No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * |
KEGG DRUG * |
DrugBank |
指定難病告示番号 * |
1 | Adrenergic signaling in cardiomyocytes 6 genes, 1 drug (DrugBank) and 2 diseases shown |
6件: ADRA1A, ADRA1B, ADRA1D, ADRB1, KCNQ1, SCN5A |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
2 | Alcoholism 5 genes, 2 drugs (DrugBank) and 7 diseases shown |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
3 | Aldosterone synthesis and secretion 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: KCNJ5 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
4 | Alzheimer disease 5 genes, 2 drugs (DrugBank) and 7 diseases shown |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
5 | Amphetamine addiction 5 genes, 2 drugs (DrugBank) and 7 diseases shown |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
6 | AMPK signaling pathway 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: ADRA1A |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
7 | Amyotrophic lateral sclerosis (ALS) 5 genes, 2 drugs (DrugBank) and 7 diseases shown |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
8 | Calcium signaling pathway 9 genes, 4 drugs (DrugBank) and 11 diseases shown |
4件: ADRA1A, ADRA1B, ADRA1D, ADRB1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
4件: GRIN1, GRIN2A, GRIN2C, GRIN2D |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
1件: OXTR |
D00089 |
Oxytocin |
4件: 127, 193, 206, 226 |
9 | cAMP signaling pathway 7 genes, 4 drugs (DrugBank) and 11 diseases shown |
1件: ADRB1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
1件: OXTR |
D00089 |
Oxytocin |
4件: 127, 193, 206, 226 |
10 | cGMP-PKG signaling pathway 5 genes, 1 drug (DrugBank) and 2 diseases shown |
5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, KCNJ8 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
11 | Cholinergic synapse 4 genes, 3 drugs (DrugBank) and 10 diseases shown |
1件: ACHE |
D00670 |
Donepezil |
9件: 5, 6, 13, 46, 78, 124, 127, 156, 206 |
D07869 |
D02173 |
Galantamine |
2件: 6, 127 |
D04292 |
3件: KCNJ12, KCNJ3, KCNQ1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
12 | Circadian entrainment 7 genes, 3 drugs (DrugBank) and 8 diseases shown |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
2件: KCNJ3, KCNJ5 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
13 | Cocaine addiction 5 genes, 2 drugs (DrugBank) and 7 diseases shown |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
14 | Dilated cardiomyopathy (DCM) 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: ADRB1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
15 | Dopaminergic synapse 6 genes, 4 drugs (DrugBank) and 8 diseases shown |
1件: COMT |
D00786 |
Tolcapone |
3件: 6, 28, 127 |
2件: GRIN2A, GRIN2B |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
3件: KCNJ3, KCNJ5, SCN1A |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
16 | Estrogen signaling pathway 2 genes, 1 drug (DrugBank) and 2 diseases shown |
2件: KCNJ3, KCNJ5 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
17 | Gap junction 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: ADRB1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
18 | Gastric acid secretion 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: KCNQ1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
19 | Glutamatergic synapse 6 genes, 3 drugs (DrugBank) and 8 diseases shown |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
1件: KCNJ3 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
20 | Glycerophospholipid metabolism 1 gene, 2 drugs (DrugBank) and 9 diseases shown |
1件: ACHE |
D00670 |
Donepezil |
9件: 5, 6, 13, 46, 78, 124, 127, 156, 206 |
D07869 |
D02173 |
Galantamine |
2件: 6, 127 |
D04292 |
21 | GnRH secretion 3 genes, 1 drug (DrugBank) and 2 diseases shown |
3件: KCNJ11, KCNJ3, KCNJ5 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
22 | Huntington disease 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: GRIN1, GRIN2B |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
23 | Insulin secretion 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: KCNJ11 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
24 | Long-term potentiation 5 genes, 2 drugs (DrugBank) and 7 diseases shown |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
25 | Metabolic pathways 1 gene, 1 drug (DrugBank) and 3 diseases shown |
1件: COMT |
D00786 |
Tolcapone |
3件: 6, 28, 127 |
26 | Morphine addiction 2 genes, 1 drug (DrugBank) and 2 diseases shown |
2件: KCNJ3, KCNJ5 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
27 | Neuroactive ligand-receptor interaction 10 genes, 4 drugs (DrugBank) and 11 diseases shown |
4件: ADRA1A, ADRA1B, ADRA1D, ADRB1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
1件: OXTR |
D00089 |
Oxytocin |
4件: 127, 193, 206, 226 |
28 | Nicotine addiction 5 genes, 2 drugs (DrugBank) and 7 diseases shown |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
29 | Oxytocin signaling pathway 4 genes, 2 drugs (DrugBank) and 5 diseases shown |
3件: KCNJ12, KCNJ3, KCNJ5 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
1件: OXTR |
D00089 |
Oxytocin |
4件: 127, 193, 206, 226 |
30 | Pancreatic secretion 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: KCNQ1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
31 | Protein digestion and absorption 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: KCNQ1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
32 | Rap1 signaling pathway 3 genes, 2 drugs (DrugBank) and 7 diseases shown |
3件: GRIN1, GRIN2A, GRIN2B |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
33 | Ras signaling pathway 3 genes, 2 drugs (DrugBank) and 7 diseases shown |
3件: GRIN1, GRIN2A, GRIN2B |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
34 | Regulation of lipolysis in adipocytes 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: ADRB1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
35 | Renin secretion 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: ADRB1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
36 | Retrograde endocannabinoid signaling 2 genes, 1 drug (DrugBank) and 2 diseases shown |
2件: KCNJ3, KCNJ5 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
37 | Salivary secretion 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: ADRA1A, ADRA1B, ADRA1D, ADRB1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
38 | Serotonergic synapse 3 genes, 2 drugs (DrugBank) and 4 diseases shown |
2件: KCNJ3, KCNJ5 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
1件: SLC6A4 |
D00822 |
Citalopram |
3件: 8, 46, 127 |
D07704 |
39 | Steroid hormone biosynthesis 1 gene, 1 drug (DrugBank) and 3 diseases shown |
1件: COMT |
D00786 |
Tolcapone |
3件: 6, 28, 127 |
40 | Synaptic vesicle cycle 1 gene, 1 drug (DrugBank) and 3 diseases shown |
1件: SLC6A4 |
D00822 |
Citalopram |
3件: 8, 46, 127 |
D07704 |
41 | Systemic lupus erythematosus 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: GRIN2A, GRIN2B |
D00777 |
Amantadine |
4件: 6, 8, 13, 127 |
D07441 |
D04905 |
Memantine |
7件: 2, 6, 8, 13, 49, 127, 205 |
D08174 |
42 | Taste transduction 3 genes, 1 drug (DrugBank) and 2 diseases shown |
3件: SCN2A, SCN3A, SCN9A |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
43 | Type II diabetes mellitus 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: KCNJ11 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
44 | Tyrosine metabolism 1 gene, 1 drug (DrugBank) and 3 diseases shown |
1件: COMT |
D00786 |
Tolcapone |
3件: 6, 28, 127 |
45 | Vascular smooth muscle contraction 3 genes, 1 drug (DrugBank) and 2 diseases shown |
3件: ADRA1A, ADRA1B, ADRA1D |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |
46 | Vibrio cholerae infection 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: KCNQ1 |
D00636 |
Amiodarone |
2件: 28, 127 |
D02910 |