No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * |
KEGG DRUG * |
DrugBank |
指定難病告示番号 * |
1 | Allograft rejection 3 genes, 3 drugs (DrugBank) and 27 diseases shown |
2件: CD80, CD86 |
D03203 |
Abatacept |
24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
2 | Antifolate resistance 2 genes, 1 drug (DrugBank) and 33 diseases shown |
2件: DHFR, DHFR2 |
D00142 |
Methotrexate |
33件: 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 |
D02115 |
3 | Asthma 1 gene, 2 drugs (DrugBank) and 4 diseases shown |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
4 | Autoimmune thyroid disease 3 genes, 3 drugs (DrugBank) and 27 diseases shown |
2件: CD80, CD86 |
D03203 |
Abatacept |
24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
5 | Cell adhesion molecules (CAMs) 2 genes, 1 drug (DrugBank) and 24 diseases shown |
2件: CD80, CD86 |
D03203 |
Abatacept |
24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
6 | cGMP-PKG signaling pathway 1 gene, 1 drug (DrugBank) and 11 diseases shown |
1件: OPRD1 |
D02095 |
Naltrexone |
11件: 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 |
D05113 |
7 | Complement and coagulation cascades 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: C5AR1 |
D11093 |
Avacopan |
4件: 43, 44, 222, 223 |
8 | Cytokine-cytokine receptor interaction 3 genes, 4 drugs (DrugBank) and 11 diseases shown |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
1件: IL5RA |
D09874 |
Benralizumab |
2件: 44, 45 |
1件: TNFSF13B |
D03068 |
Belimumab |
8件: 11, 43, 44, 46, 49, 51, 53, 222 |
9 | Estrogen signaling pathway 1 gene, 1 drug (DrugBank) and 11 diseases shown |
1件: OPRM1 |
D02095 |
Naltrexone |
11件: 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 |
D05113 |
10 | Fc epsilon RI signaling pathway 1 gene, 2 drugs (DrugBank) and 4 diseases shown |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
11 | Folate biosynthesis 2 genes, 1 drug (DrugBank) and 33 diseases shown |
2件: DHFR, DHFR2 |
D00142 |
Methotrexate |
33件: 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 |
D02115 |
12 | Graft-versus-host disease 2 genes, 1 drug (DrugBank) and 24 diseases shown |
2件: CD80, CD86 |
D03203 |
Abatacept |
24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
13 | Hematopoietic cell lineage 3 genes, 4 drugs (DrugBank) and 43 diseases shown |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
1件: IL5RA |
D09874 |
Benralizumab |
2件: 44, 45 |
1件: MS4A1 |
D02994 |
Rituximab |
42件: 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 |
14 | IL-17 signaling pathway 1 gene, 2 drugs (DrugBank) and 4 diseases shown |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
15 | Inflammatory bowel disease (IBD) 1 gene, 2 drugs (DrugBank) and 4 diseases shown |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
16 | Intestinal immune network for IgA production 4 genes, 4 drugs (DrugBank) and 28 diseases shown |
2件: CD80, CD86 |
D03203 |
Abatacept |
24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
1件: TNFSF13B |
D03068 |
Belimumab |
8件: 11, 43, 44, 46, 49, 51, 53, 222 |
17 | JAK-STAT signaling pathway 2 genes, 3 drugs (DrugBank) and 4 diseases shown |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
1件: IL5RA |
D09874 |
Benralizumab |
2件: 44, 45 |
18 | Kaposi sarcoma-associated herpesvirus infection 1 gene, 1 drug (DrugBank) and 24 diseases shown |
1件: CD86 |
D03203 |
Abatacept |
24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
19 | Metabolic pathways 2 genes, 1 drug (DrugBank) and 33 diseases shown |
2件: DHFR, DHFR2 |
D00142 |
Methotrexate |
33件: 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 |
D02115 |
20 | Morphine addiction 1 gene, 1 drug (DrugBank) and 11 diseases shown |
1件: OPRM1 |
D02095 |
Naltrexone |
11件: 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 |
D05113 |
21 | Neuroactive ligand-receptor interaction 5 genes, 5 drugs (DrugBank) and 60 diseases shown |
1件: C5AR1 |
D11093 |
Avacopan |
4件: 43, 44, 222, 223 |
1件: NR3C1 |
D00472 |
Prednisolone |
38件: 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 |
D00980 |
D00981 |
D00982 |
D01239 |
D01998 |
D02156 |
D03301 |
D00473 |
Prednisone |
44件: 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 |
D00385 |
Triamcinolone |
18件: 6, 10, 13, 35, 40, 41, 42, 43, 44, 45, 46, 56, 70, 90, 96, 97, 226, 298 |
D00983 |
D00984 |
D00985 |
D06216 |
3件: OPRD1, OPRK1, OPRM1 |
D02095 |
Naltrexone |
11件: 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 |
D05113 |
22 | NF-kappa B signaling pathway 1 gene, 1 drug (DrugBank) and 8 diseases shown |
1件: TNFSF13B |
D03068 |
Belimumab |
8件: 11, 43, 44, 46, 49, 51, 53, 222 |
23 | One carbon pool by folate 2 genes, 1 drug (DrugBank) and 33 diseases shown |
2件: DHFR, DHFR2 |
D00142 |
Methotrexate |
33件: 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 |
D02115 |
24 | Pathways in cancer 2 genes, 3 drugs (DrugBank) and 4 diseases shown |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
1件: IL5RA |
D09874 |
Benralizumab |
2件: 44, 45 |
25 | Rheumatoid arthritis 3 genes, 2 drugs (DrugBank) and 25 diseases shown |
2件: CD80, CD86 |
D03203 |
Abatacept |
24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
1件: TNFSF13B |
D03068 |
Belimumab |
8件: 11, 43, 44, 46, 49, 51, 53, 222 |
26 | Sphingolipid signaling pathway 1 gene, 1 drug (DrugBank) and 11 diseases shown |
1件: OPRD1 |
D02095 |
Naltrexone |
11件: 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 |
D05113 |
27 | Staphylococcus aureus infection 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: C5AR1 |
D11093 |
Avacopan |
4件: 43, 44, 222, 223 |
28 | Systemic lupus erythematosus 2 genes, 1 drug (DrugBank) and 24 diseases shown |
2件: CD80, CD86 |
D03203 |
Abatacept |
24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
29 | T cell receptor signaling pathway 1 gene, 2 drugs (DrugBank) and 4 diseases shown |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
30 | Th1 and Th2 cell differentiation 1 gene, 2 drugs (DrugBank) and 4 diseases shown |
1件: IL5 |
D04923 |
Mepolizumab |
4件: 44, 45, 98, 162 |
D08985 |
Reslizumab |
3件: 44, 45, 98 |
31 | Toll-like receptor signaling pathway 2 genes, 1 drug (DrugBank) and 24 diseases shown |
2件: CD80, CD86 |
D03203 |
Abatacept |
24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
32 | Transcriptional misregulation in cancer 1 gene, 1 drug (DrugBank) and 24 diseases shown |
1件: CD86 |
D03203 |
Abatacept |
24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
33 | Type I diabetes mellitus 2 genes, 1 drug (DrugBank) and 24 diseases shown |
2件: CD80, CD86 |
D03203 |
Abatacept |
24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
34 | Viral myocarditis 2 genes, 1 drug (DrugBank) and 24 diseases shown |
2件: CD80, CD86 |
D03203 |
Abatacept |
24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |