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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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55 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adrenergic signaling in cardiomyocytes 
 6 genes, 3 drugs (DrugBank), 6 diseases shown 		  [5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] KCNQ1   D09569   Ezogabine   [2] 2, 144 
 [1] SCN5A   D05775   Rufinamide   [1] 144 
 2  Aldosterone synthesis and secretion 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 3  Alzheimer disease 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 4  Amphetamine addiction 
 6 genes, 2 drugs (DrugBank), 6 diseases shown 		  [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 5  Amyotrophic lateral sclerosis (ALS) 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [2] GRIA1, GRIA2   D08964   Perampanel   [3] 2, 6, 144 
 D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 6  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 7  Bile secretion 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 8  Calcium signaling pathway 
 7 genes, 2 drugs (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [3] HTR2A, HTR2B, HTR2C   D04148   Fenfluramine   [2] 140, 144 
 D07945 
 9  cAMP signaling pathway 
 8 genes, 2 drugs (DrugBank), 6 diseases shown 		  [8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 10  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CACNA1D   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 11  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 12  Cellular senescence 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CACNA1D   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 13  cGMP-PKG signaling pathway 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 14  Cholinergic synapse 
 9 genes, 2 drugs (DrugBank), 6 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5   D09569   Ezogabine   [2] 2, 144 
 15  Circadian entrainment 
 8 genes, 3 drugs (DrugBank), 12 diseases shown 		  [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 [2] MTNR1A, MTNR1B   D08170   Melatonin   [8] 6, 13, 46, 49, 90, 97, 144, 202 
 16  Cocaine addiction 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] GRIA2   D08964   Perampanel   [3] 2, 6, 144 
 D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 17  Collecting duct acid secretion 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 18  Cortisol synthesis and secretion 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 19  Cushing syndrome 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 20  Dilated cardiomyopathy (DCM) 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 21  Dopaminergic synapse 
 7 genes, 3 drugs (DrugBank), 6 diseases shown 		  [7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 [1] SCN1A   D05775   Rufinamide   [1] 144 
 22  GABAergic synapse 
 20 genes, 2 drugs (DrugBank), 5 diseases shown 		  [20] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D01253   Clobazam   [2] 140, 144 
 23  Gap junction 
 3 genes, 1 drug (DrugBank), 2 diseases shown 		  [3] HTR2A, HTR2B, HTR2C   D04148   Fenfluramine   [2] 140, 144 
 D07945 
 24  Gastric acid secretion 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] CA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] KCNQ1   D09569   Ezogabine   [2] 2, 144 
 25  Glutamatergic synapse 
 11 genes, 2 drugs (DrugBank), 6 diseases shown 		  [11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 26  GnRH secretion 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 27  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 28  Growth hormone synthesis, secretion and action 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 29  Hypertrophic cardiomyopathy (HCM) 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 30  Inflammatory mediator regulation of TRP channels 
 3 genes, 1 drug (DrugBank), 2 diseases shown 		  [3] HTR2A, HTR2B, HTR2C   D04148   Fenfluramine   [2] 140, 144 
 D07945 
 31  Insulin secretion 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 32  Long-term depression 
 3 genes, 2 drugs (DrugBank), 6 diseases shown 		  [3] GRIA1, GRIA2, GRIA3   D08964   Perampanel   [3] 2, 6, 144 
 D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 33  Long-term potentiation 
 3 genes, 2 drugs (DrugBank), 6 diseases shown 		  [3] CACNA1C, GRIA1, GRIA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [2] GRIA1, GRIA2   D08964   Perampanel   [3] 2, 6, 144 
 34  MAPK signaling pathway 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 35  Metabolic pathways 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] CA2, CA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 36  Morphine addiction 
 16 genes, 2 drugs (DrugBank), 5 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D01253   Clobazam   [2] 140, 144 
 D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 37  Neuroactive ligand-receptor interaction 
 32 genes, 6 drugs (DrugBank), 18 diseases shown 		  [2] CNR1, CNR2   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D01253   Clobazam   [2] 140, 144 
 [25] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 [3] HTR2A, HTR2B, HTR2C   D04148   Fenfluramine   [2] 140, 144 
 D07945 
 [2] MTNR1A, MTNR1B   D08170   Melatonin   [8] 6, 13, 46, 49, 90, 97, 144, 202 
 38  Nicotine addiction 
 20 genes, 3 drugs (DrugBank), 6 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D01253   Clobazam   [2] 140, 144 
 [20] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 39  Nitrogen metabolism 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] CA2, CA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 40  Oxytocin signaling pathway 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 41  Pancreatic secretion 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] CA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] KCNQ1   D09569   Ezogabine   [2] 2, 144 
 42  Protein digestion and absorption 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] KCNQ1   D09569   Ezogabine   [2] 2, 144 
 43  Proximal tubule bicarbonate reclamation 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] CA2, CA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 44  Rap1 signaling pathway 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 45  Renin secretion 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 46  Retrograde endocannabinoid signaling 
 25 genes, 4 drugs (DrugBank), 15 diseases shown 		  [24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D01253   Clobazam   [2] 140, 144 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 47  Serotonergic synapse 
 11 genes, 3 drugs (DrugBank), 5 diseases shown 		  [7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [3] GABRB1, GABRB2, GABRB3   D01253   Clobazam   [2] 140, 144 
 [4] HTR2A, HTR2B, HTR2C, SLC6A4   D04148   Fenfluramine   [2] 140, 144 
 D07945 
 48  Synaptic vesicle cycle 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SLC6A4   D04148   Fenfluramine   [2] 140, 144 
 D07945 
 49  Taste transduction 
 10 genes, 3 drugs (DrugBank), 5 diseases shown 		  [10] CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6   D01253   Clobazam   [2] 140, 144 
 [3] SCN2A, SCN3A, SCN9A   D05775   Rufinamide   [1] 144 
 50  Thermogenesis 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 51  Tight junction 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CACNA1D   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 52  Transcriptional misregulation in cancer 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] GRIA3   D08964   Perampanel   [3] 2, 6, 144 
 D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 53  Type II diabetes mellitus 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] CACNA1C, CACNA1D   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 54  Vascular smooth muscle contraction 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 55  Vibrio cholerae infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] KCNQ1   D09569   Ezogabine   [2] 2, 144 

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