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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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145 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 2  Adherens junction 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] FGFR1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 3  Adipocytokine signaling pathway 
 3 genes, 4 drugs (DrugBank), 28 diseases shown 		  [1] JAK2   D09959   Ruxolitinib   [1] 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4  Adrenergic signaling in cardiomyocytes 
 1 gene, 2 drugs (DrugBank), 14 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 5  African trypanosomiasis 
 4 genes, 2 drugs (DrugBank), 21 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 6  AGE-RAGE signaling pathway in diabetic complications 
 6 genes, 3 drugs (DrugBank), 21 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK2   D09959   Ruxolitinib   [1] 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 7  Allograft rejection 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 8  Alzheimer disease 
 7 genes, 4 drugs (DrugBank), 61 diseases shown 		  [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 9  Amoebiasis 
 4 genes, 2 drugs (DrugBank), 21 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 10  Amphetamine addiction 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 11  AMPK signaling pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 12  Amyotrophic lateral sclerosis (ALS) 
 6 genes, 4 drugs (DrugBank), 61 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 13  Antifolate resistance 
 3 genes, 2 drugs (DrugBank), 21 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 14  Antigen processing and presentation 
 1 gene, 2 drugs (DrugBank), 21 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 15  Apelin signaling pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 16  Apoptosis 
 1 gene, 2 drugs (DrugBank), 21 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 17  Asthma 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 18  Autoimmune thyroid disease 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL10   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 19  Autophagy - animal 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 20  Autophagy - other 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 21  Axon guidance 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 22  B cell receptor signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 23  Bladder cancer 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] FGFR3   D10481   Nintedanib   [4] 51, 85, 89, 228 
 24  Breast cancer 
 3 genes, 2 drugs (DrugBank), 11 diseases shown 		  [2] FGFR1, FLT4   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 25  C-type lectin receptor signaling pathway 
 9 genes, 4 drugs (DrugBank), 61 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 26  Calcium signaling pathway 
 9 genes, 6 drugs (DrugBank), 62 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] CYSLTR1   D00529   Montelukast   [5] 13, 46, 85, 98, 228 
 D08229 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 27  cAMP signaling pathway 
 1 gene, 2 drugs (DrugBank), 14 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 28  Cellular senescence 
 8 genes, 4 drugs (DrugBank), 62 diseases shown 		  [2] IL1A, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 29  Central carbon metabolism in cancer 
 6 genes, 2 drugs (DrugBank), 11 diseases shown 		  [5] FGFR1, FGFR2, FGFR3, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 30  cGMP-PKG signaling pathway 
 6 genes, 4 drugs (DrugBank), 61 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 31  Chagas disease (American trypanosomiasis) 
 7 genes, 3 drugs (DrugBank), 26 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 32  Chemokine signaling pathway 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] CCL2   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK2   D09959   Ruxolitinib   [1] 228 
 33  Choline metabolism in cancer 
 3 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 34  Cholinergic synapse 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] JAK2   D09959   Ruxolitinib   [1] 228 
 35  Colorectal cancer 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 36  Cytokine-cytokine receptor interaction 
 10 genes, 4 drugs (DrugBank), 29 diseases shown 		  [6] CCL2, IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 37  Cytosolic DNA-sensing pathway 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 38  Dilated cardiomyopathy (DCM) 
 1 gene, 2 drugs (DrugBank), 21 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 39  Dopaminergic synapse 
 3 genes, 2 drugs (DrugBank), 55 diseases shown 		  [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 40  Drug metabolism - other enzymes 
 2 genes, 1 drug (DrugBank), 34 diseases shown 		  [2] IMPDH1, IMPDH2   D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 41  EGFR tyrosine kinase inhibitor resistance 
 9 genes, 5 drugs (DrugBank), 19 diseases shown 		  [5] FGFR2, FGFR3, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 42  Endocrine and other factor-regulated calcium reabsorption 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 43  Endocrine resistance 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 44  Endocytosis 
 4 genes, 2 drugs (DrugBank), 10 diseases shown 		  [3] FGFR2, FGFR3, PDGFRA   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 45  Epstein-Barr virus infection 
 3 genes, 4 drugs (DrugBank), 22 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 D09959   Ruxolitinib   [1] 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 46  ErbB signaling pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 47  Fc epsilon RI signaling pathway 
 1 gene, 2 drugs (DrugBank), 21 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 48  Fluid shear stress and atherosclerosis 
 5 genes, 3 drugs (DrugBank), 22 diseases shown 		  [4] CCL2, IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] KDR   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 49  Focal adhesion 
 5 genes, 1 drug (DrugBank), 4 diseases shown 		  [5] FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 50  FoxO signaling pathway 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 51  Gap junction 
 2 genes, 1 drug (DrugBank), 4 diseases shown 		  [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 52  Gastric cancer 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] FGFR2   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 53  Glioma 
