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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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210 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY
 On map, Yellow: Drug target, Red: Disease-related 
 KEGG GENES
 [Number of genes] 
 KEGG DRUG  DrugBank   Disease ID
 [Number of diseases] 
 1  Acute myeloid leukemia 
 3 genes, 5 drugs (DrugBank), 43 diseases shown 
 [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 2  Adipocytokine signaling pathway 
 6 genes, 4 drugs (DrugBank), 46 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [3] RXRA, RXRB, RXRG   D03106   Bexarotene   [2] 13, 75 
 3  Adrenergic signaling in cardiomyocytes 
 11 genes, 13 drugs (DrugBank), 38 diseases shown 
 [1] ADRA1A   D01692   Alfuzosin   [1] 13 
 D07124 
 D01965   Silodosin   [2] 6, 13 
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] ADRB2   D08092   Isoxsuprine   [1] 13 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 D02716   Pregabalin   [5] 13, 36, 46, 70, 298 
 [1] SCN5A   D00354   Lamotrigine   [3] 13, 34, 114 
 D00358   Lidocaine   [10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 D00533   Oxcarbazepine   [1] 13 
 D00512   Phenytoin   [1] 13 
 D02103 
 D00642   Quinidine   [3] 2, 8, 13 
 D00643 
 D02272 
 D08458 
 4  African trypanosomiasis 
 2 genes, 1 drug (DrugBank), 16 diseases shown 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 5  AGE-RAGE signaling pathway in diabetic complications 
 2 genes, 2 drugs (DrugBank), 25 diseases shown 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 6  Alcoholism 
 10 genes, 12 drugs (DrugBank), 31 diseases shown 
 [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D00458   Quetiapine   [2] 6, 13 
 D08456 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] SLC6A3   D03215   Armodafinil   [3] 6, 13, 84 
 D08130   Lisdexamfetamine   [1] 13 
 D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 7  Aldosterone synthesis and secretion 
 2 genes, 2 drugs (DrugBank), 26 diseases shown 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 8  Aldosterone-regulated sodium reabsorption 
 3 genes, 1 drug (DrugBank), 3 diseases shown 
 [3] SCNN1A, SCNN1B, SCNN1G   D00649   Amiloride   [3] 13, 225, 299 
 D07447 
 9  Allograft rejection 
 24 genes, 3 drugs (DrugBank), 30 diseases shown 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 10  Alzheimer disease 
 14 genes, 7 drugs (DrugBank), 42 diseases shown 
 [4] APH1A, NCSTN, PSEN1, PSENEN   D09010   Tarenflurbil   [1] 13 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 11  Amoebiasis 
 4 genes, 2 drugs (DrugBank), 24 diseases shown 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 12  Amphetamine addiction 
 16 genes, 10 drugs (DrugBank), 48 diseases shown 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SLC6A3   D03215   Armodafinil   [3] 6, 13, 84 
 D08130   Lisdexamfetamine   [1] 13 
 D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 13  AMPK signaling pathway 
 6 genes, 10 drugs (DrugBank), 66 diseases shown 
 [1] ADRA1A   D01692   Alfuzosin   [1] 13 
 D07124 
 D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 D01965   Silodosin   [2] 6, 13 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 14  Amyotrophic lateral sclerosis (ALS) 
 12 genes, 6 drugs (DrugBank), 42 diseases shown 
 [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 15  Antifolate resistance 
 2 genes, 1 drug (DrugBank), 33 diseases shown 
 [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 16  Antigen processing and presentation 
 20 genes, 1 drug (DrugBank), 4 diseases shown 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 17  Apelin signaling pathway 
 5 genes, 5 drugs (DrugBank), 53 diseases shown 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDE3B   D01385   Ibudilast   [2] 2, 13 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 18  Arachidonic acid metabolism 
 2 genes, 6 drugs (DrugBank), 18 diseases shown 
 [2] PTGS1, PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 19  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 5 genes, 4 drugs (DrugBank), 13 diseases shown 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 D02716   Pregabalin   [5] 13, 36, 46, 70, 298 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 20  Asthma 
 14 genes, 1 drug (DrugBank), 4 diseases shown 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 21  Autoimmune thyroid disease 
 22 genes, 2 drugs (DrugBank), 26 diseases shown 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 22  Autophagy - animal 
 3 genes, 3 drugs (DrugBank), 46 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 23  Autophagy - other 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 24  Axon guidance 
 8 genes, 4 drugs (DrugBank), 37 diseases shown 
 [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] RGMA   D11355   Elezanumab   [1] 13 
 [1] SEMA4D   D11469   Pepinemab   [2] 8, 13 
 25  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 26  Bile secretion 
 3 genes, 5 drugs (DrugBank), 37 diseases shown 
 [1] CA2   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [1] RXRA   D03106   Bexarotene   [2] 13, 75 
 27  Bladder cancer 
 1 gene, 1 drug (DrugBank), 9 diseases shown 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 28  Breast cancer 
 5 genes, 12 drugs (DrugBank), 44 diseases shown 
 [1] ESR1   D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D00185   Estriol   [2] 13, 227 
 D01986 
 [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PGR   D01217   Dydrogesterone   [1] 13 
 D00950   Levonorgestrel   [1] 13 
 D07222   Nomegestrol   [1] 13 
 D08281   Nomegestrol acetate   [1] 13 
 D00182   Norethisterone   [4] 13, 46, 49, 299 
 D00953 
 29  C-type lectin receptor signaling pathway 
 9 genes, 8 drugs (DrugBank), 46 diseases shown 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 30  Caffeine metabolism 
 1 gene, 1 drug (DrugBank), 3 diseases shown 
 [1] XDH   D01206   Febuxostat   [3] 2, 6, 13 
 31  Calcium signaling pathway 
 28 genes, 28 drugs (DrugBank), 64 diseases shown 
 [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] ADRA1A   D01692   Alfuzosin   [1] 13 
 D07124 
 D01965   Silodosin   [2] 6, 13 
 [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] ADRB2   D08092   Isoxsuprine   [1] 13 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] ADRB3   D09535   Mirabegron   [3] 6, 13, 226 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] CHRM3   D01699   Darifenacin   [2] 6, 13 
 D03654 
 [1] CYSLTR1   D01385   Ibudilast   [2] 2, 13 
 D00529   Montelukast   [5] 13, 46, 85, 98, 228 
