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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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156 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adherens junction 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 2  Adipocytokine signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 3  Adrenergic signaling in cardiomyocytes 
 11 genes, 8 drugs (DrugBank), 35 diseases shown 		  [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2   D00255   Carvedilol   [4] 6, 57, 86, 113 
 D03415 
 [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] SCN5A   D00639   Mexiletine   [5] 1, 2, 10, 113, 114 
 D08215 
 4  African trypanosomiasis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 5  AGE-RAGE signaling pathway in diabetic complications 
 6 genes, 3 drugs (DrugBank), 25 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 6  Alcoholism 
 6 genes, 2 drugs (DrugBank), 10 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [1] SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 7  Aldosterone synthesis and secretion 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] MC2R   D00284   Tetracosactide   [5] 78, 83, 113, 145, 222 
 8  Aldosterone-regulated sodium reabsorption 
 1 gene, 2 drugs (DrugBank), 8 diseases shown 		  [1] NR3C2   D01115   Eplerenone   [3] 75, 113, 215 
 D00443   Spironolactone   [6] 58, 67, 86, 113, 218, 225 
 9  Alzheimer disease 
 11 genes, 4 drugs (DrugBank), 64 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 10  Amoebiasis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 11  Amphetamine addiction 
 11 genes, 4 drugs (DrugBank), 63 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 12  AMPK signaling pathway 
 4 genes, 3 drugs (DrugBank), 18 diseases shown 		  [1] ADRA1A   D00255   Carvedilol   [4] 6, 57, 86, 113 
 D03415 
 [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 13  Amyotrophic lateral sclerosis (ALS) 
 14 genes, 4 drugs (DrugBank), 59 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 14  Antifolate resistance 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 15  Apelin signaling pathway 
 4 genes, 3 drugs (DrugBank), 30 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] CCN2   D10969   Pamrevlumab   [2] 85, 113 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 16  Arachidonic acid metabolism 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] ALOX5   D01773   Oxatomide   [1] 113 
 [2] PTGS1, PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 17  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 1 gene, 3 drugs (DrugBank), 1 disease shown 		  [1] DMD   D10114   Drisapersen   [1] 113 
 D09900   Eteplirsen   [1] 113 
 D11528   Viltolarsen   [1] 113 
 18  Autophagy - animal 
 3 genes, 2 drugs (DrugBank), 17 diseases shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 19  Axon guidance 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 20  B cell receptor signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 21  Breast cancer 
 3 genes, 3 drugs (DrugBank), 8 diseases shown 		  [2] ESR1, ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 22  C-type lectin receptor signaling pathway 
 11 genes, 6 drugs (DrugBank), 64 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 23  Calcium signaling pathway 
 16 genes, 10 drugs (DrugBank), 71 diseases shown 		  [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2   D00255   Carvedilol   [4] 6, 57, 86, 113 
 D03415 
 [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TBXA2R   D04500   Ifetroban   [3] 51, 86, 113 
 24  cAMP signaling pathway 
 8 genes, 7 drugs (DrugBank), 29 diseases shown 		  [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [2] ADRB1, ADRB2   D00255   Carvedilol   [4] 6, 57, 86, 113 
 D03415 
 [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [1] MC2R   D00284   Tetracosactide   [5] 78, 83, 113, 145, 222 
 25  Cellular senescence 
 9 genes, 3 drugs (DrugBank), 55 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 26  cGMP-PKG signaling pathway 
 15 genes, 11 drugs (DrugBank), 82 diseases shown 		  [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2   D00255   Carvedilol   [4] 6, 57, 86, 113 
 D03415 
 [3] ADRA2A, ADRA2B, ADRA2C   D00514   Dexmedetomidine   [11] 2, 4, 6, 21, 34, 70, 113, 212, 215, 226, 280 
 D01205 
 [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 D02008   Tadalafil   [6] 6, 51, 75, 84, 86, 113 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 27  Chagas disease (American trypanosomiasis) 
 6 genes, 5 drugs (DrugBank), 16 diseases shown 		  [1] ACE   D00621   Enalapril   [4] 19, 46, 66, 113 
 D07892 
 D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 28  Chemical carcinogenesis 
