No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * |
KEGG DRUG * |
DrugBank |
指定難病告示番号 * |
1 | Adipocytokine signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
2 | Alcoholism 7 genes, 5 drugs (DrugBank) and 14 diseases shown |
1件: DRD2 |
D01164 |
Aripiprazole |
2件: 6, 206 |
D00426 |
Risperidone |
5件: 8, 156, 179, 187, 206 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
1件: SLC6A3 |
D01296 |
Methylphenidate |
7件: 6, 13, 34, 84, 113, 179, 206 |
D04999 |
3 | Alzheimer disease 5 genes, 2 drugs (DrugBank) and 8 diseases shown |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
4 | Amphetamine addiction 10 genes, 3 drugs (DrugBank) and 12 diseases shown |
9件: GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
1件: SLC6A3 |
D01296 |
Methylphenidate |
7件: 6, 13, 34, 84, 113, 179, 206 |
D04999 |
5 | AMPK signaling pathway 3 genes, 2 drugs (DrugBank) and 24 diseases shown |
1件: HMGCR |
D00359 |
Lovastatin |
10件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
6 | Amyotrophic lateral sclerosis (ALS) 7 genes, 2 drugs (DrugBank) and 8 diseases shown |
7件: GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
7 | Apelin signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
8 | Autophagy - animal 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
9 | Bile secretion 1 gene, 1 drug (DrugBank) and 10 diseases shown |
1件: HMGCR |
D00359 |
Lovastatin |
10件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 |
10 | Calcium signaling pathway 6 genes, 5 drugs (DrugBank) and 14 diseases shown |
4件: GRIN1, GRIN2A, GRIN2C, GRIN2D |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
1件: HTR2A |
D01164 |
Aripiprazole |
2件: 6, 206 |
D00426 |
Risperidone |
5件: 8, 156, 179, 187, 206 |
1件: OXTR |
D00089 |
Oxytocin |
4件: 127, 193, 206, 226 |
11 | cAMP signaling pathway 14 genes, 6 drugs (DrugBank) and 14 diseases shown |
1件: DRD2 |
D00426 |
Risperidone |
5件: 8, 156, 179, 187, 206 |
2件: DRD2, HTR1A |
D01164 |
Aripiprazole |
2件: 6, 206 |
2件: GABBR1, GABBR2 |
D09791 |
Arbaclofen |
2件: 13, 206 |
9件: GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
1件: OXTR |
D00089 |
Oxytocin |
4件: 127, 193, 206, 226 |
12 | Cholinergic synapse 1 gene, 1 drug (DrugBank) and 9 diseases shown |
1件: ACHE |
D00670 |
Donepezil |
9件: 5, 6, 13, 46, 78, 124, 127, 156, 206 |
D07869 |
13 | Circadian entrainment 9 genes, 2 drugs (DrugBank) and 8 diseases shown |
9件: GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
14 | Circadian rhythm 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
15 | Cocaine addiction 8 genes, 5 drugs (DrugBank) and 14 diseases shown |
1件: DRD2 |
D01164 |
Aripiprazole |
2件: 6, 206 |
D00426 |
Risperidone |
5件: 8, 156, 179, 187, 206 |
6件: GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
1件: SLC6A3 |
D01296 |
Methylphenidate |
7件: 6, 13, 34, 84, 113, 179, 206 |
D04999 |
16 | Dopaminergic synapse 9 genes, 5 drugs (DrugBank) and 14 diseases shown |
1件: DRD2 |
D00426 |
Risperidone |
5件: 8, 156, 179, 187, 206 |
2件: DRD2, DRD3 |
D01164 |
Aripiprazole |
2件: 6, 206 |
6件: GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
2件: GRIN2A, GRIN2B |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
1件: SLC6A3 |
D01296 |
Methylphenidate |
7件: 6, 13, 34, 84, 113, 179, 206 |
D04999 |
17 | Estrogen signaling pathway 2 genes, 1 drug (DrugBank) and 2 diseases shown |
2件: GABBR1, GABBR2 |
D09791 |
Arbaclofen |
2件: 13, 206 |
18 | Fluid shear stress and atherosclerosis 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
