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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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98 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 2 genes, 2 drugs (DrugBank), 36 diseases shown 		  [1] MPO   D11684   Verdiperstat   [1] 17 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 2  Adipocytokine signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 3  Adrenergic signaling in cardiomyocytes 
 7 genes, 7 drugs (DrugBank), 25 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2   D01277   Droxidopa   [3] 5, 6, 17 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] AGTR1, AGTR2   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 4  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 2 drugs (DrugBank), 20 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 5  Alcoholism 
 9 genes, 6 drugs (DrugBank), 14 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [2] DRD1, DRD2   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 6  Aldosterone synthesis and secretion 
 1 gene, 2 drugs (DrugBank), 20 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 7  Aldosterone-regulated sodium reabsorption 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] NR3C2   D00986   Fludrocortisone   [3] 6, 17, 81 
 D07967 
 8  Alzheimer disease 
 5 genes, 1 drug (DrugBank), 7 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 9  Amphetamine addiction 
 12 genes, 5 drugs (DrugBank), 12 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] DRD1   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 10  AMPK signaling pathway 
 2 genes, 4 drugs (DrugBank), 39 diseases shown 		  [1] ADRA1A   D01277   Droxidopa   [3] 5, 6, 17 
 D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 11  Amyotrophic lateral sclerosis (ALS) 
 7 genes, 1 drug (DrugBank), 7 diseases shown 		  [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 12  Apelin signaling pathway 
 2 genes, 3 drugs (DrugBank), 46 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 13  Arginine and proline metabolism 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 14  Autophagy - animal 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 15  Autophagy - other 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 16  Breast cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 17  Calcium signaling pathway 
 13 genes, 9 drugs (DrugBank), 32 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3   D01277   Droxidopa   [3] 5, 6, 17 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] DRD1, DRD5   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 18  cAMP signaling pathway 
 14 genes, 7 drugs (DrugBank), 21 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [2] ADRB1, ADRB2   D01277   Droxidopa   [3] 5, 6, 17 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 [3] DRD1, DRD2, DRD5   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 19  Cellular senescence 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 20  Central carbon metabolism in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 21  cGMP-PKG signaling pathway 
 10 genes, 7 drugs (DrugBank), 25 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3   D01277   Droxidopa   [3] 5, 6, 17 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 22  Chagas disease (American trypanosomiasis) 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ACE   D00251   Captopril   [2] 17, 86 
 23  Choline metabolism in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 24  Circadian entrainment 
 9 genes, 1 drug (DrugBank), 7 diseases shown 		  [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 25  Cocaine addiction 
 10 genes, 6 drugs (DrugBank), 14 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [2] DRD1, DRD2   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 [6] GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 26  Colorectal cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 27  Cortisol synthesis and secretion 
 1 gene, 2 drugs (DrugBank), 20 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 28  Cushing syndrome 
 1 gene, 2 drugs (DrugBank), 20 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 29  Dilated cardiomyopathy (DCM) 
 1 gene, 4 drugs (DrugBank), 10 diseases shown 		  [1] ADRB1   D01277   Droxidopa   [3] 5, 6, 17 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 30  Dopaminergic synapse 
 14 genes, 7 drugs (DrugBank), 14 diseases shown 		  [1] COMT   D00781   Entacapone   [2] 6, 17 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [5] DRD1, DRD2, DRD3, DRD4, DRD5   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 31  Drug metabolism - cytochrome P450 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 32  Drug metabolism - other enzymes 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] MPO   D11684   Verdiperstat   [1] 17 
 33  EGFR tyrosine kinase inhibitor resistance 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 34  Endocrine resistance 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 35  ErbB signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 36  GABAergic synapse 
 16 genes, 1 drug (DrugBank), 5 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 37  Gap junction 
 3 genes, 6 drugs (DrugBank), 18 diseases shown 		  [1] ADRB1   D01277   Droxidopa   [3] 5, 6, 17 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 [2] DRD1, DRD2   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 38  Gastric cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 39  Glioma 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 40  Glutamatergic synapse 
 14 genes, 1 drug (DrugBank), 7 diseases shown 		  [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 41  Glycine, serine and threonine metabolism 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 42  Growth hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 43  Hematopoietic cell lineage 
 1 gene, 1 drug (DrugBank), 42 diseases shown 		  [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 44  Hepatocellular carcinoma 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 45  Herpes simplex virus 1 infection 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 46  HIF-1 signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 47  Histidine metabolism 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 48  Human cytomegalovirus infection 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 49  Human immunodeficiency virus 1 infection 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 50  Human papillomavirus infection 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 51  Huntington disease 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] GRIN1, GRIN2B   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 52  Hypertrophic cardiomyopathy (HCM) 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ACE   D00251   Captopril   [2] 17, 86 
