| No. |
DrugBank |
Drug (Description in trials)
[Number of descriptions] |
KEGG DRUG * | KEGG GENES *
[Number of genes] |
KEGG PATHWAY
[Number of pathways] |
Disease ID *
[Number of diseases] |
| 1 | Acetaminophen | [8] Acetaminophen; Acetaminophen tab 650mg; Acetaminophen tablets; Acetaminophen/paracetamol; Oxycodone/acetaminophen; Paracetamol (acetaminophen); Tramadol /acetaminophen; Tramadol hydrochloride + acetaminophen; | D00217 |
[2] PTGS1, PTGS2 |
[21] Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway |
[13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 |
| 2 | Acetate | [76] 11c acetate; 11c-acetate; 20mg/0.5ml glatiramer acetate; 40 mg glatiramer acetate; [n-trans-3-hexenoyl] human growth hormone releasing factor (1-44) acetate; Abiraterone acetate; Acetate; Bazedoxifene acetate; Betamethasone sodium phosphate/betamethasone acetate (celestone® soluspan®), 30 mg im once a day for four days; Caspofungin acetate; Conventional glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone); Cortisone acetate; Cosyntropin acetate; Cyclophosphamide/glatiramer acetate; Delmitide acetate; Depot leuprolide acetate 3.75 mg; Desmopressin acetate; Desmopressin acetate trihydrate; Dirucotide acetate; Experimental glatiramer acetate; Flecainide acetate; Glatiramer acetate; Glatiramer acetate (copaxone®); Glatiramer acetate (db); Glatiramer acetate (ga); Glatiramer acetate (ga) 40 mg; Glatiramer acetate (ol); Glatiramer acetate 150mg enteric coated tablets; Glatiramer acetate 150mg enteric-coated (gastro-resistant) tablets; Glatiramer acetate 20 mg; Glatiramer acetate 20 mg, with mitoxantrone; Glatiramer acetate 20 mg/0.5 ml; Glatiramer acetate 40 mg; Glatiramer acetate injection with oral cetirizine hydrochloride; Glatiramer acetate with minocycline; Glatiramer acetate, (copaxone®); Glatiramer acetate, ifn-beta 1a (im), ifn-beta 1a (subcutaneous), and ifn-beta 1b; Glatiramer acetate, n-acetylcysteine; Gonadorelin acetate and triptorelin acetate; Human interferon beta-1a and glatiramer acetate; Hydrocortisone sodium acetate; L-lysyl-d-prolyl-l-threonine acetate; Lanreotide acetate; Leuprolide acetate (la); Leuprolide acetate 11.25 mg; Leuprolide acetate 3 month depot; Leuprolide acetate 30 mg; Leuprolide acetate 45 mg; Leuprolide acetate depot; Leuprorelin acetate; Leuprorelin acetate 3.75mg injection; Loestrin (norethindrone acetate and ethinyl estradiol); Loestrin 1.5/30 (1.5 mg norethindrone acetate/30 µg ethinyl estradiol); Luphere depot 3.75mg(leuprolide acetate 3.75mg); Lupron (leuprolide acetate); Macimorelin acetate; Megestrol acetate; Megestrol acetate tablet; Nomegestrol acetate; Phosphate and betamethasone acetate, 2 ml.; Plovamer acetate; Prednisolone acetate; Prednisone acetate; Prednisone acetate tablets; Sodium acetate; Sodium-[o-[(2,6-dichlorophenyl)-amino]-phenyl]-acetate; Sotrastaurin (inn) acetate; Tetracosactide acetate; Tocopherol acetate; Tocopheryl acetate; Triptorelin acetate and gonadorelin acetate; Ulipristal acetate; Zinc acetate; Zinc acetate (20mg/d); Zinc acetate dihydrate; Zuretinol acetate; | - |
- |
- |
[40] 1, 2, 6, 10, 13, 35, 40, 46, 49, 51, 60, 64, 70, 71, 73, 75, 76, 78, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 235, 265, 288, 298, 299 |
| 3 | Acetic acid C-11 | - | - |
- |
- |
[3] 13, 86, 88 |
| 4 | Acetylsalicylic acid | [2] Acetylsalicylic acid; Acetylsalicylic acid at 1st visit,; | D00109 |
[2] PTGS1, PTGS2 |
[21] Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway |
[10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 |
| 5 | Activated charcoal | - | D03251 |
- |
- |
[8] 6, 13, 46, 85, 86, 96, 97, 298 |
| 6 | Ambrisentan | [8] Ambrisentan; Ambrisentan - high dose; Ambrisentan - low dose; Ambrisentan 5 mg; Ambrisentan 5 mg film-coated tablets; Ambrisentan plus spironolactone; Bosentan, ambrisentan; Tadalafil and ambrisentan upfront combination therapy; | D07077 |
[1] EDNRA |
[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
[6] 51, 84, 85, 86, 88, 211 |
| 7 | Anakinra | [8] Anakinra; Anakinra (kineret®); Anakinra (r-methuil-1ra); Anakinra / kineret; Anakinra and peg stnf-r1; Kineret® (anakinra); Kineret® or anakinra; Response to anakinra associated with methotrexate; | D02934 |
[2] IL1R1, IL1R2 |
[15] Amoebiasis, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer |
[17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
| 8 | Anastrozole | [2] Anastrozole; Arimidex (anastrozole); | D00960 |
[1] CYP19A1 |
[3] Metabolic pathways, Ovarian steroidogenesis, Steroid hormone biosynthesis |
[3] 78, 86, 193 |
| 9 | Angiotensin II | [2] Angiotensin ii; Symptomatic treatment (converting enzyme inhibitor, angiotensin ii, anti-renin, aldosterone antagonist diuretic, beta blocker, calcium inhibitor, statin); | D00150