 1 gene, 2 drugs (DrugBank), 13 diseases shown 		  [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 29  Circadian entrainment 
 5 genes, 1 drug (DrugBank), 6 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 30  Circadian rhythm 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 31  Cocaine addiction 
 6 genes, 2 drugs (DrugBank), 10 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [1] SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 32  Cortisol synthesis and secretion 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] MC2R   D00284   Tetracosactide   [5] 78, 83, 113, 145, 222 
 33  Cushing syndrome 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] MC2R   D00284   Tetracosactide   [5] 78, 83, 113, 145, 222 
 34  Cytokine-cytokine receptor interaction 
 4 genes, 5 drugs (DrugBank), 48 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] GHR   D04870   Mecasermin rinfabate   [1] 113 
 D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] MSTN   D11047   Domagrozumab   [1] 113 
 35  Cytosolic DNA-sensing pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 36  Dilated cardiomyopathy (DCM) 
 2 genes, 7 drugs (DrugBank), 11 diseases shown 		  [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 D00255   Carvedilol   [4] 6, 57, 86, 113 
 D03415 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [1] DMD   D10114   Drisapersen   [1] 113 
 D09900   Eteplirsen   [1] 113 
 D11528   Viltolarsen   [1] 113 
 37  Dopaminergic synapse 
 11 genes, 6 drugs (DrugBank), 66 diseases shown 		  [2] GRIN2A, GRIN2B   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SCN1A   D00639   Mexiletine   [5] 1, 2, 10, 113, 114 
 D08215 
 [1] SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 38  EGFR tyrosine kinase inhibitor resistance 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 39  Endocrine and other factor-regulated calcium reabsorption 
 2 genes, 3 drugs (DrugBank), 9 diseases shown 		  [1] ESR1   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [1] VDR   D00122   Calcifediol   [2] 113, 299 
 40  Endocrine resistance 
 7 genes, 4 drugs (DrugBank), 9 diseases shown 		  [2] ESR1, ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 41  Endocytosis 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 42  Epithelial cell signaling in Helicobacter pylori infection 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 43  Epstein-Barr virus infection 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 44  Estrogen signaling pathway 
 2 genes, 2 drugs (DrugBank), 8 diseases shown 		  [2] ESR1, ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 45  Fc epsilon RI signaling pathway 
 5 genes, 2 drugs (DrugBank), 2 diseases shown 		  [1] ALOX5   D01773   Oxatomide   [1] 113 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 46  Fluid shear stress and atherosclerosis 
 7 genes, 3 drugs (DrugBank), 25 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 47  Focal adhesion 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 48  FoxO signaling pathway 
 7 genes, 3 drugs (DrugBank), 18 diseases shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 49  Gap junction 
 1 gene, 4 drugs (DrugBank), 11 diseases shown 		  [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 D00255   Carvedilol   [4] 6, 57, 86, 113 
 D03415 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 50  Glioma 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 51  Glucagon signaling pathway 
 7 genes, 3 drugs (DrugBank), 64 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 52  Glutamatergic synapse 
 10 genes, 3 drugs (DrugBank), 59 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 53  GnRH secretion 
 1 gene, 2 drugs (DrugBank), 8 diseases shown 		  [1] ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 54  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 55  Graft-versus-host disease 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 56  Growth hormone synthesis, secretion and action 
 5 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] GHR   D04870   Mecasermin rinfabate   [1] 113 
 D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 57  Hematopoietic cell lineage 
 2 genes, 2 drugs (DrugBank), 35 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 58  Hepatitis B 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 59  Hepatocellular carcinoma 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 60  Herpes simplex virus 1 infection 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 61  HIF-1 signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 62  Hippo signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CCN2   D10969   Pamrevlumab   [2] 85, 113 
 63  Human cytomegalovirus infection 
