EN ( DrugBank: - )

3 diseases

ID	Disease name (Link within this page)	Number of trials
6	Parkinson disease	256
46	Malignant rheumatoid arthritis	439
97	Ulcerative colitis	295

6. Parkinson disease

Clinical trials : 2,298 / Drugs : 2,202 - (DrugBank : 350) / Drug target genes : 188 - Drug target pathways : 202

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04858074 (ClinicalTrials.gov)	January 3, 2022	7/4/2021	Study to Investigate the Effect of Hypoestes Rosea Powder in Parkinson's Disease	A Proof of Concept (POC) Study to Investigate the Effect of 100% Hypoestes Rosea Powder in Parkinson ...	Parkinson Disease	Drug: Hypoestoxide	University of Ibadan	NULL	Enrolling by invitation	30 Years	85 Years	All	30	Phase 1/Phase 2	Nigeria
2	NCT05173701 (ClinicalTrials.gov)	November 22, 2021	8/11/2021	Effects of Probiotics on Peripheral Immunity in Parkinson's Disease	Effects of Probiotics on Peripheral Immunity in Parkinson's Disease	Parkinson's Disease	Dietary Supplement: Probiotics;Dietary Supplement: Placebo	Franca Marino	Università degli Studi del Piemonte Orientale Amedeo Avogadro;Università degli Studi dell'Insubria	Enrolling by invitation	N/A	N/A	All	88	N/A	Italy
3	NCT05022147 (ClinicalTrials.gov)	October 4, 2021	9/8/2021	Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease	ENGAGE-PD: Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease	Parkinson Disease;Gait Disorders, Neurologic;Disease Progression;Subthalamic Nucleus;Accidental Fall ...	Device: High-Frequency-Only Stimulation;Device: Low-Frequency-Only Stimulation;Device: Alternating, ...	The Cleveland Clinic	NULL	Recruiting	21 Years	N/A	All	12	Phase 1	United States
4	NCT04871464 (ClinicalTrials.gov)	September 2021	29/4/2021	Role and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's Disease ...	Role and Mechanism of Bifidobacterium Triple Viable Capsules in Improving Motor Symptoms in Patients ...	Parkinson Disease;Parkinsonian Disorders;Basal Ganglia Diseases;Brain Diseases;Movement Disorders;Ne ...	Drug: Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules;Other: Placebo	Beijing Friendship Hospital	NULL	Recruiting	40 Years	80 Years	All	240	Phase 4	China
5	NCT04986995 (ClinicalTrials.gov)	June 9, 2021	27/7/2021	OpicApone Sleep dISorder	Open-label, Single-arm, Pilot Study to Evaluate the Effect of Opicapone 50 mg on Parkinson's Disease ...	Parkinson Disease	Drug: Opicapone	Bial - Portela C S.A.	NULL	Recruiting	30 Years	N/A	All	30	Phase 4	Portugal
6	NCT04863118 (ClinicalTrials.gov)	June 1, 2021	11/4/2021	Acute Effects of Strength Training and High Intensity Training on Functional and Biochemical Measure ...	Acute Effects of Strength Training in Shallow Water and Dry Land and High-intensity Training in Shal ...	Parkinson Disease and Hydrotherapy	Other: Strength training in shallow water and dry land;Other: High-intensity training in shallow and ...	Federal University of Health Science of Porto Alegre	NULL	Not yet recruiting	50 Years	70 Years	All	60	N/A	NULL
7	EUCTR2020-004997-23-ES (EUCTR)	25/05/2021	01/09/2021	A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants with Early P ...	A PHASE IIB, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICAC ...	Early Parkinson's disease MedDRA version: 20.0;Level: PT;Classification code 10061536;Term: Parkinso ...	Product Name: aSyn Mab Product Code: RO7046015 INN or Proposed INN: Prasinezumab Other descriptive name ...	Roche Farma S. A. U. que realiza el ensayo enEspaña y que actúa como representante F. Hoffmann-La Ro ...	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	575	Phase 2	France;United States;Canada;Poland;Spain;Austria;United Kingdom;Italy
8	EUCTR2020-001176-15-DE (EUCTR)	07/05/2021	17/12/2020	Clinical study to investigate if Opicapone 50mg can reduce sleep disorders associated to Parkinson's ...	Open-label, single-arm, pilot study to evaluate the effect of opicapone 50 mg on Parkinson’s disease ...	Parkinson's disease patients with wearing-off motor fluctuations and associated sleep disorders. Med ...	Trade Name: Ongentys Product Name: Ongentys 50 mg hard capsules INN or Proposed INN: OPICAPONE Other de ...	Bial - Portela & Ca, S.A.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	30	Phase 4	Portugal;Germany
9	EUCTR2021-000826-89-FR (EUCTR)	23/04/2021	25/03/2021	Etude pharmacocinétique de l’apomorphine enperfusion sous-cutanée continue diurne chez le patient pa ...	Etude pharmacocinétique de l’apomorphine enperfusion sous-cutanée continue diurne chez le patient pa ...	Parkinson's disease MedDRA version: 20.0;Level: PT;Classification code 10061536;Term: Parkinson's di ...	Trade Name: APOKINON Product Name: APOKINON Product Code: N04BC07	CHU Rennes	NULL	Authorised-recruitment may be ongoing or finished			Female: no Male: yes	20	Phase 4	France
10	EUCTR2020-001176-15-PT (EUCTR)	19/03/2021	04/01/2021	Clinical study to investigate if Opicapone 50mg can reduce sleep disorders associated to Parkinson's ...	Open-label, single-arm, pilot study to evaluate the effect of opicapone 50 mg on Parkinson’s disease ...	Parkinson's disease patients with wearing-off motor fluctuations and associated sleep disorders. Med ...	Trade Name: Ongentys Product Name: Ongentys 50 mg hard capsules INN or Proposed INN: OPICAPONE Other de ...	Bial - Portela & Ca, S.A.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	30	Phase 4	Portugal;Germany

