Target Gene/Pathway(薬物標的遺伝子/パスウェイリスト)💬 Info on mouse-over
No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related |
KEGG GENES | KEGG DRUG | DrugBank | 指定難病告示番号 |
1 | ABC transporters 💬 2 genes, 9 drugs (DrugBank) and 6 diseases |
ABCC8 1件: ABCC8 💬 |
D00418 D00418 💬 |
Minoxidil | 179 1件: 179 💬 |
2 | Adrenergic signaling in cardiomyocytes 💬 26 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
3 | Adrenergic signaling in cardiomyocytes 💬 26 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
4 | AGE-RAGE signaling pathway in diabetic complications 💬 23 genes, 40 drugs (DrugBank) and 84 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
5 | AGE-RAGE signaling pathway in diabetic complications 💬 23 genes, 40 drugs (DrugBank) and 84 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
6 | Alcoholism 💬 28 genes, 69 drugs (DrugBank) and 52 diseases |
DRD2 1件: DRD2 💬 |
D00426 D00426 💬 |
Risperidone | 008 5件: 8 , 156, 179, 187, 206 💬 |
7 | Alcoholism 💬 28 genes, 69 drugs (DrugBank) and 52 diseases |
SLC6A3 1件: SLC6A3 💬 |
D01296 D01296 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
8 | Alcoholism 💬 28 genes, 69 drugs (DrugBank) and 52 diseases |
SLC6A3 1件: SLC6A3 💬 |
D04999 D04999 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
9 | Aldosterone synthesis and secretion 💬 18 genes, 34 drugs (DrugBank) and 64 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
10 | Aldosterone synthesis and secretion 💬 18 genes, 34 drugs (DrugBank) and 64 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
11 | Amphetamine addiction 💬 24 genes, 48 drugs (DrugBank) and 87 diseases |
SLC6A3 1件: SLC6A3 💬 |
D01296 D01296 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
12 | Amphetamine addiction 💬 24 genes, 48 drugs (DrugBank) and 87 diseases |
SLC6A3 1件: SLC6A3 💬 |
D04999 D04999 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
13 | Apelin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
14 | Apelin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
15 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
16 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
17 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
HTR2A 1件: HTR2A 💬 |
D00426 D00426 💬 |
Risperidone | 008 5件: 8 , 156, 179, 187, 206 💬 |
18 | cAMP signaling pathway 💬 63 genes, 157 drugs (DrugBank) and 108 diseases |
DRD2 1件: DRD2 💬 |
D00426 D00426 💬 |
Risperidone | 008 5件: 8 , 156, 179, 187, 206 💬 |
19 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
20 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
21 | Cocaine addiction 💬 14 genes, 58 drugs (DrugBank) and 47 diseases |
DRD2 1件: DRD2 💬 |
D00426 D00426 💬 |
Risperidone | 008 5件: 8 , 156, 179, 187, 206 💬 |
22 | Cocaine addiction 💬 14 genes, 58 drugs (DrugBank) and 47 diseases |
SLC6A3 1件: SLC6A3 💬 |
D01296 D01296 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
23 | Cocaine addiction 💬 14 genes, 58 drugs (DrugBank) and 47 diseases |
SLC6A3 1件: SLC6A3 💬 |
D04999 D04999 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
24 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
25 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
26 | Cortisol synthesis and secretion 💬 14 genes, 30 drugs (DrugBank) and 62 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
27 | Cortisol synthesis and secretion 💬 14 genes, 30 drugs (DrugBank) and 62 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
28 | Cushing syndrome 💬 21 genes, 43 drugs (DrugBank) and 66 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
29 | Cushing syndrome 💬 21 genes, 43 drugs (DrugBank) and 66 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
30 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
31 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
32 | Dopaminergic synapse 💬 30 genes, 93 drugs (DrugBank) and 97 diseases |
DRD2 1件: DRD2 💬 |
D00426 D00426 💬 |
Risperidone | 008 5件: 8 , 156, 179, 187, 206 💬 |
33 | Dopaminergic synapse 💬 30 genes, 93 drugs (DrugBank) and 97 diseases |
SLC6A3 1件: SLC6A3 💬 |
D01296 D01296 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
34 | Dopaminergic synapse 💬 30 genes, 93 drugs (DrugBank) and 97 diseases |
SLC6A3 1件: SLC6A3 💬 |
D04999 D04999 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
35 | Gap junction 💬 25 genes, 76 drugs (DrugBank) and 72 diseases |
