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e.g. Sirolimus, Adalimumab

ABCDEFGH I JKLMNOPQRSTUVWXYZother

347 / 17,542 descriptions

No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes		 Disease ID
 1  Abatacept (aba) + methotrexate (mtx), double-blind (db)  Abatacept  [3] D00142, D02115, D03203 💬  [4] CD80, CD86, DHFR, DHFR2 💬  [17] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis  [1] 46 💬 
 2  Abatacept + methotrexate  Abatacept  [3] D00142, D02115, D03203 💬  [4] CD80, CD86, DHFR, DHFR2 💬  [17] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis  [1] 46 💬 
 3  Abatacept active treatment  Abatacept  [1] D03203 💬  [2] CD80, CD86 💬  [12] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis  [1] 50 💬 
 4  Abatacept delayed-onset treatment  Abatacept  [1] D03203 💬  [2] CD80, CD86 💬  [12] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis  [1] 50 💬 
 5  Active investigational treatment ent-01  -  -  -  -  [1]  6  💬 
 6  Active treatment group 7% hypertonic saline  -  -  -  -  [1] 299 💬 
 7  Adalimumab with methotrexate  Adalimumab  [3] D00142, D02115, D02597 💬  [3] DHFR, DHFR2, TNF 💬  [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 8  Azathioprine or methotrexate  Azathioprine  [4] D00142, D00238, D02115, D03033 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 96 💬 
 9  Baseline treatment  -  -  -  -  [1] 13 💬 
 10  Bdmard treatment  -  -  -  -  [1] 271 💬 
 11  Behavioral: co-op treatment protocol  -  -  -  -  [1]  6  💬 
 12  Behavioral: conservative treatment  -  -  -  -  [1] 291 💬 
 13  Bendamustine  Bendamustine  [2] D07085, D07501 💬  -  -  [2] 28, 61 💬 
 14  Bendamustine hydrochloride  Bendamustine  [2] D07085, D07501 💬  -  -  [1] 61 💬 
 15  Bendamustine, rituximab  Bendamustine  [3] D02994, D07085, D07501 💬  [1] MS4A1 💬  [1] Hematopoietic cell lineage  [1] 61 💬 
 16  Best medical treatment  -  -  -  -  [1]  6  💬 
 17  Best médical treatment  -  -  -  -  [1]  6  💬 
 18  Bisphosphonate treatment  -  -  -  -  [2] 113, 299 💬 
 19  Bms-582949 and methotrexate  BMS-582949  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 20  Botulism toxin treatment  -  -  -  -  [1] 161 💬 
 21  Break in l-carnitine treatment  Levocarnitine  [3] D02030, D02176, D04713 💬  -  -  [1] 316 💬 
 22  Busulfan/fludarabine phosphate/tacrolimus/methotrexate/g-csf  Busulfan  [8] D00107, D00142, D00248, D01907, D02115, D03235, D07966, D08556 💬  [9] CSF3R, DHFR, DHFR2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, RRM1 💬  [46] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Drug metabolism - other enzymes, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Glutathione metabolism, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Pyrimidine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway  [1] 60 💬 
 23  C-trelin od tab(5mg taltirelin hydrate)  -  -  -  -  [1] 18 💬 
 24  Certolizumab pegol + methotrexate (mtx)  Certolizumab pegol  [3] D00142, D02115, D03441 💬  [3] DHFR, DHFR2, TNF 💬  [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 25  Cf patients with a g551d mutation and treated with ivacaftor  Ivacaftor  [1] D09916 💬  [1] CFTR 💬  [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway  [1] 299 💬 
 26  Classic dmards treatment group  -  -  -  -  [1] 46 💬 
 27  Clobetasol propionate + methotrexate  Clobetasol  [4] D00142, D01272, D02115, D07715 💬  [3] DHFR, DHFR2, NR3C1 💬  [6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate  [1] 162 💬 
 28  Clobetasol propionate cream treatment  Clobetasol  [2] D01272, D07715 💬  [1] NR3C1 💬  [1] Neuroactive ligand-receptor interaction  [1] 162 💬 
 29  Combination product: active treatment with dual therapy  -  -  -  -  [1]  2  💬 
 30  Combination product: implantable system for remodulin (treprostinil)  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 31  Combination product: methotrexate  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 32  Combination product: treprostinil via implanted pump  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 33  Corticosteroid treatment (methylprednisolone or prednisolone)  Methylprednisolone  [14] D00407, D00472, D00751, D00979, D00980, D00981, D00982, D01239, D01998, D02156, D03301, D05000, D05001, D05002 💬  [1] NR3C1 💬  [1] Neuroactive ligand-receptor interaction  [1] 64 💬 
 34  Cp-690,550 + methotrexate  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 35  Current lipid-lowering treatment  -  -  -  -  [1] 79 💬 
 36  Cutaneous iontophoresis of treprostinil  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 51 💬 
 37  Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids  Azathioprine  [6] D00142, D00238, D00287, D02115, D03033, D07760 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 44 💬 
