No. |
DrugBank |
薬物名(臨床試験情報から抽出) |
KEGG DRUG * | KEGG GENES * |
KEGG PATHWAY |
指定難病告示番号 * |
1 | Alirocumab | 2件: Alirocumab; Alirocumab sar236553 (regn727); | D10335 |
1件: PCSK9 |
1件: Cholesterol metabolism |
1件: 79 |
2 | Atorvastatin | 9件: Atorvastatin; Atorvastatin 10mg; Atorvastatin 20mg; Atorvastatin calcium; Atorvastatin tablet 20 mg; Interferon beta treatment to add-on atorvastatin treatment; Interferon beta-1b/atorvastatin group; Lisinopril, losartan, and atorvastatin; Untreated to atorvastatin treatment; | D00258 D00887 D07474 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 |
3 | Calcium | 25件: Amorphous calcium carbonate; Ascal(r) / carbasalate calcium; Atorvastatin calcium; Calcitriol & calcium; Calcium; Calcium and cholecalciferol; Calcium carbonate; Calcium carbonate and alphacalcidol; Calcium channel blockers; Calcium channel blockers (amlodipine, azelnidipine); Calcium citrate; Calcium citrate with vitamin d2; Calcium gluconate; Calcium lactate; Calcium levofolinate; Calcium rosuvastatin; Calcium, dietary; Carbasalate calcium; Crestor tablets (calcium rosuvastatin) film-coated tablets; Crystalline calcium supplements; Ibandronate+alfacalcidol+calcium; Low molecular weight heparin calcium injection; Rosuvastatin calcium; Symptomatic treatment (converting enzyme inhibitor, angiotensin ii, anti-renin, aldosterone antagonist diuretic, beta blocker, calcium inhibitor, statin); Vidofludimus calcium; | - |
- |
- |
24件: 6, 13, 19, 46, 49, 51, 65, 68, 75, 79, 84, 93, 94, 95, 96, 97, 214, 215, 222, 224, 235, 265, 298, 299 |
4 | Cholestyramine | 1件: Cholestyramine; | - |
- |
- |
5件: 13, 79, 93, 254, 297 |
5 | Dextran | 4件: Dextran; Dextran sulfate sodium; Iron dextran; Iron(iii)- hydroxide dextran complex; | D00060 |
- |
- |
5件: 2, 62, 79, 96, 97 |
6 | Evinacumab | 2件: Evinacumab; Evinacumab (regn1500); | - |
- |
- |
1件: 79 |
7 | Evolocumab | 3件: Evolocumab; Evolocumab (amg 145); Repatha® (evolocumab); | D10557 |
1件: PCSK9 |
1件: Cholesterol metabolism |
2件: 79, 222 |
8 | Ezetimibe | 5件: Comparator: ezetimibe; Ezetimibe; Ezetimibe + other lipid-lowering medication(s); Ezetimibe+simvastatin drug combination; Mk0653, ezetimibe; | D01966 |
1件: NPC1L1 |
1件: Fat digestion and absorption |
4件: 49, 79, 93, 260 |
9 | Fenofibrate | 2件: Fenofibrate; Fenofibrate (insoluble drug delivery-micro particle fenofibrate (idd-p); | D00565 |
1件: PPARA |
7件: Adipocytokine signaling pathway, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), PPAR signaling pathway, cAMP signaling pathway |
5件: 8, 79, 93, 94, 265 |
10 | Fluvastatin | 2件: Benazepril, valsartan and fluvastatin; Fluvastatin; | D00892 D07983 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
3件: 79, 218, 222 |
11 | Gemcabene | 6件: 300mg gemcabene; 600mg gemcabene; Gemcabene; Gemcabene 300 mg; Gemcabene 600 mg; Gemcabene 900 mg; | - |
- |
- |
2件: 79, 265 |
12 | Heparin | 7件: Alkalinized lidocaine-heparin; Bladder instillation with heparin/ lidocaine; Heparin; Heparin 25mg inhalation powder, hard capsule; Heparin sodium; Intralipid/heparin; Low molecular weight heparin calcium injection; | D07510 |
1件: SERPINC1 |
1件: Complement and coagulation cascades |
11件: 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 |
13 | Implitapide | 1件: Implitapide; | - |
- |
- |
1件: 79 |
14 | Inclisiran | 3件: Inclisiran; Inclisiran for injection; Inclisiran sodium; | - |
- |
- |
1件: 79 |
15 | Lomitapide | 1件: Lomitapide; | D09637 |
1件: MTTP |
1件: Fat digestion and absorption |
1件: 79 |
16 | Lovastatin | 5件: Lovastatin; Lovastatin 60 mg; Lovastatin ™; Lovastatin, then minocycline/lovastatin; Minocycline, then minocycline/lovastatin; | D00359 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
10件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 |
17 | MBX-8025 | 8件: Mbx 8025; Mbx-8025; Mbx-8025 10 mg capsule; Mbx-8025 2 mg capsule; Mbx-8025 5 mg capsule; Mbx-8025 50 mg (dose escalation period 1); Mbx-8025 50 mg or 100 mg (dose escalation period 2); Mbx-8025 50 mg, 100 mg or 200 mg (dose escalation period 3); | - |
- |
- |
2件: 79, 93 |
18 | Niacin | 5件: Dose-establishing study 1 niacin 250mg; Dose-establishing study 1 niacin 500mg; Dose-establishing study 2 niacin 500mg; Niacin; Niacin first; | D00049 |
- |
- |
4件: 6, 78, 79, 265 |
19 | Omega-3 fatty acids | 6件: Dietary supplement omega3 fatty acids aand vitamins; Lipoic acid and omega-3 fatty acids; Omega 3 fatty acids; Omega-3 fatty acids; Omega3 fatty acids; Triomar™ (omega-3 fatty acids); | - |
- |
- |
7件: 13, 46, 49, 66, 79, 96, 299 |
20 | Pravastatin | 4件: Lonafarnib, zoledronic acid, and pravastatin; Montelukast, flurbiprofen, midazolam, digoxin, pravastatin and bms-986142; Pravastatin; Pravastatin sodium; | D00893 D08410 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
9件: 13, 46, 49, 67, 79, 96, 164, 265, 333 |
21 | Rosuvastatin | 6件: Calcium rosuvastatin; Crestor tablets (calcium rosuvastatin) film-coated tablets; Rosuvastatin; Rosuvastatin 10 mg; Rosuvastatin 20mg; Rosuvastatin calcium; | D01915 D08492 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
8件: 6, 46, 49, 51, 79, 96, 271, 299 |
22 | Simvastatin | 11件: Encapsulated simvastatin tablets; Ezetimibe+simvastatin drug combination; Simvastatin; Simvastatin 20mg/5ml oral suspension; Simvastatin 40 mg film-coated tablets; Simvastatin 40mg; Simvastatin alternova; Simvastatin susp.; Simvastatin treatment for 28 days; Simvastatin-ratiopharm; Simvastatin-ratiopharm®; | D00434 |
1件: HMGCR |
4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
19件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 |
23 | Sulfate ion | - | - |
- |
- |
22件: 2, 6, 11, 13, 26, 34, 36, 46, 49, 60, 61, 64, 66, 79, 86, 96, 222, 226, 265, 296, 297, 299 |
24 | TAK-475 | 1件: Tak-475; | - |
- |
- |
1件: 79 |