No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * |
KEGG DRUG * |
DrugBank |
指定難病告示番号 * |
1 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
2 | Cell adhesion molecules (CAMs) 2 genes, 2 drugs (DrugBank) and 6 diseases shown |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
1件: PDCD1 |
D10574 |
Pembrolizumab |
1件: 25 |
3 | Cytokine-cytokine receptor interaction 3 genes, 3 drugs (DrugBank) and 30 diseases shown |
1件: CSF3R |
D03235 |
Filgrastim |
28件: 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
4 | Dilated cardiomyopathy (DCM) 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
5 | ECM-receptor interaction 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
6 | Epstein-Barr virus infection 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
7 | Focal adhesion 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
8 | Hematopoietic cell lineage 2 genes, 2 drugs (DrugBank) and 30 diseases shown |
1件: CSF3R |
D03235 |
Filgrastim |
28件: 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
9 | Hepatitis B 1 gene, 2 drugs (DrugBank) and 7 diseases shown |
1件: IFNAR1 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
10 | Hepatitis C 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
11 | Herpes simplex virus 1 infection 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
12 | Human papillomavirus infection 3 genes, 3 drugs (DrugBank) and 11 diseases shown |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
13 | Hypertrophic cardiomyopathy (HCM) 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
14 | Influenza A 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
15 | Intestinal immune network for IgA production 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
16 | JAK-STAT signaling pathway 3 genes, 3 drugs (DrugBank) and 30 diseases shown |
1件: CSF3R |
D03235 |
Filgrastim |
28件: 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
17 | Kaposi sarcoma-associated herpesvirus infection 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
18 | Leishmaniasis 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
19 | Leukocyte transendothelial migration 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
20 | Measles 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
21 | Metabolic pathways 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: DHODH |
D10172 |
Teriflunomide |
2件: 13, 25 |
22 | Natural killer cell mediated cytotoxicity 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
23 | Necroptosis 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
24 | Neuroactive ligand-receptor interaction 1 gene, 2 drugs (DrugBank) and 49 diseases shown |
1件: NR3C1 |
D00407 |
Methylprednisolone |
36件: 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 |
D00751 |
D00979 |
D05000 |
D05001 |
D05002 |
D00472 |
Prednisolone |
38件: 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 |
D00980 |
D00981 |
D00982 |
D01239 |
D01998 |
D02156 |
D03301 |
25 | NOD-like receptor signaling pathway 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
26 | Osteoclast differentiation 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
27 | Pathways in cancer 3 genes, 3 drugs (DrugBank) and 30 diseases shown |
1件: CSF3R |
D03235 |
Filgrastim |
28件: 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
28 | PD-L1 expression and PD-1 checkpoint pathway in cancer 1 gene, 1 drug (DrugBank) and 1 disease shown |
1件: PDCD1 |
D10574 |
Pembrolizumab |
1件: 25 |
29 | PI3K-Akt signaling pathway 4 genes, 4 drugs (DrugBank) and 32 diseases shown |
1件: CSF3R |
D03235 |
Filgrastim |
28件: 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
30 | Pyrimidine metabolism 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: DHODH |
D10172 |
Teriflunomide |
2件: 13, 25 |
31 | Regulation of actin cytoskeleton 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |
32 | T cell receptor signaling pathway 1 gene, 1 drug (DrugBank) and 1 disease shown |
1件: PDCD1 |
D10574 |
Pembrolizumab |
1件: 25 |
33 | Toll-like receptor signaling pathway 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
2件: IFNAR1, IFNAR2 |
D03305 |
Interferon alfa |
5件: 25, 26, 28, 56, 96 |
D02745 |
Interferon alfa-2b |
3件: 25, 34, 227 |
34 | Yersinia infection 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: ITGA4 |
D06886 |
Natalizumab |
6件: 13, 15, 25, 46, 63, 96 |