D02014 |
[2] AGTR1, AGTR2 |
[14] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Cortisol synthesis and secretion, Cushing syndrome, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway |
[7] 17, 19, 46, 66, 86, 222, 224 |
| 10 | Apabetalone | [1] Apabetalone; | D11131 |
- |
- |
[1] 86 |
| 11 | Ascorbic acid | [4] 2l polyethylene glycol/ascorbic acid; Ascorbic acid; Ascorbic acid (vitamin c); Ascorbic acid vit c; | D00018 |
- |
- |
[13] 10, 13, 49, 62, 86, 96, 97, 192, 206, 211, 212, 254, 284 |
| 12 | Aviptadil | [2] Aviptadil; Aviptadil, 66 microgram/ml; | - |
- |
- |
[4] 49, 51, 85, 86 |
| 13 | Bardoxolone | [4] Bardoxolone; Bardoxolone methyl; Bardoxolone methyl capsules; Bardoxolone methyl oral capsule; | D09584 |
- |
- |
[7] 66, 67, 84, 85, 86, 218, 222 |
| 14 | Bardoxolone methyl | [3] Bardoxolone methyl; Bardoxolone methyl capsules; Bardoxolone methyl oral capsule; | D09585 |
- |
- |
[7] 66, 67, 84, 85, 86, 218, 222 |
| 15 | Benzbromarone | [1] Benzbromarone; | D01056 |
- |
- |
[1] 86 |
| 16 | Beraprost | [4] Beraprost; Beraprost sodium; Beraprost sodium 314d modified release tablets; Beraprost sodium modified release; | D02720 |
[1] PTGIR |
[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
[1] 86 |
| 17 | Bevacizumab | [4] Bevacizumab; Bevacizumab (avastin) and imatinib mesylate (gleevec); Bevacizumab (genitical recombination); Submucosal bevacizumab; | D06409 |
[1] VEGFA |
[21] AGE-RAGE signaling pathway in diabetic complications, Bladder cancer, EGFR tyrosine kinase inhibitor resistance, Fluid shear stress and atherosclerosis, Focal adhesion, HIF-1 signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, MAPK signaling pathway, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis, VEGF signaling pathway |
[9] 13, 34, 85, 86, 87, 89, 227, 280, 331 |
| 18 | Bisoprolol | [2] Bisoprolol; Bisoprolol fumarate; | D00634
D02342 |
[1] ADRB1 |
[10] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy (DCM), Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway |
[3] 67, 86, 113 |
| 19 | Bosentan | [14] Bosentan; Bosentan (tracleer); Bosentan 125 mg; Bosentan 62.5 mg; Bosentan administration; Bosentan and sildenafil; Bosentan group; Bosentan monohydrat; Bosentan monohydrate; Bosentan mylan; Bosentan, ambrisentan; Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan); Sildenafil 20mg and bosentan 62.5mg; Sildenafil singly or in association with bosentan; | D01227
D07538 |
[2] EDNRA, EDNRB |
[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
[10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
| 20 | CXA-10 | [3] 150mg cxa-10; 75mg cxa-10; Cxa-10; | - |
- |
- |
[2] 86, 222 |
| 21 | Capsaicin | [4] Capsaicin; Capsaicin challenge; Capsaicin vapor; Qutenza (8% capsaicin); | D00250 |
[1] TRPV1 |
[2] Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction |
[6] 2, 6, 19, 86, 113, 226 |
| 22 | Captopril | [2] Captopril; Spironolactone captopril carvedilol; | D00251 |
[1] ACE |
[4] Chagas disease (American trypanosomiasis), Hypertrophic cardiomyopathy (HCM), Renin secretion, Renin-angiotensin system |
[2] 17, 86 |
| 23 | Carbon monoxide | [2] Carbon monoxide; Inhaled carbon monoxide; | D09706 |
- |
- |
[3] 85, 86, 298 |
| 24 | Carvedilol | [2] Carvedilol; Spironolactone captopril carvedilol; | D00255
D03415 |
[5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 |
[12] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy (DCM), Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
[4] 6, 57, 86, 113 |
| 25 | Cetuximab | [1] Cetuximab; | D03455 |
[1] EGFR |
[45] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Choline metabolism in cancer, Colorectal cancer, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis |
[5] 34, 51, 86, 89, 331 |
| 26 | Chlorhexidine | [5] 2% chlorhexidine solution wipes; 4% chlorhexidine gluconate liquid skin cleanser; Chlorhexidine; Chlorhexidine gluconate; Chlorhexidine gluconate oral rinse; | D00858
D01345
D03463
D07668 |
- |
- |
[2] 86, 299 |
| 27 | Cicletanine | [1] Cicletanine; | D03487 |
- |
- |
[1] 86 |
| 28 | Clopidogrel | [1] Clopidogrel; | D00769
D07729
D10823
D10824 |
[1] P2RY12 |
[1] Platelet activation |
[2] 49, 86 |
| 29 | Conivaptan | [2] Conivaptan; Spironolactone and conivaptan; | D01236
D07748 |
[2] AVPR1A, AVPR2 |
[5] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption |
[1] 86 |
| 30 | Cyanocobalamin | - | D00166
D03615
D03616
D03617 |
- |
- |
[12] 6, 13, 49, 62, 86, 96, 97, 201, 229, 254, 284, 299 |
| 31 | D-glucose | [3] 2-deoxy-2 [f-18] fluoro-2-d-glucose; [18f]fluoro-2-deoxy-2-d-glucose; D-glucose; | D00009 |
- |
- |
[6] 6, 13, 49, 86, 88, 299 |
| 32 | Dichloroacetic acid | - | - |
- |
- |
[1] 86 |
| 33 | Diltiazem | [3] Diltiazem; Diltiazem hydrochloride; Dofetilide and diltiazem; | D00616