 D08229 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] HRH1   D00664   Cetirizine   [2] 13, 35 
 D07662 
 D00666   Clemastine   [1] 13 
 D03535 
 D07803   Dexchlorpheniramine   [1] 13 
 D00364   Loratadine   [3] 6, 13, 46 
 [1] HRH2   D00422   Ranitidine   [2] 13, 65 
 D00673 
 [1] HTR2A   D00458   Quetiapine   [2] 6, 13 
 D08456 
 [2] HTR2A, HTR4   D00274   Cisapride   [1] 13 
 D02092 
 [1] HTR4   D09205   Prucalopride   [3] 13, 51, 96 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TBXA2R   D01128   Ramatroban   [1] 13 
 32  cAMP signaling pathway 
 25 genes, 20 drugs (DrugBank), 50 diseases shown 
 [2] ADORA1, ADORA2A   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [2] ADRB1, ADRB2   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] ADRB2   D08092   Isoxsuprine   [1] 13 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D00458   Quetiapine   [2] 6, 13 
 D08456 
 [1] EDNRA   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [2] GABBR1, GABBR2   D09791   Arbaclofen   [2] 13, 206 
 D08861   Arbaclofen Placarbil   [1] 13 
 D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] HTR4   D00274   Cisapride   [1] 13 
 D02092 
 D09205   Prucalopride   [3] 13, 51, 96 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D01385   Ibudilast   [2] 2, 13 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D01783   Rolipram   [2] 8, 13 
 33  Cardiac muscle contraction 
 4 genes, 2 drugs (DrugBank), 9 diseases shown 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 D02716   Pregabalin   [5] 13, 36, 46, 70, 298 
 34  Cell adhesion molecules (CAMs) 
 25 genes, 6 drugs (DrugBank), 33 diseases shown 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 35  Cell cycle 
 1 gene, 1 drug (DrugBank), 11 diseases shown 
 [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 36  Cellular senescence 
 12 genes, 4 drugs (DrugBank), 50 diseases shown 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 37  Central carbon metabolism in cancer 
 4 genes, 5 drugs (DrugBank), 43 diseases shown 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 38  cGMP-PKG signaling pathway 
 23 genes, 17 drugs (DrugBank), 59 diseases shown 
 [2] ADORA1, ADORA3   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] ADRA1A   D01692   Alfuzosin   [1] 13 
 D07124 
 D01965   Silodosin   [2] 6, 13 
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [3] ADRA2A, ADRA2B, ADRA2C   D04375   Guanabenz   [2] 2, 13 
 D00776   Tizanidine   [1] 13 
 D08611 
 [1] ADRB2   D08092   Isoxsuprine   [1] 13 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] ADRB3   D09535   Mirabegron   [3] 6, 13, 226 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [1] OPRD1   D00729   Loperamide   [2] 13, 97 
 D07113 
 D08144 
 D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 D03783   Oxycodone   [7] 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 [2] PDE3A, PDE3B   D01385   Ibudilast   [2] 2, 13 
 [1] PDE5A   D02731   Vardenafil   [3] 13, 86, 299 
 D03260 
 D08668 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 39  Chagas disease (American trypanosomiasis) 
 2 genes, 1 drug (DrugBank), 16 diseases shown 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 40  Chemical carcinogenesis 
 1 gene, 6 drugs (DrugBank), 18 diseases shown 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 41  Choline metabolism in cancer 
 2 genes, 3 drugs (DrugBank), 39 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 42  Cholinergic synapse 
 2 genes, 3 drugs (DrugBank), 9 diseases shown 
 [1] ACHE   D00670   Donepezil   [9] 5, 6, 13, 46, 78, 124, 127, 156, 206 
 D07869 
 D02558   Rivastigmine   [3] 5, 6, 13 
 D03822 
 [1] CHRM3   D01699   Darifenacin   [2] 6, 13 
 D03654 
 43  Chronic myeloid leukemia 
 1 gene, 1 drug (DrugBank), 11 diseases shown 
 [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 44  Circadian entrainment 
 11 genes, 6 drugs (DrugBank), 22 diseases shown 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [2] MTNR1A, MTNR1B   D08170   Melatonin   [8] 6, 13, 46, 49, 90, 97, 144, 202 
 45  Circadian rhythm 
 2 genes, 1 drug (DrugBank), 17 diseases shown 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 46  Cocaine addiction 
 9 genes, 11 drugs (DrugBank), 28 diseases shown 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D00458   Quetiapine   [2] 6, 13 
 D08456 
 [6] GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] SLC6A3   D03215   Armodafinil   [3] 6, 13, 84 
 D08130   Lisdexamfetamine   [1] 13 
 D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 47  Collecting duct acid secretion 
 3 genes, 3 drugs (DrugBank), 20 diseases shown 
 [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 D02593   Pantoprazole   [2] 13, 65 
 D05353 
 [1] CA2   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 48  Colorectal cancer 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 49  Complement and coagulation cascades 
 1 gene, 1 drug (DrugBank), 7 diseases shown 
 [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 50  Cortisol synthesis and secretion 
 4 genes, 4 drugs (DrugBank), 29 diseases shown 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] CYP17A1   D00351   Ketoconazole   [3] 8, 13, 75 
 [1] KCNA4   D04127   Dalfampridine   [3] 3, 4, 13 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 51  Cushing syndrome 
 4 genes, 4 drugs (DrugBank), 29 diseases shown 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] CYP17A1   D00351   Ketoconazole   [3] 8, 13, 75 
 [1] KCNA4   D04127   Dalfampridine   [3] 3, 4, 13 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 52  Cytokine-cytokine receptor interaction 
 16 genes, 13 drugs (DrugBank), 66 diseases shown 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL17A   D09967   Secukinumab   [7] 13, 37, 41, 46, 160, 269, 271 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RA   D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] LTB   D08866   Baminercept   [4] 13, 46, 53, 97 
 [2] TNFSF13, TNFSF13B   D09704   Atacicept   [4] 13, 46, 49, 66 
 53  Dilated cardiomyopathy (DCM) 
 6 genes, 5 drugs (DrugBank), 17 diseases shown 
 [1] ADRB1   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 D02716   Pregabalin   [5] 13, 36, 46, 70, 298 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 54  Dopaminergic synapse 
 13 genes, 17 drugs (DrugBank), 53 diseases shown 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D00458   Quetiapine   [2] 6, 13 
 D08456 
 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [2] GRIN2A, GRIN2B   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [3] PPP3CA, PPP3CB, PPP3CC   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SCN1A   D00354   Lamotrigine   [3] 13, 34, 114 