19 | FoxO signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
20 | GABAergic synapse 18 genes, 4 drugs (DrugBank) and 8 diseases shown |
2件: GABBR1, GABBR2 |
D09791 |
Arbaclofen |
2件: 13, 206 |
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D00697 |
Flumazenil |
5件: 6, 13, 17, 18, 206 |
D04282 |
Gaboxadol |
2件: 201, 206 |
D04300 |
Ganaxolone |
3件: 145, 152, 206 |
21 | Gap junction 2 genes, 2 drugs (DrugBank) and 6 diseases shown |
2件: DRD2, HTR2A |
D01164 |
Aripiprazole |
2件: 6, 206 |
D00426 |
Risperidone |
5件: 8, 156, 179, 187, 206 |
22 | Glucagon signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
23 | Glutamatergic synapse 14 genes, 2 drugs (DrugBank) and 8 diseases shown |
14件: GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
24 | Glycerophospholipid metabolism 1 gene, 1 drug (DrugBank) and 9 diseases shown |
1件: ACHE |
D00670 |
Donepezil |
9件: 5, 6, 13, 46, 78, 124, 127, 156, 206 |
D07869 |
25 | GnRH secretion 2 genes, 1 drug (DrugBank) and 2 diseases shown |
2件: GABBR1, GABBR2 |
D09791 |
Arbaclofen |
2件: 13, 206 |
26 | Huntington disease 2 genes, 2 drugs (DrugBank) and 8 diseases shown |
2件: GRIN1, GRIN2B |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
27 | Hypertrophic cardiomyopathy (HCM) 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
28 | Inflammatory mediator regulation of TRP channels 1 gene, 2 drugs (DrugBank) and 6 diseases shown |
1件: HTR2A |
D01164 |
Aripiprazole |
2件: 6, 206 |
D00426 |
Risperidone |
5件: 8, 156, 179, 187, 206 |
29 | Insulin resistance 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
30 | Insulin signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
31 | Long-term depression 3 genes, 1 drug (DrugBank) and 7 diseases shown |
3件: GRIA1, GRIA2, GRIA3 |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
32 | Long-term potentiation 7 genes, 2 drugs (DrugBank) and 8 diseases shown |
7件: GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
33 | Longevity regulating pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
34 | Longevity regulating pathway - multiple species 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
35 | Metabolic pathways 1 gene, 1 drug (DrugBank) and 10 diseases shown |
1件: HMGCR |
D00359 |
Lovastatin |
10件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 |
36 | Morphine addiction 18 genes, 4 drugs (DrugBank) and 8 diseases shown |
2件: GABBR1, GABBR2 |
D09791 |
Arbaclofen |
2件: 13, 206 |
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D00697 |
Flumazenil |
5件: 6, 13, 17, 18, 206 |
D04282 |
Gaboxadol |
2件: 201, 206 |
D04300 |
Ganaxolone |
3件: 145, 152, 206 |
37 | mTOR signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
38 | Neuroactive ligand-receptor interaction 37 genes, 9 drugs (DrugBank) and 18 diseases shown |
4件: DRD2, DRD3, HTR1A, HTR2A |
D01164 |
Aripiprazole |
2件: 6, 206 |
2件: DRD2, HTR2A |
D00426 |
Risperidone |
5件: 8, 156, 179, 187, 206 |
2件: GABBR1, GABBR2 |
D09791 |
Arbaclofen |
2件: 13, 206 |
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D00697 |
Flumazenil |
5件: 6, 13, 17, 18, 206 |
D04282 |
Gaboxadol |
2件: 201, 206 |
D04300 |
Ganaxolone |
3件: 145, 152, 206 |
14件: GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
1件: OXTR |
D00089 |
Oxytocin |
4件: 127, 193, 206, 226 |
39 | Nicotine addiction 25 genes, 5 drugs (DrugBank) and 12 diseases shown |
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D00697 |
Flumazenil |
5件: 6, 13, 17, 18, 206 |
D04282 |
