No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * |
KEGG DRUG * |
DrugBank |
指定難病告示番号 * |
1 | Adrenergic signaling in cardiomyocytes 6 genes, 3 drugs (DrugBank) and 6 diseases shown |
5件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: KCNQ1 |
D09569 |
Ezogabine |
2件: 2, 144 |
1件: SCN5A |
D05775 |
Rufinamide |
1件: 144 |
2 | Aldosterone synthesis and secretion 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
3 | Alzheimer disease 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
4 | Amphetamine addiction 6 genes, 2 drugs (DrugBank) and 6 diseases shown |
6件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
4件: GRIA1, GRIA2, GRIA3, GRIA4 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
5 | Amyotrophic lateral sclerosis (ALS) 2 genes, 2 drugs (DrugBank) and 6 diseases shown |
2件: GRIA1, GRIA2 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
6 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
7 | Bile secretion 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: CA2 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
8 | Calcium signaling pathway 7 genes, 2 drugs (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
3件: HTR2A, HTR2B, HTR2C |
D04148 |
Fenfluramine |
2件: 140, 144 |
D07945 |
9 | cAMP signaling pathway 8 genes, 2 drugs (DrugBank) and 6 diseases shown |
8件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
4件: GRIA1, GRIA2, GRIA3, GRIA4 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
10 | Carbohydrate digestion and absorption 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: CACNA1D |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
11 | Cardiac muscle contraction 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
12 | Cellular senescence 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: CACNA1D |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
13 | cGMP-PKG signaling pathway 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
14 | Cholinergic synapse 9 genes, 2 drugs (DrugBank) and 6 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
5件: KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 |
D09569 |
Ezogabine |
2件: 2, 144 |
15 | Circadian entrainment 8 genes, 3 drugs (DrugBank) and 12 diseases shown |
6件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
4件: GRIA1, GRIA2, GRIA3, GRIA4 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
2件: MTNR1A, MTNR1B |
D08170 |
Melatonin |
8件: 6, 13, 46, 49, 90, 97, 144, 202 |
16 | Cocaine addiction 1 gene, 2 drugs (DrugBank) and 6 diseases shown |
1件: GRIA2 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
17 | Collecting duct acid secretion 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: CA2 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
18 | Cortisol synthesis and secretion 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
19 | Cushing syndrome 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
20 | Dilated cardiomyopathy (DCM) 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
21 | Dopaminergic synapse 7 genes, 3 drugs (DrugBank) and 6 diseases shown |
7件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
4件: GRIA1, GRIA2, GRIA3, GRIA4 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
1件: SCN1A |
D05775 |
Rufinamide |
1件: 144 |
22 | GABAergic synapse 20 genes, 2 drugs (DrugBank) and 5 diseases shown |
20件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D01253 |
Clobazam |
2件: 140, 144 |
23 | Gap junction 3 genes, 1 drug (DrugBank) and 2 diseases shown |
3件: HTR2A, HTR2B, HTR2C |
D04148 |
Fenfluramine |
2件: 140, 144 |
D07945 |
24 | Gastric acid secretion 2 genes, 2 drugs (DrugBank) and 6 diseases shown |
1件: CA2 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: KCNQ1 |
D09569 |
Ezogabine |
2件: 2, 144 |
25 | Glutamatergic synapse 11 genes, 2 drugs (DrugBank) and 6 diseases shown |
11件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
4件: GRIA1, GRIA2, GRIA3, GRIA4 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
26 | GnRH secretion 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
27 | GnRH signaling pathway 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
28 | Growth hormone synthesis, secretion and action 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
29 | Hypertrophic cardiomyopathy (HCM) 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
30 | Inflammatory mediator regulation of TRP channels 3 genes, 1 drug (DrugBank) and 2 diseases shown |
3件: HTR2A, HTR2B, HTR2C |
D04148 |
Fenfluramine |
2件: 140, 144 |
D07945 |
31 | Insulin secretion 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