D03830
D07845 |
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S |
[34] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy (DCM), Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy (HCM), Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
[3] 58, 86, 130 |
| 34 | Dimethyl fumarate | [4] Dimethyl fumarate; Dimethyl fumarate (dmf); Dimethyl fumarate [dmf]; Tecifdera (dimethyl fumarate); | D03846 |
[1] KEAP1 |
[4] Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Pathways in cancer, Ubiquitin mediated proteolysis |
[5] 13, 46, 49, 51, 86 |
| 35 | Diphenhydramine | [1] Diphenhydramine; | D00300
D00669
D02419
D03285
D03360
D03854 |
[1] HRH1 |
[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction |
[5] 49, 51, 70, 86, 256 |
| 36 | Docusate | - | D00305 |
- |
- |
[7] 13, 62, 86, 96, 97, 254, 284 |
| 37 | Elafin | [1] Elafin; | - |
- |
- |
[1] 86 |
| 38 | Epicatechin | [3] (+)- epicatechin; (-)-epicatechin; Epicatechin; | - |
- |
- |
[2] 86, 113 |
| 39 | Epinephrine | [4] Bupivacaine/epinephrine/dexamethasone; Epinephrine; Lap tap bupivacaine/epinephrine; Us tap bupivacaine/epinephrine; | D00095
D00996
D02149 |
[9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 |
[13] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy (DCM), Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| 40 | Epoprostenol | [7] Act-385781a (actelion epoprostenol); Current marketed flolan (epoprostenol sodium); Epoprostenol; Epoprostenol for injection; Epoprostenol sodium; Epoprostenol-actelion; New thermo stable formulation of epoprostenol sodium; | D00106
D01337 |
[1] PTGIR |
[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
[1] 86 |
| 41 | Esomeprazole | [3] Esomeprazole; Esomeprazole 20 mg; Nexium (esomeprazole magnesium); | D01984
D04056
D07917
D09339 |
[2] ATP4A, ATP4B |
[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation |
[6] 6, 46, 86, 98, 298, 299 |
| 42 | Ethanol | [7] Andrographis paniculata (ethanol extract); Ethanol; Ethanol (96 per cent); Ethanol 96% gel; Ethanol 98% solution; Ethanol bp; Ethanol gel; | D00068
D02798
D04855
D06542 |
- |
- |
[49] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 58, 61, 63, 64, 65, 66, 81, 84, 85, 86, 88, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 279, 280, 283, 284, 285, 288, 298, 299, 300, 331 |
| 43 | Famotidine | [2] Famotidine; Famotidine 20 mg; | D00318 |
[1] HRH2 |
[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction |
[3] 6, 46, 86 |
| 44 | Ferric carboxymaltose | [2] Ferric carboxymaltose; Intravenous administration of ferric carboxymaltose; | D08920 |
- |
- |
[4] 86, 96, 97, 299 |
| 45 | Fluoxetine | [4] Amitriptyline, fluoxetine and tramadol alone (control group); Fluoxetine; Fluoxetine hydrochloride; Sc recombinant growth hormone + amitriptyline, fluoxetine and tramadol (treated group); | D00326
D00823 |
[1] SLC6A4 |
[2] Serotonergic synapse, Synaptic vesicle cycle |
[6] 13, 17, 78, 86, 179, 206 |
| 46 | Folic acid | [5] Folic acid; Folic acid or folate; Folic acid, vitamin b6, vitamin b12; Methotrexate and folic acid; Rituximab, mtx, folic acid; | D00070 |
- |
- |
[11] 6, 13, 46, 49, 62, 84, 86, 96, 97, 254, 284 |
| 47 | Fulvestrant | [1] Fulvestrant; | D01161 |
[2] ESR1, ESR2 |
[9] Breast cancer, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway |
[1] 86 |
| 48 | Gadobenic acid | - | D04283
D08018 |
- |
- |
[3] 13, 86, 88 |
| 49 | Glycine | [4] Flolan tm and glycine diluent; Flolan™ and glycine diluent; Glycine; Glycine buffer; | D00011 |
- |
- |
[4] 35, 86, 226, 299 |
| 50 | Hydroxyurea | [1] Hydroxyurea; | D00341 |
[1] RRM2 |
[6] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway |
[8] 3, 13, 19, 20, 65, 85, 86, 284 |
| 51 | Ifetroban | [2] Ifetroban; Oral ifetroban; | D04500 |
[1] TBXA2R |
[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation |
[3] 51, 86, 113 |
| 52 | Iloprost | [21] Aerosolized iloprost; Commercial ventavis® (iloprost); Iloprost; Iloprost (5 µg); Iloprost (ventavis bayq6256); Iloprost (ventavis inhaled, bayq6256); Iloprost (ventavis, bayq 6256); Iloprost (ventavis, bayq6256); Iloprost (ventavis®); Iloprost inhalation solution (ventavis); Iloprost injection, for intravenous use; Iloprost low dose; Iloprost pd-15; Iloprost pd-6; Iloprost sale di trometamolo; Iloprost therapy up to 2 ng/kg x min; Iloprost trometamol; Iloprost,(ventavis, bayq6256); Inhaled iloprost (ventavis, bayq6256); Ventavis (iloprost, bayq6256); Ventavis(iloprost); | D02721 |
[1] PTGIR |
[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
[4] 51, 84, 85, 86 |
| 53 | Imatinib | [6] Bevacizumab (avastin) and imatinib mesylate (gleevec); Imatinib; Imatinib mesilate; Imatinib mesylate; Imatinib mesylate (gleevec); Imatinib mesylate 400mg capsule; | D01441
D08066 |
[3] ABL1, KIT, PDGFRA |