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46. Malignant rheumatoid arthritis

Clinical trials : 4,325 / Drugs : 2,671 - (DrugBank : 417) / Drug target genes : 187 - Drug target pathways : 224

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04688398 (ClinicalTrials.gov)	January 10, 2022	14/12/2020	Study of the Impact of Fatty Acids From Seal Oil on the Relief of Symptoms Associated With Rheumatoi ...	Study of the Impact of Fatty Acids From Seal Oil on the Relief of Symptoms Associated With Rheumatoi ...	Polyarthritis	Dietary Supplement: Seal oil;Dietary Supplement: Control	Laval University	Ministry of Agriculture, Fisheries and Food, Quebec;Groupe De Recherche EnRhumatologie Et Maladies O ...	Not yet recruiting	18 Years	N/A	All	130	N/A	NULL
2	NCT04885751 (ClinicalTrials.gov)	June 1, 2021	26/4/2021	Compare the Effect of Eupatilin and Rebamipide on the Prevention of Gastroenteropathy	Compare the Effect of Eupatilin and Rebamipide on the Prevention of Gastroenteropathy in Patients Wi ...	Rheumatoid Arthritis;Osteoarthritis;Ankylosing Spondylitis;Other Musculoskeletal Disorder;Gastric Ul ...	Drug: Eupatilin;Drug: Rebamipide	Seoul National University Boramae Hospital	Dong-A ST Co., Ltd.	Not yet recruiting	19 Years	70 Years	All	50	Phase 4	NULL
3	EUCTR2020-005096-12-SE (EUCTR)	31/05/2021	09/04/2021	Utvärdering av två kortison behandlingsstrategier hos patienter med nydiagnostiserad, tidigare obeha ...	Utvärdering av två kortison behandlingsstrategier hos patienter med nydiagnostiserad, tidigare obeha ...	Rheumatoid arthritis MedDRA version: 23.1;Level: PT;Classification code 10039073;Term: Rheumatoid ar ...	Trade Name: Prednisolon Pfizer Product Name: Prednisolon Pfizer INN or Proposed INN: PREDNISOLONE	Karolinska Universitetssjukhuset	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	166	Phase 4	Sweden
4	JPRN-jRCTs071200107	25/05/2021	03/03/2021	Efficacy and safety of selective JAK 1 inhibitor Filgotinib in active rheumatoid arthritis patients ...	Efficacy and safety of selective JAK 1 inhibitor Filgotinib in active rheumatoid arthritis patients ...	Rheumatoid arthritis	In patients with active RA for whom continuous MTX treatment (including other concurrent csDMARDs) f ...	Kawakami Atsushi	NULL	Recruiting	>= 20age old	Not applicable	Both	400	N/A	Japan
5	NCT04798287 (ClinicalTrials.gov)	March 10, 2021	11/3/2021	Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)-Cancer Endpoints	Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)-Cancer Endpoints	Rheumatoid Arthritis	Drug: Tofacitinib;Drug: TNF Inhibitor	Brigham and Women's Hospital	NULL	Active, not recruiting	18 Years	N/A	All	105711		United States
6	NCT04772248 (ClinicalTrials.gov)	February 22, 2021	23/2/2021	Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)- Cardiovascular E ...	Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)- Cardiovascular E ...	Rheumatoid Arthritis	Drug: Tofacitinib;Drug: TNF Inhibitor	Brigham and Women's Hospital	NULL	Completed	18 Years	N/A	All	105711		United States
7	NCT04559412 (ClinicalTrials.gov)	January 2, 2021	3/9/2020	Study to Assess the Safety and Efficacy of Enbrel Administered by Sofusa DoseConnect for Rheumatoid ...	Phase 1b Proof-of-concept, Open-label Study to Assess the Safety and Pilot Efficacy of Enbrel® Admin ...	Rheumatoid Arthritis	Device: Sofusa DoseConnect;Drug: Enbrel	Sorrento Therapeutics, Inc.	NULL	Recruiting	18 Years	80 Years	All	10	Phase 1	United States
8	EUCTR2018-004558-30-DK (EUCTR)	18/12/2020	05/10/2020	A 3-arm, randomized, open-label, parallel active controlled, multicenter international study to comp ...	A 3-arm, randomized, open-label, parallel active controlled, multicenter international study to comp ...	rheumatoid arthritis MedDRA version: 23.1;Level: PT;Classification code 10039073;Term: Rheumatoid ar ...	Trade Name: Olumiant Product Name: Olumiant INN or Proposed INN: BARICITINIB Trade Name: Enbrel Product ...	Fundación Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	186	Phase 4	Portugal;Spain;Denmark
9	JPRN-jRCTs071200054	18/11/2020	18/11/2020	Effectiveness of Etanercept Biosimilar Initiating for Etanercept -Naive Patients, using Ultrasound, ...	Effectiveness of Etanercept Biosimilar Initiating for Etanercept -Naive Patients, using Ultrasound, ...	Rheumatoid arthritis	Rheumatoid arthritis patients with moderate or high disease activity will be introduce for etanercep ...	Kawakami Atsushi	NULL	Recruiting	>= 20age old	Not applicable	Both	40	Phase 4	Japan
10	NCT04638426 (ClinicalTrials.gov)	September 10, 2020	13/11/2020	Phase 2a Clinical Trial of HL237 for Rheumatoid Arthritis	For 12 Weeks, the Multi Center, Randomized, Double Blinded, Placebo Controlled, Parallel, Dose-findi ...	Rheumatoid Arthritis	Drug: HL237 tablet;Drug: Placebo of HL237 tablet	Hanlim Pharm. Co., Ltd.	NULL	Enrolling by invitation	19 Years	N/A	All	196	Phase 2	Korea, Republic of

