Antibiotics ( DrugBank: - )


1 disease
IDDisease name (Link within this page)Number of trials
96Crohn disease6

96. Crohn disease


Clinical trials : 2,400 Drugs : 1,391 - (DrugBank : 267) / Drug target genes : 170 - Drug target pathways : 215
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PhaseCountries
1NCT04970446
(ClinicalTrials.gov)
August 1, 202118/7/2021The MIRO II Study: Microbial Restoration in Inflammatory Bowel DiseasesThe MIRO II Study: Microbial Restoration in Inflammatory Bowel DiseasesFecal Microbiota Transplantation;Crohn Disease;Inflammatory Bowel Diseases;MicrobiomeDrug: Antibiotics;Dietary Supplement: Dietician designed diet;Drug: FMT;Other: PlaceboSt Vincent's Hospital MelbourneThe Queen Elizabeth Hospital;BiomeBank Adelaide;The University of Queensland;Monash UniversityNot yet recruiting18 Years70 YearsAll120Phase 2/Phase 3NULL
2JPRN-jRCTs031180415
01/02/201722/03/2019A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel diseaseSingle center non-randomized study: A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease Inflammatory Bowel Disease (Ulcerative Colitis, Crohn's Disease)
Inflammatory Bowel Disease (Ulcerative Colitis, Crohn's Disease)
AFM therapy arm : three antibiotics, amoxicillin (1500 mg/day), fosfomycin (3000 mg/day) and metronidazole (750 mg/day) are administered orally to patients for 2 weeks. For pediatric patients, amoxicillin (50mg/kg), fosfomycin (120mg/kg) and metronidazole (20mg/kg) are administered orally for 2 weeks (the upper limit is the same amount as adults).
FMT arm : Approximately 150 to 250 g of donor stool is diluted with saline (500 mL) and filtered to remove crude components. The diluted and filtered fecal suspension is transferred into the patients colon from cecum to rectum during total colonoscopy. As usual examinations, the patient undergoes biopsy of inflammatory site.
A-FMT arm : Patient undergoes FMT two days after AFM therapy.
Ishikawa DaiNULLRecruiting>= 6age oldNot applicableBoth120N/AJapan
3JPRN-UMIN000025846
2017/02/0101/02/2017A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease ulcerative colitis, Crohn's diseaseAdministration of the fecal material from healthy donors to patients after taking three kinds of antibiotics (Amoxicillin, fosmycin, metronidazole) for two weeksJuntendo university school of medicineDepartment of gastroenterologyNULLRecruiting16years-oldNot applicableMale and Female60Not selectedJapan
4JPRN-UMIN000013369
2014/04/0120/03/2014Efficacy of preoperative oral antibiotics prophylaxis for prevention of surgical site infections in patients with Crohn's disease Crohn's diseaseOral antibiotics will be administrated on the day before surgery (500mg of kanamycin and 500mg of metronidazole at 14:00, 15:00, and 21:00)
without oral antibiotics
Hyogo college of medicineNULLComplete: follow-up complete20years-old70years-oldMale and Female240Phase 2Japan
5NCT01783106
(ClinicalTrials.gov)
February 1, 201431/1/2013Antibiotics and Hydroxychloroquine in Crohn'sA Pilot Randomised Study to Compare Combination Antibiotic Therapy (Ciprofloxacin, Doxycycline and Hydroxychloroquine) With Standard Therapy (Budesonide) in the Treatment of Active Crohn's DiseaseCrohn's DiseaseDrug: Ciprofloxacin;Drug: Doxycycline;Drug: Hydroxychloroquine;Drug: BudesonideRoyal Liverpool University HospitalNational Association for Colitis and Crohn's Disease;National Institute for Health Research, United KingdomCompleted18 YearsN/AAll59Phase 2United Kingdom
6NCT00257699
(ClinicalTrials.gov)
May 200622/11/2005Study of Antibiotics in the Treatment of Colonic Crohn's DiseaseMetronidazole and Ciprofloxacin in the Treatment of Colonic Crohn's Disease: The MACINTOCC Trial.Crohn's DiseaseDrug: Metronidazole placebo;Drug: ciprofloxacin placebo;Drug: ciprofloxacin;Drug: metronidazoleMount Sinai Hospital, CanadaCrohn's and Colitis FoundationTerminated16 YearsN/ABoth12Phase 2Canada