No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * |
KEGG DRUG * |
DrugBank |
指定難病告示番号 * |
1 | AMPK signaling pathway 1 gene, 1 drug (DrugBank) and 17 diseases shown |
1件: HMGCR |
D00887 |
Atorvastatin |
17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 |
D07474 |
2 | Bile secretion 1 gene, 1 drug (DrugBank) and 17 diseases shown |
1件: HMGCR |
D00887 |
Atorvastatin |
17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 |
D07474 |
3 | Calcium signaling pathway 2 genes, 3 drugs (DrugBank) and 10 diseases shown |
1件: EDNRA |
D07077 |
Ambrisentan |
6件: 51, 84, 85, 86, 88, 211 |
2件: EDNRA, EDNRB |
D01227 |
Bosentan |
10件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
D07538 |
D10135 |
Macitentan |
5件: 51, 85, 86, 88, 210 |
4 | cAMP signaling pathway 1 gene, 3 drugs (DrugBank) and 10 diseases shown |
1件: EDNRA |
D07077 |
Ambrisentan |
6件: 51, 84, 85, 86, 88, 211 |
D01227 |
Bosentan |
10件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
D07538 |
D10135 |
Macitentan |
5件: 51, 85, 86, 88, 210 |
5 | cGMP-PKG signaling pathway 5 genes, 4 drugs (DrugBank) and 12 diseases shown |
1件: EDNRA |
D07077 |
Ambrisentan |
6件: 51, 84, 85, 86, 88, 211 |
2件: EDNRA, EDNRB |
D01227 |
Bosentan |
10件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
D07538 |
D10135 |
Macitentan |
5件: 51, 85, 86, 88, 210 |
3件: GUCY1A1, GUCY1A2, GUCY1B1 |
D09572 |
Riociguat |
6件: 51, 84, 86, 88, 225, 299 |
6 | Circadian entrainment 3 genes, 1 drug (DrugBank) and 6 diseases shown |
3件: GUCY1A1, GUCY1A2, GUCY1B1 |
D09572 |
Riociguat |
6件: 51, 84, 86, 88, 225, 299 |
7 | Complement and coagulation cascades 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: F10 |
D09710 |
Edoxaban |
2件: 46, 88 |
8 | Fluid shear stress and atherosclerosis 1 gene, 1 drug (DrugBank) and 10 diseases shown |
1件: NQO1 |
D00564 |
Warfarin |
10件: 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 |
D01280 |
D08682 |
9 | Gap junction 3 genes, 1 drug (DrugBank) and 6 diseases shown |
3件: GUCY1A1, GUCY1A2, GUCY1B1 |
D09572 |
Riociguat |
6件: 51, 84, 86, 88, 225, 299 |
10 | Hepatocellular carcinoma 1 gene, 1 drug (DrugBank) and 10 diseases shown |
1件: NQO1 |
D00564 |
Warfarin |
10件: 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 |
D01280 |
D08682 |
11 | Long-term depression 3 genes, 1 drug (DrugBank) and 6 diseases shown |
3件: GUCY1A1, GUCY1A2, GUCY1B1 |
D09572 |
Riociguat |
6件: 51, 84, 86, 88, 225, 299 |
12 | Melanogenesis 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: EDNRB |
D01227 |
Bosentan |
10件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
D07538 |
D10135 |
Macitentan |
5件: 51, 85, 86, 88, 210 |
13 | Metabolic pathways 6 genes, 3 drugs (DrugBank) and 23 diseases shown |
3件: GUCY1A1, GUCY1A2, GUCY1B1 |
D09572 |
Riociguat |
6件: 51, 84, 86, 88, 225, 299 |
1件: HMGCR |
D00887 |
Atorvastatin |
17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 |
D07474 |
2件: NQO1, VKORC1 |
D00564 |
Warfarin |
10件: 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 |
D01280 |
D08682 |