 D00358   Lidocaine   [10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 D00533   Oxcarbazepine   [1] 13 
 D00512   Phenytoin   [1] 13 
 D02103 
 D00642   Quinidine   [3] 2, 8, 13 
 D00643 
 D02272 
 D08458 
 [1] SLC6A3   D03215   Armodafinil   [3] 6, 13, 84 
 D08130   Lisdexamfetamine   [1] 13 
 D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 55  Drug metabolism - other enzymes 
 5 genes, 6 drugs (DrugBank), 41 diseases shown 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] RRM1   D01370   Cladribine   [2] 13, 94 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 [1] XDH   D01206   Febuxostat   [3] 2, 6, 13 
 56  ECM-receptor interaction 
 2 genes, 3 drugs (DrugBank), 9 diseases shown 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [1] SV2A   D00709   Levetiracetam   [4] 2, 4, 6, 13 
 57  EGFR tyrosine kinase inhibitor resistance 
 5 genes, 6 drugs (DrugBank), 52 diseases shown 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 58  Endocrine and other factor-regulated calcium reabsorption 
 2 genes, 4 drugs (DrugBank), 17 diseases shown 
 [1] ESR1   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D00185   Estriol   [2] 13, 227 
 D01986 
 D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 59  Endocrine resistance 
 3 genes, 5 drugs (DrugBank), 39 diseases shown 
 [1] ESR1   D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D00185   Estriol   [2] 13, 227 
 D01986 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 60  Endocytosis 
 9 genes, 4 drugs (DrugBank), 22 diseases shown 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IL2RA   D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 61  Epstein-Barr virus infection 
 23 genes, 5 drugs (DrugBank), 14 diseases shown 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 62  ErbB signaling pathway 
 2 genes, 3 drugs (DrugBank), 39 diseases shown 
 [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 63  Estrogen signaling pathway 
 7 genes, 15 drugs (DrugBank), 25 diseases shown 
 [1] ESR1   D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D00185   Estriol   [2] 13, 227 
 D01986 
 [2] GABBR1, GABBR2   D09791   Arbaclofen   [2] 13, 206 
 D08861   Arbaclofen Placarbil   [1] 13 
 D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 [1] OPRM1   D00729   Loperamide   [2] 13, 97 
 D07113 
 D08144 
 D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 D03783   Oxycodone   [7] 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 [1] PGR   D01217   Dydrogesterone   [1] 13 
 D00950   Levonorgestrel   [1] 13 
 D07222   Nomegestrol   [1] 13 
 D08281   Nomegestrol acetate   [1] 13 
 D00182   Norethisterone   [4] 13, 46, 49, 299 
 D00953 
 [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 64  Fluid shear stress and atherosclerosis 
 7 genes, 5 drugs (DrugBank), 41 diseases shown 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] KEAP1   D03846   Dimethyl fumarate   [5] 13, 46, 49, 51, 86 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 65  Focal adhesion 
 3 genes, 4 drugs (DrugBank), 18 diseases shown 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 66  Folate biosynthesis 
 2 genes, 1 drug (DrugBank), 33 diseases shown 
 [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 67  FoxO signaling pathway 
 4 genes, 5 drugs (DrugBank), 23 diseases shown 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] S1PR1   D10001   Fingolimod   [4] 2, 13, 14, 156 
 D11215   Ponesimod   [1] 13 
 D11460   Siponimod   [2] 13, 50 
 [2] S1PR1, S1PR4   D10968   Ozanimod   [3] 13, 96, 97 
 68  GABAergic synapse 
 19 genes, 7 drugs (DrugBank), 17 diseases shown 
 [2] GABBR1, GABBR2   D09791   Arbaclofen   [2] 13, 206 
 D08861   Arbaclofen Placarbil   [1] 13 
 D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D02624   Eszopiclone   [3] 6, 13, 46 
 D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] SLC6A1   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 69  Gap junction 
 4 genes, 5 drugs (DrugBank), 19 diseases shown 
 [1] ADRB1   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 [2] DRD2, HTR2A   D00458   Quetiapine   [2] 6, 13 
 D08456 
 [1] HTR2A   D00274   Cisapride   [1] 13 
 D02092 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 70  Gastric acid secretion 
 5 genes, 5 drugs (DrugBank), 20 diseases shown 
 [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 D02593   Pantoprazole   [2] 13, 65 
 D05353 
 [1] CA2   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 [1] CHRM3   D01699   Darifenacin   [2] 6, 13 
 D03654 
 [1] HRH2   D00422   Ranitidine   [2] 13, 65 
 D00673 
 71  Gastric cancer 
 6 genes, 5 drugs (DrugBank), 41 diseases shown 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 [3] RXRA, RXRB, RXRG   D03106   Bexarotene   [2] 13, 75 
 72  Glioma 
 2 genes, 3 drugs (DrugBank), 39 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 73  Glucagon signaling pathway 
 8 genes, 3 drugs (DrugBank), 40 diseases shown 
 [1] PDE3B   D01385   Ibudilast   [2] 2, 13 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 74  Glutamatergic synapse 
 19 genes, 6 drugs (DrugBank), 42 diseases shown 
 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 75  Glutathione metabolism 
 2 genes, 3 drugs (DrugBank), 22 diseases shown 
 [1] RRM1   D01370   Cladribine   [2] 13, 94 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 76  Glycerophospholipid metabolism 
 1 gene, 2 drugs (DrugBank), 9 diseases shown 
 [1] ACHE   D00670   Donepezil   [9] 5, 6, 13, 46, 78, 124, 127, 156, 206 
 D07869 
 D02558   Rivastigmine   [3] 5, 6, 13 
 D03822 
 77  GnRH secretion 
 3 genes, 5 drugs (DrugBank), 11 diseases shown 
 [1] ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D00185   Estriol   [2] 13, 227 
 D01986 
 [2] GABBR1, GABBR2   D09791   Arbaclofen   [2] 13, 206 
 D08861   Arbaclofen Placarbil   [1] 13 
 D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 78  Graft-versus-host disease 
 22 genes, 2 drugs (DrugBank), 26 diseases shown 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 79  Growth hormone synthesis, secretion and action 
 3 genes, 4 drugs (DrugBank), 50 diseases shown 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] GHRHR   D08523   Somatorelin   [2] 13, 78 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 80  Hematopoietic cell lineage 
 23 genes, 14 drugs (DrugBank), 72 diseases shown 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RA   D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MS4A1   D05218   Ocrelizumab   [3] 13, 46, 49 
 D09314   Ofatumumab   [3] 13, 35, 46 
