No. |
薬物名(臨床試験情報から抽出) |
DrugBank |
KEGG DRUG * |
KEGG GENES * |
KEGG PATHWAY |
指定難病告示番号 * |
1 |
(4s,5r)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4’- |
- |
- |
- |
- |
1件: 79 |
2 |
Aav directed hldlr gene therapy |
- |
- |
- |
- |
1件: 79 |
3 |
Aegr-733 |
- |
- |
- |
- |
1件: 79 |
4 |
Ak102 |
- |
- |
- |
- |
1件: 79 |
5 |
Akcea-angptl3-lrx |
- |
- |
- |
- |
2件: 79, 265 |
6 |
Alirocumab |
Alirocumab |
D10335 |
1件: PCSK9 |
1件: Cholesterol metabolism |
1件: 79 |
7 |
Alirocumab sar236553 (regn727) |
Alirocumab |
D10335 |
1件: PCSK9 |
1件: Cholesterol metabolism |
1件: 79 |
8 |
Aln-pcssc |
- |
- |
- |
- |
1件: 79 |
9 |
Amg 145 |
- |
- |
- |
- |
1件: 79 |
10 |
Amg145 |
- |
- |
- |
- |
1件: 79 |
11 |
Atorvastatin |
Atorvastatin |
D00258, D00887, D07474 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 |
12 |
Calcium |
Calcium |
- |
- |
- |
24件: 6, 13, 19, 46, 49, 51, 65, 68, 75, 79, 84, 93, 94, 95, 96, 97, 214, 215, 222, 224, 235, 265, 298, 299 |
13 |
Calcium rosuvastatin |
Rosuvastatin |
D01915, D08492 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 79 |
14 |
Cer-001 |
- |
- |
- |
- |
1件: 79 |
15 |
Cholestyramine |
Cholestyramine |
- |
- |
- |
2件: 13, 79 |
16 |
Comparator: ezetimibe |
Ezetimibe |
D01966 |
1件: NPC1L1 |
1件: Fat digestion and absorption |
2件: 79, 260 |
17 |
Crestor |
Rosuvastatin |
D01915, D08492 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
3件: 49, 79, 299 |
18 |
Crestor film-coated tablet |
Rosuvastatin |
D01915, D08492 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 79 |
19 |
Crestor tablets (calcium rosuvastatin) film-coated tablets |
Rosuvastatin |
D01915, D08492 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 79 |
20 |
Dextran |
Dextran |
D00060 |
- |
- |
5件: 2, 62, 79, 96, 97 |
21 |
Evinacumab |
Evinacumab |
- |
- |
- |
1件: 79 |
22 |
Evinacumab (regn1500) |
Evinacumab |
- |
- |
- |
1件: 79 |
23 |
Evolocumab |
Evolocumab |
D10557 |
1件: PCSK9 |
1件: Cholesterol metabolism |
2件: 79, 222 |
24 |
Evolocumab (amg 145) |
Evolocumab |
D10557 |
1件: PCSK9 |
1件: Cholesterol metabolism |
1件: 79 |
25 |
Ezetimibe |
Ezetimibe |
D01966 |
1件: NPC1L1 |
1件: Fat digestion and absorption |
4件: 49, 79, 93, 260 |
26 |
Fenofibrate |
Fenofibrate |
D00565 |
1件: PPARA |
7件: Adipocytokine signaling pathway, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), PPAR signaling pathway, cAMP signaling pathway |
5件: 8, 79, 93, 94, 265 |
27 |
Fluvastatin |
Fluvastatin |
D00892, D07983 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
3件: 79, 218, 222 |
28 |
Gemcabene |
Gemcabene |
- |
- |
- |
2件: 79, 265 |
29 |
Gemcabene 300 mg |
Gemcabene |
- |
- |
- |
1件: 79 |
30 |
Gemcabene 600 mg |
Gemcabene |
- |
- |
- |
1件: 79 |
31 |
Gemcabene 900 mg |
Gemcabene |
- |
- |
- |
1件: 79 |
32 |
Heparin |
Heparin |
D07510 |
1件: SERPINC1 |
1件: Complement and coagulation cascades |
11件: 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 |
33 |
Ibi306 |
- |
- |
- |
- |
1件: 79 |
34 |
Implitapide |
Implitapide |
- |
- |
- |
1件: 79 |
35 |
Inclisiran |
Inclisiran |
- |
- |
- |
1件: 79 |
36 |
Inclisiran for injection |
Inclisiran |
- |
- |
- |
1件: 79 |
37 |
Inclisiran sodium |
Inclisiran |
- |
- |
- |
1件: 79 |
38 |
Isis 301012 |
- |
- |
- |
- |
1件: 79 |
39 |
Isis 301012 phosphorothioate oligonucleotide |
- |
- |
- |
- |
1件: 79 |
40 |
Isis 703802 |
- |
- |
- |
- |
1件: 79 |
41 |
Lib003 |
- |
- |
- |
- |
1件: 79 |
42 |
Lomitapide |
Lomitapide |
D09637 |
1件: MTTP |
1件: Fat digestion and absorption |
1件: 79 |
43 |
Lovastatin |
Lovastatin |
D00359 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
10件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 |
44 |
Mbx-8025 |
- |
- |
- |
- |
2件: 79, 93 |
45 |
Mbx-8025 50 mg (dose escalation period 1) |
- |
- |
- |
- |
1件: 79 |
46 |
Mbx-8025 50 mg or 100 mg (dose escalation period 2) |
- |
- |
- |
- |
1件: 79 |
47 |
Mbx-8025 50 mg, 100 mg or 200 mg (dose escalation period 3) |
- |
- |
- |
- |
1件: 79 |
48 |
Mk-0859 |
- |
- |
- |
- |
1件: 79 |
49 |
Nicotinic acid |
Niacin |
D00049 |
- |
- |
1件: 79 |
50 |
Omega-3 |
Omega-3 fatty acids |
- |
- |
- |
7件: 13, 46, 49, 66, 79, 96, 299 |
51 |
Omega-3 fatty acids |
Omega-3 fatty acids |
- |
- |
- |
2件: 13, 79 |
52 |
Placebo |
- |
- |
- |
- |
20件: 3, 6, 13, 14, 40, 46, 49, 50, 51, 66, 67, 79, 85, 86, 88, 96, 97, 144, 149, 226 |
53 |
Praluent |
Alirocumab |
D10335 |
1件: PCSK9 |
1件: Cholesterol metabolism |
1件: 79 |
54 |
Pravastatin |
Pravastatin |
D00893, D08410 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
9件: 13, 46, 49, 67, 79, 96, 164, 265, 333 |
55 |
Regn1500 |
- |
- |
- |
- |
1件: 79 |
56 |
Repatha 140 mg solution for injection in pre-filled pen |
Evolocumab |
D10557 |
1件: PCSK9 |
1件: Cholesterol metabolism |
1件: 79 |
57 |
Repatha 420 mg solution for injection in cartridge |
Evolocumab |
D10557 |
1件: PCSK9 |
1件: Cholesterol metabolism |
1件: 79 |
58 |
Repatha® (evolocumab) |
Evolocumab |
D10557 |
1件: PCSK9 |
1件: Cholesterol metabolism |
1件: 79 |
59 |
Rosuvastatin |
Rosuvastatin |
D01915, D08492 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
8件: 6, 46, 49, 51, 79, 96, 271, 299 |
60 |
Rosuvastatin 20mg |
Rosuvastatin |
D01915, D08492 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 79 |
61 |
Rosuvastatin calcium |
Rosuvastatin |
D01915, D08492 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
3件: 49, 79, 299 |
62 |
Sar236553 |
- |
- |
- |
- |
1件: 79 |
63 |
Simvastatin |
Simvastatin |
D00434 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
19件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 |
64 |
Single intravenous (iv) dose of human low density lipoprotein receptor (ldlr) gene therapy |
- |
- |
- |
- |
1件: 79 |
65 |
Standard of care |
- |
- |
- |
- |
8件: 6, 13, 14, 49, 51, 64, 79, 85 |
66 |
Statins |
- |
- |
- |
- |
2件: 46, 79 |
67 |
Sulfate |
Sulfate ion |
- |
- |
- |
22件: 2, 6, 11, 13, 26, 34, 36, 46, 49, 60, 61, 64, 66, 79, 86, 96, 222, 226, 265, 296, 297, 299 |
68 |
Tak-475 |
- |
- |
- |
- |
1件: 79 |
69 |
Zd4522 |
Rosuvastatin |
D01915, D08492 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
1件: 79 |