 38  Cyclosporin, methotrexate (gvhd prophylaxis)  Cyclosporine  [3] D00142, D00184, D02115 💬  [7] DHFR, DHFR2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬  [37] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway  [1] 326 💬 
 39  Cytokine-treated veto cells  -  -  -  -  [1] 60 💬 
 40  Deferiprone treated  Deferiprone  [1] D07416 💬  -  -  [1] 120 💬 
 41  Detoxifying agents for antineoplastic treatment  -  -  -  -  [1] 299 💬 
 42  Device: trekking pole (tp).  -  -  -  -  [1] 13 💬 
 43  Dietanolamina de treprostinilo  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 44  Dmards (methotrexate  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 45  Dopamine agonist treatment  Dopamine  [2] D00633, D07870 💬  [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬  [11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway  [1] 74 💬 
 46  Drug treatment  -  -  -  -  [4] 46, 51, 74, 271 💬 
 47  Early immunosuppressants (azathioprine, methotrexate)  Azathioprine  [4] D00142, D00238, D02115, D03033 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 96 💬 
 48  Era as specific pah treatment  -  -  -  -  [1] 86 💬 
 49  Etanercept + methotrexate  Etanercept  [3] D00142, D00742, D02115 💬  [4] DHFR, DHFR2, LTA, TNF 💬  [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 50  Etanercept , methotrexate  Etanercept  [3] D00142, D00742, D02115 💬  [4] DHFR, DHFR2, LTA, TNF 💬  [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 51  Etanercept treatment  Etanercept  [1] D00742 💬  [2] LTA, TNF 💬  [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 52  Etanercept, methotrexate and depomedrone  Etanercept  [3] D00142, D00742, D02115 💬  [4] DHFR, DHFR2, LTA, TNF 💬  [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 53  Etanercept, methotrexate, prednisolone  Etanercept  [11] D00142, D00472, D00742, D00980, D00981, D00982, D01239, D01998, D02115, D02156, D03301 💬  [5] DHFR, DHFR2, LTA, NR3C1, TNF 💬  [70] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 56 💬 
 54  Eutonic treprostinil solution  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 55  Experimental (non immunosuppressive symptomatic treatment (nist) and rituximab)  Rituximab  [1] D02994 💬  [1] MS4A1 💬  [1] Hematopoietic cell lineage  [1] 222 💬 
 56  Exposure to one or more disease-modifying drug(s)(dmds) used to treat ms  -  -  -  -  [1] 13 💬 
 57  Fibrate treatment  -  -  -  -  [1] 160 💬 
 58  Foliglurax 10 mg (treatment a)  Foliglurax  -  -  -  [1]  6  💬 
 59  Foliglurax 30 mg (treatment b)  Foliglurax  -  -  -  [1]  6  💬 
 60  From august 2020 'no additional treatment'  -  -  -  -  [1] 51 💬 
 61  Genotropin (somatropin) is a growth hormone treatment. it is an exact copy of the natural growth hormone that our bodies make. the main difference is that genotropin is man-made.  Somatotropin  [1] D02691 💬  [1] GHR 💬  [5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway  [1] 193 💬 
 62  Glucocorticoid treatment  -  -  -  -  [1] 41 💬 
 63  Golimumab treatment optimization.  Golimumab  [1] D04358 💬  [1] TNF 💬  [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 97 💬 
 64  Group 1 or orencia treated group  -  -  -  -  [1] 46 💬 
 65  Guselkumab  Guselkumab  [1] D10438 💬  [1] IL23A 💬  [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis  [4] 37, 41, 96, 97 💬 
 66  Guselkumab 100 mg  Guselkumab  [1] D10438 💬  [1] IL23A 💬  [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis  [1] 37 💬 
 67  Guselkumab dose 1  Guselkumab  [1] D10438 💬  [1] IL23A 💬  [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis  [2] 96, 97 💬 
 68  Guselkumab dose 2  Guselkumab  [1] D10438 💬  [1] IL23A 💬  [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis  [2] 96, 97 💬 
 69  Guselkumab dose 3  Guselkumab  [1] D10438 💬  [1] IL23A 💬  [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis  [1] 96 💬 
 70  Guselkumab dose 4  Guselkumab  [1] D10438 💬  [1] IL23A 💬  [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis  [1] 96 💬 
 71  Guselkumab dose 5  Guselkumab  [1] D10438 💬  [1] IL23A 💬  [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis  [1] 96 💬 
 72  Hcq/cq and cab combined treatment  -  -  -  -  [1] 74 💬 
 73  Herbal treatment (sa100)  -  -  -  -  [1] 97 💬 
 74  Hyperpolarized 129 xenon gas comparing idiopathic pulmonary fibrosis (ipf) treatment  Xenon  [2] D01901, D06339 💬  -  -  [1] 85 💬 
 75  Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate)  Azathioprine  [8] D00142, D00238, D00752, D02115, D03033, D05094, D05095, D05096 💬  [4] DHFR, DHFR2, IMPDH1, IMPDH2 💬  [7] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Purine metabolism  [1] 49 💬 
 76  Immunosuppressive treatment  -  -  -  -  [1] 66 💬 
