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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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147 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adipocytokine signaling pathway 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 2  Adrenergic signaling in cardiomyocytes 
 6 genes, 3 drugs (DrugBank), 24 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] AGTR1, AGTR2   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 3  African trypanosomiasis 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 4  AGE-RAGE signaling pathway in diabetic complications 
 2 genes, 3 drugs (DrugBank), 29 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 5  Alcoholism 
 11 genes, 1 drug (DrugBank), 2 diseases shown 		  [11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9   D06320   Vorinostat   [2] 19, 96 
 6  Aldosterone synthesis and secretion 
 1 gene, 2 drugs (DrugBank), 20 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 7  Allograft rejection 
 3 genes, 2 drugs (DrugBank), 30 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 8  Alzheimer disease 
 6 genes, 2 drugs (DrugBank), 50 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 9  Amoebiasis 
 3 genes, 2 drugs (DrugBank), 26 diseases shown 		  [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 10  Amphetamine addiction 
 7 genes, 2 drugs (DrugBank), 45 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 11  Amyotrophic lateral sclerosis (ALS) 
 6 genes, 2 drugs (DrugBank), 50 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 12  Antifolate resistance 
 3 genes, 2 drugs (DrugBank), 39 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 13  Antigen processing and presentation 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 14  Apelin signaling pathway 
 3 genes, 3 drugs (DrugBank), 20 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] HDAC4, HDAC5   D06320   Vorinostat   [2] 19, 96 
 15  Apoptosis 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 16  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 1 drug (DrugBank), 7 diseases shown 		  [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 17  Asthma 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 18  Autoimmune thyroid disease 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 19  Axon guidance 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 20  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 21  C-type lectin receptor signaling pathway 
 6 genes, 2 drugs (DrugBank), 50 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 22  Calcium signaling pathway 
 10 genes, 4 drugs (DrugBank), 58 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CHRM1, CHRM2, CHRM3, CHRM5   D00397   Tropicamide   [2] 6, 19 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 23  cAMP signaling pathway 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] CHRM1, CHRM2   D00397   Tropicamide   [2] 6, 19 
 24  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank), 7 diseases shown 		  [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 25  Cell adhesion molecules (CAMs) 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 26  Cell cycle 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 27  Cellular senescence 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 28  cGMP-PKG signaling pathway 
 6 genes, 3 drugs (DrugBank), 57 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 29  Chagas disease (American trypanosomiasis) 
 2 genes, 2 drugs (DrugBank), 17 diseases shown 		  [1] ACE   D00621   Enalapril   [4] 19, 46, 66, 113 
 D07892 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 30  Cholesterol metabolism 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] LIPA   D10377   Sebelipase alfa   [1] 19 
 31  Cholinergic synapse 
 5 genes, 1 drug (DrugBank), 2 diseases shown 		  [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5   D00397   Tropicamide   [2] 6, 19 
 32  Chronic myeloid leukemia 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 33  Cortisol synthesis and secretion 
 1 gene, 2 drugs (DrugBank), 20 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 34  Cushing syndrome 
 1 gene, 2 drugs (DrugBank), 20 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 35  Cytokine-cytokine receptor interaction 
 4 genes, 3 drugs (DrugBank), 38 diseases shown 		  [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 36  Dilated cardiomyopathy (DCM) 
 5 genes, 2 drugs (DrugBank), 19 diseases shown 		  [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 37  DNA replication 
 2 genes, 1 drug (DrugBank), 9 diseases shown 		  [2] POLA1, POLA2   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 38  Dopaminergic synapse 
 3 genes, 1 drug (DrugBank), 44 diseases shown 		  [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 39  Drug metabolism - other enzymes 