Gaboxadol |
2件: 201, 206 |
D04300 |
Ganaxolone |
3件: 145, 152, 206 |
9件: GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
40 | Non-alcoholic fatty liver disease (NAFLD) 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
41 | Oxytocin signaling pathway 3 genes, 2 drugs (DrugBank) and 20 diseases shown |
1件: OXTR |
D00089 |
Oxytocin |
4件: 127, 193, 206, 226 |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
42 | Parkinson disease 2 genes, 3 drugs (DrugBank) and 10 diseases shown |
1件: DRD2 |
D01164 |
Aripiprazole |
2件: 6, 206 |
D00426 |
Risperidone |
5件: 8, 156, 179, 187, 206 |
1件: SLC6A3 |
D01296 |
Methylphenidate |
7件: 6, 13, 34, 84, 113, 179, 206 |
D04999 |
43 | PI3K-Akt signaling pathway 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
44 | Rap1 signaling pathway 4 genes, 4 drugs (DrugBank) and 11 diseases shown |
1件: DRD2 |
D01164 |
Aripiprazole |
2件: 6, 206 |
D00426 |
Risperidone |
5件: 8, 156, 179, 187, 206 |
3件: GRIN1, GRIN2A, GRIN2B |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
45 | Ras signaling pathway 3 genes, 2 drugs (DrugBank) and 8 diseases shown |
3件: GRIN1, GRIN2A, GRIN2B |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
46 | Retrograde endocannabinoid signaling 20 genes, 4 drugs (DrugBank) and 12 diseases shown |
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D00697 |
Flumazenil |
5件: 6, 13, 17, 18, 206 |
D04282 |
Gaboxadol |
2件: 201, 206 |
D04300 |
Ganaxolone |
3件: 145, 152, 206 |
4件: GRIA1, GRIA2, GRIA3, GRIA4 |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
47 | Serotonergic synapse 6 genes, 7 drugs (DrugBank) and 14 diseases shown |
3件: GABRB1, GABRB2, GABRB3 |
D00697 |
Flumazenil |
5件: 6, 13, 17, 18, 206 |
D04282 |
Gaboxadol |
2件: 201, 206 |
D04300 |
Ganaxolone |
3件: 145, 152, 206 |
2件: HTR1A, HTR2A |
D01164 |
Aripiprazole |
2件: 6, 206 |
1件: HTR2A |
D00426 |
Risperidone |
5件: 8, 156, 179, 187, 206 |
1件: SLC6A4 |
D00326 |
Fluoxetine |
6件: 13, 17, 78, 86, 179, 206 |
D00823 |
D00825 |
Sertraline |
3件: 6, 8, 206 |
D02360 |
48 | Synaptic vesicle cycle 3 genes, 3 drugs (DrugBank) and 11 diseases shown |
2件: SLC6A2, SLC6A3 |
D01296 |
Methylphenidate |
7件: 6, 13, 34, 84, 113, 179, 206 |
D04999 |
1件: SLC6A4 |
D00326 |
Fluoxetine |
6件: 13, 17, 78, 86, 179, 206 |
D00823 |
D00825 |
Sertraline |
3件: 6, 8, 206 |
D02360 |
49 | Systemic lupus erythematosus 2 genes, 2 drugs (DrugBank) and 8 diseases shown |
2件: GRIN2A, GRIN2B |
D02780 |
Acamprosate |
2件: 6, 206 |
D07058 |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |
50 | Taste transduction 9 genes, 5 drugs (DrugBank) and 8 diseases shown |
2件: GABBR1, GABBR2 |
D09791 |
Arbaclofen |
2件: 13, 206 |
6件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 |
D00697 |
Flumazenil |
5件: 6, 13, 17, 18, 206 |
D04282 |
Gaboxadol |
2件: 201, 206 |
D04300 |
Ganaxolone |
3件: 145, 152, 206 |
1件: HTR1A |
D01164 |
Aripiprazole |
2件: 6, 206 |
51 | Terpenoid backbone biosynthesis 1 gene, 1 drug (DrugBank) and 10 diseases shown |
1件: HMGCR |
D00359 |
Lovastatin |
10件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 |
52 | Thermogenesis 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
53 | Tight junction 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: PRKAA1, PRKAA2 |
D00944 |
Metformin |
17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
D04966 |
54 | Transcriptional misregulation in cancer 1 gene, 1 drug (DrugBank) and 7 diseases shown |
1件: GRIA3 |
D00775 |
Riluzole |
7件: 2, 3, 5, 8, 13, 17, 206 |