14 | Neuroactive ligand-receptor interaction 3 genes, 5 drugs (DrugBank) and 11 diseases shown |
1件: EDNRA |
D07077 |
Ambrisentan |
6件: 51, 84, 85, 86, 88, 211 |
2件: EDNRA, EDNRB |
D01227 |
Bosentan |
10件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
D07538 |
D10135 |
Macitentan |
5件: 51, 85, 86, 88, 210 |
1件: PTGIR |
D09994 |
Selexipag |
5件: 51, 70, 84, 86, 88 |
D06213 |
Treprostinil |
5件: 51, 84, 85, 86, 88 |
15 | Oxytocin signaling pathway 3 genes, 1 drug (DrugBank) and 6 diseases shown |
3件: GUCY1A1, GUCY1A2, GUCY1B1 |
D09572 |
Riociguat |
6件: 51, 84, 86, 88, 225, 299 |
16 | Pathways in cancer 3 genes, 4 drugs (DrugBank) and 17 diseases shown |
1件: EDNRA |
D07077 |
Ambrisentan |
6件: 51, 84, 85, 86, 88, 211 |
2件: EDNRA, EDNRB |
D01227 |
Bosentan |
10件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
D07538 |
D10135 |
Macitentan |
5件: 51, 85, 86, 88, 210 |
1件: NQO1 |
D00564 |
Warfarin |
10件: 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 |
D01280 |
D08682 |
17 | Platelet activation 4 genes, 3 drugs (DrugBank) and 8 diseases shown |
3件: GUCY1A1, GUCY1A2, GUCY1B1 |
D09572 |
Riociguat |
6件: 51, 84, 86, 88, 225, 299 |
1件: PTGIR |
D09994 |
Selexipag |
5件: 51, 70, 84, 86, 88 |
D06213 |
Treprostinil |
5件: 51, 84, 85, 86, 88 |
18 | Purine metabolism 3 genes, 1 drug (DrugBank) and 6 diseases shown |
3件: GUCY1A1, GUCY1A2, GUCY1B1 |
D09572 |
Riociguat |
6件: 51, 84, 86, 88, 225, 299 |
19 | Relaxin signaling pathway 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: EDNRB |
D01227 |
Bosentan |
10件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
D07538 |
D10135 |
Macitentan |
5件: 51, 85, 86, 88, 210 |
20 | Renin secretion 4 genes, 4 drugs (DrugBank) and 12 diseases shown |
1件: EDNRA |
D07077 |
Ambrisentan |
6件: 51, 84, 85, 86, 88, 211 |
D01227 |
Bosentan |
10件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
D07538 |
D10135 |
Macitentan |
5件: 51, 85, 86, 88, 210 |
3件: GUCY1A1, GUCY1A2, GUCY1B1 |
D09572 |
Riociguat |
6件: 51, 84, 86, 88, 225, 299 |
21 | Salivary secretion 3 genes, 1 drug (DrugBank) and 6 diseases shown |
3件: GUCY1A1, GUCY1A2, GUCY1B1 |
D09572 |
Riociguat |
6件: 51, 84, 86, 88, 225, 299 |
22 | Terpenoid backbone biosynthesis 1 gene, 1 drug (DrugBank) and 17 diseases shown |
1件: HMGCR |
D00887 |
Atorvastatin |
17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 |
D07474 |
23 | Ubiquinone and other terpenoid-quinone biosynthesis 2 genes, 1 drug (DrugBank) and 10 diseases shown |
2件: NQO1, VKORC1 |
D00564 |
Warfarin |
10件: 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 |
D01280 |
D08682 |
24 | Vascular smooth muscle contraction 5 genes, 6 drugs (DrugBank) and 13 diseases shown |
1件: EDNRA |
D07077 |
Ambrisentan |
6件: 51, 84, 85, 86, 88, 211 |
D01227 |
Bosentan |
10件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
D07538 |
D10135 |
Macitentan |
5件: 51, 85, 86, 88, 210 |
3件: GUCY1A1, GUCY1A2, GUCY1B1 |
D09572 |
Riociguat |
6件: 51, 84, 86, 88, 225, 299 |
1件: PTGIR |
D09994 |
Selexipag |
5件: 51, 70, 84, 86, 88 |
D06213 |
Treprostinil |
5件: 51, 84, 85, 86, 88 |