 5 genes, 5 drugs (DrugBank), 39 diseases shown 		  [1] GUSB   D11004   Vestronidase alfa   [1] 19 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 40  Endocrine and other factor-regulated calcium reabsorption 
 1 gene, 2 drugs (DrugBank), 17 diseases shown 		  [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 D00930   Paricalcitol   [3] 19, 66, 218 
 41  Epstein-Barr virus infection 
 3 genes, 2 drugs (DrugBank), 15 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 42  Fc epsilon RI signaling pathway 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 43  Fluid shear stress and atherosclerosis 
 4 genes, 3 drugs (DrugBank), 31 diseases shown 		  [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 44  Folate biosynthesis 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 45  GABAergic synapse 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] SLC6A1   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 46  Galactose metabolism 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] GLA   D03228   Agalsidase beta   [1] 19 
 47  Gastric acid secretion 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CHRM3   D00397   Tropicamide   [2] 6, 19 
 48  Glucagon signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 49  Glutamatergic synapse 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 50  Glutathione metabolism 
 2 genes, 2 drugs (DrugBank), 15 diseases shown 		  [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 51  Glycerolipid metabolism 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] GLA   D03228   Agalsidase beta   [1] 19 
 52  Glycosaminoglycan degradation 
 5 genes, 5 drugs (DrugBank), 1 disease shown 		  [1] ARSB   D06565   Galsulfase   [1] 19 
 [1] GALNS   D10333   Elosulfase alfa   [1] 19 
 [1] GUSB   D11004   Vestronidase alfa   [1] 19 
 [1] IDS   D04499   Idursulfase   [1] 19 
 [1] IDUA   D04670   Laronidase   [1] 19 
 53  Glycosphingolipid biosynthesis - globo and isoglobo series 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] GLA   D03228   Agalsidase beta   [1] 19 
 54  Graft-versus-host disease 
 3 genes, 2 drugs (DrugBank), 30 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 55  Growth hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 56  Hematopoietic cell lineage 
 3 genes, 2 drugs (DrugBank), 26 diseases shown 		  [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 57  Hepatitis B 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 58  Hepatitis C 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 59  Hepatocellular carcinoma 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 60  Herpes simplex virus 1 infection 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 61  Human cytomegalovirus infection 
 7 genes, 3 drugs (DrugBank), 58 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 62  Human immunodeficiency virus 1 infection 
 6 genes, 2 drugs (DrugBank), 50 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 63  Human papillomavirus infection 
 3 genes, 2 drugs (DrugBank), 15 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 64  Human T-cell leukemia virus 1 infection 
 9 genes, 4 drugs (DrugBank), 58 diseases shown 		  [1] FDPS   D00939   Alendronic acid   [7] 19, 41, 46, 50, 271, 274, 299 
 D07119 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 65  Huntington disease 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 66  Hypertrophic cardiomyopathy (HCM) 
 6 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] ACE   D00621   Enalapril   [4] 19, 46, 66, 113 
 D07892 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 67  IL-17 signaling pathway 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 68  Inflammatory bowel disease (IBD) 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 69  Inflammatory mediator regulation of TRP channels 
 2 genes, 2 drugs (DrugBank), 20 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TRPV1   D00250   Capsaicin   [6] 2, 6, 19, 86, 113, 226 
 70  Influenza A 
 2 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] FDPS   D00939   Alendronic acid   [7] 19, 41, 46, 50, 271, 274, 299 
 D07119 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 71  Insulin resistance 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 72  Insulin secretion 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CHRM3   D00397   Tropicamide   [2] 6, 19 
 73  Intestinal immune network for IgA production 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 74  JAK-STAT signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 75  Kaposi sarcoma-associated herpesvirus infection 
 6 genes, 2 drugs (DrugBank), 53 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 76  Legionellosis 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 77  Leishmaniasis 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 78  Long-term potentiation 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 79  Longevity regulating pathway - multiple species 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 80  Lysosome 