[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Shigellosis, Viral myocarditis |
[11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 |
| 54 | Ipratropium | [4] Ipratropium; Ipratropium bromide (drug); Nebulized combination ipratropium bromide with salbutamol; Nebulized ipratropium bromide; | D02212 |
[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 |
[11] Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway |
[2] 6, 86 |
| 55 | Iron | [14] Injection of iron; Iron; Iron chelating agents; Iron dextran; Iron oxide; Iron sucrose; Iron sulphate; Iron sulphate 200mg coated tablets; Iron supplement; Iron supplement 300-600 mg/day; Iron(iii)- hydroxide dextran complex; Oral iron; Ultra small particles of iron oxide (uspio); Ultrasmall particles of iron oxide; | - |
- |
- |
[7] 13, 62, 86, 96, 97, 254, 284 |
| 56 | L-Citrulline | [5] 750 mg metformin and 7.5 g l-citrulline daily p.o.; L-citrulline; L-citrulline and metformin & l-citrulline; L-citrulline malate; Metformin and metformin & l-citrulline; | D07706 |
- |
- |
[2] 86, 113 |
| 57 | L-Threonine | [2] L-lysyl-d-prolyl-l-threonine acetate; L-threonine; | D00041 |
- |
- |
[3] 86, 96, 97 |
| 58 | Lidocaine | [8] 5% lidocaine/5 mg/ml estradiol compound cream; Alkalinized lidocaine-heparin; Bladder instillation with heparin/ lidocaine; Lidocaine; Lidocaine injection 2%; Lidocaine patch 5%; Lidocaine releasing intravesical system - liris®; Local anesthesia (lidocaine hydrochloride); | D00358
D02086
D08127 |
[5] SCN1A, SCN2A, SCN3A, SCN5A, SCN9A |
[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction |
[10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 |
| 59 | Lisuride | [5] Lisuride; Lisuride hydrogenmaleate; Lisuride transdermal system; Lisuride tts 10cm²; Lisuride tts 20cm²; | D01462
D08132 |
[3] DRD2, DRD3, DRD4 |
[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway |
[2] 6, 86 |
| 60 | Macitentan | [8] Act-064992 (macitentan); Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan); Fdc macitentan/tadalafil; Macitentan; Macitentan 10 mg; Macitentan 10 mg tablet, once daily.; Macitentan group; Opsumit (macitentan); | D10135 |
[2] EDNRA, EDNRB |
[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
[5] 51, 85, 86, 88, 210 |
| 61 | Medical air | [4] Medical air; Medical air (sham o2); Medical air vs oxygen; Sham o2 (medical air); | - |
- |
- |
[3] 85, 86, 193 |
| 62 | Mercaptopurine | [8] 6 mercaptopurine; 6-mercaptopurine; Azathioprine (aza) or 6-mercaptopurine (6-mp); Azathioprine or 6-mercaptopurine; Delayed release 6 mercaptopurine; Mercaptopurine; Mercaptopurine (puri-nethol); Products containing azathioprine or 6-mercaptopurine; | D00161
D04931 |
[1] HPRT1 |
[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism |
[5] 86, 94, 96, 97, 164 |
| 63 | Metformin | [12] 750 mg metformin and 7.5 g l-citrulline daily p.o.; Glucophage (metformin); L-citrulline and metformin & l-citrulline; Metformin; Metformin (generic); Metformin 500mg; Metformin and metformin & l-citrulline; Metformin hcl; Metformin hydrochloride; Metformin/cp-690,550; Pioglitazone or metformin; Sitagliptin and metformin; | D00944
D04966 |
[2] PRKAA1, PRKAA2 |
[19] AMPK signaling pathway, Adipocytokine signaling pathway, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease (NAFLD), Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway |
[17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 |
| 64 | Methylprednisolone | [29] Administration of rituximab and methylprednisolone; Corticosteroid treatment (methylprednisolone or prednisolone); Cyclophosphamide, azathioprine,prednisone,methylprednisolone; Infliximab, methylprednisolone, methotrexate; Intravenous (i.v.) methylprednisolone 1000 mg, total 9; Intravenous methylprednisolone; Iv methylprednisolone; Iv methylprednisolone (steroids); Megadose oral methylprednisolone; Methotrexate + methylprednisolone; Methylprednisolone; Methylprednisolone (drug); Methylprednisolone (mp); Methylprednisolone (mp) or prednisone (pred); Methylprednisolone (or other glucocorticoid); Methylprednisolone bolus iv 15 mg/kg/d for 3 days.; Methylprednisolone hemisuccinate; Methylprednisolone iv; Methylprednisolone mylan générique; Methylprednisolone or budesonide; Methylprednisolone or prednisolone; Methylprednisolone pulse; Methylprednisolone sodium hemisuccinate; Methylprednisolone sodium succinate; Methylprednisolone(intravenously in the 1st-2nd-3rd month ); Methylprednisolone(intravenously in the 1st-3rd-5th month); Oral 5-asa+/-topical 5-asa+iv corticosteroids / po methylprednisolone; Prednisone (and methylprednisolone); Prednisone, methylprednisolone,cyclophosphamides; | D00407
D00751
D00979
D05000
D05001
D05002 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 |
| 65 | Morphine | [6] Intraarticular morphine; Morphine; Morphine hexal; Morphine pca; Morphine sulfate; Morphine sulphate in intrasite gel; | D00842
D02271
D08233 |
[1] OPRM1 |
[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction |
[4] 36, 46, 70, 86 |
| 66 | Moxifloxacin | [5] Avelox- moxifloxacin; Moxifloxacin; Moxifloxacin 400 mg; Moxifloxacin hydrochloride; Moxifloxacin infusion; | D00874
D08237 |
- |
- |
[8] 2, 6, 46, 49, 85, 86, 240, 299 |
| 67 | Nicardipine | [1] Nicardipine; | D00617
D08270 |
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S |
[34] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy (DCM), Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy (HCM), Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
[2] 70, 86 |
| 68 | Nilotinib | [8] Cohort 1:nilotinib oral capsules (150mg or 300mg); Cohort 2: nilotinib oral capsules (dose to be determined from cohort 1); Nilotinib; Nilotinib (tasigna); Nilotinib 150 mg; Nilotinib 150mg oral capsule [tasigna]; Nilotinib 300mg oral capsule [tasigna]; Nilotinib hydrochloride monohydrate; | D08953 |
[4] ABL1, KIT, PDGFRA, PDGFRB |
[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Shigellosis, Viral myocarditis |
[5] 6, 8, 34, 51, 86 |
| 69 | Nitric Oxide | [11] Inhaled nitric oxide; Inhaled nitric oxide & inopulse delivery; Inhaled nitric oxide - 30 mcg/kg ibw/hr; Inhaled nitric oxide 5,10,15 mcg/kg ibw/hr; Inhaled nitric oxide 75 mcg/kg ibw/hr; Nitric oxide; Nitric oxide 160 ppm; Nitric oxide for inhalation; Nitric oxide generated by the geno nitrosyl delivery system; Nitric oxide plus oxygen; Nitric oxide supplement; | D00074 |
- |
- |
[7] 46, 85, 86, 98, 251, 294, 299 |
| 70 | Nitrite | [9] 120 mg sodium nitrite inhalation solution; 15 mg sodium nitrite inhalation solution; 25% mtd sodium nitrite inhalation solution; 45 mg sodium nitrite inhalation solution; 90 mg sodium nitrite inhalation solution; Air001 (sodium nitrite inhalation solution); Nitrite; Sodium nitrite; Sodium nitrite inhalation solution; | - |
- |
- |
[2] 86, 299 |
| 71 | Olaparib | [1] Olaparib; | D09730 |
[3] PARP1, PARP2, PARP3 |
[4] Apoptosis, Base excision repair, NF-kappa B signaling pathway, Necroptosis |
[1] 86 |
| 72 | Oxygen | [9] Continuous oxygen; Helium / oxygen mixed gas inhalation therapy; Medical air vs oxygen; Medical grade oxygen; Nitric oxide plus oxygen; Oxygen; Oxygen 40 %; Oxygen supplementation; Perfluorinated gas/oxygen mixture; | D00003 |
- |
- |
[18] 5, 6, 17, 46, 49, 70, 84, 85, 86, 88, 90, 96, 97, 193, 211, 226, 299, 330 |
| 73 | PF-00489791 | [1] Pf-00489791; | - |
- |
- |
[1] 86 |
| 74 | Pioglitazone | [6] Actos (pioglitazone); Pioglitazone; Pioglitazone 15 mg; Pioglitazone and tretinoin; Pioglitazone or metformin; Tretinoin and pioglitazone hcl; | D00945
D08378 |
[1] PPARG |
[9] AMPK signaling pathway, Huntington disease, Longevity regulating pathway, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer |
[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 |
| 75 | Prasterone | [2] Prasterone; Prasterone (gl701); | D08409 |
[3] AR, ESR1, ESR2 |
[11] Breast cancer, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Oocyte meiosis, Pathways in cancer, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Thyroid hormone signaling pathway |
[6] 49, 53, 83, 86, 96, 113 |
| 76 | Prednisone | [57] 0 mg prednisone; 5 mg prednisone; 5-aminosalicylic acid(5-asa) and/or prednisone; 5-asa, prednisone, azathioprine or remicade; Azathioprine/prednisone; Chinese herb prescription granule plus prednisone; Conventional glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone); Corticosteroids (prednisone or prednisolone); Cyclophosphamide, azathioprine,prednisone,methylprednisolone; Cyclophosphamide-prednisone-azathioprine; Glucocorticoid (prednisone or prednisolone); Granulocyte-colony stimulating factor (g-csf) and prednisone; Hormone (prednisone); Hydroxychloroquine + prednisone; Leflunomide 20 mg+prednisone 0.5mg/kg/d; Methylprednisolone (mp) or prednisone (pred); Mycophenolate mofetil plus lower dose of prednisone; Oral prednisone; Oral prednisone 5mg; Over encapsulated prednisone; Prednisone; Prednisone (and methylprednisolone); Prednisone + inhibace/cozaar; Prednisone - azathioprine; Prednisone 0,5 mg/kg orally on alternate days; Prednisone 15 mg; Prednisone 5 mg; Prednisone 7.5 mg; Prednisone acetate; Prednisone acetate tablets; Prednisone alone; Prednisone and cyclophosphamide; Prednisone and mycophenolate mofetil; Prednisone and ustekinumab treatment; Prednisone arrow 20mg; Prednisone arrow 5 mg; Prednisone capsules; Prednisone discontinuation; Prednisone in full dose; Prednisone or prednisolone; Prednisone plus cyclophosphamide; Prednisone tablets usp, 1 mg; Prednisone tablets usp, 2.5 mg; Prednisone tablets usp, 5 mg; Prednisone tablets, usp; Prednisone therapy and pharmacokinetic; Prednisone treatment; Prednisone, cyclophosphamide; Prednisone, fk506, mmf; Prednisone, methylprednisolone,cyclophosphamides; Prednisone/prednisolone; Rayos (delayed-release prednisone); Sotatercept with prednisone boost; Tacrolimus combined with prednisone; Thalidomide, cyclophosphamide and prednisone; Treatment systemic therapy (prednisone); Treatment with systemic therapy (prednisone); | D00473 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 |
| 77 | Ralinepag | [1] Ralinepag; | D10725 |
[1] PTGIR |
[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
[1] 86 |
| 78 | Ranolazine | [7] Ranolazine; Ranolazine 1000 mg; Ranolazine 1000 mg pr tablets; Ranolazine 500 mg; Ranolazine 500 mg pr tablets; Ranolazine 750 mg pr tablets; Ranolazine pr (prolonged-release) 500 mg 1 tablet bis in die and 750 mg 1 tablet bis in die; | D05700
D05701 |
- |
- |
[6] 2, 58, 86, 113, 114, 130 |
| 79 | Rifampicin | [1] Rifampicin; | D00211 |
- |
- |
[7] 6, 13, 17, 46, 84, 86, 299 |
| 80 | Riociguat | [12] Adempas (riociguat, bay63-2521); Riociguat; Riociguat (adempas, bay63-2521); Riociguat (bay63-2521); Riociguat coated tablet 0.5 mg; Riociguat coated tablet 1.0 mg; Riociguat coated tablet 1.5 mg; Riociguat coated tablet 2.0 mg; Riociguat coated tablet 2.5 mg; Riociguat granules 0.3% for oral application; Riociguat oral product; Riociguat pill; | D09572 |
[3] GUCY1A1, GUCY1A2, GUCY1B1 |
[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway |
[6] 51, 84, 86, 88, 225, 299 |
| 81 | Ritonavir | [9] Atazanavir (atv) + ritonavir (rtv), continuation of backbone 2 nucleoside reverse transcriptase inhibitor (nrtis); Atazanavir/ritonavir; Lopinavir / ritonavir; Lopinavir/ritonavir; Lopinavir/ritonavir + nevirapine; Lopinavir/ritonavir + zidovudine + lamivudine; Ritonavir; Ritonavir (norvir); Saquinavir and ritonavir; | D00427 |
- |
- |
[5] 2, 86, 130, 265, 299 |
| 82 | Rituximab | [52] Abatacept, rituximab or tocilizumab; Abp 798 - biosimilar to rituximab; Administration of rituximab and methylprednisolone; Alemtuzumab and rituximab; Alemtuzumab, rituximab; Bendamustine, rituximab; Combination of protein a immunoadsorption, rituximab, dexamethasone plus azathioprine; Combined plasma exchange (pex), rituximab, and corticosteroids; Dexamethasone and rituximab; Experimental (non immunosuppressive symptomatic treatment (nist) and rituximab); Gp2013 - a proposed biosimilar rituximab; Idec-c2b8 (rituximab); Immunosuppressive treatment (eg, rituximab); Individualized dose of rituximab; Intravenous rituximab; Mabthera (rituximab); Mabthera or biosimilar rituximab; Mabthera or biosimilar rituximab product; Mabthera® (rituximab); Originator rituximab - rituxan ® or mabthera ®; Rhtpo in combination with rituximab; Rituxan (inn: rituximab), brand name in the united states; Rituxan (rituximab); Rituxan® (rituximab); Rituximab; Rituximab (anti-cd20); Rituximab (arm a); Rituximab (arm b); Rituximab (mabthera® or rituxan®).; Rituximab (mabthera®); Rituximab (rituxan); Rituximab (rtx) and azathioprine (aza); Rituximab - mabthera; Rituximab 1g iv; Rituximab [mabthera/rituxan]; Rituximab [mabthera]; Rituximab and cyclophosphamide iv; Rituximab combined with omalizumab; Rituximab infusion; Rituximab it; Rituximab iv; Rituximab mabthera; Rituximab or rituximab hyaluronidase human; Rituximab, mtx, folic acid; Rituximab, observational study amon patients with active ra; Rituximab-eu+ rituximab-pfizer x 2 courses; Rituximab-pfizer (pf-05280586) x 3 courses; Rituximab-us + rituximab-pfizer x 2 courses; Rituximab/ mabthera; Sait101 (proposed rituximab biosimilar); Standard dose of rituximab; The standard steroid treatment, plasma exchange and rituximab; | D02994 |
[1] MS4A1 |
[1] Hematopoietic cell lineage |
[42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 |
| 83 | Salbutamol | [5] Nebulized combination ipratropium bromide with salbutamol; R-salbutamol; R-salbutamol sulphate; Salbutamol; Salbutamol 4mg tablet; | D02147 |
[1] ADRB2 |
[8] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway |
[13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 |
| 84 | Sapropterin | [10] Kuvan® (sapropterin dihydrochloride); Sapropterin; Sapropterin (kuvan); Sapropterin dihydrochloride; Sapropterin dihydrochloride (6r-bh4); Sapropterin dihydrochloride, 6r-bh4, tetrahydrobiopterin; Sapropterin dihydrocholoride; Sapropterin hydrochloride; Sapropterin, sapropterin dihydrochloride; Sapropterin, sapropterin hydrochloride; | D08505 |
- |
- |
[3] 86, 124, 240 |
| 85 | Saquinavir | [2] Saquinavir; Saquinavir and ritonavir; | D00429
D01160 |
- |
- |
[2] 86, 265 |
| 86 | Selexipag | [4] I.v. selexipag; Oral selexipag (uptravi); Selexipag; Selexipag (uptravi); | D09994 |
[1] PTGIR |
[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
[5] 51, 70, 84, 86, 88 |
| 87 | Selonsertib | [1] Selonsertib; | D10988 |
[1] MAP3K5 |
[12] Amyotrophic lateral sclerosis (ALS), Apoptosis, Fluid shear stress and atherosclerosis, MAPK signaling pathway, Neurotrophin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Platinum drug resistance, Protein processing in endoplasmic reticulum, Sphingolipid signaling pathway, TNF signaling pathway, Thermogenesis, Tight junction |
[1] 86 |
| 88 | Serine | [4] D-serine; D-serine (~2g/day); L-serine; Serine; | D00016 |
- |
- |
[3] 2, 6, 86 |
| 89 | Sildenafil | [25] 20 mg sildenafil citrate by mouth; 5% sildenafil cream; Access program - sildenafil citrate, viagra, revatio; Acute (1 hour) sildenafil; Bosentan and sildenafil; Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan); Oral sildenafil; Sildenafil; Sildenafil (50 mg); Sildenafil (as citrate); Sildenafil (revatio); Sildenafil (revatio) 20 mg tid; Sildenafil 20 mg tablets; Sildenafil 20mg; Sildenafil 20mg and bosentan 62.5mg; Sildenafil 40mg oral capsule; Sildenafil and losartan; Sildenafil citrate; Sildenafil citrate (uk-92,480); Sildenafil singly or in association with bosentan; Sildenafil therapy; Sitaxsentan and sildenafil; Sodium tanshinone iia sulfonate diluted with 5% glucose solution,20mg sildenafil citrate by mouth; Sub-chronic (4 weeks) sildenafil; Tadalafil and sildenafil; | D02229
D08514 |
[1] PDE5A |
[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway |
[16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 |
| 90 | Simvastatin | [11] Encapsulated simvastatin tablets; Ezetimibe+simvastatin drug combination; Simvastatin; Simvastatin 20mg/5ml oral suspension; Simvastatin 40 mg film-coated tablets; Simvastatin 40mg; Simvastatin alternova; Simvastatin susp.; Simvastatin treatment for 28 days; Simvastatin-ratiopharm; Simvastatin-ratiopharm®; | D00434 |
[1] HMGCR |
[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
[19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 |
| 91 | Sirolimus | [14] Rapamycin, sirolimus; Sirolimus; Sirolimus (formerly known as rapamycin); Sirolimus 0,1% crème; Sirolimus 0.2%; Sirolimus 0.4%; Sirolimus 2 mg; Sirolimus 2%; Sirolimus and hydroxychloroquine; Sirolimus oral liquid product 1mg/ml; Sirolimus, 2%; Skincerity plus sirolimus/rapamycin; Skinercity plus sirolimus/rapamycin; Topical 0.1% sirolimus; | D00753 |
[1] MTOR |
[43] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Choline metabolism in cancer, Colorectal cancer, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway |
[36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 |
| 92 | Sitaxentan | [2] Sitaxentan; Sitaxentan sodium; | D07171 |
[1] EDNRA |
[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
[1] 86 |
| 93 | Sodium chloride | [14] 0.9% sodium chloride; 0.9% sodium chloride (normal saline); 0.9% sodium chloride injection; 0.9% w/v sodium chloride solution; Isotonic sodium chloride solution; Physiological serum (sodium chloride); Sodium chloride; Sodium chloride (7%); Sodium chloride 0,9%; Sodium chloride 6%; Sodium chloride solution; Sodium chloride solution 0.9%; Sodium chloride solvent; Sodium pyruvate in 0.9% sodium chloride solution; | D02056 |
- |
- |
[19] 6, 11, 13, 14, 17, 34, 46, 51, 53, 67, 78, 86, 97, 168, 193, 227, 228, 288, 299 |
| 94 | Sorafenib | [3] Nexavar (bay 43-9006) (sorafenib); Sorafenib; Sorafenib (as tosylate); | D06272
D08524 |
[8] BRAF, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET |
[83] Acute myeloid leukemia, Alcoholism, Apelin signaling pathway, Apoptosis, Autophagy - animal, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Breast cancer, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Central carbon metabolism in cancer, Chemokine signaling pathway, Choline metabolism in cancer, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endometrial cancer, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Renal cell carcinoma, Serotonergic synapse, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, VEGF signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway, mTOR signaling pathway |
[2] 34, 86 |
| 95 | Sotatercept | [2] Sotatercept; Sotatercept with prednisone boost; | D09670 |
[1] ACVR2A |
[4] Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway |
[2] 86, 284 |
| 96 | Spironolactone | [4] Ambrisentan plus spironolactone; Spironolactone; Spironolactone and conivaptan; Spironolactone captopril carvedilol; | D00443 |
[1] NR3C2 |
[1] Aldosterone-regulated sodium reabsorption |
[6] 58, 67, 86, 113, 218, 225 |
| 97 | Sulfate ion | - | - |
- |
- |
[22] 2, 6, 11, 13, 26, 34, 36, 46, 49, 60, 61, 64, 66, 79, 86, 96, 222, 226, 265, 296, 297, 299 |
