No. |
DrugBank |
薬物名(臨床試験情報から抽出) |
KEGG DRUG * | KEGG GENES * |
KEGG PATHWAY |
指定難病告示番号 * |
1 | ACR-16 | 5件: Acr16; Acr16 10 mg; Acr16 22.5 mg; Acr16 45 mg; Acr16 hydrochloride, asp2314 hydrochloride, fr310826; | - |
- |
- |
1件: 8 |
2 | Alprazolam | 1件: Alprazolam; | D00225 |
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction |
1件: 8 |
3 | Amantadine | 10件: 240mg amantadine hcl er tablets; 320mg amantadine hcl er tablets; Ads-5102 (extended release amantadine hcl); Amantadine; Amantadine 300 mg; Amantadine hcl er; Amantadine hcl extended release; Amantadine hydrochloride; Amantadine sulfate; Pk-merz® 200mg/500ml inj(amantadine) , normal saline 500ml inj; | D00777 D07441 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
17件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Rap1 signaling pathway, Ras signaling pathway, Systemic lupus erythematosus, cAMP signaling pathway |
4件: 6, 8, 13, 127 |
4 | Atomoxetine | 1件: Atomoxetine; | D02574 D07473 |
1件: SLC6A2 |
1件: Synaptic vesicle cycle |
3件: 6, 8, 13 |
5 | Bevantolol | 2件: Bevantolol; Bevantolol hydrochloride; | - |
- |
- |
1件: 8 |
6 | Bupropion | 2件: Bupropion; Wellbutrin (bupropion); | D00817 D07591 D07938 |
2件: SLC6A2, SLC6A3 |
6件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Synaptic vesicle cycle |
2件: 8, 96 |
7 | Citalopram | 2件: 20mg daily citalopram; Citalopram; | D00822 D07704 |
1件: SLC6A4 |
2件: Serotonergic synapse, Synaptic vesicle cycle |
3件: 8, 46, 127 |
8 | Creatine | 4件: Creatine; Creatine monohydrate; Creatine-13c; Pyruvate, creatine, niacinamide; | - |
- |
- |
12件: 1, 2, 5, 6, 8, 13, 46, 49, 50, 113, 156, 201 |
9 | Cysteamine | 9件: Cystagon (cysteamine bitartrate) immediate-release capsules; Cystagon® (cysteamine bitartrate); Cysteamine; Cysteamine (mercaptamine) viscous solution; Cysteamine bitartrate; Cysteamine bitartrate (cystagon); Cysteamine bitartrate (inn: mercaptamine bitartrate ); Cysteamine bitartrate delayed-release capsules (rp103); Cysteamine hydrochloride; | D03634 D03635 |
- |
- |
4件: 8, 19, 21, 299 |
10 | Dextromethorphan | 9件: Dextromethorphan; Dextromethorphan 30 mg; Dextromethorphan and caffeine; Dextromethorphan hbr and quinidine sulfate; Dextromethorphan hydrobromide; Dextromethorphan hydrobromide 20 mg and quinidine sulfate 10 mg; Dextromethorphan hydrobromide 30 mg and quinidine sulfate 10 mg; Dextromethorphan/quinidine 20mg/10mg (dm/q 20mg/10mg); Dimebon + dextromethorphan; | D00848 D03742 D03744 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
17件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Rap1 signaling pathway, Ras signaling pathway, Systemic lupus erythematosus, cAMP signaling pathway |
9件: 2, 6, 8, 13, 46, 78, 96, 97, 156 |
11 | Digoxin | 3件: Bms drug-drug interaction cocktail (montelukast, flurbiprofen, omeprazole, midazolam, and digoxin); Digoxin; Montelukast, flurbiprofen, midazolam, digoxin, pravastatin and bms-986142; | D00298 |
4件: ATP1A1, ATP1A2, ATP1A3, ATP1A4 |
18件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway |
2件: 8, 46 |
12 | Fenofibrate | 2件: Fenofibrate; Fenofibrate (insoluble drug delivery-micro particle fenofibrate (idd-p); | D00565 |
1件: PPARA |
7件: Adipocytokine signaling pathway, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), PPAR signaling pathway, cAMP signaling pathway |
5件: 8, 79, 93, 94, 265 |
13 | GSK-356278 | 1件: Gsk356278; | - |
- |
- |
1件: 8 |
14 | Haloperidol | 1件: Haloperidol; | D00136 D01898 |
1件: DRD2 |
8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway |
1件: 8 |
15 | Icosapent ethyl | - | D01892 |
- |
- |
1件: 8 |
16 | Ketoconazole | 2件: Dimebon + ketoconazole; Ketoconazole; | D00351 |
1件: CYP17A1 |
6件: Cortisol synthesis and secretion, Cushing syndrome, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling pathway, Steroid hormone biosynthesis |
3件: 8, 13, 75 |
17 | LAX-101 | 1件: Lax-101; | - |
- |
- |
1件: 8 |