DRD2 2件: DRD2, HTR2A 💬 |
D00426 D00426 💬 |
Risperidone | 008 5件: 8 , 156, 179, 187, 206 💬 |
36 | GnRH secretion 💬 19 genes, 36 drugs (DrugBank) and 53 diseases |
KCNJ11 1件: KCNJ11 💬 |
D00418 D00418 💬 |
Minoxidil | 179 1件: 179 💬 |
37 | Inflammatory mediator regulation of TRP channels 💬 22 genes, 38 drugs (DrugBank) and 55 diseases |
HTR2A 1件: HTR2A 💬 |
D00426 D00426 💬 |
Risperidone | 008 5件: 8 , 156, 179, 187, 206 💬 |
38 | Insulin secretion 💬 13 genes, 40 drugs (DrugBank) and 43 diseases |
ABCC8 2件: ABCC8, KCNJ11 💬 |
D00418 D00418 💬 |
Minoxidil | 179 1件: 179 💬 |
39 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
40 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
41 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
DRD2 2件: DRD2, HTR2A 💬 |
D00426 D00426 💬 |
Risperidone | 008 5件: 8 , 156, 179, 187, 206 💬 |
42 | Parkinson disease 💬 21 genes, 64 drugs (DrugBank) and 63 diseases |
DRD2 1件: DRD2 💬 |
D00426 D00426 💬 |
Risperidone | 008 5件: 8 , 156, 179, 187, 206 💬 |
43 | Parkinson disease 💬 21 genes, 64 drugs (DrugBank) and 63 diseases |
SLC6A3 1件: SLC6A3 💬 |
D01296 D01296 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
44 | Parkinson disease 💬 21 genes, 64 drugs (DrugBank) and 63 diseases |
SLC6A3 1件: SLC6A3 💬 |
D04999 D04999 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
45 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
46 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
47 | Pathways of neurodegeneration - multiple diseases 💬 56 genes, 111 drugs (DrugBank) and 117 diseases |
SLC6A3 1件: SLC6A3 💬 |
D01296 D01296 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
48 | Pathways of neurodegeneration - multiple diseases 💬 56 genes, 111 drugs (DrugBank) and 117 diseases |
SLC6A3 1件: SLC6A3 💬 |
D04999 D04999 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
49 | Phospholipase D signaling pathway 💬 23 genes, 45 drugs (DrugBank) and 75 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
50 | Phospholipase D signaling pathway 💬 23 genes, 45 drugs (DrugBank) and 75 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
51 | Rap1 signaling pathway 💬 40 genes, 91 drugs (DrugBank) and 82 diseases |
DRD2 1件: DRD2 💬 |
D00426 D00426 💬 |
Risperidone | 008 5件: 8 , 156, 179, 187, 206 💬 |
52 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
53 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
54 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 32 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
55 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 32 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
56 | Serotonergic synapse 💬 37 genes, 105 drugs (DrugBank) and 73 diseases |
HTR2A 1件: HTR2A 💬 |
D00426 D00426 💬 |
Risperidone | 008 5件: 8 , 156, 179, 187, 206 💬 |
57 | Serotonergic synapse 💬 37 genes, 105 drugs (DrugBank) and 73 diseases |
SLC6A4 1件: SLC6A4 💬 |
D00326 D00326 💬 |
Fluoxetine | 013 6件: 13, 17, 78, 86, 179, 206 💬 |
58 | Serotonergic synapse 💬 37 genes, 105 drugs (DrugBank) and 73 diseases |
SLC6A4 1件: SLC6A4 💬 |
D00823 D00823 💬 |
Fluoxetine | 013 6件: 13, 17, 78, 86, 179, 206 💬 |
59 | Synaptic vesicle cycle 💬 7 genes, 29 drugs (DrugBank) and 37 diseases |
SLC6A2 2件: SLC6A2, SLC6A3 💬 |
D01296 D01296 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
60 | Synaptic vesicle cycle 💬 7 genes, 29 drugs (DrugBank) and 37 diseases |
SLC6A2 2件: SLC6A2, SLC6A3 💬 |
D04999 D04999 💬 |
Methylphenidate | 006 7件: 6 , 13, 34, 84, 113, 179, 206 💬 |
61 | Synaptic vesicle cycle 💬 7 genes, 29 drugs (DrugBank) and 37 diseases |
SLC6A4 1件: SLC6A4 💬 |
D00326 D00326 💬 |
Fluoxetine | 013 6件: 13, 17, 78, 86, 179, 206 💬 |
62 | Synaptic vesicle cycle 💬 7 genes, 29 drugs (DrugBank) and 37 diseases |
SLC6A4 1件: SLC6A4 💬 |
D00823 D00823 💬 |
Fluoxetine | 013 6件: 13, 17, 78, 86, 179, 206 💬 |
63 | Type II diabetes mellitus 💬 14 genes, 38 drugs (DrugBank) and 90 diseases |
ABCC8 2件: ABCC8, KCNJ11 💬 |
D00418 D00418 💬 |
Minoxidil | 179 1件: 179 💬 |
64 | Vascular smooth muscle contraction 💬 30 genes, 71 drugs (DrugBank) and 65 diseases |
AGTR1 1件: AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
65 | Vascular smooth muscle contraction 💬 30 genes, 71 drugs (DrugBank) and 65 diseases |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |