DDrare: Database of Drug Development for Rare Diseases

Target Gene/Pathway

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15 / 275 pathways found* Show info (disease name, etc.) on mouse-over.

No.	KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related	KEGG GENES * [Number of genes]	KEGG DRUG *	DrugBank	Disease ID * [Number of diseases]
1	Adrenergic signaling in cardiomyocytes 2 genes, 2 drugs (DrugBank), 6 diseases shown	[1] ADRB2	D07713	Clenbuterol	[2] 1, 256
		[1] SCN5A	D00639	Mexiletine	[5] 1, 2, 10, 113, 114
		[1] SCN5A	D08215	Mexiletine	[5] 1, 2, 10, 113, 114
2	Calcium signaling pathway 1 gene, 1 drug (DrugBank), 2 diseases shown	[1] ADRB2	D07713	Clenbuterol	[2] 1, 256
3	cAMP signaling pathway 1 gene, 1 drug (DrugBank), 2 diseases shown	[1] ADRB2	D07713	Clenbuterol	[2] 1, 256
4	cGMP-PKG signaling pathway 1 gene, 1 drug (DrugBank), 2 diseases shown	[1] ADRB2	D07713	Clenbuterol	[2] 1, 256
5	Dopaminergic synapse 1 gene, 1 drug (DrugBank), 5 diseases shown	[1] SCN1A	D00639	Mexiletine	[5] 1, 2, 10, 113, 114
5		[1] SCN1A	D08215	Mexiletine	[5] 1, 2, 10, 113, 114
6	GnRH signaling pathway 1 gene, 2 drugs (DrugBank), 5 diseases shown	[1] GNRHR	D00573	Goserelin	[1] 1
			D04405	Goserelin	[1] 1
			D00989	Leuprolide	[5] 1, 2, 3, 51, 76
7	Neuroactive ligand-receptor interaction 2 genes, 3 drugs (DrugBank), 6 diseases shown	[1] ADRB2	D07713	Clenbuterol	[2] 1, 256
		[1] GNRHR	D00573	Goserelin	[1] 1
			D04405	Goserelin	[1] 1
			D00989	Leuprolide	[5] 1, 2, 3, 51, 76
8	Oocyte meiosis 1 gene, 1 drug (DrugBank), 7 diseases shown	[1] AR	D00075	Testosterone	[7] 1, 2, 3, 13, 78, 113, 265
			D00957
			D00958
			D00959
			D06085
			D06087
9	Pathways in cancer 1 gene, 1 drug (DrugBank), 7 diseases shown	[1] AR	D00075	Testosterone	[7] 1, 2, 3, 13, 78, 113, 265
			D00957
			D00958
			D00959
			D06085
			D06087
10	Prostate cancer 2 genes, 2 drugs (DrugBank), 7 diseases shown	[1] AR	D00075	Testosterone	[7] 1, 2, 3, 13, 78, 113, 265
			D00957
			D00958
			D00959
			D06085
			D06087
		[1] SRD5A2	D03820	Dutasteride	[1] 1
11	Regulation of lipolysis in adipocytes 1 gene, 1 drug (DrugBank), 2 diseases shown	[1] ADRB2	D07713	Clenbuterol	[2] 1, 256
12	Renin secretion 1 gene, 1 drug (DrugBank), 2 diseases shown	[1] ADRB2	D07713	Clenbuterol	[2] 1, 256
13	Salivary secretion 1 gene, 1 drug (DrugBank), 2 diseases shown	[1] ADRB2	D07713	Clenbuterol	[2] 1, 256
14	Steroid hormone biosynthesis 2 genes, 1 drug (DrugBank), 1 disease shown	[2] SRD5A1, SRD5A2	D03820	Dutasteride	[1] 1
15	Taste transduction 3 genes, 1 drug (DrugBank), 5 diseases shown	[3] SCN2A, SCN3A, SCN9A	D00639	Mexiletine	[5] 1, 2, 10, 113, 114
15		[3] SCN2A, SCN3A, SCN9A	D08215	Mexiletine	[5] 1, 2, 10, 113, 114