 D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 D11243   Ublituximab   [1] 13 
 81  Hepatitis B 
 1 gene, 3 drugs (DrugBank), 5 diseases shown 
 [1] IFNAR1   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 82  Hepatitis C 
 3 genes, 4 drugs (DrugBank), 6 diseases shown 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [1] RXRA   D03106   Bexarotene   [2] 13, 75 
 83  Hepatocellular carcinoma 
 3 genes, 4 drugs (DrugBank), 40 diseases shown 
 [1] KEAP1   D03846   Dimethyl fumarate   [5] 13, 46, 49, 51, 86 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 84  Herpes simplex virus 1 infection 
 26 genes, 8 drugs (DrugBank), 53 diseases shown 
 [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 85  HIF-1 signaling pathway 
 3 genes, 4 drugs (DrugBank), 48 diseases shown 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 86  Human cytomegalovirus infection 
 17 genes, 14 drugs (DrugBank), 72 diseases shown 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 87  Human immunodeficiency virus 1 infection 
 12 genes, 4 drugs (DrugBank), 50 diseases shown 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 88  Human papillomavirus infection 
 13 genes, 16 drugs (DrugBank), 51 diseases shown 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PSEN1   D09010   Tarenflurbil   [1] 13 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 89  Human T-cell leukemia virus 1 infection 
 30 genes, 6 drugs (DrugBank), 45 diseases shown 
 [1] FDPS   D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RA   D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 90  Huntington disease 
 3 genes, 6 drugs (DrugBank), 29 diseases shown 
 [2] GRIN1, GRIN2B   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 91  Hypertrophic cardiomyopathy (HCM) 
 7 genes, 5 drugs (DrugBank), 27 diseases shown 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 D02716   Pregabalin   [5] 13, 36, 46, 70, 298 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 92  IL-17 signaling pathway 
 2 genes, 7 drugs (DrugBank), 22 diseases shown 
 [1] IL17A   D09967   Secukinumab   [7] 13, 37, 41, 46, 160, 269, 271 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 93  Inflammatory bowel disease (IBD) 
 18 genes, 3 drugs (DrugBank), 19 diseases shown 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL17A   D09967   Secukinumab   [7] 13, 37, 41, 46, 160, 269, 271 
 94  Inflammatory mediator regulation of TRP channels 
 3 genes, 7 drugs (DrugBank), 19 diseases shown 
 [1] HRH1   D00664   Cetirizine   [2] 13, 35 
 D07662 
 D00666   Clemastine   [1] 13 
 D03535 
 D07803   Dexchlorpheniramine   [1] 13 
 D00364   Loratadine   [3] 6, 13, 46 
 [1] HTR2A   D00274   Cisapride   [1] 13 
 D02092 
 D00458   Quetiapine   [2] 6, 13 
 D08456 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 95  Influenza A 
 19 genes, 6 drugs (DrugBank), 25 diseases shown 
 [1] FDPS   D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 96  Insulin resistance 
 3 genes, 3 drugs (DrugBank), 46 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 97  Insulin secretion 
 2 genes, 2 drugs (DrugBank), 13 diseases shown 
 [1] CHRM3   D01699   Darifenacin   [2] 6, 13 
 D03654 
 [1] SNAP25   D00783   Botulinum toxin type A   [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226 
 98  Insulin signaling pathway 
 4 genes, 4 drugs (DrugBank), 46 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDE3B   D01385   Ibudilast   [2] 2, 13 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 99  Intestinal immune network for IgA production 
 19 genes, 5 drugs (DrugBank), 30 diseases shown 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [2] TNFSF13, TNFSF13B   D09704   Atacicept   [4] 13, 46, 49, 66 
 100  JAK-STAT signaling pathway 
 12 genes, 12 drugs (DrugBank), 82 diseases shown 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RA   D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 101  Kaposi sarcoma-associated herpesvirus infection 
 17 genes, 15 drugs (DrugBank), 68 diseases shown 
 [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 102  Legionellosis 
 2 genes, 1 drug (DrugBank), 16 diseases shown 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 103  Leishmaniasis 
 18 genes, 10 drugs (DrugBank), 34 diseases shown 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 104  Leukocyte transendothelial migration 
 2 genes, 3 drugs (DrugBank), 12 diseases shown 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 105  Long-term depression 
 3 genes, 1 drug (DrugBank), 7 diseases shown 
 [3] GRIA1, GRIA2, GRIA3   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 106  Long-term potentiation 
 12 genes, 6 drugs (DrugBank), 42 diseases shown 
 [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 107  Longevity regulating pathway 
 4 genes, 4 drugs (DrugBank), 50 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 108  Longevity regulating pathway - multiple species 
 3 genes, 3 drugs (DrugBank), 46 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 109  Malaria 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 
 [1] IL12A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 110  MAPK signaling pathway 
 14 genes, 8 drugs (DrugBank), 54 diseases shown 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 D02716   Pregabalin   [5] 13, 36, 46, 70, 298 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 111  Measles 
 5 genes, 5 drugs (DrugBank), 21 diseases shown 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RA   D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 112  Melanogenesis 
 2 genes, 3 drugs (DrugBank), 21 diseases shown 
 [1] EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 113  Melanoma 
 1 gene, 1 drug (DrugBank), 11 diseases shown 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 114  Metabolic pathways 
 38 genes, 27 drugs (DrugBank), 87 diseases shown 
 [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 D02593   Pantoprazole   [2] 13, 65 
 D05353 
 [13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 [1] CYP17A1   D00351   Ketoconazole   [3] 8, 13, 75 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] DHODH   D10172   Teriflunomide   [2] 13, 25 
 [1] FDPS   D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D01385   Ibudilast   [2] 2, 13 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D01783   Rolipram   [2] 8, 13 
 [1] PDE5A   D02731   Vardenafil   [3] 13, 86, 299 
 D03260 
 D08668 
 [2] PTGS1, PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 [1] RRM1   D01370   Cladribine   [2] 13, 94 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 [1] XDH   D01206   Febuxostat   [3] 2, 6, 13 
 115  MicroRNAs in cancer 