 10 genes, 12 drugs (DrugBank), 1 disease shown 		  [1] ARSB   D06565   Galsulfase   [1] 19 
 [1] GALNS   D10333   Elosulfase alfa   [1] 19 
 [1] GBA   D03020   Imiglucerase   [1] 19 
 D09675   Taliglucerase alfa   [1] 19 
 D09029   Velaglucerase alfa   [1] 19 
 [1] GLA   D03228   Agalsidase beta   [1] 19 
 [1] GUSB   D11004   Vestronidase alfa   [1] 19 
 [1] IDS   D04499   Idursulfase   [1] 19 
 [1] IDUA   D04670   Laronidase   [1] 19 
 [1] LIPA   D10377   Sebelipase alfa   [1] 19 
 [1] MAN2B1   D11024   Velmanase alfa   [1] 19 
 [1] TPP1   D10813   Cerliponase alfa   [1] 19 
 81  Malaria 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 82  MAPK signaling pathway 
 11 genes, 4 drugs (DrugBank), 61 diseases shown 		  [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 83  Metabolic pathways 
 17 genes, 20 drugs (DrugBank), 57 diseases shown 		  [1] ARSB   D06565   Galsulfase   [1] 19 
 [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] FDPS   D00939   Alendronic acid   [7] 19, 41, 46, 50, 271, 274, 299 
 D07119 
 [1] GALNS   D10333   Elosulfase alfa   [1] 19 
 [1] GBA   D03020   Imiglucerase   [1] 19 
 D09675   Taliglucerase alfa   [1] 19 
 D09029   Velaglucerase alfa   [1] 19 
 [1] GLA   D03228   Agalsidase beta   [1] 19 
 [1] GUSB   D11004   Vestronidase alfa   [1] 19 
 [1] IDS   D04499   Idursulfase   [1] 19 
 [1] IDUA   D04670   Laronidase   [1] 19 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 [1] UGCG   D09893   Eliglustat   [1] 19 
 D11439   Lucerastat   [1] 19 
 D05032   Miglustat   [3] 19, 256, 299 
 D11633   Venglustat   [2] 19, 67 
 84  MicroRNAs in cancer 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] HDAC1, HDAC2, HDAC4, HDAC5   D06320   Vorinostat   [2] 19, 96 
 85  Mineral absorption 
 1 gene, 2 drugs (DrugBank), 17 diseases shown 		  [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 D00930   Paricalcitol   [3] 19, 66, 218 
 86  mTOR signaling pathway 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 87  Natural killer cell mediated cytotoxicity 
 6 genes, 2 drugs (DrugBank), 50 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 88  Necroptosis 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 89  Neuroactive ligand-receptor interaction 
 9 genes, 5 drugs (DrugBank), 34 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] AGTR1, AGTR2   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5   D00397   Tropicamide   [2] 6, 19 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] TRPV1   D00250   Capsaicin   [6] 2, 6, 19, 86, 113, 226 
 90  NF-kappa B signaling pathway 
 2 genes, 2 drugs (DrugBank), 26 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 91  NOD-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 92  Non-alcoholic fatty liver disease (NAFLD) 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 93  Notch signaling pathway 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 94  One carbon pool by folate 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 95  Oocyte meiosis 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 96  Osteoclast differentiation 
 7 genes, 3 drugs (DrugBank), 58 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 97  Other glycan degradation 
 2 genes, 4 drugs (DrugBank), 1 disease shown 		  [1] GBA   D03020   Imiglucerase   [1] 19 
 D09675   Taliglucerase alfa   [1] 19 
 D09029   Velaglucerase alfa   [1] 19 
 [1] MAN2B1   D11024   Velmanase alfa   [1] 19 
 98  Oxytocin signaling pathway 
 9 genes, 2 drugs (DrugBank), 48 diseases shown 		  [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 99  p53 signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 100  Pancreatic secretion 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CHRM3   D00397   Tropicamide   [2] 6, 19 
 101  Parathyroid hormone synthesis, secretion and action 
 1 gene, 2 drugs (DrugBank), 17 diseases shown 		  [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 D00930   Paricalcitol   [3] 19, 66, 218 
 102  Pathogenic Escherichia coli infection 
 2 genes, 2 drugs (DrugBank), 26 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 103  Pathways in cancer 
 4 genes, 4 drugs (DrugBank), 24 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 104  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 105  Pentose and glucuronate interconversions 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] GUSB   D11004   Vestronidase alfa   [1] 19 
 106  Pertussis 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 107  Phospholipase D signaling pathway 
 1 gene, 2 drugs (DrugBank), 20 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 108  PI3K-Akt signaling pathway 
 3 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] CHRM1, CHRM2   D00397   Tropicamide   [2] 6, 19 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 109  Porphyrin and chlorophyll metabolism 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] GUSB   D11004   Vestronidase alfa   [1] 19 