 53  Insulin resistance 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 54  Insulin secretion 
 1 gene, 1 drug (DrugBank), 13 diseases shown 		  [1] SNAP25   D00783   Botulinum toxin type A   [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226 
 55  Insulin signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 56  JAK-STAT signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 57  Kaposi sarcoma-associated herpesvirus infection 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 58  Long-term depression 
 3 genes, 1 drug (DrugBank), 7 diseases shown 		  [3] GRIA1, GRIA2, GRIA3   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 59  Long-term potentiation 
 7 genes, 1 drug (DrugBank), 7 diseases shown 		  [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 60  Longevity regulating pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 61  Longevity regulating pathway - multiple species 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 62  Metabolic pathways 
 3 genes, 4 drugs (DrugBank), 9 diseases shown 		  [1] COMT   D00781   Entacapone   [2] 6, 17 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 63  MicroRNAs in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 64  Morphine addiction 
 17 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] DRD1   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 65  mTOR signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 66  Neuroactive ligand-receptor interaction 
 47 genes, 12 drugs (DrugBank), 35 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3   D01277   Droxidopa   [3] 5, 6, 17 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] AGTR1, AGTR2   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 [1] CHRNA10   D00612   Trimethaphan   [1] 17 
 [5] DRD1, DRD2, DRD3, DRD4, DRD5   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 67  Nicotine addiction 
 25 genes, 2 drugs (DrugBank), 9 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 68  Pancreatic cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 69  Parkinson disease 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] DRD1, DRD2   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 70  Pathways in cancer 
 2 genes, 3 drugs (DrugBank), 46 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 71  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 72  Phagosome 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] MPO   D11684   Verdiperstat   [1] 17 
 73  Phenylalanine metabolism 
 2 genes, 3 drugs (DrugBank), 9 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 74  Phospholipase D signaling pathway 
 2 genes, 3 drugs (DrugBank), 46 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 75  PI3K-Akt signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 76  Prostate cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 77  Proteoglycans in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 78  Rap1 signaling pathway 
 4 genes, 3 drugs (DrugBank), 14 diseases shown 		  [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [3] GRIN1, GRIN2A, GRIN2B   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 79  Ras signaling pathway 
 3 genes, 1 drug (DrugBank), 7 diseases shown 		  [3] GRIN1, GRIN2A, GRIN2B   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 80  Regulation of lipolysis in adipocytes 
 3 genes, 4 drugs (DrugBank), 10 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [3] ADRB1, ADRB2, ADRB3   D01277   Droxidopa   [3] 5, 6, 17 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 81  Renin secretion 
 5 genes, 7 drugs (DrugBank), 25 diseases shown 		  [1] ACE   D00251   Captopril   [2] 17, 86 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 [3] ADRB1, ADRB2, ADRB3   D01277   Droxidopa   [3] 5, 6, 17 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 82  Renin-angiotensin system 
 3 genes, 3 drugs (DrugBank), 20 diseases shown 		  [1] ACE   D00251   Captopril   [2] 17, 86 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] AGTR1, AGTR2   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 83  Retrograde endocannabinoid signaling 
 20 genes, 2 drugs (DrugBank), 9 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 84  Salivary secretion 
 6 genes, 5 drugs (DrugBank), 10 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3   D01277   Droxidopa   [3] 5, 6, 17 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 D05127   Nebivolol   [3] 17, 113, 167 
 85  Serotonergic synapse 
 6 genes, 5 drugs (DrugBank), 14 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [3] GABRB1, GABRB2, GABRB3   D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 [1] SLC6A4   D00326   Fluoxetine   [6] 13, 17, 78, 86, 179, 206 
 D00823 
 86  Shigellosis 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 87  Steroid hormone biosynthesis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] COMT   D00781   Entacapone   [2] 6, 17 
 88  Synaptic vesicle cycle 
 2 genes, 2 drugs (DrugBank), 17 diseases shown 		  [1] SLC6A4   D00326   Fluoxetine   [6] 13, 17, 78, 86, 179, 206 
 D00823 
 [1] SNAP25   D00783   Botulinum toxin type A   [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226 
 89  Systemic lupus erythematosus 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] GRIN2A, GRIN2B   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 90  Taste transduction 
 6 genes, 1 drug (DrugBank), 5 diseases shown 		  [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6   D00697   Flumazenil   [5] 6, 13, 17, 18, 206 
 91  Th17 cell differentiation 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 92  Thermogenesis 
 2 genes, 3 drugs (DrugBank), 38 diseases shown 		  [1] ADRB3   D01277   Droxidopa   [3] 5, 6, 17 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 93  Thyroid hormone signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 94  Transcriptional misregulation in cancer 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [1] GRIA3   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] MPO   D11684   Verdiperstat   [1] 17 
 95  Tryptophan metabolism 
 2 genes, 3 drugs (DrugBank), 9 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 96  Type II diabetes mellitus 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 97  Tyrosine metabolism 
 3 genes, 4 drugs (DrugBank), 9 diseases shown 		  [1] COMT   D00781   Entacapone   [2] 6, 17 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 D10158   Safinamide   [2] 6, 17 
 98  Vascular smooth muscle contraction 
 4 genes, 5 drugs (DrugBank), 22 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D01277   Droxidopa   [3] 5, 6, 17 
 D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 D00485   Pseudoephedrine   [1] 17 
 D05648 
 D05649 
 D08449 
 [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 

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