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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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52 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  African trypanosomiasis 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 2  AGE-RAGE signaling pathway in diabetic complications 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 3  Alzheimer disease 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 4  Amoebiasis 
 3 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 5  Antifolate resistance 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 6  C-type lectin receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 7  Cellular senescence 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] IL1A   D06635   Rilonacept   [4] 51, 106, 107, 266 
 8  Chagas disease (American trypanosomiasis) 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 9  Cytokine-cytokine receptor interaction 
 5 genes, 4 drugs (DrugBank), 28 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 10  Cytosolic DNA-sensing pathway 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 11  EGFR tyrosine kinase inhibitor resistance 
 1 gene, 1 drug (DrugBank), 16 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 12  Fluid shear stress and atherosclerosis 
 4 genes, 3 drugs (DrugBank), 21 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 13  Gap junction 
 9 genes, 1 drug (DrugBank), 5 diseases shown 		  [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D00570   Colchicine   [5] 2, 42, 56, 93, 266 
 14  Graft-versus-host disease 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 15  Hematopoietic cell lineage 
 5 genes, 4 drugs (DrugBank), 28 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 16  Herpes simplex virus 1 infection 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 17  HIF-1 signaling pathway 
 1 gene, 1 drug (DrugBank), 16 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 18  Human cytomegalovirus infection 
 3 genes, 4 drugs (DrugBank), 28 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 19  Human T-cell leukemia virus 1 infection 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 20  IL-17 signaling pathway 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 21  Inflammatory bowel disease (IBD) 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 22  Inflammatory mediator regulation of TRP channels 
 2 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 23  Influenza A 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 24  JAK-STAT signaling pathway 
 1 gene, 1 drug (DrugBank), 16 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 25  Legionellosis 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 26  Leishmaniasis 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 27  Malaria 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 28  MAPK signaling pathway 
 3 genes, 3 drugs (DrugBank), 21 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 29  Measles 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 30  Necroptosis 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 31  NF-kappa B signaling pathway 
 2 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 32  NOD-like receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 33  Non-alcoholic fatty liver disease (NAFLD) 
 3 genes, 3 drugs (DrugBank), 22 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 34  Osteoclast differentiation 
 3 genes, 3 drugs (DrugBank), 21 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 35  Pathogenic Escherichia coli infection 
 11 genes, 4 drugs (DrugBank), 23 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D00570   Colchicine   [5] 2, 42, 56, 93, 266 
 36  Pathways in cancer 
 1 gene, 1 drug (DrugBank), 16 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 37  Pertussis 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 38  Phagosome 
 9 genes, 1 drug (DrugBank), 5 diseases shown 		  [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D00570   Colchicine   [5] 2, 42, 56, 93, 266 
 39  PI3K-Akt signaling pathway 
 1 gene, 1 drug (DrugBank), 16 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 40  Prion diseases 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 41  Prostate cancer 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 42  Rheumatoid arthritis 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 43  Salmonella infection 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 44  Shigellosis 
 2 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 45  Th17 cell differentiation 
 3 genes, 4 drugs (DrugBank), 28 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 46  TNF signaling pathway 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 47  Toll-like receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 48  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 49  Tuberculosis 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 50  Type I diabetes mellitus 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 51  Viral protein interaction with cytokine and cytokine receptor 
 1 gene, 1 drug (DrugBank), 16 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 52  Yersinia infection 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D06635   Rilonacept   [4] 51, 106, 107, 266 

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