 77  Immunosuppressive treatment (eg, rituximab)  Rituximab  [1] D02994 💬  [1] MS4A1 💬  [1] Hematopoietic cell lineage  [1] 64 💬 
 78  In double-blind phase: treatment with tofacitinib  Tofacitinib  [1] D09970 💬  [4] JAK1, JAK2, JAK3, TYK2 💬  [35] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis  [1] 107 💬 
 79  In open-label phase: treatment with tofacitinib  Tofacitinib  [1] D09970 💬  [4] JAK1, JAK2, JAK3, TYK2 💬  [35] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis  [1] 107 💬 
 80  Infliximab + methotrexate (mtx)  Infliximab  [3] D00142, D02115, D02598 💬  [3] DHFR, DHFR2, TNF 💬  [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 81  Infliximab, methylprednisolone, methotrexate  Infliximab  [9] D00142, D00407, D00751, D00979, D02115, D02598, D05000, D05001, D05002 💬  [4] DHFR, DHFR2, NR3C1, TNF 💬  [70] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 82  Inhaled dry powder treprostinil (liq861)  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 83  Inhaled treprostinil  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [2] 84, 86 💬 
 84  Interferon beta treatment to add-on atorvastatin treatment  Atorvastatin  [3] D00258, D00887, D07474 💬  [1] HMGCR 💬  [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis  [1] 13 💬 
 85  Intrathecal methotrexate  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 13 💬 
 86  Intravenous treprostinil  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 87  Intravenous/subcutaneous treprostinil  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 88  Iontophoresis of treprostinil  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 51 💬 
 89  Iv treatment with igsc, 10%  -  -  -  -  [1] 65 💬 
 90  L606 (liposomal treprostinil) inhalation solution 51ug  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 91  Lapaquistat acetate and current lipid-lowering treatment  Acetate  -  -  -  [1] 79 💬 
 92  Liq861 inhaled treprostinil  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 93  Lumacaftor-ivacaftor treatment  Ivacaftor  [2] D09916, D10134 💬  [1] CFTR 💬  [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway  [1] 299 💬 
 94  Metformin treatment  Metformin  [2] D00944, D04966 💬  [2] PRKAA1, PRKAA2 💬  [19] AMPK signaling pathway, Adipocytokine signaling pathway, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway  [1] 46 💬 
 95  Methotrexate  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬 
 96  Methotrexate 'lederle' 2,5mg tablets  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 97  Methotrexate 'lederle' 2.5mg tablets  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 98  Methotrexate 'lederle' tablets  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 99  Methotrexate (metoject® prefilled pen)  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 100  Methotrexate (mtx)  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 101  Methotrexate (stable dose)  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 102  Methotrexate (tapering dose)  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 103  Methotrexate + biologic administration  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 104  Methotrexate + infliximab  Infliximab  [3] D00142, D02115, D02598 💬  [3] DHFR, DHFR2, TNF 💬  [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 105  Methotrexate + methylprednisolone  Methotrexate  [8] D00142, D00407, D00751, D00979, D02115, D05000, D05001, D05002 💬  [3] DHFR, DHFR2, NR3C1 💬  [6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate  [1] 46 💬 
 106  Methotrexate + salazopyrine + hydroxychloroquine administration  Hydroxychloroquine  [3] D00142, D02115, D08050 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 107  Methotrexate - amneal  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 108  Methotrexate - dava  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 109  Methotrexate - delay  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 110  Methotrexate - etanercept - prednisolone arm  Etanercept  [11] D00142, D00472, D00742, D00980, D00981, D00982, D01239, D01998, D02115, D02156, D03301 💬  [5] DHFR, DHFR2, LTA, NR3C1, TNF 💬  [70] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 111  Methotrexate - immediate  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 112  Methotrexate 10 mg  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 113  Methotrexate 10 mg tablets  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 114  Methotrexate 2.5 mg  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 44 💬 
 115  Methotrexate 2.5 mg tablets  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 116  Methotrexate 2.5mg tablets  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 117  Methotrexate 2.5mg tablets bp  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 118  Methotrexate 25 mg  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 44 💬 
