Target Gene/Pathway(薬物標的遺伝子/パスウェイリスト)💬 Info on mouse-over
No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related |
KEGG GENES | KEGG DRUG | DrugBank | 指定難病告示番号 |
1 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
EDNRA 2件: EDNRA, EDNRB 💬 |
D01227 D01227 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
2 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
EDNRA 2件: EDNRA, EDNRB 💬 |
D07538 D07538 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
3 | cAMP signaling pathway 💬 63 genes, 157 drugs (DrugBank) and 108 diseases |
EDNRA 1件: EDNRA 💬 |
D01227 D01227 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
4 | cAMP signaling pathway 💬 63 genes, 157 drugs (DrugBank) and 108 diseases |
EDNRA 1件: EDNRA 💬 |
D07538 D07538 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
5 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
ADRA2A 3件: ADRA2A, ADRA2B, ADRA2C 💬 |
D00514 D00514 💬 |
Dexmedetomidine | 002 12件: 2 , 4 , 6 , 21, 34, 46, 70, 113, 212, 215, 226, 280 💬 |
6 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
ADRA2A 3件: ADRA2A, ADRA2B, ADRA2C 💬 |
D01205 D01205 💬 |
Dexmedetomidine | 002 12件: 2 , 4 , 6 , 21, 34, 46, 70, 113, 212, 215, 226, 280 💬 |
7 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
EDNRA 2件: EDNRA, EDNRB 💬 |
D01227 D01227 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
8 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
EDNRA 2件: EDNRA, EDNRB 💬 |
D07538 D07538 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
9 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
PDE5A 1件: PDE5A 💬 |
D02229 D02229 💬 |
Sildenafil | 006 17件: 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 |
10 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
PDE5A 1件: PDE5A 💬 |
D08514 D08514 💬 |
Sildenafil | 006 17件: 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 |
11 | Melanogenesis 💬 5 genes, 11 drugs (DrugBank) and 25 diseases |
EDNRB 1件: EDNRB 💬 |
D01227 D01227 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
12 | Melanogenesis 💬 5 genes, 11 drugs (DrugBank) and 25 diseases |
EDNRB 1件: EDNRB 💬 |
D07538 D07538 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
13 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
PDE5A 1件: PDE5A 💬 |
D02229 D02229 💬 |
Sildenafil | 006 17件: 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 |
14 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
PDE5A 1件: PDE5A 💬 |
D08514 D08514 💬 |
Sildenafil | 006 17件: 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 |
15 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
ADRA2A 3件: ADRA2A, ADRA2B, ADRA2C 💬 |
D00514 D00514 💬 |
Dexmedetomidine | 002 12件: 2 , 4 , 6 , 21, 34, 46, 70, 113, 212, 215, 226, 280 💬 |
16 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
ADRA2A 3件: ADRA2A, ADRA2B, ADRA2C 💬 |
D01205 D01205 💬 |
Dexmedetomidine | 002 12件: 2 , 4 , 6 , 21, 34, 46, 70, 113, 212, 215, 226, 280 💬 |
17 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
EDNRA 2件: EDNRA, EDNRB 💬 |
D01227 D01227 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
18 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
EDNRA 2件: EDNRA, EDNRB 💬 |
D07538 D07538 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
19 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
THRA 2件: THRA, THRB 💬 |
D01011 D01011 💬 |
Liothyronine | 013 4件: 13, 78, 210, 212 💬 |
20 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
THRA 2件: THRA, THRB 💬 |
D08128 D08128 💬 |
Liothyronine | 013 4件: 13, 78, 210, 212 💬 |
21 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
EDNRA 2件: EDNRA, EDNRB 💬 |
D01227 D01227 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
22 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
EDNRA 2件: EDNRA, EDNRB 💬 |
D07538 D07538 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
23 | Purine metabolism 💬 30 genes, 31 drugs (DrugBank) and 68 diseases |
PDE5A 1件: PDE5A 💬 |
D02229 D02229 💬 |
Sildenafil | 006 17件: 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 |
24 | Purine metabolism 💬 30 genes, 31 drugs (DrugBank) and 68 diseases |
PDE5A 1件: PDE5A 💬 |
D08514 D08514 💬 |
Sildenafil | 006 17件: 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 |
25 | Relaxin signaling pathway 💬 18 genes, 25 drugs (DrugBank) and 38 diseases |
EDNRB 1件: EDNRB 💬 |
D01227 D01227 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
26 | Relaxin signaling pathway 💬 18 genes, 25 drugs (DrugBank) and 38 diseases |
EDNRB 1件: EDNRB 💬 |
D07538 D07538 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
27 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
EDNRA 1件: EDNRA 💬 |
D01227 D01227 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
28 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
EDNRA 1件: EDNRA 💬 |
D07538 D07538 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
29 | Thyroid hormone signaling pathway 💬 22 genes, 35 drugs (DrugBank) and 61 diseases |
THRA 2件: THRA, THRB 💬 |
D01011 D01011 💬 |
Liothyronine | 013 4件: 13, 78, 210, 212 💬 |
30 | Thyroid hormone signaling pathway 💬 22 genes, 35 drugs (DrugBank) and 61 diseases |
THRA 2件: THRA, THRB 💬 |
D08128 D08128 💬 |
Liothyronine | 013 4件: 13, 78, 210, 212 💬 |
31 | Vascular smooth muscle contraction 💬 30 genes, 71 drugs (DrugBank) and 65 diseases |
EDNRA 1件: EDNRA 💬 |
D01227 D01227 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |
32 | Vascular smooth muscle contraction 💬 30 genes, 71 drugs (DrugBank) and 65 diseases |
EDNRA 1件: EDNRA 💬 |
D07538 D07538 💬 |
Bosentan | 013 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 |