No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * |
KEGG DRUG * |
DrugBank |
指定難病告示番号 * |
1 | Adipocytokine signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
2 | Adrenergic signaling in cardiomyocytes 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
3 | Aldosterone synthesis and secretion 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
4 | Aldosterone-regulated sodium reabsorption 1 gene, 1 drug (DrugBank) and 3 diseases shown |
1件: NR3C2 |
D00986 |
Fludrocortisone |
3件: 6, 17, 81 |
D07967 |
5 | Alzheimer disease 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
6 | Amphetamine addiction 2 genes, 1 drug (DrugBank) and 2 diseases shown |
2件: CACNA1C, CACNA1D |
D00437 |
Nifedipine |
2件: 50, 81 |
7 | AMPK signaling pathway 3 genes, 2 drugs (DrugBank) and 25 diseases shown |
1件: PPARG |
D00945 |
Pioglitazone |
17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 |
D08378 |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
8 | Apelin signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
9 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
10 | Autophagy - animal 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
11 | Calcium signaling pathway 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
12 | cAMP signaling pathway 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
13 | Carbohydrate digestion and absorption 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: CACNA1D |
D00437 |
Nifedipine |
2件: 50, 81 |
14 | Cardiac muscle contraction 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
15 | Cellular senescence 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: CACNA1D |
D00437 |
Nifedipine |
2件: 50, 81 |
16 | cGMP-PKG signaling pathway 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
17 | Cholinergic synapse 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
18 | Circadian entrainment 2 genes, 1 drug (DrugBank) and 2 diseases shown |
2件: CACNA1C, CACNA1D |
D00437 |
Nifedipine |
2件: 50, 81 |
19 | Circadian rhythm 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
20 | Cortisol synthesis and secretion 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
21 | Cushing syndrome 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
22 | Dilated cardiomyopathy (DCM) 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
23 | Dopaminergic synapse 2 genes, 1 drug (DrugBank) and 2 diseases shown |
2件: CACNA1C, CACNA1D |
D00437 |
Nifedipine |
2件: 50, 81 |
24 | Fluid shear stress and atherosclerosis 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
25 | FoxO signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
26 | GABAergic synapse 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
27 | Glucagon signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
28 | Glutamatergic synapse 2 genes, 1 drug (DrugBank) and 2 diseases shown |
2件: CACNA1C, CACNA1D |
D00437 |
Nifedipine |
2件: 50, 81 |
29 | GnRH secretion 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
30 | GnRH signaling pathway 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
31 | Growth hormone synthesis, secretion and action 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
32 | Huntington disease 1 gene, 1 drug (DrugBank) and 17 diseases shown |
1件: PPARG |
D00945 |
Pioglitazone |
17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 |
D08378 |
33 | Hypertrophic cardiomyopathy (HCM) 6 genes, 2 drugs (DrugBank) and 18 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
34 | Insulin resistance 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
35 | Insulin secretion 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
36 | Insulin signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
37 | Long-term potentiation 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: CACNA1C |
D00437 |
Nifedipine |
2件: 50, 81 |
38 | Longevity regulating pathway 3 genes, 2 drugs (DrugBank) and 25 diseases shown |
1件: PPARG |
D00945 |
Pioglitazone |
17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 |
D08378 |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
39 | Longevity regulating pathway - multiple species 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
40 | MAPK signaling pathway 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
41 | Metabolic pathways 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: CYP19A1 |
D00964 |
Letrozole |
2件: 81, 89 |
42 | mTOR signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
43 | Neuroactive ligand-receptor interaction 1 gene, 9 drugs (DrugBank) and 61 diseases shown |
1件: NR3C1 |
D07749 |
Cortisone |
1件: 81 |
D00973 |
Cortisone acetate |
1件: 81 |
D00292 |
Dexamethasone |
20件: 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 |
D00975 |
D01510 |
D01615 |
D01632 |
D01948 |
D02174 |
D02591 |
D02592 |
D00088 |
Hydrocortisone |
8件: 6, 53, 75, 78, 81, 83, 97, 299 |
D00165 |
Hydrocortisone acetate |
8件: 6, 53, 75, 78, 81, 83, 97, 299 |
D00976 |
Hydrocortisone cypionate |
2件: 81, 83 |
D01442 |
Hydrocortisone succinate |
3件: 6, 81, 83 |
D00472 |
Prednisolone |
38件: 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 |
D00980 |
D00981 |
D00982 |
D01239 |
D01998 |
D02156 |
D03301 |
D00473 |
Prednisone |
44件: 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 |
44 | Non-alcoholic fatty liver disease (NAFLD) 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
45 | Oocyte meiosis 1 gene, 1 drug (DrugBank) and 1 disease shown |
1件: AR |
D00586 |
Flutamide |
1件: 81 |
46 | Osteoclast differentiation 1 gene, 1 drug (DrugBank) and 17 diseases shown |
1件: PPARG |
D00945 |
Pioglitazone |
17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 |
D08378 |
47 | Ovarian steroidogenesis 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: CYP19A1 |
D00964 |
Letrozole |
2件: 81, 89 |
48 | Oxytocin signaling pathway 6 genes, 2 drugs (DrugBank) and 18 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
49 | Pathways in cancer 2 genes, 2 drugs (DrugBank) and 17 diseases shown |
1件: AR |
D00586 |
Flutamide |
1件: 81 |
1件: PPARG |
D00945 |
Pioglitazone |
17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 |
D08378 |
50 | PI3K-Akt signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
51 | PPAR signaling pathway 1 gene, 1 drug (DrugBank) and 17 diseases shown |
1件: PPARG |
D00945 |
Pioglitazone |
17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 |
D08378 |
52 | Prostate cancer 1 gene, 1 drug (DrugBank) and 1 disease shown |
1件: AR |
D00586 |
Flutamide |
1件: 81 |
53 | Renin secretion 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
54 | Retrograde endocannabinoid signaling 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
55 | Serotonergic synapse 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |
56 | Steroid hormone biosynthesis 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: CYP19A1 |
D00964 |
Letrozole |
2件: 81, 89 |
57 | Taste transduction 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: CACNA1C |
D00437 |
Nifedipine |
2件: 50, 81 |
58 | Thermogenesis 3 genes, 2 drugs (DrugBank) and 25 diseases shown |
1件: PPARG |
D00945 |
Pioglitazone |
17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 |
D08378 |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
59 | Thyroid cancer 1 gene, 1 drug (DrugBank) and 17 diseases shown |
1件: PPARG |
D00945 |
Pioglitazone |
17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 |
D08378 |
60 | Tight junction 3 genes, 2 drugs (DrugBank) and 18 diseases shown |
1件: CACNA1D |
D00437 |
Nifedipine |
2件: 50, 81 |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
61 | Transcriptional misregulation in cancer 1 gene, 1 drug (DrugBank) and 17 diseases shown |
1件: PPARG |
D00945 |
Pioglitazone |
17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 |
D08378 |
62 | Type II diabetes mellitus 2 genes, 1 drug (DrugBank) and 2 diseases shown |
2件: CACNA1C, CACNA1D |
D00437 |
Nifedipine |
2件: 50, 81 |
63 | Vascular smooth muscle contraction 4 genes, 1 drug (DrugBank) and 2 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00437 |
Nifedipine |
2件: 50, 81 |