 119  Methotrexate 50mg/ml solution for injection, pre-filled syringe  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 120  Methotrexate ``lederle`` 2.5mg tablets  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 121  Methotrexate and folic acid  Folic acid  [3] D00070, D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 49 💬 
 122  Methotrexate as methotrexate disodium  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 123  Methotrexate bellon  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 97 💬 
 124  Methotrexate bellon 25mg/ml  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 97 💬 
 125  Methotrexate capsules  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 126  Methotrexate disodium  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [3] 46, 96, 97 💬 
 127  Methotrexate ebewe  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 128  Methotrexate hospira 2,5 mg tablety  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 129  Methotrexate hospira 2.5 mg tablety  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 130  Methotrexate injection  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [2] 96, 97 💬 
 131  Methotrexate lachema 5inj. sol  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 50 💬 
 132  Methotrexate lederle 2.5 mg tablets  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 133  Methotrexate pfizer 2,5 mg tabletter  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 134  Methotrexate placebo  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 135  Methotrexate plus enbrel or enbrel alone  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 136  Methotrexate plus erb-041 for 12 weeks  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 137  Methotrexate plus sulfasalazine  Methotrexate  [3] D00142, D00448, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 138  Methotrexate pre-filled pen  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 139  Methotrexate prefilled pen  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 140  Methotrexate prefilled syringe  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 141  Methotrexate sodium  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [2] 46, 256 💬 
 142  Methotrexate sodium 2.5mg tablets  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 143  Methotrexate sodium tablets 2.5 mg  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 144  Methotrexate sodium tablets 2.5mg  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 145  Methotrexate tablets  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 40 💬 
 146  Methotrexate tablets 2.5 mg  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 147  Methotrexate treatment  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [2] 41, 46 💬 
 148  Methotrexate wyeth 2,5mg  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 50 💬 
 149  Methotrexate wyeth 2,5mg tbl.  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 50 💬 
 150  Methotrexate ® 2.5mg tablets  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 151  Methotrexate(mtx)  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 152  Methotrexate(mtx) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 153  Methotrexate(mtx) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol.  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 154  Methotrexate(necessary)  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 155  Methotrexate*100cpr 2,5mg  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 156  Methotrexate*10mg/1,33ml 4s  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 157  Methotrexate*15mg/2ml 4sir  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 158  Methotrexate*2,5mg 25cpr  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 159  Methotrexate*20mg/2,66ml 4s  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 160  Methotrexate*25cpr 2,5mg  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 161  Methotrexate*7,5mg/ml 4sir.  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 162  Methotrexate, leucovorin and bms-986142  BMS-986142  [5] D00142, D01211, D02115, D07986, D07987 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 163  Methotrexate,adalimumab  Adalimumab  [3] D00142, D02115, D02597 💬  [3] DHFR, DHFR2, TNF 💬  [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 164  Methotrexate-lachema  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 165  Methotrexate-sulfasalazine-hydroxychloroquine  Hydroxychloroquine  [4] D00142, D00448, D02115, D08050 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 166  Methotrexate® 2.5 mg tablets  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 167  Mk0812 / duration of treatment: 12 weeks  -  -  -  -  [1] 46 💬 
