Mrna-3927    (DrugBank: -)

1 disease
IDDisease name (Link within this page)Number of trials
245Propionic acidemia2

245. Propionic acidemia    [ 9 clinical trials,   15 drugs,   (DrugBank: 3 drugs),   1 drug target gene,   6 drug target pathways]
Searched query = "Propionic acidemia"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 9 trials found
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agemin
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PhaseCountries
1EUCTR2019-003529-36-GB
(EUCTR)
18/12/202003/03/2020A clinical study to evaluate the medicinal product in Patients with Propionic AcidemiaA Global, Phase 1/2, Open-label, Dose Optimization Study to Evaluate the Safety, Pharmacodynamics, and Pharmacokinetics of mRNA-3927 in Participants with Propionic Acidemia Propionic Acidemia- Propionic acidemia is an autosomal recessive disorder caused by loss-of-function mutations in PCCA or PCCB (and in rare instances, mutations in both PCCA and PCCB), resulting in the lossof enzymatic activity of the mitochondrial complex PCC
MedDRA version: 21.0;Level: LLT;Classification code 10080615;Term: Propionic acidemia;System Organ Class: 100000004850;Therapeutic area: Body processes [G] - Metabolic Phenomena [G03]
Product Name: mRNA-3927
INN or Proposed INN: N/A
Other descriptive name: CX-016492
INN or Proposed INN: NA
Other descriptive name: CX-017950
ModernaTX, IncNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
36Phase 1;Phase 2United States;Canada;United Kingdom
2NCT04159103
(ClinicalTrials.gov)
March 20207/11/2019Open Label Study of mRNA-3927 in Patients With Propionic AcidemiaA Global, Phase 1/2, Open-label, Dose Escalation Study to Evaluate the Safety, Pharmacodynamics, and Pharmacokinetics of mRNA-3927 in Participants With Propionic AcidemiaPropionic AcidemiaBiological: mRNA-3927ModernaTX, Inc.NULLNot yet recruiting1 YearN/AAll46Phase 1;Phase 2NULL