 5 genes, 10 drugs (DrugBank), 48 diseases shown 
 [2] ABL1, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 116  Mineral absorption 
 2 genes, 2 drugs (DrugBank), 16 diseases shown 
 [1] CLCN2   D04790   Lubiprostone   [4] 6, 13, 290, 299 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 117  Morphine addiction 
 26 genes, 12 drugs (DrugBank), 26 diseases shown 
 [1] ADORA1   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [2] GABBR1, GABBR2   D09791   Arbaclofen   [2] 13, 206 
 D08861   Arbaclofen Placarbil   [1] 13 
 D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D02624   Eszopiclone   [3] 6, 13, 46 
 D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] OPRM1   D00729   Loperamide   [2] 13, 97 
 D07113 
 D08144 
 D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 D03783   Oxycodone   [7] 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D01385   Ibudilast   [2] 2, 13 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D01783   Rolipram   [2] 8, 13 
 118  mTOR signaling pathway 
 3 genes, 3 drugs (DrugBank), 46 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 119  Natural killer cell mediated cytotoxicity 
 13 genes, 6 drugs (DrugBank), 34 diseases shown 
 [5] HLA-A, HLA-B, HLA-C, HLA-E, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 120  Necroptosis 
 2 genes, 3 drugs (DrugBank), 5 diseases shown 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 121  Neuroactive ligand-receptor interaction 
 79 genes, 58 drugs (DrugBank), 108 diseases shown 
 [4] ADORA1, ADORA2A, ADORA2B, ADORA3   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] ADRA1A   D01692   Alfuzosin   [1] 13 
 D07124 
 D01965   Silodosin   [2] 6, 13 
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [3] ADRA2A, ADRA2B, ADRA2C   D04375   Guanabenz   [2] 2, 13 
 D00776   Tizanidine   [1] 13 
 D08611 
 [1] ADRB2   D08092   Isoxsuprine   [1] 13 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] ADRB3   D09535   Mirabegron   [3] 6, 13, 226 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 [1] CHRM3   D01699   Darifenacin   [2] 6, 13 
 D03654 
 [2] CNR1, CNR2   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D00306   Dronabinol   [5] 2, 13, 46, 271, 298 
 D05099   Nabilone   [2] 6, 13 
 [1] CYSLTR1   D00529   Montelukast   [5] 13, 46, 85, 98, 228 
 D08229 
 [2] CYSLTR1, PTGIR   D01385   Ibudilast   [2] 2, 13 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 [2] DRD2, HTR2A   D00458   Quetiapine   [2] 6, 13 
 D08456 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [2] GABBR1, GABBR2   D09791   Arbaclofen   [2] 13, 206 
 D08861   Arbaclofen Placarbil   [1] 13 
 D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D02624   Eszopiclone   [3] 6, 13, 46 
 D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] GHRHR   D08523   Somatorelin   [2] 13, 78 
 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [2] HCRTR1, HCRTR2   D10082   Suvorexant   [3] 5, 6, 13 
 [1] HRH1   D00664   Cetirizine   [2] 13, 35 
 D07662 
 D00666   Clemastine   [1] 13 
 D03535 
 D07803   Dexchlorpheniramine   [1] 13 
 D00364   Loratadine   [3] 6, 13, 46 
 [1] HRH2   D00422   Ranitidine   [2] 13, 65 
 D00673 
 [2] HTR2A, HTR4   D00274   Cisapride   [1] 13 
 D02092 
 [1] HTR4   D09205   Prucalopride   [3] 13, 51, 96 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [2] MTNR1A, MTNR1B   D08170   Melatonin   [8] 6, 13, 46, 49, 90, 97, 144, 202 
 [1] NR3C1   D00292   Dexamethasone   [20] 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 
 D00975 
 D01510 
 D01615 
 D01632 
 D01948 
 D02174 
 D02591 
 D02592 
 D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D05000   Methylprednisolone hemisuccinate   [2] 13, 97 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 D00385   Triamcinolone   [18] 6, 10, 13, 35, 40, 41, 42, 43, 44, 45, 46, 56, 70, 90, 96, 97, 226, 298 
 D00983 
 D00984 
 D00985 
 D06216 
 [3] OPRD1, OPRK1, OPRM1   D00729   Loperamide   [2] 13, 97 
 D07113 
 D08144 
 D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 D03783   Oxycodone   [7] 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 [2] PTGDR, TBXA2R   D01128   Ramatroban   [1] 13 
 [1] S1PR1   D10001   Fingolimod   [4] 2, 13, 14, 156 
 D11215   Ponesimod   [1] 13 
 [5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5   D10968   Ozanimod   [3] 13, 96, 97 
 [2] S1PR1, S1PR5   D11460   Siponimod   [2] 13, 50 
 [2] THRA, THRB   D01011   Liothyronine   [3] 13, 78, 212 
 D08128 
 122  Neurotrophin signaling pathway 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 
 [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] PSEN1   D09010   Tarenflurbil   [1] 13 
 123  NF-kappa B signaling pathway 
 4 genes, 9 drugs (DrugBank), 32 diseases shown 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] LTB   D08866   Baminercept   [4] 13, 46, 53, 97 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 [1] TNFSF13B   D09704   Atacicept   [4] 13, 46, 49, 66 
 124  Nicotine addiction 
 25 genes, 8 drugs (DrugBank), 22 diseases shown 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D02624   Eszopiclone   [3] 6, 13, 46 
 D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 125  Nitrogen metabolism 
 13 genes, 1 drug (DrugBank), 6 diseases shown 
 [13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 126  NOD-like receptor signaling pathway 
 2 genes, 3 drugs (DrugBank), 5 diseases shown 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 127  Non-alcoholic fatty liver disease (NAFLD) 
 4 genes, 3 drugs (DrugBank), 30 diseases shown 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] RXRA   D03106   Bexarotene   [2] 13, 75 
 128  Non-small cell lung cancer 
 4 genes, 2 drugs (DrugBank), 5 diseases shown 
 [1] RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 [3] RXRA, RXRB, RXRG   D03106   Bexarotene   [2] 13, 75 
 129  Notch signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 
 [4] APH1A, NCSTN, PSEN1, PSENEN   D09010   Tarenflurbil   [1] 13 
 130  One carbon pool by folate 
 2 genes, 1 drug (DrugBank), 33 diseases shown 
 [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 131  Oocyte meiosis 
 7 genes, 8 drugs (DrugBank), 34 diseases shown 
 [1] AR   D00075   Testosterone   [7] 1, 2, 3, 13, 78, 113, 265 
 D00957 
 D00958 
 D00959 
 D06085 
 D06087 
 D06087   Testosterone undecanoate   [1] 13 
 [1] PGR   D01217   Dydrogesterone   [1] 13 
 D00950   Levonorgestrel   [1] 13 
 D07222   Nomegestrol   [1] 13 
 D08281   Nomegestrol acetate   [1] 13 
 D00182   Norethisterone   [4] 13, 46, 49, 299 
 D00953 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 132  Osteoclast differentiation 