 11 genes, 6 drugs (DrugBank), 64 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 64  Human immunodeficiency virus 1 infection 
 9 genes, 3 drugs (DrugBank), 55 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 65  Human papillomavirus infection 
 1 gene, 2 drugs (DrugBank), 13 diseases shown 		  [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 66  Human T-cell leukemia virus 1 infection 
 6 genes, 3 drugs (DrugBank), 56 diseases shown 		  [1] FDPS   D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 67  Huntington disease 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] GRIN1, GRIN2B   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 68  Hypertrophic cardiomyopathy (HCM) 
 4 genes, 7 drugs (DrugBank), 22 diseases shown 		  [1] ACE   D00621   Enalapril   [4] 19, 46, 66, 113 
 D07892 
 D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 [1] DMD   D10114   Drisapersen   [1] 113 
 D09900   Eteplirsen   [1] 113 
 D11528   Viltolarsen   [1] 113 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 69  IL-17 signaling pathway 
 6 genes, 4 drugs (DrugBank), 21 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 70  Inflammatory bowel disease (IBD) 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 71  Inflammatory mediator regulation of TRP channels 
 6 genes, 3 drugs (DrugBank), 15 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TRPV1   D00250   Capsaicin   [6] 2, 6, 19, 86, 113, 226 
 72  Influenza A 
 2 genes, 2 drugs (DrugBank), 14 diseases shown 		  [1] FDPS   D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 73  Insulin resistance 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 74  Insulin secretion 
 1 gene, 1 drug (DrugBank), 13 diseases shown 		  [1] SNAP25   D00783   Botulinum toxin type A   [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226 
 75  Insulin signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 76  JAK-STAT signaling pathway 
 2 genes, 3 drugs (DrugBank), 41 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] GHR   D04870   Mecasermin rinfabate   [1] 113 
 D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 77  Kaposi sarcoma-associated herpesvirus infection 
 10 genes, 5 drugs (DrugBank), 59 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 78  Legionellosis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 79  Leishmaniasis 
 6 genes, 4 drugs (DrugBank), 21 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 80  Leukocyte transendothelial migration 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 81  Long-term depression 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 82  Long-term potentiation 
 10 genes, 3 drugs (DrugBank), 59 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 83  Longevity regulating pathway 
 3 genes, 2 drugs (DrugBank), 17 diseases shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 84  Longevity regulating pathway - multiple species 
 3 genes, 2 drugs (DrugBank), 17 diseases shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 85  Malaria 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 86  MAPK signaling pathway 
 11 genes, 5 drugs (DrugBank), 60 diseases shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 87  Measles 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 88  Melanoma 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 89  Metabolic pathways 
 5 genes, 6 drugs (DrugBank), 30 diseases shown 		  [1] ALOX5   D01773   Oxatomide   [1] 113 
 [1] FDPS   D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 D02008   Tadalafil   [6] 6, 51, 75, 84, 86, 113 
 [2] PTGS1, PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 90  MicroRNAs in cancer 
 1 gene, 2 drugs (DrugBank), 13 diseases shown 		  [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 91  Mineral absorption 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] VDR   D00122   Calcifediol   [2] 113, 299 
 92  mTOR signaling pathway 
 3 genes, 2 drugs (DrugBank), 17 diseases shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 93  Natural killer cell mediated cytotoxicity 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 94  Necroptosis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 95  Neuroactive ligand-receptor interaction 
 19 genes, 17 drugs (DrugBank), 87 diseases shown 		  [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2   D00255   Carvedilol   [4] 6, 57, 86, 113 
 D03415 
 [3] ADRA2A, ADRA2B, ADRA2C   D00514   Dexmedetomidine   [11] 2, 4, 6, 21, 34, 70, 113, 212, 215, 226, 280 
 D01205 
 [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] GHR   D04870   Mecasermin rinfabate   [1] 113 
 D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [1] MC2R   D00284   Tetracosactide   [5] 78, 83, 113, 145, 222 