32 | Long-term depression 3 genes, 2 drugs (DrugBank) and 6 diseases shown |
3件: GRIA1, GRIA2, GRIA3 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
33 | Long-term potentiation 3 genes, 2 drugs (DrugBank) and 6 diseases shown |
3件: CACNA1C, GRIA1, GRIA2 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
2件: GRIA1, GRIA2 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
34 | MAPK signaling pathway 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
35 | Metabolic pathways 2 genes, 1 drug (DrugBank) and 5 diseases shown |
2件: CA2, CA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
36 | Morphine addiction 16 genes, 2 drugs (DrugBank) and 5 diseases shown |
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D01253 |
Clobazam |
2件: 140, 144 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
37 | Neuroactive ligand-receptor interaction 32 genes, 6 drugs (DrugBank) and 18 diseases shown |
2件: CNR1, CNR2 |
D10915 |
Cannabidiol |
14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 |
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D01253 |
Clobazam |
2件: 140, 144 |
25件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
4件: GRIA1, GRIA2, GRIA3, GRIA4 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
3件: HTR2A, HTR2B, HTR2C |
D04148 |
Fenfluramine |
2件: 140, 144 |
D07945 |
2件: MTNR1A, MTNR1B |
D08170 |
Melatonin |
8件: 6, 13, 46, 49, 90, 97, 144, 202 |
38 | Nicotine addiction 20 genes, 3 drugs (DrugBank) and 6 diseases shown |
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D01253 |
Clobazam |
2件: 140, 144 |
20件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
4件: GRIA1, GRIA2, GRIA3, GRIA4 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
39 | Nitrogen metabolism 2 genes, 1 drug (DrugBank) and 5 diseases shown |
2件: CA2, CA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
40 | Oxytocin signaling pathway 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
41 | Pancreatic secretion 2 genes, 2 drugs (DrugBank) and 6 diseases shown |
1件: CA2 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: KCNQ1 |
D09569 |
Ezogabine |
2件: 2, 144 |
42 | Protein digestion and absorption 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: KCNQ1 |
D09569 |
Ezogabine |
2件: 2, 144 |
43 | Proximal tubule bicarbonate reclamation 2 genes, 1 drug (DrugBank) and 5 diseases shown |
2件: CA2, CA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
44 | Rap1 signaling pathway 1 gene, 1 drug (DrugBank) and 14 diseases shown |
1件: CNR1 |
D10915 |
Cannabidiol |
14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 |
45 | Renin secretion 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
46 | Retrograde endocannabinoid signaling 25 genes, 4 drugs (DrugBank) and 15 diseases shown |
24件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: CNR1 |
D10915 |
Cannabidiol |
14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 |
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D01253 |
Clobazam |
2件: 140, 144 |
4件: GRIA1, GRIA2, GRIA3, GRIA4 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
47 | Serotonergic synapse 11 genes, 3 drugs (DrugBank) and 5 diseases shown |
7件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
3件: GABRB1, GABRB2, GABRB3 |
D01253 |
Clobazam |
2件: 140, 144 |
4件: HTR2A, HTR2B, HTR2C, SLC6A4 |
D04148 |
Fenfluramine |
2件: 140, 144 |
D07945 |
48 | Synaptic vesicle cycle 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: SLC6A4 |
D04148 |
Fenfluramine |
2件: 140, 144 |
D07945 |
49 | Taste transduction 10 genes, 3 drugs (DrugBank) and 5 diseases shown |
10件: CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
6件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 |
D01253 |
Clobazam |
2件: 140, 144 |
3件: SCN2A, SCN3A, SCN9A |
D05775 |
Rufinamide |
1件: 144 |
50 | Thermogenesis 1 gene, 1 drug (DrugBank) and 14 diseases shown |
1件: CNR1 |
D10915 |
Cannabidiol |
14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 |
51 | Tight junction 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: CACNA1D |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
52 | Transcriptional misregulation in cancer 1 gene, 2 drugs (DrugBank) and 6 diseases shown |
1件: GRIA3 |
D08964 |
Perampanel |
3件: 2, 6, 144 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
53 | Type II diabetes mellitus 2 genes, 1 drug (DrugBank) and 5 diseases shown |
2件: CACNA1C, CACNA1D |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
54 | Vascular smooth muscle contraction 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
55 | Vibrio cholerae infection 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: KCNQ1 |
D09569 |
Ezogabine |
2件: 2, 144 |