 9 genes, 6 drugs (DrugBank), 49 diseases shown 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 133  Ovarian steroidogenesis 
 2 genes, 7 drugs (DrugBank), 20 diseases shown 
 [1] CYP17A1   D00351   Ketoconazole   [3] 8, 13, 75 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 134  Oxidative phosphorylation 
 2 genes, 2 drugs (DrugBank), 16 diseases shown 
 [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 D02593   Pantoprazole   [2] 13, 65 
 D05353 
 135  Oxytocin signaling pathway 
 12 genes, 10 drugs (DrugBank), 50 diseases shown 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 D02716   Pregabalin   [5] 13, 36, 46, 70, 298 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 136  p53 signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 137  Pancreatic cancer 
 2 genes, 3 drugs (DrugBank), 38 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 138  Pancreatic secretion 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 
 [1] CA2   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 [1] CHRM3   D01699   Darifenacin   [2] 6, 13 
 D03654 
 139  Parathyroid hormone synthesis, secretion and action 
 8 genes, 4 drugs (DrugBank), 18 diseases shown 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D01385   Ibudilast   [2] 2, 13 
 D01783   Rolipram   [2] 8, 13 
 [3] RXRA, RXRB, RXRG   D03106   Bexarotene   [2] 13, 75 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 140  Parkinson disease 
 3 genes, 6 drugs (DrugBank), 14 diseases shown 
 [1] ADORA2A   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D00458   Quetiapine   [2] 6, 13 
 D08456 
 [1] SLC6A3   D03215   Armodafinil   [3] 6, 13, 84 
 D08130   Lisdexamfetamine   [1] 13 
 D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 141  Pathogenic Escherichia coli infection 
 2 genes, 2 drugs (DrugBank), 25 diseases shown 
 [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 142  Pathways in cancer 
 30 genes, 32 drugs (DrugBank), 95 diseases shown 
 [3] ABL1, KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] AR   D00075   Testosterone   [7] 1, 2, 3, 13, 78, 113, 265 
 D00957 
 D00958 
 D00959 
 D06085 
 D06087 
 D06087   Testosterone undecanoate   [1] 13 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [1] ESR1   D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D00185   Estriol   [2] 13, 227 
 D01986 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RA   D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] KEAP1   D03846   Dimethyl fumarate   [5] 13, 46, 49, 51, 86 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 [2] RARA, RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 [3] RXRA, RXRB, RXRG   D03106   Bexarotene   [2] 13, 75 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 143  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 7 genes, 4 drugs (DrugBank), 51 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 144  Peroxisome 
 1 gene, 1 drug (DrugBank), 3 diseases shown 
 [1] XDH   D01206   Febuxostat   [3] 2, 6, 13 
 145  Pertussis 
 4 genes, 2 drugs (DrugBank), 22 diseases shown 
 [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 146  Phagosome 
 20 genes, 1 drug (DrugBank), 4 diseases shown 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 147  Phenylalanine metabolism 
 1 gene, 1 drug (DrugBank), 8 diseases shown 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 148  Phospholipase D signaling pathway 
 4 genes, 5 drugs (DrugBank), 50 diseases shown 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 149  PI3K-Akt signaling pathway 
 16 genes, 18 drugs (DrugBank), 87 diseases shown 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [1] IL2RA   D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] RXRA   D03106   Bexarotene   [2] 13, 75 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 150  Platelet activation 
 3 genes, 8 drugs (DrugBank), 19 diseases shown 
 [1] PTGIR   D01385   Ibudilast   [2] 2, 13 
 [1] PTGS1   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 [1] TBXA2R   D01128   Ramatroban   [1] 13 
 151  Platinum drug resistance 
 2 genes, 4 drugs (DrugBank), 11 diseases shown 
 [2] TOP2A, TOP2B   D03730   Dexrazoxane   [1] 13 
 D00125   Etoposide   [11] 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331 
 D04107 
 D02166   Mitoxantrone   [1] 13 
 D08224 
 D05522   Pixantrone   [2] 11, 13 
 152  PPAR signaling pathway 
 4 genes, 2 drugs (DrugBank), 18 diseases shown 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [3] RXRA, RXRB, RXRG   D03106   Bexarotene   [2] 13, 75 
 153  Prion diseases 
 1 gene, 1 drug (DrugBank), 7 diseases shown 
 [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 154  Progesterone-mediated oocyte maturation 
 2 genes, 6 drugs (DrugBank), 5 diseases shown 
 [1] PDE3B   D01385   Ibudilast   [2] 2, 13 
 [1] PGR   D01217   Dydrogesterone   [1] 13 
 D00950   Levonorgestrel   [1] 13 
 D07222   Nomegestrol   [1] 13 
 D08281   Nomegestrol acetate   [1] 13 
 D00182   Norethisterone   [4] 13, 46, 49, 299 
 D00953 
 155  Prolactin signaling pathway 
 3 genes, 4 drugs (DrugBank), 8 diseases shown 
 [1] CYP17A1   D00351   Ketoconazole   [3] 8, 13, 75 
 [1] ESR1   D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D00185   Estriol   [2] 13, 227 
 D01986 
 156  Prostate cancer 
 5 genes, 7 drugs (DrugBank), 56 diseases shown 
 [1] AR   D00075   Testosterone   [7] 1, 2, 3, 13, 78, 113, 265 
 D00957 
 D00958 
 D00959 
 D06085 
 D06087 
 D06087   Testosterone undecanoate   [1] 13 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 157  Proteasome 
 1 gene, 1 drug (DrugBank), 4 diseases shown 
 [1] PSMB5   D10130   Ixazomib   [4] 13, 16, 28, 61 
 158  Proteoglycans in cancer 
 4 genes, 7 drugs (DrugBank), 51 diseases shown 
 [1] ESR1   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D00185   Estriol   [2] 13, 227 
 D01986 
 D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [1] IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 159  Proximal tubule bicarbonate reclamation 
 2 genes, 1 drug (DrugBank), 6 diseases shown 
 [2] CA2, CA4   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 160  Purine metabolism 
 12 genes, 9 drugs (DrugBank), 43 diseases shown 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D01385   Ibudilast   [2] 2, 13 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D01783   Rolipram   [2] 8, 13 
 [1] PDE5A   D02731   Vardenafil   [3] 13, 86, 299 
 D03260 
 D08668 
 [1] RRM1   D01370   Cladribine   [2] 13, 94 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 [1] XDH   D01206   Febuxostat   [3] 2, 6, 13 
 161  Pyrimidine metabolism 
 3 genes, 4 drugs (DrugBank), 23 diseases shown 