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97. Ulcerative colitis

Clinical trials : 2,527 / Drugs : 1,465 - (DrugBank : 259) / Drug target genes : 144 - Drug target pathways : 202

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-jRCT1051210145	28/12/2021	28/12/2021	Efficacy of therapeutic intervention with vedolizumab for ulcerative colitis patients with no or mil ...	Efficacy of therapeutic intervention with vedolizumab for ulcerative colitis patients with no or mil ...	ulcerative colitis ulcerative colitis;D003093	Administration of vedolizumab 300mg/day at 0,2, and 6 weeks, then at 8-week intervals for up to 54 w ...	ooi makoto	NULL	Recruiting	>= 18age old	<= 80age old	Both	150	Phase 3	Japan
2	EUCTR2020-004300-34-IT (EUCTR)	13/10/2021	30/08/2021	A study to evaluate efficacy and safety of Vedolizumab in pediatric subjects with moderately to seve ...	A Randomized, Double-Blind, Phase 3 Study to Evaluate the Efficacy and Safety of Vedolizumab Intrave ...	Moderately to severely active Ulcerative Colitis (UC) MedDRA version: 20.1;Level: LLT;Classification ...	Trade Name: ENTYVIO - 300 MG - POLVERE PE RCONCENTRATO PER SOLUZIONE PER INFUSIONE - USO ENDOVENOSO ...	TAKEDA DEVELOPMENT CENTER AMERICAS INC.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	120	Phase 3	United States;Slovakia;Greece;Spain;Ukraine;Russian Federation;Israel;Italy;France;Australia;China;B ...
3	NCT03843385 (ClinicalTrials.gov)	October 2021	14/2/2019	Transfer of FRozen Encapsulated Multidonor Stool Filtrate for Active Ulcerative COlitis	Longterm Transfer of FRozen Encapsulated Multidonor Stool Filtrate or Encapsulated Multidonor Microb ...	Ulcerative Colitis;Inflammatory Bowel Diseases	Drug: encapsulated faecal microbiota filtrate;Drug: encapsulated faecal microbiota;Drug: Placebo	Jena University Hospital	German Federal Ministry of Education and Research	Not yet recruiting	18 Years	75 Years	All	174	Phase 2/Phase 3	NULL
4	EUCTR2019-002485-12-IT (EUCTR)	23/09/2021	22/10/2020	Determination of the Optimal Treatment Target in Ulcerative Colitis	VERDICT: In actiVE ulcerative colitis, a RanDomIzed Controlled Trial for determination of the optima ...	Ulcerative Colitis (UC) MedDRA version: 20.1;Level: LLT;Classification code 10045365;Term: Ulcerativ ...	Trade Name: Entyvio Product Name: Entyvio Product Code: [NA] Other descriptive name: VEDULIZUMAB Trade N ...	ALIMENTIV INC.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	660	Phase 4	United States;France;Belarus;Canada;Poland;Belgium;Ukraine;Russian Federation;Netherlands;United Kin ...
5	JPRN-jRCTs031210326	21/09/2021	21/09/2021	Evaluation of biomarkers in BF treatment	A multicenter study to evaluate the effectiveness of budesonide enema foam treatment and the usefuln ...	Ulcerative colitis Ulcerative colitis	Budesonide foam was administered as a study drug	Matsuoka Katsuyoshi	EA Pharma Co., Ltd.	Recruiting	>= 16age old	Not applicable	Both	20	N/A	Japan
