No. |
薬物名(臨床試験情報から抽出) |
DrugBank |
KEGG DRUG * |
KEGG GENES * |
KEGG PATHWAY |
指定難病告示番号 * |
1 |
Aclasta |
Zoledronic acid |
D01968, D06378, D06379, D08689 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
3件: 13, 271, 274 |
2 |
Actonel 5mg film coated tablets |
Risedronic acid |
D00942, D03234, D08484 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 274 |
3 |
Actonel once a week 35 mg film-coated tablets |
Risedronic acid |
D00942, D03234, D08484 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 274 |
4 |
Actonel/optinate 5mg film-coated tablets |
Risedronic acid |
D00942, D03234, D08484 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 274 |
5 |
Alendronate |
Alendronic acid |
D00939, D07119 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
7件: 19, 41, 46, 50, 271, 274, 299 |
6 |
Amg 162 |
Denosumab |
D03684 |
1件: TNFSF11 |
7件: Breast cancer, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis |
2件: 46, 274 |
7 |
Anti-sclerostin monoclonal antibody |
- |
- |
- |
- |
1件: 274 |
8 |
Bisphosphonates |
- |
- |
- |
- |
2件: 6, 274 |
9 |
Blood sample |
- |
- |
- |
- |
12件: 8, 13, 46, 49, 51, 53, 61, 66, 97, 274, 288, 299 |
10 |
Bone marrow transplant |
- |
- |
- |
- |
1件: 274 |
11 |
Boost cells |
- |
- |
- |
- |
1件: 274 |
12 |
Bps804 |
- |
- |
- |
- |
2件: 172, 274 |
13 |
Busulfan |
Busulfan |
D00248 |
- |
- |
13件: 19, 20, 28, 36, 49, 51, 60, 65, 164, 274, 284, 285, 326 |
14 |
Calcichew tablets |
- |
- |
- |
- |
1件: 274 |
15 |
Celulas madre mesenquimales troncales adultas alogenicas de médula ósea no expandida |
- |
- |
- |
- |
1件: 274 |
16 |
Cyclophosphamide |
Cyclophosphamide |
D00287, D07760 |
- |
- |
43件: 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 61, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 222, 224, 265, 274, 283, 284, 285, 288, 326, 331 |
17 |
Cyclosporin |
Ciclosporin |
D00184 |
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
30件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway |
16件: 14, 38, 39, 49, 53, 56, 60, 62, 63, 97, 113, 164, 222, 223, 274, 326 |
18 |
Células mesenquimales troncales adultas alogénicas de médula ósea no expandidas |
- |
- |
- |
- |
1件: 274 |
19 |
Células mesenquimales troncales adultas alogénicas de médula ósea no expandidas(ref cruzada pei nº 12-088) |
- |
- |
- |
- |
1件: 274 |
20 |
Denosumab |
Denosumab |
D03684 |
1件: TNFSF11 |
7件: Breast cancer, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis |
7件: 46, 50, 93, 95, 96, 274, 299 |
21 |
Denosumab - immunoglobulin g2 human monoclonal antibody to rank ligand |
Denosumab |
D03684 |
1件: TNFSF11 |
7件: Breast cancer, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis |
1件: 274 |
22 |
Denusomab |
- |
- |
- |
- |
1件: 274 |
23 |
Expanded human first trimester fetal liver-derived mesenchymal stem cells |
- |
- |
- |
- |
1件: 274 |
24 |
Forsteo |
- |
- |
- |
- |
3件: 70, 235, 274 |
25 |
Fresolimumab |
Fresolimumab |
D09620 |
3件: TGFB1, TGFB2, TGFB3 |
34件: AGE-RAGE signaling pathway in diabetic complications, Amoebiasis, Cell cycle, Cellular senescence, Chagas disease (American trypanosomiasis), Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy (DCM), FoxO signaling pathway, Gastric cancer, Hepatitis B, Hepatocellular carcinoma, Hippo signaling pathway, Human T-cell leukemia virus 1 infection, Hypertrophic cardiomyopathy (HCM), Inflammatory bowel disease (IBD), Intestinal immune network for IgA production, Leishmaniasis, MAPK signaling pathway, Malaria, MicroRNAs in cancer, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, Pancreatic cancer, Pathways in cancer, Proteoglycans in cancer, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis, TGF-beta signaling pathway, Th17 cell differentiation, Toxoplasmosis, Tuberculosis |