 [1] DHODH   D10172   Teriflunomide   [2] 13, 25 
 [1] RRM1   D01370   Cladribine   [2] 13, 94 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 162  Rap1 signaling pathway 
 12 genes, 16 drugs (DrugBank), 49 diseases shown 
 [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D00306   Dronabinol   [5] 2, 13, 46, 271, 298 
 D05099   Nabilone   [2] 6, 13 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D00458   Quetiapine   [2] 6, 13 
 D08456 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [3] GRIN1, GRIN2A, GRIN2B   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 163  Ras signaling pathway 
 8 genes, 9 drugs (DrugBank), 34 diseases shown 
 [3] ABL1, KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [3] GRIN1, GRIN2A, GRIN2B   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 164  Regulation of actin cytoskeleton 
 5 genes, 6 drugs (DrugBank), 25 diseases shown 
 [1] CHRM3   D01699   Darifenacin   [2] 6, 13 
 D03654 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 165  Regulation of lipolysis in adipocytes 
 7 genes, 12 drugs (DrugBank), 29 diseases shown 
 [1] ADORA1   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [3] ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] ADRB2   D08092   Isoxsuprine   [1] 13 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] ADRB3   D09535   Mirabegron   [3] 6, 13, 226 
 [1] PDE3B   D01385   Ibudilast   [2] 2, 13 
 [2] PTGS1, PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 166  Relaxin signaling pathway 
 2 genes, 2 drugs (DrugBank), 16 diseases shown 
 [1] EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 167  Renal cell carcinoma 
 1 gene, 1 drug (DrugBank), 9 diseases shown 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 168  Renin secretion 
 13 genes, 9 drugs (DrugBank), 51 diseases shown 
 [1] ADORA1   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [3] ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] ADRB2   D08092   Isoxsuprine   [1] 13 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] ADRB3   D09535   Mirabegron   [3] 6, 13, 226 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] EDNRA   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [2] PDE3A, PDE3B   D01385   Ibudilast   [2] 2, 13 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 169  Renin-angiotensin system 
 1 gene, 1 drug (DrugBank), 18 diseases shown 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 170  Retrograde endocannabinoid signaling 
 22 genes, 13 drugs (DrugBank), 33 diseases shown 
 [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D00306   Dronabinol   [5] 2, 13, 46, 271, 298 
 D05099   Nabilone   [2] 6, 13 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D02624   Eszopiclone   [3] 6, 13, 46 
 D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 171  Rheumatoid arthritis 
 23 genes, 8 drugs (DrugBank), 42 diseases shown 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IL17A   D09967   Secukinumab   [7] 13, 37, 41, 46, 160, 269, 271 
 [1] IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] LTB   D08866   Baminercept   [4] 13, 46, 53, 97 
 [2] TNFSF13, TNFSF13B   D09704   Atacicept   [4] 13, 46, 49, 66 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 172  RIG-I-like receptor signaling pathway 
 2 genes, 1 drug (DrugBank), 16 diseases shown 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 173  Salivary secretion 
 7 genes, 7 drugs (DrugBank), 18 diseases shown 
 [1] ADRA1A   D01692   Alfuzosin   [1] 13 
 D07124 
 D01965   Silodosin   [2] 6, 13 
 [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] ADRB2   D08092   Isoxsuprine   [1] 13 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] ADRB3   D09535   Mirabegron   [3] 6, 13, 226 
 [1] CHRM3   D01699   Darifenacin   [2] 6, 13 
 D03654 
 174  Serotonergic synapse 
 11 genes, 19 drugs (DrugBank), 31 diseases shown 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [3] GABRB1, GABRB2, GABRB3   D02624   Eszopiclone   [3] 6, 13, 46 
 D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] HTR2A   D00458   Quetiapine   [2] 6, 13 
 D08456 
 [3] HTR2A, HTR3A, HTR4   D00274   Cisapride   [1] 13 
 D02092 
 [1] HTR4   D09205   Prucalopride   [3] 13, 51, 96 
 [1] KCND2   D04127   Dalfampridine   [3] 3, 4, 13 
 [2] PTGS1, PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 [1] SLC6A4   D01179   Duloxetine   [3] 6, 13, 49 
 D07880 
 D02567   Escitalopram   [3] 2, 6, 13 
 D07704 
 D07913 
 D00326   Fluoxetine   [6] 13, 17, 78, 86, 179, 206 
 D00823 
 D02260   Paroxetine   [3] 6, 13, 46 
 D02362 
 D05374 
 D05375 
 D00821   Venlafaxine   [3] 6, 13, 46 
 D08670 
 175  Shigellosis 
 3 genes, 4 drugs (DrugBank), 49 diseases shown 
 [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 176  Signaling pathways regulating pluripotency of stem cells 
 1 gene, 1 drug (DrugBank), 4 diseases shown 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 177  Small cell lung cancer 
 5 genes, 8 drugs (DrugBank), 21 diseases shown 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 [1] RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 [3] RXRA, RXRB, RXRG   D03106   Bexarotene   [2] 13, 75 
 178  Sphingolipid signaling pathway 
 8 genes, 8 drugs (DrugBank), 23 diseases shown 
 [2] ADORA1, ADORA3   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] OPRD1   D00729   Loperamide   [2] 13, 97 
 D07113 
 D08144 
 D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 D03783   Oxycodone   [7] 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 [1] S1PR1   D10001   Fingolimod   [4] 2, 13, 14, 156 
 D11215   Ponesimod   [1] 13 
 [5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5   D10968   Ozanimod   [3] 13, 96, 97 
 [2] S1PR1, S1PR5   D11460   Siponimod   [2] 13, 50 
 179  Staphylococcus aureus infection 
 16 genes, 3 drugs (DrugBank), 16 diseases shown 
 [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 180  Steroid hormone biosynthesis 
 1 gene, 1 drug (DrugBank), 3 diseases shown 
 [1] CYP17A1   D00351   Ketoconazole   [3] 8, 13, 75 
 181  Synaptic vesicle cycle 
 5 genes, 11 drugs (DrugBank), 25 diseases shown 
 [1] SLC6A1   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [1] SLC6A2   D02574   Atomoxetine   [3] 6, 8, 13 
 D07473 
 [2] SLC6A2, SLC6A3   D08130   Lisdexamfetamine   [1] 13 
 D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 [2] SLC6A2, SLC6A4   D01179   Duloxetine   [3] 6, 13, 49 
 D07880 
 D00821   Venlafaxine   [3] 6, 13, 46 
 D08670 
 [1] SLC6A3   D03215   Armodafinil   [3] 6, 13, 84 
 [1] SLC6A4   D02567   Escitalopram   [3] 2, 6, 13 
 D07704 
 D07913 
 D00326   Fluoxetine   [6] 13, 17, 78, 86, 179, 206 
 D00823 