6	EUCTR2020-004300-34-SK (EUCTR)	18/09/2021	28/04/2021	A study to evaluate efficacy and safety of Vedolizumab in pediatric subjects with moderately to seve ...	A Randomized, Double-Blind, Phase 3 Study to Evaluate the Efficacy and Safety of Vedolizumab Intrave ...	Moderately to severely active Ulcerative Colitis (UC) MedDRA version: 20.1;Level: LLT;Classification ...	Trade Name: ENTYVIO INN or Proposed INN: Vedolizumab Other descriptive name: MLN0002	Takeda Development Center Americas, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	120	Phase 3	United States;Slovakia;Greece;Spain;Ukraine;Russian Federation;Israel;Italy;France;Australia;China;B ...
7	JPRN-jRCT2051210087	17/09/2021	22/09/2021	Safety and pharmacokinetics study in healthy Japanese volunteers	A Phase 1 study to assess the safety, tolerability and pharmacokinetics after single and multiple do ...	Ulcerative colitis	Part A Part A includes the following two dose regimen groups: - 25 mg dose regimen group: ABX464 25 m ...	Owada Yasuko	NULL	Pending	>= 20age old	<= 45age old	Male	48	Phase 1	Japan
8	EUCTR2021-003023-14-SE (EUCTR)	02/09/2021	23/06/2021	Pharmacokinetics of Cobitolimod Enemas in Participants with active Ulcerative Colitis	Pharmacokinetics of Cobitolimod Enemas in Participants with active Ulcerative Colitis	Moderate to Severe Active Ulcerative Colitis MedDRA version: 20.1;Level: LLT;Classification code 100 ...	Product Code: DIMS0150 INN or Proposed INN: Cobitolimod Other descriptive name: DIMS0150	InDex Pharmaceuticals AB	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	20	Phase 1;Phase 2	Sweden
9	EUCTR2020-004300-34-HR (EUCTR)	18/08/2021	02/09/2021	A study to evaluate efficacy and safety of Vedolizumab in pediatric subjects with moderately to seve ...	A Randomized, Double-Blind, Phase 3 Study to Evaluate the Efficacy and Safety of Vedolizumab Intrave ...	Moderately to severely active Ulcerative Colitis (UC) MedDRA version: 20.1;Level: LLT;Classification ...	Trade Name: ENTYVIO Product Name: Vedolizumab INN or Proposed INN: Vedolizumab Other descriptive name: ...	Takeda Development Center Americas, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	120	Phase 3	United States;Slovakia;Greece;Spain;Ukraine;Russian Federation;Israel;Italy;France;Australia;China;B ...
10	EUCTR2020-004300-34-HU (EUCTR)	06/08/2021	28/04/2021	A study to evaluate efficacy and safety of Vedolizumab in pediatric subjects with moderately to seve ...	A Randomized, Double-Blind, Phase 3 Study to Evaluate the Efficacy and Safety of Vedolizumab Intrave ...	Moderately to severely active Ulcerative Colitis (UC) MedDRA version: 20.1;Level: LLT;Classification ...	Trade Name: ENTYVIO Product Name: Vedolizumab INN or Proposed INN: Vedolizumab Other descriptive name: ...	Takeda Development Center Americas, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	120	Phase 3	United States;Slovakia;Greece;Spain;Ukraine;Russian Federation;Israel;Italy;France;Australia;China;B ...

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