 [1] NR3C1   D03671   Deflazacort   [2] 30, 113 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 D11000   Vamorolone   [1] 113 
 [1] TBXA2R   D04500   Ifetroban   [3] 51, 86, 113 
 [1] TRPV1   D00250   Capsaicin   [6] 2, 6, 19, 86, 113, 226 
 96  Neurotrophin signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 97  NF-kappa B signaling pathway 
 2 genes, 3 drugs (DrugBank), 20 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 98  Nicotine addiction 
 5 genes, 1 drug (DrugBank), 6 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 99  NOD-like receptor signaling pathway 
 5 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 100  Non-alcoholic fatty liver disease (NAFLD) 
 3 genes, 2 drugs (DrugBank), 24 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 101  Oocyte meiosis 
 11 genes, 7 drugs (DrugBank), 60 diseases shown 		  [1] AR   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 D00075   Testosterone   [7] 1, 2, 3, 13, 78, 113, 265 
 D00957 
 D00958 
 D00959 
 D06085 
 D06087 
 D00958   Testosterone enanthate   [1] 113 
 [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 102  Osteoclast differentiation 
 10 genes, 4 drugs (DrugBank), 60 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 103  Ovarian steroidogenesis 
 3 genes, 4 drugs (DrugBank), 13 diseases shown 		  [1] ALOX5   D01773   Oxatomide   [1] 113 
 [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 104  Oxytocin signaling pathway 
 8 genes, 5 drugs (DrugBank), 68 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 105  Parathyroid hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] VDR   D00122   Calcifediol   [2] 113, 299 
 106  Parkinson disease 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 107  Pathogenic Escherichia coli infection 
 5 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 108  Pathways in cancer 
 7 genes, 9 drugs (DrugBank), 52 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] AR   D00075   Testosterone   [7] 1, 2, 3, 13, 78, 113, 265 
 D00957 
 D00958 
 D00959 
 D06085 
 D06087 
 D00958   Testosterone enanthate   [1] 113 
 [3] AR, ESR1, ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] ESR1, ESR2   D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 109  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 9 genes, 3 drugs (DrugBank), 55 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 110  Pertussis 
 5 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 111  Phospholipase D signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 112  PI3K-Akt signaling pathway 
 5 genes, 4 drugs (DrugBank), 49 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [2] GHR, IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 113  Platelet activation 
 6 genes, 4 drugs (DrugBank), 14 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] PTGS1   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 [1] TBXA2R   D04500   Ifetroban   [3] 51, 86, 113 
 114  Prion diseases 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 115  Progesterone-mediated oocyte maturation 
 5 genes, 2 drugs (DrugBank), 2 diseases shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 116  Prolactin signaling pathway 
 6 genes, 3 drugs (DrugBank), 9 diseases shown 		  [2] ESR1, ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 117  Prostate cancer 
 2 genes, 4 drugs (DrugBank), 12 diseases shown 		  [1] AR   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 D00075   Testosterone   [7] 1, 2, 3, 13, 78, 113, 265 
 D00957 
 D00958 
 D00959 
 D06085 
 D06087 
 D00958   Testosterone enanthate   [1] 113 
 [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 118  Proteoglycans in cancer 
 6 genes, 4 drugs (DrugBank), 9 diseases shown 		  [1] ESR1   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 119  Purine metabolism 
 1 gene, 2 drugs (DrugBank), 18 diseases shown 		  [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 D02008   Tadalafil   [6] 6, 51, 75, 84, 86, 113 
 120  Rap1 signaling pathway 
 8 genes, 3 drugs (DrugBank), 7 diseases shown 		  [3] GRIN1, GRIN2A, GRIN2B   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 121  Ras signaling pathway 
 4 genes, 2 drugs (DrugBank), 6 diseases shown 		  [3] GRIN1, GRIN2A, GRIN2B   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 122  Regulation of lipolysis in adipocytes 
 4 genes, 7 drugs (DrugBank), 29 diseases shown 		  [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [2] ADRB1, ADRB2   D00255   Carvedilol   [4] 6, 57, 86, 113 
 D03415 
 [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [2] PTGS1, PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 123  Relaxin signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 124  Renin secretion 