 D02260   Paroxetine   [3] 6, 13, 46 
 D02362 
 D05374 
 D05375 
 [1] SNAP25   D00783   Botulinum toxin type A   [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226 
 182  Systemic lupus erythematosus 
 20 genes, 9 drugs (DrugBank), 43 diseases shown 
 [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] ELANE   D03788   Sivelestat   [3] 13, 85, 96 
 [2] GRIN2A, GRIN2B   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 183  T cell receptor signaling pathway 
 6 genes, 2 drugs (DrugBank), 32 diseases shown 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 184  Taste transduction 
 16 genes, 14 drugs (DrugBank), 25 diseases shown 
 [1] CHRM3   D01699   Darifenacin   [2] 6, 13 
 D03654 
 [2] GABBR1, GABBR2   D09791   Arbaclofen   [2] 13, 206 
 D08861   Arbaclofen Placarbil   [1] 13 
 D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6   D02624   Eszopiclone   [3] 6, 13, 46 
 D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] HTR3A   D00274   Cisapride   [1] 13 
 D02092 
 [3] SCN2A, SCN3A, SCN9A   D00354   Lamotrigine   [3] 13, 34, 114 
 D00358   Lidocaine   [10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 D00533   Oxcarbazepine   [1] 13 
 D00512   Phenytoin   [1] 13 
 D02103 
 D00642   Quinidine   [3] 2, 8, 13 
 D00643 
 D02272 
 D08458 
 [3] SCNN1A, SCNN1B, SCNN1G   D00649   Amiloride   [3] 13, 225, 299 
 D07447 
 185  Terpenoid backbone biosynthesis 
 2 genes, 4 drugs (DrugBank), 35 diseases shown 
 [1] FDPS   D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 186  TGF-beta signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 
 [1] RGMA   D11355   Elezanumab   [1] 13 
 187  Th1 and Th2 cell differentiation 
 22 genes, 4 drugs (DrugBank), 39 diseases shown 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RA   D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 188  Th17 cell differentiation 
 29 genes, 11 drugs (DrugBank), 69 diseases shown 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IL17A   D09967   Secukinumab   [7] 13, 37, 41, 46, 160, 269, 271 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RA   D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 [3] RXRA, RXRB, RXRG   D03106   Bexarotene   [2] 13, 75 
 189  Thermogenesis 
 6 genes, 9 drugs (DrugBank), 60 diseases shown 
 [1] ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 D09535   Mirabegron   [3] 6, 13, 226 
 [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D00306   Dronabinol   [5] 2, 13, 46, 271, 298 
 D05099   Nabilone   [2] 6, 13 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 190  Thyroid cancer 
 4 genes, 2 drugs (DrugBank), 18 diseases shown 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [3] RXRA, RXRB, RXRG   D03106   Bexarotene   [2] 13, 75 
 191  Thyroid hormone signaling pathway 
 7 genes, 7 drugs (DrugBank), 42 diseases shown 
 [1] ESR1   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D00185   Estriol   [2] 13, 227 
 D01986 
 D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [3] RXRA, RXRB, RXRG   D03106   Bexarotene   [2] 13, 75 
 [2] THRA, THRB   D01011   Liothyronine   [3] 13, 78, 212 
 D08128 
 192  Tight junction 
 2 genes, 1 drug (DrugBank), 17 diseases shown 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 193  TNF signaling pathway 
 1 gene, 6 drugs (DrugBank), 18 diseases shown 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 194  Toll-like receptor signaling pathway 
 6 genes, 5 drugs (DrugBank), 30 diseases shown 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 D00746   Interferon beta-1b   [1] 13 
 D10483   Peginterferon beta-1a   [1] 13 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 195  Toxoplasmosis 
 16 genes, 2 drugs (DrugBank), 18 diseases shown 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 196  Transcriptional misregulation in cancer 
 9 genes, 7 drugs (DrugBank), 48 diseases shown 
 [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] ELANE   D03788   Sivelestat   [3] 13, 85, 96 
 [1] GRIA3   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 [3] RXRA, RXRB, RXRG   D03106   Bexarotene   [2] 13, 75 
 197  Tryptophan metabolism 
 1 gene, 1 drug (DrugBank), 8 diseases shown 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 198  Tuberculosis 
 23 genes, 4 drugs (DrugBank), 44 diseases shown 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 199  Type I diabetes mellitus 
 24 genes, 3 drugs (DrugBank), 30 diseases shown 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 200  Type II diabetes mellitus 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 201  Tyrosine metabolism 
 1 gene, 1 drug (DrugBank), 8 diseases shown 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 202  Ubiquinone and other terpenoid-quinone biosynthesis 
 2 genes, 1 drug (DrugBank), 10 diseases shown 
 [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 203  Ubiquitin mediated proteolysis 
 1 gene, 1 drug (DrugBank), 5 diseases shown 
 [1] KEAP1   D03846   Dimethyl fumarate   [5] 13, 46, 49, 51, 86 
 204  Vascular smooth muscle contraction 
 8 genes, 7 drugs (DrugBank), 34 diseases shown 
 [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] ADRA1A   D01692   Alfuzosin   [1] 13 
 D07124 
 D01965   Silodosin   [2] 6, 13 
 [3] ADRA1A, ADRA1B, ADRA1D   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] EDNRA   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [1] PTGIR   D01385   Ibudilast   [2] 2, 13 
 205  VEGF signaling pathway 
 7 genes, 8 drugs (DrugBank), 44 diseases shown 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00903   Diclofenac   [4] 13, 34, 46, 271 
 D00904 
 D07816 
 D00330   Flurbiprofen   [2] 13, 46 
 D01475 
 D02290 
 D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 D00118   Naproxen   [3] 13, 46, 271 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 206  Viral carcinogenesis 
 6 genes, 1 drug (DrugBank), 4 diseases shown 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 207  Viral myocarditis 
 24 genes, 4 drugs (DrugBank), 37 diseases shown 
 [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 208  Viral protein interaction with cytokine and cytokine receptor 
 2 genes, 2 drugs (DrugBank), 22 diseases shown 
 [1] IL2RA   D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 209  Wnt signaling pathway 
 6 genes, 2 drugs (DrugBank), 30 diseases shown 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PSEN1   D09010   Tarenflurbil   [1] 13 
 210  Yersinia infection 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 
 [1] ITGA4   D06590   Firategrast   [1] 13 
 D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 

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