 168  Monthly autologous treg cells infusions + 3 times per week interleukin-2 injections  Human interleukin-2  -  -  -  [1]  2  💬 
 169  Mp-435(dose1) + methotrexate  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 170  Msc treatment  -  -  -  -  [1] 49 💬 
 171  Msc treatment 01  -  -  -  -  [1] 96 💬 
 172  Msc treatment 02  -  -  -  -  [1] 96 💬 
 173  Mycophenolate mofetil,methotrexate  Methotrexate  [6] D00142, D00752, D02115, D05094, D05095, D05096 💬  [4] DHFR, DHFR2, IMPDH1, IMPDH2 💬  [7] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Purine metabolism  [3] 42, 43, 45 💬 
 174  Natalizumab treatment  Natalizumab  [1] D06886 💬  [1] ITGA4 💬  [14] Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection  [1] 13 💬 
 175  Nifurtimox-eflronithine combination treatment (nect)  Nifurtimox  [1] D00833 💬  -  -  [1] 65 💬 
 176  Nusinersen treatments  Nusinersen  [1] D10881 💬  [1] SMN2 💬  [1] RNA transport  [1]  3  💬 
 177  Nutrition treat  -  -  -  -  [1] 96 💬 
 178  Observational study with patients treated with tracleer, ventavis, veletri, opsumit and/or uptravi  -  -  -  -  [1] 86 💬 
 179  Oc oral solution treatment a  -  -  -  -  [1]  6  💬 
 180  Oc oral solution treatment b  -  -  -  -  [1]  6  💬 
 181  Oc oral solution treatment c  -  -  -  -  [1]  6  💬 
 182  Oc oral solution treatment d  -  -  -  -  [1]  6  💬 
 183  Only 1 arm: treatment with msc-afp  -  -  -  -  [1] 96 💬 
 184  Optimized antiparkinsonian treatment  -  -  -  -  [1]  6  💬 
 185  Oral anticoagulant treatment  -  -  -  -  [1] 86 💬 
 186  Oral methotrexate  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 187  Oral treprostinil  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [2] 51, 86 💬 
 188  Oral treprostinil (ut-15c) sustained release tablets  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 189  Other parkinson's disease treatments  -  -  -  -  [1]  6  💬 
 190  Other: adalimumab treatment  Adalimumab  [1] D02597 💬  [1] TNF 💬  [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 151 💬 
 191  Other: best medical treatment  -  -  -  -  [1]  6  💬 
 192  Other: cd-treat diet  -  -  -  -  [1] 96 💬 
 193  Other: control wound treatment  -  -  -  -  [1] 36 💬 
 194  Other: crohn's disease treatment-with-eating diet (cd-treat diet)  -  -  -  -  [1] 96 💬 
 195  Other: current treatment  -  -  -  -  [1] 46 💬 
 196  Other: dead sea solar and water treatment  Water  [1] D00001 💬  -  -  [1] 46 💬 
 197  Other: diet treatment  -  -  -  -  [1] 240 💬 
 198  Other: group 2 (dmards treated group)  -  -  -  -  [1] 46 💬 
 199  Other: intensify treatment with the existing drug  -  -  -  -  [2] 96, 97 💬 
 200  Other: methotrexate therapy  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 201  Other: motor assessments before taking regular pd treatment  -  -  -  -  [1]  6  💬 
 202  Other: motor assessments on regular pd treatment  -  -  -  -  [1]  6  💬 
 203  Other: multidisciplinary intensive rehabilitation treatment  -  -  -  -  [1]  6  💬 
 204  Other: no active treatment  -  -  -  -  [1] 274 💬 
 205  Other: no anti-inflammatory treatment  -  -  -  -  [1] 271 💬 
 206  Other: no it treatment  -  -  -  -  [1] 19 💬 
 207  Other: no treatment  -  -  -  -  [2] 53, 256 💬 
 208  Other: no treatment arm  -  -  -  -  [1] 13 💬 
 209  Other: no treatment given  -  -  -  -  [1] 78 💬 
 210  Other: observation of ocrelizumab as treatment in rrms patients  Ocrelizumab  [1] D05218 💬  [1] MS4A1 💬  [1] Hematopoietic cell lineage  [1] 13 💬 
 211  Other: on-demand treatment  -  -  -  -  [1] 299 💬 
 212  Other: other: symptomatic treatment of als  -  -  -  -  [1]  2  💬 
 213  Other: sle treatment  -  -  -  -  [1] 49 💬 
 214  Other: standard steroid treatment  -  -  -  -  [1] 113 💬 
 215  Other: standard treatment  -  -  -  -  [1] 227 💬 
 216  Other: standard treatment according to the clinical protocols  -  -  -  -  [1] 49 💬 
 217  Other: usual drug treatment of parkinson's disease  -  -  -  -  [1]  6  💬 
 218  Ova-treg  -  -  -  -  [1] 96 💬 
 219  Ovastat 1000 (treosulfan injection)  Treosulfan  [1] D07253 💬  -  -  [1] 65 💬 
 220  Ovastat 5000 (treosulfan injection)  Treosulfan  [1] D07253 💬  -  -  [1] 65 💬 
 221  Parenteral remodulin (treprostinil) injection  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 222  Patient treated with dmard  -  -  -  -  [1] 46 💬 
 223  Pentoxifylline  Pentoxifylline  [1] D00501 💬  -  -  [10] 26, 56, 84, 93, 96, 113, 220, 222, 296, 298 💬 