18 | Laquinimod | 8件: Laquinimod; Laquinimod 0.6; Laquinimod 1.2; Laquinimod capsules 0.3 mg; Laquinimod capsules 0.6 mg; Laquinimod cápsulas 0.5 mg; Laquinimod sodium (usan); Laquinimod tablets 0.3 mg; | - |
- |
- |
4件: 8, 13, 49, 96 |
19 | Latrepirdine | 2件: Dimebon (latrepirdine); Latrepirdine; | D09917 |
6件: ACHE, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
19件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Calcium signaling pathway, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Glycerophospholipid metabolism, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Rap1 signaling pathway, Ras signaling pathway, Systemic lupus erythematosus, cAMP signaling pathway |
1件: 8 |
20 | Lithium carbonate | 1件: Lithium carbonate; | D00801 |
- |
- |
8件: 2, 5, 7, 8, 13, 17, 19, 127 |
21 | Lithium citrate | - | D04749 |
- |
- |
4件: 2, 5, 7, 8 |
22 | Memantine | 3件: Memantine; Memantine (ebixa); Memantine hydrochloride; | D04905 D08174 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
17件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Rap1 signaling pathway, Ras signaling pathway, Systemic lupus erythematosus, cAMP signaling pathway |
7件: 2, 6, 8, 13, 49, 127, 205 |
23 | Minocycline | 7件: Combination of minocycline and mtx or mtx alone; Glatiramer acetate with minocycline; Lovastatin, then minocycline/lovastatin; Minocycline; Minocycline 100 mg film-coated tablets; Minocycline hydrochloride; Minocycline, then minocycline/lovastatin; | D00850 D05045 |
- |
- |
14件: 2, 6, 8, 13, 46, 84, 85, 90, 94, 162, 201, 206, 280, 299 |
24 | Neflamapimod | 1件: Neflamapimod; | D10959 |
4件: MAPK11, MAPK12, MAPK13, MAPK14 |
53件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Amyotrophic lateral sclerosis (ALS), C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease (American trypanosomiasis), Dopaminergic synapse, Endocrine resistance, Epithelial cell signaling in Helicobacter pylori infection, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hepatitis B, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, IL-17 signaling pathway, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Leukocyte transendothelial migration, MAPK signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathogenic Escherichia coli infection, Pertussis, Platelet activation, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rap1 signaling pathway, Relaxin signaling pathway, Retrograde endocannabinoid signaling, Salmonella infection, Shigellosis, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Thermogenesis, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, VEGF signaling pathway, Yersinia infection |
1件: 8 |
25 | Nilotinib | 8件: Cohort 1:nilotinib oral capsules (150mg or 300mg); Cohort 2: nilotinib oral capsules (dose to be determined from cohort 1); Nilotinib; Nilotinib (tasigna); Nilotinib 150 mg; Nilotinib 150mg oral capsule [tasigna]; Nilotinib 300mg oral capsule [tasigna]; Nilotinib hydrochloride monohydrate; | D08953 |
4件: ABL1, KIT, PDGFRA, PDGFRB |
33件: Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Shigellosis, Viral myocarditis |
5件: 6, 8, 34, 51, 86 |
26 | Olanzapine | 1件: Olanzapine; | D00454 D06623 |
11件: ADRA1A, ADRA1B, ADRA1D, DRD2, DRD3, DRD4, HRH1, HTR2A, HTR2B, HTR2C, HTR6 |
16件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Salivary secretion, Serotonergic synapse, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
2件: 2, 8 |
27 | Omeprazole | 16件: Bms drug-drug interaction cocktail (montelukast, flurbiprofen, omeprazole, midazolam, and digoxin); Clartihromycin, amoxicillin, and omeprazole; Diclofenac + omeprazole; Dimebon + omeprazole; Naproxen 500 mg tablets (pn 200 minus omeprazole); Omeprazole; Omeprazole (uk licensed generic product); Omeprazole 20 mg; Omeprazole 20mg; Omeprazole 20mg bid; Omeprazole 40 mg; Omeprazole 40mg capsule; Omeprazole magnesium; Omeprazole rectally 1mg/kg; Pn 200 tablets (500 mg naproxen and 20 mg omeprazole); Rifaximin+omeprazole+miralax; | D00455 D01207 D05259 D05261 |
