No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * |
KEGG DRUG * |
DrugBank |
指定難病告示番号 * |
1 | Adrenergic signaling in cardiomyocytes 6 genes, 5 drugs (DrugBank) and 14 diseases shown |
3件: ADRA1A, ADRA1B, ADRA1D |
D00608 |
Doxazosin |
2件: 57, 67 |
D07874 |
5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 |
D00255 |
Carvedilol |
4件: 6, 57, 86, 113 |
D03415 |
1件: ADRB1 |
D00632 |
Dobutamine |
3件: 57, 58, 215 |
D03879 |
D03880 |
D03881 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
2 | AGE-RAGE signaling pathway in diabetic complications 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
3 | Aldosterone synthesis and secretion 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
4 | AMPK signaling pathway 1 gene, 2 drugs (DrugBank) and 5 diseases shown |
1件: ADRA1A |
D00255 |
Carvedilol |
4件: 6, 57, 86, 113 |
D03415 |
D00608 |
Doxazosin |
2件: 57, 67 |
D07874 |
5 | Apelin signaling pathway 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
6 | Caffeine metabolism 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: XDH |
D00224 |
Allopurinol |
6件: 6, 46, 57, 66, 96, 97 |
7 | Calcium signaling pathway 6 genes, 5 drugs (DrugBank) and 14 diseases shown |
3件: ADRA1A, ADRA1B, ADRA1D |
D00608 |
Doxazosin |
2件: 57, 67 |
D07874 |
5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 |
D00255 |
Carvedilol |
4件: 6, 57, 86, 113 |
D03415 |
1件: ADRB1 |
D00632 |
Dobutamine |
3件: 57, 58, 215 |
D03879 |
D03880 |
D03881 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
8 | cAMP signaling pathway 2 genes, 3 drugs (DrugBank) and 10 diseases shown |
1件: ADRB1 |
D00632 |
Dobutamine |
3件: 57, 58, 215 |
D03879 |
D03880 |
D03881 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
2件: ADRB1, ADRB2 |
D00255 |
Carvedilol |
4件: 6, 57, 86, 113 |
D03415 |
9 | cGMP-PKG signaling pathway 6 genes, 5 drugs (DrugBank) and 14 diseases shown |
3件: ADRA1A, ADRA1B, ADRA1D |
D00608 |
Doxazosin |
2件: 57, 67 |
D07874 |
5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 |
D00255 |
Carvedilol |
4件: 6, 57, 86, 113 |
D03415 |
1件: ADRB1 |
D00632 |
Dobutamine |
3件: 57, 58, 215 |
D03879 |
D03880 |
D03881 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
10 | Chagas disease (American trypanosomiasis) 1 gene, 1 drug (DrugBank) and 3 diseases shown |
1件: ACE |
D00620 |
Benazepril |
3件: 57, 218, 224 |
D07499 |
11 | Cortisol synthesis and secretion 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
12 | Cushing syndrome 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
13 | Cytokine-cytokine receptor interaction 1 gene, 1 drug (DrugBank) and 3 diseases shown |
1件: CSF3R |
D03247 |
Lenograstim |
3件: 2, 57, 65 |
14 | Dilated cardiomyopathy (DCM) 1 gene, 3 drugs (DrugBank) and 10 diseases shown |
1件: ADRB1 |
D00255 |
Carvedilol |
4件: 6, 57, 86, 113 |
D03415 |
D00632 |
Dobutamine |
3件: 57, 58, 215 |
D03879 |
D03880 |
D03881 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
15 | Drug metabolism - other enzymes 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: XDH |
D00224 |
Allopurinol |
6件: 6, 46, 57, 66, 96, 97 |
16 | Gap junction 1 gene, 3 drugs (DrugBank) and 10 diseases shown |
1件: ADRB1 |
D00255 |
Carvedilol |
4件: 6, 57, 86, 113 |
D03415 |
D00632 |
Dobutamine |
3件: 57, 58, 215 |