 224  Phase 1: methotrexate  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 225  Pioglitazone and tretinoin  Pioglitazone  [3] D00094, D00945, D08378 💬  [4] PML, PPARG, RARA, RARB 💬  [19] AMPK signaling pathway, Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Huntington disease, Influenza A, Longevity regulating pathway, Non-small cell lung cancer, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis  [1]  2  💬 
 226  Plasma from healthy young people treatment + riluzole  Riluzole  [1] D00775 💬  [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬  [23] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway  [1]  2  💬 
 227  Pooled plasma (human), solvent/detergent treated  -  -  -  -  [1] 64 💬 
 228  Ppi treatment  -  -  -  -  [1] 299 💬 
 229  Prednisone and ustekinumab treatment  Prednisone  [2] D00473, D09214 💬  [4] IL12A, IL12B, IL23A, NR3C1 💬  [27] African trypanosomiasis, Allograft rejection, Amoebiasis, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Legionellosis, Leishmaniasis, Malaria, Measles, Neuroactive ligand-receptor interaction, Pathways in cancer, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus  [1] 41 💬 
 230  Prednisone treatment  Prednisone  [1] D00473 💬  [1] NR3C1 💬  [1] Neuroactive ligand-receptor interaction  [1] 41 💬 
 231  Probiotic treatment  -  -  -  -  [1] 294 💬 
 232  Procedure: in vitro-treated bone marrow transplantation  -  -  -  -  [1] 60 💬 
 233  Procedure: in vitro-treated peripheral blood stem cell transplantation  -  -  -  -  [2] 60, 65 💬 
 234  Procedure: surgery treatment  -  -  -  -  [1] 291 💬 
 235  Procedure: transsphenoidal surgery treatment  -  -  -  -  [1] 74 💬 
 236  Procedure: treatment according to current standards without knowledge of serum infliximab and anti-infliximab ab status  Infliximab  [1] D02598 💬  [1] TNF 💬  [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 96 💬 
 237  Propranolol treatment  Propranolol  [2] D00483, D08443 💬  [3] ADRB1, ADRB2, ADRB3 💬  [11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cAMP signaling pathway, cGMP-PKG signaling pathway  [1] 227 💬 
 238  Rapid dose titration group of subcutaneous treprostinil  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 239  Regular treatment  -  -  -  -  [1] 97 💬 
 240  Remodulin (treprostinil sodium)  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 241  Remodulin® (treprostinil) 1 mg/ml solution for infusion  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 242  Remodulin® (treprostinil) 10 mg/ml solution for infusion  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 243  Remodulin® (treprostinil) 2.5 mg/ml solution for infusion  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 244  Remodulin® (treprostinil) 5 mg/ml solution for infusion  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 245  Repository corticotropin injection -treatment extension  Corticotropin  [1] D00146 💬  [1] MC2R 💬  [5] Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Neuroactive ligand-receptor interaction, cAMP signaling pathway  [1] 84 💬 
 246  Response to anakinra associated with methotrexate  Anakinra  [3] D00142, D02115, D02934 💬  [4] DHFR, DHFR2, IL1R1, IL1R2 💬  [20] Amoebiasis, Antifolate resistance, Biosynthesis of cofactors, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Folate biosynthesis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, Metabolic pathways, NF-kappa B signaling pathway, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer  [1] 46 💬 
 247  Response to infliximab associated with methotrexate  Infliximab  [3] D00142, D02115, D02598 💬  [3] DHFR, DHFR2, TNF 💬  [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 248  Routine treatment of cd  -  -  -  -  [1] 96 💬 
 249  Sc recombinant growth hormone + amitriptyline, fluoxetine and tramadol (treated group)  Amitriptyline  [7] D00326, D00809, D00823, D01355, D02691, D07448, D08623 💬  [4] GHR, OPRM1, SLC6A2, SLC6A4 💬  [9] Cytokine-cytokine receptor interaction, Estrogen signaling pathway, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Serotonergic synapse, Synaptic vesicle cycle  [1] 78 💬 
 250  Sc treatment with igsc, 10% with rhuph20 followed by iv/igsc, 10% only (safety)  -  -  -  -  [1] 65 💬 
 251  Sc treatment with igsc, 10% with rhuph20 followed by sc/igsc, 10% only (safety)  -  -  -  -  [1] 65 💬 
 252  Simvastatin treatment for 28 days  Simvastatin  [1] D00434 💬  [1] HMGCR 💬  [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis  [1] 299 💬 
 253  Slow dose titration group of subcutaneous treprostinil  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 254  Stable weekly dose of methotrexate  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 255  Standard of care treatment  -  -  -  -  [2] 245, 246 💬 
 256  Standard steroid treatment  -  -  -  -  [1] 85 💬 