 9 genes, 11 drugs (DrugBank), 71 diseases shown 		  [1] ACE   D00621   Enalapril   [4] 19, 46, 66, 113 
 D07892 
 D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [2] ADRB1, ADRB2   D00255   Carvedilol   [4] 6, 57, 86, 113 
 D03415 
 [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 125  Renin-angiotensin system 
 2 genes, 4 drugs (DrugBank), 21 diseases shown 		  [1] ACE   D00621   Enalapril   [4] 19, 46, 66, 113 
 D07892 
 D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 126  Retrograde endocannabinoid signaling 
 5 genes, 3 drugs (DrugBank), 14 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 127  Rheumatoid arthritis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 128  RIG-I-like receptor signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 129  Salivary secretion 
 5 genes, 5 drugs (DrugBank), 22 diseases shown 		  [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2   D00255   Carvedilol   [4] 6, 57, 86, 113 
 D03415 
 [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 130  Salmonella infection 
 5 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 131  Serotonergic synapse 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] ALOX5   D01773   Oxatomide   [1] 113 
 [2] PTGS1, PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 132  Shigellosis 
 5 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 133  Signaling pathways regulating pluripotency of stem cells 
 5 genes, 2 drugs (DrugBank), 2 diseases shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 134  Small cell lung cancer 
 1 gene, 2 drugs (DrugBank), 13 diseases shown 		  [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 135  Sphingolipid signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 136  Synaptic vesicle cycle 
 3 genes, 2 drugs (DrugBank), 17 diseases shown 		  [2] SLC6A2, SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 [1] SNAP25   D00783   Botulinum toxin type A   [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226 
 137  Systemic lupus erythematosus 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] GRIN2A, GRIN2B   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 138  T cell receptor signaling pathway 
 9 genes, 3 drugs (DrugBank), 55 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 139  Taste transduction 
 3 genes, 1 drug (DrugBank), 5 diseases shown 		  [3] SCN2A, SCN3A, SCN9A   D00639   Mexiletine   [5] 1, 2, 10, 113, 114 
 D08215 
 140  Terpenoid backbone biosynthesis 
 3 genes, 2 drugs (DrugBank), 8 diseases shown 		  [1] FDPS   D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 [2] FNTA, FNTB   D04768   Lonafarnib   [2] 113, 333 
 141  Th1 and Th2 cell differentiation 
 9 genes, 3 drugs (DrugBank), 55 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 142  Th17 cell differentiation 
 10 genes, 4 drugs (DrugBank), 60 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 143  Thermogenesis 
 6 genes, 2 drugs (DrugBank), 18 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 144  Thyroid hormone signaling pathway 
 1 gene, 2 drugs (DrugBank), 8 diseases shown 		  [1] ESR1   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 145  Tight junction 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 146  TNF signaling pathway 
 6 genes, 4 drugs (DrugBank), 21 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 147  Toll-like receptor signaling pathway 
 5 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 148  Toxoplasmosis 
 5 genes, 2 drugs (DrugBank), 2 diseases shown 		  [1] ALOX5   D01773   Oxatomide   [1] 113 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 149  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] IGF1R   D04870   Mecasermin rinfabate   [1] 113 
 150  Tuberculosis 
 11 genes, 5 drugs (DrugBank), 60 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] VDR   D00122   Calcifediol   [2] 113, 299 
 151  Type I diabetes mellitus 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 152  Vascular smooth muscle contraction 
 4 genes, 2 drugs (DrugBank), 21 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00255   Carvedilol   [4] 6, 57, 86, 113 
 D03415 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 153  VEGF signaling pathway 
 10 genes, 5 drugs (DrugBank), 59 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 154  Viral myocarditis 
 1 gene, 3 drugs (DrugBank), 1 disease shown 		  [1] DMD   D10114   Drisapersen   [1] 113 
 D09900   Eteplirsen   [1] 113 
 D11528   Viltolarsen   [1] 113 
 155  Wnt signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 156  Yersinia infection 
 5 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 

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