No. |
DrugBank |
Drug (Description in trials) [Number of descriptions] |
KEGG DRUG * | KEGG GENES * [Number of genes] |
KEGG PATHWAY [Number of pathways] |
Disease ID * [Number of diseases] |
1 | Alirocumab | [2] Alirocumab; Alirocumab sar236553 (regn727); | D10335 |
[1] PCSK9 |
[1] Cholesterol metabolism |
[1] 79 |
2 | Atorvastatin | [9] Atorvastatin; Atorvastatin 10mg; Atorvastatin 20mg; Atorvastatin calcium; Atorvastatin tablet 20 mg; Interferon beta treatment to add-on atorvastatin treatment; Interferon beta-1b/atorvastatin group; Lisinopril, losartan, and atorvastatin; Untreated to atorvastatin treatment; | D00258 D00887 D07474 |
[1] HMGCR |
[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 |
3 | Calcium | [25] Amorphous calcium carbonate; Ascal(r) / carbasalate calcium; Atorvastatin calcium; Calcitriol & calcium; Calcium; Calcium and cholecalciferol; Calcium carbonate; Calcium carbonate and alphacalcidol; Calcium channel blockers; Calcium channel blockers (amlodipine, azelnidipine); Calcium citrate; Calcium citrate with vitamin d2; Calcium gluconate; Calcium lactate; Calcium levofolinate; Calcium rosuvastatin; Calcium, dietary; Carbasalate calcium; Crestor tablets (calcium rosuvastatin) film-coated tablets; Crystalline calcium supplements; Ibandronate+alfacalcidol+calcium; Low molecular weight heparin calcium injection; Rosuvastatin calcium; Symptomatic treatment (converting enzyme inhibitor, angiotensin ii, anti-renin, aldosterone antagonist diuretic, beta blocker, calcium inhibitor, statin); Vidofludimus calcium; | - |
- |
- |
[24] 6, 13, 19, 46, 49, 51, 65, 68, 75, 79, 84, 93, 94, 95, 96, 97, 214, 215, 222, 224, 235, 265, 298, 299 |
4 | Cholestyramine | [1] Cholestyramine; | - |
- |
- |
[5] 13, 79, 93, 254, 297 |
5 | Dextran | [4] Dextran; Dextran sulfate sodium; Iron dextran; Iron(iii)- hydroxide dextran complex; | D00060 |
- |
- |
[5] 2, 62, 79, 96, 97 |
6 | Evinacumab | [2] Evinacumab; Evinacumab (regn1500); | - |
- |
- |
[1] 79 |
7 | Evolocumab | [3] Evolocumab; Evolocumab (amg 145); Repatha® (evolocumab); | D10557 |
[1] PCSK9 |
[1] Cholesterol metabolism |
[2] 79, 222 |
8 | Ezetimibe | [5] Comparator: ezetimibe; Ezetimibe; Ezetimibe + other lipid-lowering medication(s); Ezetimibe+simvastatin drug combination; Mk0653, ezetimibe; | D01966 |
[1] NPC1L1 |
[1] Fat digestion and absorption |
[4] 49, 79, 93, 260 |
9 | Fenofibrate | [2] Fenofibrate; Fenofibrate (insoluble drug delivery-micro particle fenofibrate (idd-p); | D00565 |
[1] PPARA |
[7] Adipocytokine signaling pathway, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), PPAR signaling pathway, cAMP signaling pathway |
[5] 8, 79, 93, 94, 265 |
10 | Fluvastatin | [2] Benazepril, valsartan and fluvastatin; Fluvastatin; | D00892 D07983 |
[1] HMGCR |
[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
[3] 79, 218, 222 |
11 | Gemcabene | [6] 300mg gemcabene; 600mg gemcabene; Gemcabene; Gemcabene 300 mg; Gemcabene 600 mg; Gemcabene 900 mg; | - |
- |
- |
[2] 79, 265 |
12 | Heparin | [7] Alkalinized lidocaine-heparin; Bladder instillation with heparin/ lidocaine; Heparin; Heparin 25mg inhalation powder, hard capsule; Heparin sodium; Intralipid/heparin; Low molecular weight heparin calcium injection; | D07510 |
[1] SERPINC1 |
[1] Complement and coagulation cascades |
[11] 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 |
13 | Implitapide | [1] Implitapide; | - |
- |
- |
[1] 79 |
14 | Inclisiran | [3] Inclisiran; Inclisiran for injection; Inclisiran sodium; | - |
- |
- |
[1] 79 |
15 | Lomitapide | [1] Lomitapide; | D09637 |
[1] MTTP |
[1] Fat digestion and absorption |
[1] 79 |
16 | Lovastatin | [5] Lovastatin; Lovastatin 60 mg; Lovastatin ™; Lovastatin, then minocycline/lovastatin; Minocycline, then minocycline/lovastatin; | D00359 |
[1] HMGCR |
[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
[10] 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 |
17 | MBX-8025 | [8] Mbx 8025; Mbx-8025; Mbx-8025 10 mg capsule; Mbx-8025 2 mg capsule; Mbx-8025 5 mg capsule; Mbx-8025 50 mg (dose escalation period 1); Mbx-8025 50 mg or 100 mg (dose escalation period 2); Mbx-8025 50 mg, 100 mg or 200 mg (dose escalation period 3); | - |
- |
- |
[2] 79, 93 |
18 | Niacin | [5] Dose-establishing study 1 niacin 250mg; Dose-establishing study 1 niacin 500mg; Dose-establishing study 2 niacin 500mg; Niacin; Niacin first; | D00049 |
- |
- |
[4] 6, 78, 79, 265 |
19 | Omega-3 fatty acids | [6] Dietary supplement omega3 fatty acids aand vitamins; Lipoic acid and omega-3 fatty acids; Omega 3 fatty acids; Omega-3 fatty acids; Omega3 fatty acids; Triomar™ (omega-3 fatty acids); | - |
- |
- |
[7] 13, 46, 49, 66, 79, 96, 299 |
20 | Pravastatin | [4] Lonafarnib, zoledronic acid, and pravastatin; Montelukast, flurbiprofen, midazolam, digoxin, pravastatin and bms-986142; Pravastatin; Pravastatin sodium; | D00893 D08410 |
[1] HMGCR |
[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 |
21 | Rosuvastatin | [6] Calcium rosuvastatin; Crestor tablets (calcium rosuvastatin) film-coated tablets; Rosuvastatin; Rosuvastatin 10 mg; Rosuvastatin 20mg; Rosuvastatin calcium; | D01915 D08492 |
[1] HMGCR |
[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
[8] 6, 46, 49, 51, 79, 96, 271, 299 |
22 | Simvastatin | [11] Encapsulated simvastatin tablets; Ezetimibe+simvastatin drug combination; Simvastatin; Simvastatin 20mg/5ml oral suspension; Simvastatin 40 mg film-coated tablets; Simvastatin 40mg; Simvastatin alternova; Simvastatin susp.; Simvastatin treatment for 28 days; Simvastatin-ratiopharm; Simvastatin-ratiopharm®; | D00434 |
[1] HMGCR |
[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
[19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 |
23 | Sulfate ion | - | - |
- |
- |
[22] 2, 6, 11, 13, 26, 34, 36, 46, 49, 60, 61, 64, 66, 79, 86, 96, 222, 226, 265, 296, 297, 299 |
24 | TAK-475 | [1] Tak-475; | - |
- |
- |
[1] 79 |