Target Gene/Pathway
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z other
No. | KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * [Number of genes] |
KEGG DRUG * | DrugBank | Disease ID * [Number of diseases] |
1 | Antifolate resistance |
[2] DHFR, DHFR2 | D00142 | Methotrexate | [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 |
D02115 | |||||
2 | Folate biosynthesis |
[1] ALPL | D10595 | Asfotase alfa | [1] 172 |
[2] DHFR, DHFR2 | D00142 | Methotrexate | [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 | ||
D02115 | |||||
3 | Metabolic pathways |
[1] ALPL | D10595 | Asfotase alfa | [1] 172 |
[2] DHFR, DHFR2 | D00142 | Methotrexate | [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 | ||
D02115 | |||||
4 | One carbon pool by folate |
[2] DHFR, DHFR2 | D00142 | Methotrexate | [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 |
D02115 | |||||
5 | Thiamine metabolism |
[1] ALPL | D10595 | Asfotase alfa | [1] 172 |