3件: 51, 222, 274 |
26 |
Genotropin*1tbf 5,3mg (16ui) |
Somatotropin |
D02691 |
1件: GHR |
5件: Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway |
1件: 274 |
27 |
H05aa02 |
- |
- |
- |
- |
1件: 274 |
28 |
High-dose vitamin d (2000 iu per day) |
Vitamin d |
- |
- |
- |
1件: 274 |
29 |
Humatrope |
Somatotropin |
D02691 |
1件: GHR |
5件: Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway |
2件: 78, 274 |
30 |
Mesenchymal stem cells |
- |
- |
- |
- |
11件: 2, 6, 13, 20, 49, 51, 60, 96, 222, 274, 299 |
31 |
Mesenchymal stromal cells |
- |
- |
- |
- |
6件: 36, 51, 96, 97, 274, 284 |
32 |
Nerixia*infus iv conc 2f 100mg |
- |
- |
- |
- |
1件: 274 |
33 |
Nutropin |
Somatotropin |
D02691 |
1件: GHR |
5件: Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway |
2件: 78, 274 |
34 |
Pamidronate |
Pamidronic acid |
D00941, D07281 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
2件: 271, 274 |
35 |
Pamidronate (aredia) |
Pamidronic acid |
D00941, D07281 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 274 |
36 |
Prolia |
Denosumab |
D03684 |
1件: TNFSF11 |
7件: Breast cancer, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis |
1件: 274 |
37 |
Ref cruzada pei nº 12-088 |
- |
- |
- |
- |
1件: 274 |
38 |
Risedronate |
Risedronic acid |
D00942, D03234, D08484 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
5件: 46, 66, 96, 113, 274 |
39 |
Risedronate oral tablet |
Risedronic acid |
D00942, D03234, D08484 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 274 |
40 |
Risedronate sodium |
Risedronic acid |
D00942, D03234, D08484 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
2件: 113, 274 |
41 |
Risedronate sodium (actonel) |
Risedronic acid |
D00942, D03234, D08484 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 274 |
42 |
Risedronate sodium 2.5mg |
Risedronic acid |
D00942, D03234, D08484 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 274 |
43 |
Risedronate sodium 5mg |
Risedronic acid |
D00942, D03234, D08484 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 274 |
44 |
Risedronic acid |
Risedronic acid |
D00942, D03234, D08484 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
3件: 93, 95, 274 |
45 |
Setrusumab |
Setrusumab |
- |
- |
- |
1件: 274 |
46 |
Somatropin |
Somatotropin |
D02691 |
1件: GHR |
5件: Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway |
15件: 2, 3, 19, 46, 74, 75, 78, 96, 113, 193, 195, 265, 274, 276, 299 |
47 |
Standard-dose vitamin d (400iu per day) |
Vitamin d |
- |
- |
- |
1件: 274 |
48 |
Teriparatide |
Teriparatide |
D06078 |
1件: PTH1R |
3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action |
6件: 46, 68, 70, 71, 235, 274 |
49 |
Teriparatide (forteo) |
Teriparatide |
D06078 |
1件: PTH1R |
3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action |
1件: 274 |
50 |
Teriparatide pen injector |
Teriparatide |
D06078 |
1件: PTH1R |
3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action |
1件: 274 |
51 |
Vari |
- |
- |
- |
- |
1件: 274 |
52 |
Vitamin d |
Vitamin d |
- |
- |
- |
18件: 13, 19, 41, 46, 49, 50, 68, 93, 95, 96, 98, 179, 222, 228, 235, 274, 298, 299 |
53 |
Xgeva |
Denosumab |
D03684 |
1件: TNFSF11 |
7件: Breast cancer, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis |
1件: 274 |
54 |
Zol446 |
- |
- |
- |
- |
1件: 274 |
55 |
Zoledronic acid |
Zoledronic acid |
D01968, D06378, D06379, D08689 |
1件: FDPS |
4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis |
9件: 6, 13, 46, 93, 95, 96, 274, 299, 333 |