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No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	[14c]-rpc1063 solution (0.1 mg/ml) for oral administration	-	-	-	-	[3] 13, 96, 97 💬
2	Administration	-	-	-	-	[1] 19 💬
3	Administration of a high dose of desipramine	Desipramine	[2] D00812, D07791 💬	[2] SLC6A2, SLC6A4 💬	[2] Serotonergic synapse, Synaptic vesicle cycle	[1] 156 💬
4	Administration of a low dose of desipramine	Desipramine	[2] D00812, D07791 💬	[2] SLC6A2, SLC6A4 💬	[2] Serotonergic synapse, Synaptic vesicle cycle	[1] 156 💬
5	Administration of an ace-inhibitor or not	-	-	-	-	[1] 210 💬
6	Administration of cimzia®	-	-	-	-	[1] 46 💬
7	Administration of drug (interferon-gamma 1-b) subcutaneously	-	-	-	-	[1] 65 💬
8	Administration of rituximab and methylprednisolone	Methylprednisolone	[7] D00407, D00751, D00979, D02994, D05000, D05001, D05002 💬	[2] MS4A1, NR3C1 💬	[2] Hematopoietic cell lineage, Neuroactive ligand-receptor interaction	[1] 51 💬
9	Administration of stable isotope-labelled leucine-	Leucine	[1] D00030 💬	-	-	[1]  6  💬
10	Avandia administration for 6-12 weeks	-	-	-	-	[1] 265 💬
11	Behavioral: administration of probiotic (l. rhamnosus and l. acidophilus)	Lactobacillus acidophilus	[1] D04349 💬	-	-	[1] 97 💬
12	Biological : i10e (human normal immunoglobulin for intravenous administration 100mg/ml)	Human immunoglobulin G	-	-	-	[1] 14 💬
13	Biological: kiovig® (human normal immunoglobulin for intravenous administration 100mg/ml)	Human immunoglobulin G	-	-	-	[1] 14 💬
14	Bosentan administration	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
15	Device: administration kit	-	-	-	-	[1] 19 💬
16	Device: nirs after bosentan administration	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 13 💬
17	Device: tcd after bosentan administration	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 13 💬
18	Docosahexaenoic acid administration: 50 mg/kg/day during 12 months	Doconexent	-	-	-	[1] 299 💬
19	Growth hormone administration for 6 months	Somatotropin	[1] D02691 💬	[1] GHR 💬	[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway	[1] 78 💬
20	Human normal 10% immunoglobulin for intravenous administration	-	-	-	-	[1] 14 💬
21	Human normal 10% immunoglobulin for intravenous administrationn	-	-	-	-	[1] 14 💬
22	Human normal immunoglobulin for intravenous (iv) administration	Human immunoglobulin G	-	-	-	[1] 51 💬
23	Human normal immunoglobulin for intravenous administration	Human immunoglobulin G	-	-	-	[3] 14, 51, 65 💬
24	Human normal immunoglobulin for subcutaneous administration	Human immunoglobulin G	-	-	-	[2] 51, 65 💬
25	Human normal immunoglobulin for subcutaneous administration (igsc)	Human immunoglobulin G	-	-	-	[1] 65 💬
26	Intrathecal administration of autologous msc-np	-	-	-	-	[1] 13 💬
27	Intravenous administration of 1 million of msc	-	-	-	-	[1]  2  💬
28	Intravenous administration of 2 million of msc	-	-	-	-	[1]  2  💬
29	Intravenous administration of 4 million of msc	-	-	-	-	[1]  2  💬
30	Intravenous administration of ferric carboxymaltose	Ferric carboxymaltose	[1] D08920 💬	-	-	[1] 86 💬
31	Levodopa (drug), intraduodenal administration	Levodopa	[1] D00059 💬	[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬	[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway	[1]  6  💬
32	Levodopa and carbidopa solution for sc administration	Carbidopa	[2] D00059, D00558 💬	[6] DDC, DRD1, DRD2, DRD3, DRD4, DRD5 💬	[16] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Phenylalanine metabolism, Rap1 signaling pathway, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism, cAMP signaling pathway	[1]  6  💬
33	Low-dose il-2 administration	Human interleukin-2	-	-	-	[1] 96 💬
34	Methotrexate + biologic administration	Methotrexate	[2] D00142, D02115 💬	[2] DHFR, DHFR2 💬	[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	[1] 46 💬
35	Methotrexate + salazopyrine + hydroxychloroquine administration	Hydroxychloroquine	[3] D00142, D02115, D08050 💬	[2] DHFR, DHFR2 💬	[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	[1] 46 💬
36	Methotrexate(mtx) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol	Methotrexate	[2] D00142, D02115 💬	[2] DHFR, DHFR2 💬	[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	[1] 46 💬
37	Methotrexate(mtx) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol.	Methotrexate	[2] D00142, D02115 💬	[2] DHFR, DHFR2 💬	[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	[1] 46 💬
38	Other: questionnaire administration	-	-	-	-	[4] 16, 34, 51, 298 💬
39	Other: tobramycin time of administration	Tobramycin	[2] D00063, D02542 💬	-	-	[1] 299 💬
40	Procedure: iv administration of genetically engineered hematopoietic stem/progenitors cells (hspcs)	-	-	-	-	[1] 285 💬
41	Qr-313 gel for topical (cutaneous) administration	-	-	-	-	[1] 36 💬
42	Raav1-cmv-gaa (study agent) administration	-	-	-	-	[1] 256 💬
43	Semi continuous intra-oral administration of ld/cd	-	-	-	-	[1]  6  💬
44	Subcutanious administration	-	-	-	-	[1] 46 💬

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