2件: ATP4A, ATP4B |
4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation |
15件: 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 |
28 | Pepinemab | - | D11469 |
1件: SEMA4D |
1件: Axon guidance |
2件: 8, 13 |
29 | Phenylbutyric acid | - | D05868 |
- |
- |
10件: 2, 3, 6, 8, 93, 94, 244, 251, 297, 299 |
30 | Phosphorus | 1件: Phosphorus; | - |
- |
- |
1件: 8 |
31 | Pridopidine | 2件: Pridopidine; Pridopidine (90 mg); | D09953 |
1件: DRD2 |
8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway |
2件: 6, 8 |
32 | Quinidine | 5件: Dextromethorphan hbr and quinidine sulfate; Dextromethorphan hydrobromide 20 mg and quinidine sulfate 10 mg; Dextromethorphan hydrobromide 30 mg and quinidine sulfate 10 mg; Dextromethorphan/quinidine 20mg/10mg (dm/q 20mg/10mg); Quinidine; | D00642 D00643 D02272 D08458 |
5件: SCN1A, SCN2A, SCN3A, SCN5A, SCN9A |
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction |
3件: 2, 8, 13 |
33 | Ramelteon | 1件: Ramelteon; | D02689 |
2件: MTNR1A, MTNR1B |
2件: Circadian entrainment, Neuroactive ligand-receptor interaction |
3件: 6, 8, 46 |
34 | Resveratrol | 1件: Resveratrol; | - |
- |
- |
3件: 8, 89, 113 |
35 | Rilmenidine | 1件: Rilmenidine; | D08482 |
3件: ADRA2A, ADRA2B, ADRA2C |
2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway |
1件: 8 |
36 | Riluzole | 5件: Riluzole; Riluzole 50 mg; Riluzole 50 mg (part b); Riluzole oral soluble film; Riluzole oral soluble film (rosf) 50 mg; | D00775 |
14件: GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway |
7件: 2, 3, 5, 8, 13, 17, 206 |
37 | Risperidone | 2件: Methylphenidate, fluoxetin, risperidone; Risperidone; | D00426 |
2件: DRD2, HTR2A |
11件: Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway |
5件: 8, 156, 179, 187, 206 |
38 | Rolipram | 1件: Rolipram; | D01783 |
4件: PDE4A, PDE4B, PDE4C, PDE4D |
5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway |
2件: 8, 13 |
39 | Sage | 4件: Sage; Sage leaf; Sage-217; Sage-718; | - |
- |
- |
2件: 6, 8 |
40 | Selisistat | 1件: Selisistat; | - |
- |
- |
1件: 8 |
41 | Sertraline | 1件: Sertraline; | D00825 D02360 |
1件: SLC6A4 |
2件: Serotonergic synapse, Synaptic vesicle cycle |
3件: 6, 8, 206 |
42 | Tetrabenazine | 2件: Tetrabenazine; Tetrabenazine withdrawal; | D08575 |
1件: SLC18A2 |
7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle |
1件: 8 |
43 | Triheptanoin | 4件: Triheptanoin; Triheptanoin 1g/kg/day; Triheptanoin oil; Ux007 (triheptanoin); | D11465 |
- |
- |
10件: 2, 8, 120, 149, 156, 248, 256, 257, 317, 324 |
44 | Ubidecarenone | - | D01065 |
- |
- |
12件: 2, 5, 6, 8, 10, 46, 57, 86, 113, 193, 214, 215 |
45 | Ubiquinol | 1件: Ubiquinol; | - |
- |
- |
3件: 6, 8, 17 |
46 | Ursadiol | - | - |
- |
- |
6件: 8, 20, 93, 97, 234, 299 |
47 | Ursodeoxycholic acid | 9件: Udca (ursodeoxycholic acid); Ursodeoxycholic acid; Ursodeoxycholic acid (udca); Ursodeoxycholic acid (urso); Ursodeoxycholic acid 300mg capsule; Ursodeoxycholic acid 300mg tablet; Ursodeoxycholic acid capsules; Ursodeoxycholic acid combination of immunosuppressive agents; Ursodiol (ursodeoxycholic acid, udca); | D00734 |
1件: NR1H4 |
1件: Bile secretion |
12件: 6, 8, 20, 67, 84, 93, 94, 95, 96, 97, 234, 299 |
48 | Valbenazine | 1件: Valbenazine; | D10675 |
1件: SLC18A2 |
7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle |
1件: 8 |
49 | Valproic Acid | 3件: Valproic acid; Valproic acid (vpa); Valproic acid and levocarnitine; | D00399 |
7件: ABAT, ALDH5A1, CACNA1G, CACNA1H, CACNA1I, GAD1, GAD2 |
17件: Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism |
14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 |
50 | Warfarin | 4件: S-warfarin; The generic name is warfarin and many producers will be involved; Warfarin; Warfarin 10 mg; | D00564 D01280 D08682 |
2件: NQO1, VKORC1 |
5件: Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis |
10件: 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 |