 110  Prostate cancer 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 111  Proteoglycans in cancer 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 112  Purine metabolism 
 4 genes, 4 drugs (DrugBank), 39 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 113  Pyrimidine metabolism 
 2 genes, 2 drugs (DrugBank), 15 diseases shown 		  [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 114  Regulation of actin cytoskeleton 
 5 genes, 1 drug (DrugBank), 2 diseases shown 		  [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5   D00397   Tropicamide   [2] 6, 19 
 115  Renin secretion 
 7 genes, 4 drugs (DrugBank), 57 diseases shown 		  [1] ACE   D00621   Enalapril   [4] 19, 46, 66, 113 
 D07892 
 [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 116  Renin-angiotensin system 
 3 genes, 3 drugs (DrugBank), 20 diseases shown 		  [1] ACE   D00621   Enalapril   [4] 19, 46, 66, 113 
 D07892 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] AGTR1, AGTR2   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 117  Rheumatoid arthritis 
 3 genes, 2 drugs (DrugBank), 30 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 118  RIG-I-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 119  Salivary secretion 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CHRM3   D00397   Tropicamide   [2] 6, 19 
 120  Shigellosis 
 2 genes, 2 drugs (DrugBank), 26 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 121  Sphingolipid metabolism 
 3 genes, 8 drugs (DrugBank), 4 diseases shown 		  [1] GBA   D03020   Imiglucerase   [1] 19 
 D09675   Taliglucerase alfa   [1] 19 
 D09029   Velaglucerase alfa   [1] 19 
 [1] GLA   D03228   Agalsidase beta   [1] 19 
 [1] UGCG   D09893   Eliglustat   [1] 19 
 D11439   Lucerastat   [1] 19 
 D05032   Miglustat   [3] 19, 256, 299 
 D11633   Venglustat   [2] 19, 67 
 122  Sphingolipid signaling pathway 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 123  Steroid biosynthesis 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] LIPA   D10377   Sebelipase alfa   [1] 19 
 124  Synaptic vesicle cycle 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] SLC6A1   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 125  Systemic lupus erythematosus 
 3 genes, 2 drugs (DrugBank), 30 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 126  T cell receptor signaling pathway 
 6 genes, 2 drugs (DrugBank), 50 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 127  Taste transduction 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CHRM3   D00397   Tropicamide   [2] 6, 19 
 128  Terpenoid backbone biosynthesis 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] FDPS   D00939   Alendronic acid   [7] 19, 41, 46, 50, 271, 274, 299 
 D07119 
 129  TGF-beta signaling pathway 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 130  Th1 and Th2 cell differentiation 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 131  Th17 cell differentiation 
 6 genes, 2 drugs (DrugBank), 54 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 132  Thyroid hormone signaling pathway 
 3 genes, 1 drug (DrugBank), 2 diseases shown 		  [3] HDAC1, HDAC2, HDAC3   D06320   Vorinostat   [2] 19, 96 
 133  TNF signaling pathway 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 134  Toll-like receptor signaling pathway 
 3 genes, 2 drugs (DrugBank), 30 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 135  Toxoplasmosis 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 136  Transcriptional misregulation in cancer 
 4 genes, 3 drugs (DrugBank), 32 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 137  Tuberculosis 
 7 genes, 4 drugs (DrugBank), 57 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 D00930   Paricalcitol   [3] 19, 66, 218 
 138  Type I diabetes mellitus 
 3 genes, 2 drugs (DrugBank), 30 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 139  Type II diabetes mellitus 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 140  Ubiquinone and other terpenoid-quinone biosynthesis 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 141  Vascular smooth muscle contraction 
 1 gene, 2 drugs (DrugBank), 20 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 142  VEGF signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 143  Viral carcinogenesis 
 11 genes, 1 drug (DrugBank), 2 diseases shown 		  [11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9   D06320   Vorinostat   [2] 19, 96 
 144  Viral myocarditis 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 145  Viral protein interaction with cytokine and cytokine receptor 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 146  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 147  Yersinia infection 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 

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