 3 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 54  Glucagon signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 55  Glutamatergic synapse 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 56  Graft-versus-host disease 
 4 genes, 2 drugs (DrugBank), 21 diseases shown 		  [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 57  Growth hormone synthesis, secretion and action 
 2 genes, 2 drugs (DrugBank), 9 diseases shown 		  [1] JAK2   D09959   Ruxolitinib   [1] 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 58  Hematopoietic cell lineage 
 5 genes, 3 drugs (DrugBank), 25 diseases shown 		  [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 59  Hepatitis B 
 4 genes, 4 drugs (DrugBank), 22 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 60  Hepatitis C 
 2 genes, 4 drugs (DrugBank), 22 diseases shown 		  [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 D09959   Ruxolitinib   [1] 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 61  Hepatocellular carcinoma 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 62  Herpes simplex virus 1 infection 
 10 genes, 6 drugs (DrugBank), 34 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 63  HIF-1 signaling pathway 
 5 genes, 4 drugs (DrugBank), 22 diseases shown 		  [1] FLT1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 64  Human cytomegalovirus infection 
 12 genes, 8 drugs (DrugBank), 66 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 D09959   Ruxolitinib   [1] 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [1] PDGFRA   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 65  Human immunodeficiency virus 1 infection 
 7 genes, 5 drugs (DrugBank), 66 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 66  Human papillomavirus infection 
 4 genes, 6 drugs (DrugBank), 29 diseases shown 		  [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 D09959   Ruxolitinib   [1] 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [1] PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 67  Human T-cell leukemia virus 1 infection 
 10 genes, 7 drugs (DrugBank), 61 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 D09959   Ruxolitinib   [1] 228 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 68  Hypertrophic cardiomyopathy (HCM) 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 69  IL-17 signaling pathway 
 4 genes, 2 drugs (DrugBank), 21 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 70  Inflammatory bowel disease (IBD) 
 7 genes, 3 drugs (DrugBank), 26 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 71  Inflammatory mediator regulation of TRP channels 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL1B   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 72  Influenza A 
 9 genes, 5 drugs (DrugBank), 27 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 73  Insulin resistance 
 3 genes, 3 drugs (DrugBank), 28 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 74  Insulin signaling pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 75  Intestinal immune network for IgA production 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 76  JAK-STAT signaling pathway 
 10 genes, 7 drugs (DrugBank), 26 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 77  Kaposi sarcoma-associated herpesvirus infection 
 10 genes, 7 drugs (DrugBank), 63 diseases shown 		  [1] IFNGR1   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 78  Legionellosis 
 3 genes, 2 drugs (DrugBank), 21 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 79  Leishmaniasis 
 8 genes, 5 drugs (DrugBank), 27 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [4] IL10, IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 80  Long-term potentiation 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 81  Longevity regulating pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 82  Longevity regulating pathway - multiple species 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 83  Malaria 
 5 genes, 2 drugs (DrugBank), 21 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 84  MAPK signaling pathway 
 16 genes, 5 drugs (DrugBank), 62 diseases shown 		  [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 85  Measles 
 5 genes, 4 drugs (DrugBank), 15 diseases shown 		  [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 D09959   Ruxolitinib   [1] 228 
 86  Melanoma 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] FGFR1, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 87  Metabolic pathways 
 2 genes, 1 drug (DrugBank), 34 diseases shown 		  [2] IMPDH1, IMPDH2   D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 88  MicroRNAs in cancer 
 4 genes, 2 drugs (DrugBank), 11 diseases shown 		  [3] FGFR3, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 89  Mineral absorption 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 90  mTOR signaling pathway 
 2 genes, 3 drugs (DrugBank), 28 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 91  Natural killer cell mediated cytotoxicity 
 8 genes, 5 drugs (DrugBank), 62 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 92  Necroptosis 
 7 genes, 5 drugs (DrugBank), 27 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 93  Neuroactive ligand-receptor interaction 
 3 genes, 7 drugs (DrugBank), 53 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] CYSLTR1   D00529   Montelukast   [5] 13, 46, 85, 98, 228 
 D08229 
 [1] NR3C1   D00246   Budesonide   [10] 66, 85, 93, 94, 95, 96, 97, 98, 228, 299 
 D07981   Fluticasone   [4] 98, 228, 299, 306 
 D01708   Fluticasone propionate   [4] 98, 228, 299, 306 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 94  NF-kappa B signaling pathway 
 3 genes, 2 drugs (DrugBank), 21 diseases shown 		  [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 95  NOD-like receptor signaling pathway 
 5 genes, 4 drugs (DrugBank), 22 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 D09959   Ruxolitinib   [1] 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 96  Non-alcoholic fatty liver disease (NAFLD) 
 4 genes, 2 drugs (DrugBank), 21 diseases shown 		  [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 97  Oocyte meiosis 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 98  Osteoclast differentiation 