 257  Standard treatment with a conventional drug  -  -  -  -  [1] 13 💬 
 258  Standrd of care treatment  -  -  -  -  [1] 64 💬 
 259  Subcutaneous treprostinil  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 260  Symptomatic treatment (converting enzyme inhibitor, angiotensin ii, anti-renin, aldosterone antagonist diuretic, beta blocker, calcium inhibitor, statin)  Aldosterone  [3] D00150, D02014, D10528 💬  [3] AGTR1, AGTR2, NR3C2 💬  [17] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway  [1] 222 💬 
 261  Symptomatic treatment, steroids, immunosuppressive agents( azathioprine, tacrolimus, mycophenolate mofetil)  Azathioprine  [8] D00107, D00238, D00752, D03033, D05094, D05095, D05096, D08556 💬  [7] IMPDH1, IMPDH2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬  [35] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Drug metabolism - other enzymes, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway  [1] 11 💬 
 262  Symptomatic treatment, steroids, immunosuppressive agents, plasma exchange(pe), intravenous immunoglobulin(ivig)  Human immunoglobulin G  -  -  -  [1] 11 💬 
 263  Systemic non-biological treatments  -  -  -  -  [2] 46, 271 💬 
 264  Tacrolimus with methotrexate  Methotrexate  [4] D00107, D00142, D02115, D08556 💬  [7] DHFR, DHFR2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬  [37] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway  [1] 46 💬 
 265  Tak-715 and methotrexate  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 266  Tak-783 and methotrexate  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 267  Tasocitinib plus methotrexate  Methotrexate  [3] D00142, D02115, D09970 💬  [6] DHFR, DHFR2, JAK1, JAK2, JAK3, TYK2 💬  [40] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis  [1] 46 💬 
 268  The comprehensive treatment regimen of traditional chinese medicine  -  -  -  -  [1] 222 💬 
 269  The standard steroid treatment, plasma exchange and rituximab  Rituximab  [1] D02994 💬  [1] MS4A1 💬  [1] Hematopoietic cell lineage  [1] 85 💬 
 270  Time delay treatment of botulinum toxin  -  -  -  -  [1] 149 💬 
 271  Tl011, anti cd20, for the treatment of rheumatoid arthritis  -  -  -  -  [1] 46 💬 
 272  Tocilizumab + methotrexate(mtx)  Methotrexate  [3] D00142, D02115, D02596 💬  [3] DHFR, DHFR2, IL6R 💬  [17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor  [1] 46 💬 
 273  Tocilizumab plus methotrexate  Methotrexate  [3] D00142, D02115, D02596 💬  [3] DHFR, DHFR2, IL6R 💬  [17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor  [1] 46 💬 
 274  Tocilizumab treatment  Tocilizumab  [1] D02596 💬  [1] IL6R 💬  [12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor  [1] 41 💬 
 275  Tocilizumab+methotrexate(mtx)  Methotrexate  [3] D00142, D02115, D02596 💬  [3] DHFR, DHFR2, IL6R 💬  [17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor  [1] 46 💬 
 276  Tofacitinib with methotrexate  Methotrexate  [3] D00142, D02115, D09970 💬  [6] DHFR, DHFR2, JAK1, JAK2, JAK3, TYK2 💬  [40] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis  [1] 46 💬 
 277  Tofacitinib without methotrexate  Methotrexate  [3] D00142, D02115, D09970 💬  [6] DHFR, DHFR2, JAK1, JAK2, JAK3, TYK2 💬  [40] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis  [1] 46 💬 
 278  Topical pentoxifylline gel (vehicle +ptx)  Pentoxifylline  [1] D00501 💬  -  -  [1] 56 💬 
 279  Tr004 (treg immunotherapy)  -  -  -  -  [1] 96 💬 
 280  Traditional treatment of cgd and tb  -  -  -  -  [1] 65 💬 
 281  Traditional treatments  -  -  -  -  [1] 97 💬 
 282  Tre  -  -  -  -  [1] 86 💬 
 283  Treat to target  -  -  -  -  [1] 46 💬 
 284  Treat with lansoprazole 30 mg bid for 2 weeks, endoscopic examination with esophageal biopsy for patients with persistent symptoms  Lansoprazole  [1] D00355 💬  [2] ATP4A, ATP4B 💬  [4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation  [1] 98 💬 
 285  Treatment  -  -  -  -  [2] 41, 299 💬 
 286  Treatment a  -  -  -  -  [2] 34, 46 💬 
 287  Treatment algorithm a  -  -  -  -  [1] 97 💬 
 288  Treatment algorithm b  -  -  -  -  [1] 97 💬 
 289  Treatment algorithm c  -  -  -  -  [1] 97 💬 
 290  Treatment as usual (tau)  -  -  -  -  [1] 85 💬 
 291  Treatment b  -  -  -  -  [2] 34, 46 💬 
 292  Treatment bx1514m  -  -  -  -  [1] 58 💬 
 293  Treatment c  -  -  -  -  [2] 34, 46 💬 
 294  Treatment d  -  -  -  -  [1] 34 💬 
 295  Treatment defined only by active substance  -  -  -  -  [1] 50 💬 
 296  Treatment i  -  -  -  -  [1] 46 💬 
 297  Treatment ii  -  -  -  -  [1] 46 💬 
 298  Treatment iii  -  -  -  -  [1] 46 💬 
 299  Treatment of mtx  -  -  -  -  [1] 46 💬 
 300  Treatment of mtx and hcq  -  -  -  -  [1] 46 💬 
 301  Treatment of mtx and twhf  -  -  -  -  [1] 46 💬 
 302  Treatment of tcm  -  -  -  -  [1] 46 💬 