| 98 | Tacrolimus | [13] Busulfan/fludarabine phosphate/tacrolimus/methotrexate/g-csf; Interferon beta-1b and tacrolimus; Lcp-tacro (tacrolimus); Non-mtx dmards (e.g. sulfasalazine, leflunomide, bucillamine, tacrolimus, or mizoribin); Rectal tacrolimus; Tacrolimus; Tacrolimus (prograf®); Tacrolimus and mmf; Tacrolimus capsule; Tacrolimus capsules; Tacrolimus combined with prednisone; Tacrolimus prolonged-release hard capsules; Tacrolimus with methotrexate; | D00107
D08556 |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
[30] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
| 99 | Tadalafil | [11] Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan); Fdc macitentan/tadalafil; Tadalafil; Tadalafil 20 mg; Tadalafil 20 mg film-coated tablets; Tadalafil 40 mg; Tadalafil and ambrisentan upfront combination therapy; Tadalafil and sildenafil; Tadalafil oral suspension; Tadalafil, placebo; Tadalafil- tablet or oral suspension; | D02008 |
[1] PDE5A |
[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway |
[6] 6, 51, 75, 84, 86, 113 |
| 100 | Tamoxifen | [3] Tamoxifen; Tamoxifen 40 mg daily for one year; Tamoxifen citrate; | D00966
D08559 |
[2] ESR1, ESR2 |
[9] Breast cancer, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway |
[4] 2, 86, 113, 227 |
| 101 | Terguride | [3] Terguride; Terguride 0.5 mg tablet; Terguride hydrogenmaleate; | D01348 |
[2] DRD2, PRL |
[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway |
[2] 51, 86 |
| 102 | Tezosentan | [1] Tezosentan; | - |
- |
- |
[1] 86 |
| 103 | Thrombin | [1] Thrombin; | D00090 |
- |
- |
[2] 86, 88 |
| 104 | Tocilizumab | [25] Abatacept, rituximab or tocilizumab; Corticoids+ tocilizumab 8mg/kg/4 weeks; Decrease tocilizumab, abatacept; Inn-tocilizumab; Intra-articular tocilizumab; Mra (tocilizumab); Mra(tocilizumab); Subcutaneous tocilizumab; Tocilizumab; Tocilizumab (actemra®); Tocilizumab (mra-sc); Tocilizumab + glucocorticoids (gcs); Tocilizumab + methotrexate(mtx); Tocilizumab 162 mg; Tocilizumab 162mg/0.9ml jeringa sc; Tocilizumab [roactemra/actemra]; Tocilizumab [roactemra]; Tocilizumab infusion roacemtra (eu); Tocilizumab injection; Tocilizumab prefilled syringe; Tocilizumab sc; Tocilizumab sc 162 mg/0.9 ml prefilled syringe with safety device (pfs); Tocilizumab treatment; Tocilizumab+methotrexate(mtx); Tocilizumab, abatacept; | D02596 |
[1] IL6R |
[11] Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor |
[16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 |
| 105 | Treprostinil | [31] Eutonic treprostinil solution; Inhaled dry powder treprostinil (liq861); Inhaled treprostinil; Intravenous treprostinil; Intravenous/subcutaneous treprostinil; Iontophoresis of treprostinil; Liq861 inhaled treprostinil; Oral treprostinil; Oral treprostinil (ut-15c) sustained release tablets; Parenteral remodulin (treprostinil) injection; Rapid dose titration group of subcutaneous treprostinil; Remodulin (treprostinil sodium); Remodulin® (treprostinil) 1 mg/ml solution for infusion; Remodulin® (treprostinil) 10 mg/ml solution for infusion; Remodulin® (treprostinil) 2.5 mg/ml solution for infusion; Remodulin® (treprostinil) 5 mg/ml solution for infusion; Slow dose titration group of subcutaneous treprostinil; Subcutaneous treprostinil; Treprostinil; Treprostinil diethanolamine; Treprostinil diolamine; Treprostinil inhalation powder; Treprostinil inhalations; Treprostinil injectable product; Treprostinil sodium; Treprostinil sodium for inhalation; Treprostinil sodium solution for inhalation; Treprostinil sodium, ut-15; Treprostinil, ut-15, lrx-15, 15au81, bw a15au, u-62, 840; Ut-15c (treprostinil diethanolamine); Ut-15c sr (treprostinil diethanolamine); | D06213 |
[1] PTGIR |
[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
[5] 51, 84, 85, 86, 88 |
| 106 | Trimetazidine | [3] Trimetazidine; Trimetazidine dihydrochloride; Trimetazidine dihydrochloride 20mg; | D01606
D08642 |
- |
- |
[2] 58, 86 |
| 107 | Tyrosine | [2] L-tyrosine; Tyrosine; | D00022 |
- |
- |
[3] 6, 86, 111 |
| 108 | Ubenimex | [1] Ubenimex; | D00087 |
[1] ANPEP |
[4] Glutathione metabolism, Hematopoietic cell lineage, Metabolic pathways, Renin-angiotensin system |
[1] 86 |
| 109 | Ubidecarenone | - | D01065 |
- |
- |
[12] 2, 5, 6, 8, 10, 46, 57, 86, 113, 193, 214, 215 |
| 110 | Udenafil | [1] Udenafil; | D10027 |
[1] PDE5A |
[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway |
[1] 86 |
| 111 | Vardenafil | [2] Vardenafil; Vardenafil (hidrocloride); | D02731
D03260
D08668 |
[1] PDE5A |
[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway |
[3] 13, 86, 299 |
| 112 | Zamicastat | [1] Zamicastat; | - |
- |
- |
[1] 86 |
| 113 | Zinc acetate | [3] Zinc acetate; Zinc acetate (20mg/d); Zinc acetate dihydrate; | D06408 |
- |
- |
[7] 49, 51, 70, 86, 171, 256, 299 |