Drug    DrugBank | All Description Patterns💬 Info on mouse-over

No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	Bosentan	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
2	Bosentan (tracleer)	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 51 💬
3	Bosentan 125 mg	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 51 💬
4	Bosentan 62.5 mg	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 51 💬
5	Bosentan administration	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
6	Bosentan and sildenafil	Bosentan	[4] D01227, D02229, D07538, D08514 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
7	Bosentan group	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 51 💬
8	Bosentan monohidrato	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
9	Bosentan monohydrat	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
10	Bosentan monohydrate	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[4] 51, 84, 86, 88 💬
11	Bosentan mylan	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 41 💬
12	Bosentan, ambrisentan	Ambrisentan	[3] D01227, D07077, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
13	Device: nirs after bosentan administration	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 13 💬
14	Device: tcd after bosentan administration	Bosentan	[2] D01227, D07538 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 13 💬
15	Duo-therapy with sildenafil + bosentan	Bosentan	[4] D01227, D02229, D07538, D08514 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
16	Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan)	Bosentan	[6] D01227, D02008, D02229, D07538, D08514, D10135 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
17	Observational study with patients treated with tracleer, ventavis, veletri, opsumit and/or uptravi	-	-	-	-	[1] 86 💬
18	Sildenafil 20mg and bosentan 62.5mg	Bosentan	[4] D01227, D02229, D07538, D08514 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[2] 51, 86 💬
19	Sildenafil singly or in association with bosentan	Bosentan	[4] D01227, D02229, D07538, D08514 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
20	Tracleer	-	-	-	-	[8] 13, 51, 84, 85, 86, 88, 210, 211 💬
21	Tracleer 125mg 56cpr riv.	-	-	-	-	[1] 88 💬
22	Tracleer 62,5 mg comprimidos recubiertos con película	-	-	-	-	[1] 86 💬
23	Tracleer 62,5mg 56cpr riv.	-	-	-	-	[1] 86 💬
24	Tracleer*125mg 56cpr riv.	-	-	-	-	[2] 51, 86 💬
25	Tracleer*56cpr riv 125mg	-	-	-	-	[3] 51, 86, 88 💬
26	Tracleer®	-	-	-	-	[1] 86 💬

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