 303  Treatment of twhf  -  -  -  -  [1] 46 💬 
 304  Treatment phase group 4  -  -  -  -  [1] 113 💬 
 305  Treatment systemic therapy (prednisone)  Prednisone  [1] D00473 💬  [1] NR3C1 💬  [1] Neuroactive ligand-receptor interaction  [1] 162 💬 
 306  Treatment with adalimumab  Adalimumab  [1] D02597 💬  [1] TNF 💬  [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 96 💬 
 307  Treatment with azathioprin  -  -  -  -  [1] 95 💬 
 308  Treatment with mycophenolat mofetil  -  -  -  -  [1] 95 💬 
 309  Treatment with polyethylene glycol (macrogol 4000)  Polyethylene glycol  [1] D03370 💬  -  -  [1] 299 💬 
 310  Treatment with systemic therapy (doxycycline)  Doxycycline  [5] D00307, D02129, D03903, D03904, D07876 💬  -  -  [1] 162 💬 
 311  Treatment with systemic therapy (methotrexate)  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 162 💬 
 312  Treatment with systemic therapy (prednisone)  Prednisone  [1] D00473 💬  [1] NR3C1 💬  [1] Neuroactive ligand-receptor interaction  [1] 162 💬 
 313  Treatment with topical superpotent corticosteroid therapy  -  -  -  -  [1] 162 💬 
 314  Tregalizumab  Tregalizumab  -  -  -  [1] 46 💬 
 315  Trehalose  Trehalose  -  -  -  [1] 113 💬 
 316  Tremfya  -  -  -  -  [2] 37, 97 💬 
 317  Tremfya®  -  -  -  -  [2] 37, 97 💬 
 318  Treosulfan  Treosulfan  [1] D07253 💬  -  -  [3] 13, 19, 65 💬 
 319  Treprosinil diethanolamine  -  -  -  -  [1] 86 💬 
 320  Treprostin  -  -  -  -  [1] 86 💬 
 321  Treprostinil  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [6] 51, 84, 85, 86, 88, 210 💬 
 322  Treprostinil dietanolamina  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 323  Treprostinil diethanolamine  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [2] 51, 86 💬 
 324  Treprostinil diolamine  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 325  Treprostinil inhalation powder  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 326  Treprostinil inhalations  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 327  Treprostinil injectable product  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 328  Treprostinil sodium  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [3] 51, 86, 88 💬 
 329  Treprostinil sodium for inhalation  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 85 💬 
 330  Treprostinil sodium solution for inhalation  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 331  Treprostinil sodium, ut-15  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 332  Treprostinil, ut-15, lrx-15, 15au81, bw a15au, u-62, 840  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 333  Treprostinilo  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 334  Tretinoin  Tretinoin  [1] D00094 💬  [3] PML, RARA, RARB 💬  [12] Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Influenza A, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis  [2]  2 , 75 💬 
 335  Tretinoin and pioglitazone hcl  Pioglitazone  [3] D00094, D00945, D08378 💬  [4] PML, PPARG, RARA, RARB 💬  [19] AMPK signaling pathway, Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Huntington disease, Influenza A, Longevity regulating pathway, Non-small cell lung cancer, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis  [1]  2  💬 
 336  Trexan  -  -  -  -  [2] 46, 97 💬 
 337  Trexan inj 25 mg/ml  -  -  -  -  [1] 97 💬 
 338  Trexan+salazopyrin+oxiklorin+prednisolone  Prednisolone  [8] D00472, D00980, D00981, D00982, D01239, D01998, D02156, D03301 💬  [1] NR3C1 💬  [1] Neuroactive ligand-receptor interaction  [1] 46 💬 
 339  Trexan+salazopyrin+oxiklorin+prednisolone + infliximab  Infliximab  [9] D00472, D00980, D00981, D00982, D01239, D01998, D02156, D02598, D03301 💬  [2] NR3C1, TNF 💬  [66] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [1] 46 💬 
 340  Untreated to atorvastatin treatment  Atorvastatin  [3] D00258, D00887, D07474 💬  [1] HMGCR 💬  [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis  [1] 13 💬 
 341  Urine samples taken to measure methotrexate and its major metabolite 7-oh-methotrexate level  Methotrexate  [2] D00142, D02115 💬  [2] DHFR, DHFR2 💬  [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate  [1] 46 💬 
 342  Usual dopaminergic per os treatment  -  -  -  -  [1]  6  💬 
 343  Ut-15c (treprostinil diethanolamine)  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 344  Ut-15c sr (treprostinil diethanolamine)  Treprostinil  [1] D06213 💬  [1] PTGIR 💬  [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [1] 86 💬 
 345  Vancomycin pre-treat  Vancomycin  [2] D00212, D00926 💬  -  -  [1] 97 💬 
 346  Vancomycin pre-treatment  Vancomycin  [2] D00212, D00926 💬  -  -  [1] 97 💬 
 347  Viral load driven treatment interruption  -  -  -  -  [1] 265 💬 

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