 11 genes, 7 drugs (DrugBank), 62 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 D09959   Ruxolitinib   [1] 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 99  Oxytocin signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 100  Pancreatic cancer 
 2 genes, 3 drugs (DrugBank), 12 diseases shown 		  [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 D09959   Ruxolitinib   [1] 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 101  Parathyroid hormone synthesis, secretion and action 
 2 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] FGFR1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 102  Pathogenic Escherichia coli infection 
 3 genes, 2 drugs (DrugBank), 21 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 103  Pathways in cancer 
 13 genes, 7 drugs (DrugBank), 26 diseases shown 		  [6] FGFR1, FGFR2, FGFR3, FLT4, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 104  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 10 genes, 6 drugs (DrugBank), 62 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 105  Pertussis 
 5 genes, 2 drugs (DrugBank), 21 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 106  Phospholipase D signaling pathway 
 3 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 107  PI3K-Akt signaling pathway 
 13 genes, 6 drugs (DrugBank), 22 diseases shown 		  [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 108  Prion diseases 
 3 genes, 1 drug (DrugBank), 10 diseases shown 		  [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 109  Prolactin signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] JAK2   D09959   Ruxolitinib   [1] 228 
 110  Prostate cancer 
 5 genes, 2 drugs (DrugBank), 11 diseases shown 		  [4] FGFR1, FGFR2, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 111  Proteasome 
 1 gene, 1 drug (DrugBank), 13 diseases shown 		  [1] PSMB5   D03150   Bortezomib   [13] 11, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 288, 331 
 112  Proteoglycans in cancer 
 4 genes, 4 drugs (DrugBank), 28 diseases shown 		  [2] FGFR1, KDR   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 113  Purine metabolism 
 2 genes, 1 drug (DrugBank), 34 diseases shown 		  [2] IMPDH1, IMPDH2   D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 114  Rap1 signaling pathway 
 8 genes, 1 drug (DrugBank), 4 diseases shown 		  [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 115  Ras signaling pathway 
 8 genes, 1 drug (DrugBank), 4 diseases shown 		  [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 116  Regulation of actin cytoskeleton 
 5 genes, 1 drug (DrugBank), 4 diseases shown 		  [5] FGFR1, FGFR2, FGFR3, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 117  Regulation of lipolysis in adipocytes 
 1 gene, 2 drugs (DrugBank), 14 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 118  Renin secretion 
 6 genes, 4 drugs (DrugBank), 61 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 119  Rheumatoid arthritis 
 6 genes, 3 drugs (DrugBank), 22 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] FLT1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 120  RIG-I-like receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 21 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 121  Salivary secretion 
 1 gene, 2 drugs (DrugBank), 14 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 122  Salmonella infection 
 5 genes, 2 drugs (DrugBank), 15 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 123  Shigellosis 
 3 genes, 3 drugs (DrugBank), 28 diseases shown 		  [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 124  Signaling pathways regulating pluripotency of stem cells 
 5 genes, 3 drugs (DrugBank), 7 diseases shown 		  [3] FGFR1, FGFR2, FGFR3   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 125  Sphingolipid signaling pathway 
 1 gene, 2 drugs (DrugBank), 21 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 126  Staphylococcus aureus infection 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL10   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 127  Systemic lupus erythematosus 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 128  T cell receptor signaling pathway 
 7 genes, 4 drugs (DrugBank), 61 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 129  TGF-beta signaling pathway 
 1 gene, 2 drugs (DrugBank), 21 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 130  Th1 and Th2 cell differentiation 
 10 genes, 6 drugs (DrugBank), 56 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 131  Th17 cell differentiation 
 13 genes, 8 drugs (DrugBank), 63 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 132  Thermogenesis 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] FGFR1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 133  Thyroid hormone signaling pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 134  TNF signaling pathway 
 5 genes, 2 drugs (DrugBank), 21 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 135  Toll-like receptor signaling pathway 
 3 genes, 2 drugs (DrugBank), 21 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 136  Toxoplasmosis 
 6 genes, 5 drugs (DrugBank), 27 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 137  Transcriptional misregulation in cancer 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] FLT1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 138  Tuberculosis 
 15 genes, 8 drugs (DrugBank), 63 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 [2] JAK1, JAK2   D09959   Ruxolitinib   [1] 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 139  Type I diabetes mellitus 
 4 genes, 2 drugs (DrugBank), 21 diseases shown 		  [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 140  Type II diabetes mellitus 
 2 genes, 3 drugs (DrugBank), 28 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 141  VEGF signaling pathway 
 6 genes, 3 drugs (DrugBank), 56 diseases shown 		  [1] KDR   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 142  Viral carcinogenesis 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] JAK1   D10944   Itacitinib   [4] 46, 60, 97, 228 
 D09959   Ruxolitinib   [1] 228 
 143  Viral protein interaction with cytokine and cytokine receptor 
 6 genes, 3 drugs (DrugBank), 25 diseases shown 		  [4] CCL2, IL10, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 144  Wnt signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 145  Yersinia infection 
 5 genes, 2 drugs (DrugBank), 21 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 

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