	Phase 3	United States;Greece;Spain;Turkey;Austria;Israel;Italy;Switzerland;United Kingdom;India;France;Mexic ...

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