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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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59 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  ABC transporters 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] ABCC8   D00294   Diazoxide   [1] 193 
 2  Adrenergic signaling in cardiomyocytes 
 6 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 3  Aldosterone synthesis and secretion 
 5 genes, 2 drugs (DrugBank), 16 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 4  Alzheimer disease 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 5  Amphetamine addiction 
 6 genes, 1 drug (DrugBank), 5 diseases shown 		  [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 6  Amyotrophic lateral sclerosis (ALS) 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] GRIA1, GRIA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 7  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 8  Bile secretion 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 9  Calcium signaling pathway 
 6 genes, 4 drugs (DrugBank), 13 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] OXTR   D07229   Carbetocin   [1] 193 
 D00089   Oxytocin   [4] 127, 193, 206, 226 
 10  cAMP signaling pathway 
 13 genes, 8 drugs (DrugBank), 29 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] GLP1R   D04121   Exenatide   [3] 6, 193, 233 
 D06404   Liraglutide   [3] 6, 75, 193 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [1] OXTR   D07229   Carbetocin   [1] 193 
 D00089   Oxytocin   [4] 127, 193, 206, 226 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 11  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CACNA1D   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 12  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 13  Cellular senescence 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CACNA1D   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 14  cGMP-PKG signaling pathway 
 6 genes, 3 drugs (DrugBank), 11 diseases shown 		  [1] ADRA2A   D00606   Guanfacine   [1] 193 
 D08031 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 15  Cholinergic synapse 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 16  Circadian entrainment 
 6 genes, 1 drug (DrugBank), 5 diseases shown 		  [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 17  Cocaine addiction 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] GRIA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 18  Collecting duct acid secretion 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 19  Cortisol synthesis and secretion 
 6 genes, 3 drugs (DrugBank), 16 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] CYP11B1   D00410   Metyrapone   [2] 75, 193 
 D05019 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 20  Cushing syndrome 
 6 genes, 3 drugs (DrugBank), 16 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] CYP11B1   D00410   Metyrapone   [2] 75, 193 
 D05019 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 21  Cytokine-cytokine receptor interaction 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 22  Dilated cardiomyopathy (DCM) 
 5 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 23  Dopaminergic synapse 
 7 genes, 1 drug (DrugBank), 5 diseases shown 		  [7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 24  GABAergic synapse 
 20 genes, 1 drug (DrugBank), 5 diseases shown 		  [20] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 25  Gap junction 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 26  Gastric acid secretion 
 2 genes, 2 drugs (DrugBank), 12 diseases shown 		  [1] CA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 27  Glutamatergic synapse 
 11 genes, 1 drug (DrugBank), 5 diseases shown 		  [11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 28  GnRH secretion 
 5 genes, 2 drugs (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] KCNJ11   D00294   Diazoxide   [1] 193 
 29  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 30  Growth hormone synthesis, secretion and action 
 6 genes, 3 drugs (DrugBank), 27 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 31  Hypertrophic cardiomyopathy (HCM) 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 32  Insulin secretion 
 7 genes, 4 drugs (DrugBank), 7 diseases shown 		  [2] ABCC8, KCNJ11   D00294   Diazoxide   [1] 193 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] GLP1R   D04121   Exenatide   [3] 6, 193, 233 
 D06404   Liraglutide   [3] 6, 75, 193 
 33  JAK-STAT signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 34  Long-term depression 
 3 genes, 1 drug (DrugBank), 5 diseases shown 		  [3] GRIA1, GRIA2, GRIA3   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 35  Long-term potentiation 
 3 genes, 1 drug (DrugBank), 5 diseases shown 		  [3] CACNA1C, GRIA1, GRIA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 36  MAPK signaling pathway 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 37  Metabolic pathways 
 4 genes, 3 drugs (DrugBank), 8 diseases shown 		  [2] CA2, CA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] CYP11B1   D00410   Metyrapone   [2] 75, 193 
 D05019 
 [1] CYP19A1   D00960   Anastrozole   [3] 78, 86, 193 
 38  Morphine addiction 
 16 genes, 1 drug (DrugBank), 5 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 39  Neuroactive ligand-receptor interaction 
 34 genes, 12 drugs (DrugBank), 44 diseases shown 		  [1] ADRA2A   D00606   Guanfacine   [1] 193 
 D08031 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] CNR1   D05731   Rimonabant   [1] 193 
 [2] CNR1, CNR2   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [25] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] GLP1R   D04121   Exenatide   [3] 6, 193, 233 
 D06404   Liraglutide   [3] 6, 75, 193 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [1] OXTR   D07229   Carbetocin   [1] 193 
 D00089   Oxytocin   [4] 127, 193, 206, 226 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 40  Nicotine addiction 
 20 genes, 1 drug (DrugBank), 5 diseases shown 		  [20] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 41  Nitrogen metabolism 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] CA2, CA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 42  Ovarian steroidogenesis 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] CYP19A1   D00960   Anastrozole   [3] 78, 86, 193 
 43  Oxytocin signaling pathway 
 5 genes, 3 drugs (DrugBank), 8 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] OXTR   D07229   Carbetocin   [1] 193 
 D00089   Oxytocin   [4] 127, 193, 206, 226 
 44  Pancreatic secretion 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 45  PI3K-Akt signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 46  Proximal tubule bicarbonate reclamation 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] CA2, CA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 47  Rap1 signaling pathway 
 1 gene, 2 drugs (DrugBank), 14 diseases shown 		  [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D05731   Rimonabant   [1] 193 
 48  Regulation of lipolysis in adipocytes 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 49  Renin secretion 
 5 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 50  Retrograde endocannabinoid signaling 
 25 genes, 3 drugs (DrugBank), 15 diseases shown 		  [24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D05731   Rimonabant   [1] 193 
 51  Salivary secretion 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 52  Serotonergic synapse 
 7 genes, 1 drug (DrugBank), 5 diseases shown 		  [7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 53  Steroid hormone biosynthesis 
 2 genes, 2 drugs (DrugBank), 4 diseases shown 		  [1] CYP11B1   D00410   Metyrapone   [2] 75, 193 
 D05019 
 [1] CYP19A1   D00960   Anastrozole   [3] 78, 86, 193 
 54  Taste transduction 
 10 genes, 1 drug (DrugBank), 5 diseases shown 		  [10] CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 55  Thermogenesis 
 1 gene, 2 drugs (DrugBank), 14 diseases shown 		  [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D05731   Rimonabant   [1] 193 
 56  Tight junction 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CACNA1D   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 57  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] GRIA3   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 58  Type II diabetes mellitus 
 4 genes, 2 drugs (DrugBank), 5 diseases shown 		  [2] ABCC8, KCNJ11   D00294   Diazoxide   [1] 193 
 [2] CACNA1C, CACNA1D   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 59  Vascular smooth muscle contraction 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 

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