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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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61 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adipocytokine signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 2  Aldosterone-regulated sodium reabsorption 
 4 genes, 2 drugs (DrugBank), 8 diseases shown 		  [1] NR3C2   D00443   Spironolactone   [6] 58, 67, 86, 113, 218, 225 
 [3] SCNN1A, SCNN1B, SCNN1G   D00649   Amiloride   [3] 13, 225, 299 
 D07447 
 3  AMPK signaling pathway 
 3 genes, 2 drugs (DrugBank), 28 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 4  Apelin signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 5  Arachidonic acid metabolism 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] PTGS1, PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 6  Autophagy - animal 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 7  Bile secretion 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [1] CA2   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 8  C-type lectin receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 9  cGMP-PKG signaling pathway 
 4 genes, 2 drugs (DrugBank), 18 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 10  Chemical carcinogenesis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 11  Circadian entrainment 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 12  Circadian rhythm 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 13  Collecting duct acid secretion 
 3 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 [1] CA2   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 14  Complement and coagulation cascades 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] F8   D00291   Desmopressin   [6] 6, 64, 72, 75, 225, 288 
 D02235 
 15  Fluid shear stress and atherosclerosis 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 16  FoxO signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 17  Gap junction 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 18  Gastric acid secretion 
 3 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 [1] CA2   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 19  Glucagon signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 20  Human cytomegalovirus infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 21  Human papillomavirus infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 22  Hypertrophic cardiomyopathy (HCM) 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 23  IL-17 signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 24  Insulin resistance 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 25  Insulin signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 26  Kaposi sarcoma-associated herpesvirus infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 27  Leishmaniasis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 28  Long-term depression 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 29  Longevity regulating pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 30  Longevity regulating pathway - multiple species 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 31  Metabolic pathways 
 22 genes, 6 drugs (DrugBank), 37 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 [13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 [2] PTGS1, PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 32  MicroRNAs in cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 33  mTOR signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 34  Neuroactive ligand-receptor interaction 
 1 gene, 2 drugs (DrugBank), 7 diseases shown 		  [1] AVPR2   D00291   Desmopressin   [6] 6, 64, 72, 75, 225, 288 
 D02235 
 D01213   Tolvaptan   [3] 67, 72, 225 
 35  NF-kappa B signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 36  Nitrogen metabolism 
 13 genes, 1 drug (DrugBank), 6 diseases shown 		  [13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 37  Non-alcoholic fatty liver disease (NAFLD) 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 38  Ovarian steroidogenesis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 39  Oxidative phosphorylation 
 2 genes, 1 drug (DrugBank), 15 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 40  Oxytocin signaling pathway 
 6 genes, 3 drugs (DrugBank), 21 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 41  Pancreatic secretion 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] CA2   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 42  Pathways in cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 43  Phospholipase D signaling pathway 
 1 gene, 2 drugs (DrugBank), 7 diseases shown 		  [1] AVPR2   D00291   Desmopressin   [6] 6, 64, 72, 75, 225, 288 
 D02235 
 D01213   Tolvaptan   [3] 67, 72, 225 
 44  PI3K-Akt signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 45  Platelet activation 
 4 genes, 2 drugs (DrugBank), 7 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [1] PTGS1   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 46  Proximal tubule bicarbonate reclamation 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] CA2, CA4   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 47  Purine metabolism 
 4 genes, 2 drugs (DrugBank), 18 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 48  Regulation of lipolysis in adipocytes 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] PTGS1, PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 49  Renin secretion 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 50  Retrograde endocannabinoid signaling 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 51  Salivary secretion 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 52  Serotonergic synapse 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] PTGS1, PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 53  Small cell lung cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 54  Taste transduction 
 3 genes, 1 drug (DrugBank), 3 diseases shown 		  [3] SCNN1A, SCNN1B, SCNN1G   D00649   Amiloride   [3] 13, 225, 299 
 D07447 
 55  Terpenoid backbone biosynthesis 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 56  Thermogenesis 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 57  Tight junction 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 58  TNF signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 
 59  Vascular smooth muscle contraction 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 60  Vasopressin-regulated water reabsorption 
 1 gene, 2 drugs (DrugBank), 7 diseases shown 		  [1] AVPR2   D00291   Desmopressin   [6] 6, 64, 72, 75, 225, 288 
 D02235 
 D01213   Tolvaptan   [3] 67, 72, 225 
 61  VEGF signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00141   Indometacin   [2] 225, 271 
 D01565 
 D02110 

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