D03879 |
D03880 |
D03881 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
17 | Hematopoietic cell lineage 1 gene, 1 drug (DrugBank) and 3 diseases shown |
1件: CSF3R |
D03247 |
Lenograstim |
3件: 2, 57, 65 |
18 | Hypertrophic cardiomyopathy (HCM) 1 gene, 1 drug (DrugBank) and 3 diseases shown |
1件: ACE |
D00620 |
Benazepril |
3件: 57, 218, 224 |
D07499 |
19 | JAK-STAT signaling pathway 1 gene, 1 drug (DrugBank) and 3 diseases shown |
1件: CSF3R |
D03247 |
Lenograstim |
3件: 2, 57, 65 |
20 | Metabolic pathways 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: XDH |
D00224 |
Allopurinol |
6件: 6, 46, 57, 66, 96, 97 |
21 | Neuroactive ligand-receptor interaction 6 genes, 5 drugs (DrugBank) and 14 diseases shown |
3件: ADRA1A, ADRA1B, ADRA1D |
D00608 |
Doxazosin |
2件: 57, 67 |
D07874 |
5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 |
D00255 |
Carvedilol |
4件: 6, 57, 86, 113 |
D03415 |
1件: ADRB1 |
D00632 |
Dobutamine |
3件: 57, 58, 215 |
D03879 |
D03880 |
D03881 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
22 | Pathways in cancer 2 genes, 2 drugs (DrugBank) and 8 diseases shown |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
1件: CSF3R |
D03247 |
Lenograstim |
3件: 2, 57, 65 |
23 | Peroxisome 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: XDH |
D00224 |
Allopurinol |
6件: 6, 46, 57, 66, 96, 97 |
24 | Phospholipase D signaling pathway 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
25 | PI3K-Akt signaling pathway 1 gene, 1 drug (DrugBank) and 3 diseases shown |
1件: CSF3R |
D03247 |
Lenograstim |
3件: 2, 57, 65 |
26 | Purine metabolism 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: XDH |
D00224 |
Allopurinol |
6件: 6, 46, 57, 66, 96, 97 |
27 | Regulation of lipolysis in adipocytes 2 genes, 3 drugs (DrugBank) and 10 diseases shown |
1件: ADRB1 |
D00632 |
Dobutamine |
3件: 57, 58, 215 |
D03879 |
D03880 |
D03881 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
2件: ADRB1, ADRB2 |
D00255 |
Carvedilol |
4件: 6, 57, 86, 113 |
D03415 |
28 | Renin secretion 4 genes, 5 drugs (DrugBank) and 14 diseases shown |
1件: ACE |
D00620 |
Benazepril |
3件: 57, 218, 224 |
D07499 |
1件: ADRB1 |
D00632 |
Dobutamine |
3件: 57, 58, 215 |
D03879 |
D03880 |
D03881 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
2件: ADRB1, ADRB2 |
D00255 |
Carvedilol |
4件: 6, 57, 86, 113 |
D03415 |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
29 | Renin-angiotensin system 2 genes, 2 drugs (DrugBank) and 7 diseases shown |
1件: ACE |
D00620 |
Benazepril |
3件: 57, 218, 224 |
D07499 |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |
30 | Salivary secretion 5 genes, 4 drugs (DrugBank) and 11 diseases shown |
3件: ADRA1A, ADRA1B, ADRA1D |
D00608 |
Doxazosin |
2件: 57, 67 |
D07874 |
5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 |
D00255 |
Carvedilol |
4件: 6, 57, 86, 113 |
D03415 |
1件: ADRB1 |
D00632 |
Dobutamine |
3件: 57, 58, 215 |
D03879 |
D03880 |
D03881 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
31 | Vascular smooth muscle contraction 4 genes, 3 drugs (DrugBank) and 10 diseases shown |
3件: ADRA1A, ADRA1B, ADRA1D |
D00255 |
Carvedilol |
4件: 6, 57, 86, 113 |
D03415 |
D00608 |
Doxazosin |
2件: 57, 67 |
D07874 |
1件: AGTR1 |
D00400 |
Valsartan |
6件: 57, 58, 66, 75, 218, 222 |